Magnesium 500 mg

Magnesium 500 mg

Nature's Life4.8 (26,261 ratings)
Format:Capsule Quantity: 250 Capsule(s) · 250 servings
Goals

Product analysis

62 out of 100

Magnesium 500 mg pairs magnesium with vitamin B6 in a relatively focused formula. The magnesium mixture includes forms of different quality without disclosing their proportions, making its likely absorption harder to judge.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality38

The magnesium mixture combines more favorable forms with magnesium oxide, a less favorable form. Unknown proportions prevent a confident picture of the blend’s quality.

Ingredient Transparency80

Amounts and forms are disclosed clearly. The missing proportions of the magnesium forms still limit a meaningful comparison of the mixture.

Value For Money47

The magnesium mixture offers middling value in the available comparison. Vitamin B6 value remains uncertain.

Customer Satisfaction94

Customer feedback is very positive across a large review base. Satisfaction alone does not establish absorption or effectiveness.

Product Focus72

The two-ingredient formula appears well aligned with its intended uses. Its broad range of goals makes the claimed purpose less concentrated.

Format
Capsule
Container
250 Capsule(s)
Per serving
$0.11
Customer rating
4.8 · 26,261 ratings
Report analysis

Goals

Energy
Impact
High effect
A Ingredient FitF PathwaysA- EvidenceA+ Formulation Logic
Magnesium · 500 mg
Study evidence
Magnesium Supportive 4 studies
Everyday Health
Impact
Highest effect
A Ingredient FitA+ PathwaysA- EvidenceA+ Formulation Logic
Magnesium · 500 mg
Study evidence
Magnesium Supportive 114 studies
Stress Relief
Impact
High effect
A Ingredient FitD PathwaysB EvidenceA+ Formulation Logic
Magnesium · 500 mgVitamin B6 · 5 mg
Study evidence
Magnesium Supportive 13 studies
Heart Health
Impact
High effect
B Ingredient FitC- PathwaysA- EvidenceA+ Formulation Logic
Magnesium · 500 mgVitamin B6 · 5 mg
Study evidence
Magnesium Supportive 158 studies
Vitamin B6 Supportive 44 studies
Cardiovascular Support
Impact
High effect
B Ingredient FitD+ PathwaysB EvidenceA+ Formulation Logic
Magnesium · 500 mgVitamin B6 · 5 mg
Study evidence
Magnesium Supportive 123 studies
Vitamin B6 Supportive 35 studies
Gut Health
Impact
Moderate effect
B Ingredient FitD- PathwaysF EvidenceA+ Formulation Logic
Magnesium · 500 mg
Study evidence
Magnesium Supportive 50 studies

Ingredients

IngredientAmount per servingScore
Vitamin B6 (Pyridoxine Hydrochloride)
5 mg
Magnesium (Magnesium Citrate, Magnesium Malate, Magnesium Oxide)
500 mg 56
Adults 18–50
Report overview
F Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD+ Value
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  2. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  3. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  4. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  5. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  6. The Effects of the AGE Inhibitor Pyridoxamine on Bone in Older Women With Type 2 Diabetes: A Randomized Clinical Trial.
    Brossfield AV; McMahon DJ; Fernando J; Omeragic B; Majeed R; Agarwal S; Sroga GE; Wang B; Vashishth D; Rubin MR · The Journal of clinical endocrinology and metabolism · 2025
    Randomized trial55 participantsBone Health forVitamin B6
  7. Dietary B vitamin intake and risk of hip fracture: the Singapore Chinese Health Study.
    Dai Z; Wang R; Ang LW; Yuan JM; Koh WP · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Cohort study63,257 participantsBone Health forVitamin B6
  8. Hip fracture patients may be vitamin B6 deficient. Controlled study of serum pyridoxal-5'-phosphate.
    Reynolds TM; Marshall PD; Brain AM · Acta orthopaedica Scandinavica · 1993
    Case-control study103 participantsBone Health forVitamin B6
  9. Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls.
    Saito M; Fujii K; Marumo K · Calcified tissue international · 2006
    Case-control study50 participantsBone Health forVitamin B6
  10. Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health.
    Rondanelli M; Tartara A; Fossari F; Vecchio V; Faliva MA; Naso M; Perna S; Nichetti M; Peroni G · Current aging science · 2022
    Narrative review35,298 participants29 studies pooledBone Health forVitamin B6
  11. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  12. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  13. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  14. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  15. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  16. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  17. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  18. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  19. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  20. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6