Extra Strength Hair Skin & Nails

Extra Strength Hair Skin & Nails

21st Century4.6 (39,016 ratings)
Format:Tablet Quantity: 90 Tablet(s) · 30 servings
Goals
$9.99 $0.33 per serving

Product analysis

58 out of 100

Extra Strength Hair Skin & Nails may help brittle nails, though the evidence for biotin is limited.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality51

Biotin and the collagen use favorable identified forms, while several minerals are also clearly specified. Comparative quality remains uncertain for many accompanying nutrients, and the calcium proportions are undisclosed.

Ingredient Transparency73

All declared amounts and most forms are disclosed, making servings easier to compare. Some forms and the proportions of the calcium blend remain unspecified.

Value For Money43

Biotin offers reasonable value, and some minerals compare favorably at the serving price. The collagen amount is very costly, while value for many other components remains uncertain.

Customer Satisfaction89

Customer ratings are generally positive. A large review base gives that feedback broad support.

Product Focus40

Biotin has limited brittle-nail support, while skin and hair benefits are clearest when intake is low. The small collagen serving is not identified as a tested skin preparation, limiting expectations for skin improvement.

Format
Tablet
Container
90 Tablet(s)
Per serving
$0.33
Customer rating
4.6 · 39,016 ratings
Report analysis

Goals

Impact
High effect
C- Ingredient FitB- PathwaysA+ EvidenceA+ Formulation Logic
Collagen · 50 mgBiotin · 5000 mcgHorsetail · 3 mg
Study evidence
Biotin Supportive 8 studies
Calcium Supportive 1 study
Collagen Supportive 4 studies
Horsetail Not classified

No linked studies yet.

Magnesium Not classified

No linked studies yet.

Vitamin C Supportive 1 study
Vitamin D Supportive 8 studies
Vitamin E Supportive 6 studies
Zinc No effect 1 study
Impact
Moderate effect
C- Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 5000 mcgVitamin D · 25 mcgZinc · 7.5 mgVitamin C · 60 mgCollagen · 50 mg
Study evidence
Biotin Supportive 4 studies
Collagen Supportive 3 studies
Folate Mixed 15 studies
Horsetail Not classified

No linked studies yet.

Niacin Disputed 2 studies
Vitamin A Disputed 13 studies
Vitamin D Disputed 34 studies
Vitamin E No effect 3 studies
Zinc Supportive 22 studies
Impact
Moderate effect
D+ Ingredient FitD- PathwaysB+ EvidenceA+ Formulation Logic
Zinc · 7.5 mgVitamin C · 60 mgCollagen · 50 mgVitamin E · 6.75 mg
Study evidence
Biotin Supportive 10 studies
Collagen Supportive 62 studies
Niacin Supportive 61 studies
Vitamin A Supportive 106 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 38 studies
Zinc Supportive 66 studies

Ingredients

IngredientAmount per servingScore
Vitamin A (Retinyl Palmitate)
1500 mcg
Vitamin C (Ascorbic Acid)
60 mg
Vitamin D3 (Cholecalciferol)
25 mcg
Vitamin E (DL-Alpha-Tocopheryl Acetate)
6.75 mg
Thiamine (Thiamine Hydrochloride)
5 mg
Riboflavin
2 mg
Niacin (Niacinamide)
25 mg 71
Vitamin B6 (Pyridoxine Hydrochloride)
5 mg
Folate
334 mcg DFE
Vitamin B12 (Cyanocobalamin)
8 mcg
Biotin (D-Biotin)
5000 mcg 89
Pantothenic Acid (D-Calcium Pantothenate)
15 mg
Choline (Choline Bitartrate)
10 mg 44
Calcium (Calcium Carbonate, Dicalcium Phosphate)
372 mg 59
Phosphorus (Dicalcium Phosphate)
180 mg 92
Magnesium (Magnesium Oxide)
50 mg
Zinc (Zinc Gluconate)
7.5 mg
Manganese (Manganese Gluconate)
2 mg 82
PABA
10 mg 60
Inositol
30 mg
Citrus Bioflavonoid / Rutin Complex
38 mg
Horsetail powder
3 mg
Collagen (hydrolyzed Gelatin)
50 mg 29
Gluten Free Adults 18–50
Report overview
B Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
Each serving provides 180 mg of phosphorus at a low cost per serving. The phosphorus comes as Dicalcium Phosphate.
How this ingredient is rated

Active Ingredient Quality & Bioavailability79

The phosphorus comes as Dicalcium Phosphate.
Phosphorus Form Quality
The phosphorus comes as Dicalcium Phosphate.
Form Disclosure Clarity
Dicalcium Phosphate is named in the supplement facts.

Dose, Safety & Label Transparency100

Each serving provides 180 mg of phosphorus. The phosphorus amount is individually listed.
Dose Adequacy and Safety
Each serving provides 180 mg of phosphorus.
Elemental Dose Transparency
The phosphorus amount is individually listed.

Value100

The cost per serving is low.
Price Per Serving Efficiency
The cost per serving is low.
A Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC Value
5,000 mcg of biotin per serving is clearly stated; the package cost also covers other vitamins and minerals, so it cannot be attributed to biotin alone. It lists D-biotin, the naturally occurring active form. It contains an artificial color.
How this ingredient is rated

Active Ingredient Quality & Bioavailability92

It lists D-biotin, the naturally occurring active form. It contains an artificial color.
Biologically Active d-Biotin Isomer
It lists D-biotin, the naturally occurring active form.
Excipient Purity
It contains an artificial color.

Dose, Safety & Label Transparency100

The serving provides 5,000 mcg of biotin. The amount is clearly listed.
Biotin Potency for Health Goals
The serving provides 5,000 mcg of biotin.
Label Transparency & Exact Disclosure
The label clearly lists 5,000 mcg of biotin per serving.

Value60

The package cost also covers other vitamins and minerals, so it cannot be attributed to biotin alone.
Price per 5,000 mcg Biotin
The package cost also covers other vitamins and minerals, so it cannot be attributed to biotin alone.
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyB+ Value
Each serving provides 2 mg of manganese at a moderate cost per serving. The source is Manganese Gluconate.
How this ingredient is rated

Active Ingredient Quality & Bioavailability80

The manganese comes from Manganese Gluconate.
Manganese Chemical Form
The stated source is Manganese Gluconate.

Dose, Safety & Label Transparency86

The serving provides 2 mg of manganese. Both the amount and source are stated.
Manganese Dosage Efficacy & Safety
A serving contains 2 mg of manganese.
Elemental Weight Disclosure
The label states the manganese amount and source.

Value80

The cost per serving is moderate.
Price per Serving vs. Median
The cost per serving is moderate.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health Nail Health Skin Health forBiotin
  2. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health Skin Health forBiotin
  3. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  4. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  5. Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diameter: A Clinical Study with Pharmacokinetic Evaluation.
    Hwang S; Won J; Kim S; Kang W; Park M · Journal of medicinal food · 2026
    Randomized trial114 participantsHair Health forCollagen
  6. Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women-A Randomized Controlled Study.
    Duangjai A; Srivilai J; Nangola S; Amornlerdpison D · Clinics and practice · 2025
    Randomized trialHair Health forCollagen
  7. Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.
    Biełach-Bazyluk A; Jurga M; Flisiak I; Zbroch E · Nutrients · 2026
    Narrative reviewHair Health forCollagen
  8. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  9. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  10. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  11. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  12. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  13. A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia.
    Draelos ZD; Jacobson EL; Kim H; Kim M; Jacobson MK · Journal of cosmetic dermatology · 2009
    Randomized trial60 participantsHair Health forNiacin
  14. Topical adenosine increases thick hair ratio in Japanese men with androgenetic alopecia.
    Watanabe Y; Nagashima T; Hanzawa N; Ishino A; Nakazawa Y; Ogo M; Iwabuchi T; Tajima M · International journal of cosmetic science · 2016
    Randomized trial102 participantsHair Health forNiacin
  15. Topical tretinoin for hair growth promotion.
    Bazzano GS; Terezakis N; Galen W · Journal of the American Academy of Dermatology · 1986
    Non-randomized trial56 participantsHair Health forVitamin A
  16. A review of isotretinoin in the treatment of frontal fibrosing alopecia.
    Shahpar A; Nezhad NZ; Sahaf AS; Ahramiyanpour N · Journal of cosmetic dermatology · 2024
    Systematic review232 participants15 studies pooledHair Health forVitamin A
  17. Efficacy of Isotretinoin and Acitretin in Treatment of Frontal Fibrosing Alopecia: Retrospective Analysis of 54 Cases.
    Rakowska A; Gradzińska A; Olszewska M; Rudnicka L · Journal of drugs in dermatology : JDD · 2018
    Cohort study54 participantsHair Health forVitamin A
  18. Systemic Treatments for Lichen Planopilaris and Frontal Fibrosing Alopecia: A Retrospective Study of 315 Patients.
    Willaert M; Van Dongen T; Dikrama P; Nijsten T; Hijnen D; Waalboer-Spuij R · Acta dermato-venereologica · 2025
    Cohort study315 participantsHair Health forVitamin A
  19. Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes.
    Sharma A; Goren A; Dhurat R; Agrawal S; Sinclair R; Trüeb RM; Vañó-Galván S; Chen G; Tan Y; Kovacevic M; Situm M; McCoy J · Dermatologic therapy · 2020
    Single-arm trialHair Health forVitamin A
  20. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12