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GABA Calm Orange Flavor

Source Naturals Serene Science
4.5
★ ★ ★ ★ ★
(3158 ratings)
GABA 125 mg
Glycine 50 mg
Product Image
Score76
Low-cost lozenge delivery makes modest-dose GABA convenient. Token supporting amounts and tyrosine reduce its nighttime depth.
How scoring works
Quantity:120 Liquid(s) • (120 servings)
Goals:
Stress Relief
Mood Support
Sleep Support

Score 76

Low-cost lozenge delivery makes modest-dose GABA convenient. Token supporting amounts and tyrosine reduce its nighttime depth.
How scoring works

Also available as

1 option
Original GABA 125 mg, Glycine 50 mg • 120 Liquid(s) • 120 servings $14.26 ($0.11 per serving)
$18.88($0.15 per serving)
Walmart
$ 19.25
Pure Formulas
$ 19.25
Amazon
$ 18.88
Vitacost
$ 19.25
iHerb
$ 19.25
Report prices

Analysis

GABA at 125 mg is a useful blend-level amount in a dissolving lozenge. The 120-serving package supports low-cost occasional or regular use.

Glycine at 50 mg, taurine at 20 mg, and magnesium at 5 mg are far below focused doses. N-acetyl tyrosine at 25 mg may be activating and does not fit a uniformly calming design.

Every active amount is disclosed and the format is convenient. The formula's practical value depends almost entirely on GABA rather than the broad-looking companion list.

Who is it for
  • Adults wanting an orange GABA lozenge
  • People seeking occasional calm
  • Users prioritizing low cost
Best for
  • Portable GABA use
  • Occasional relaxation
  • Low-dose calming support

Pros

  • Provides 125 mg GABA
  • Offers 120 servings
  • Convenient lozenge
  • Low serving cost

Cons

  • Glycine amount is minimal
  • Magnesium and taurine are token doses
  • Tyrosine may be activating
  • GABA source is unbranded

Warnings

  • GABA may cause drowsiness
  • Alcohol and sedatives may increase drowsiness
  • Tyrosine can interact with MAO inhibitors or thyroid medicines

Nutrient quality

75 High impact

A chelated magnesium form is named, while the amino acids use conventional forms without premium sourcing. GABA is useful for a calming blend, but glycine, tyrosine, taurine, and magnesium are very small.

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Ingredient transparency

79 High impact

Active amounts are stated and no proprietary blend hides a core dose. Missing excipient details and complete use directions leave the supplied label information incomplete.

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Customer satisfaction

66 High impact

The supplied aggregate satisfaction average provides a broad signal, while the response volume determines how stable it appears. No comment-level evidence is available to assess repeated complaints or confirm intended-use experiences.

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Value for money

85 Highest impact

Useful active delivery supports favorable serving value. Several token supporting amounts add limited value beside GABA.

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Report analysis

Goals

Stress Relief
Stress Relief
Impact
High effect
C+ Goal FitB- Strength of SupportB- CoverageC Formula Quality
Magnesium · 5 mgGlycine · 50 mgGABA · 125 mg

GABA provides a direct inhibitory-signaling concept, with glycine, taurine, and magnesium adding small calming roles. The lozenge may suit occasional tension, though oral GABA evidence remains uncertain.

The 125 mg GABA amount is useful for a blend, while other actives are token doses. N-acetyl tyrosine has a more activating purpose and slightly weakens the calming logic.

Study evidence
GABA Supportive 6 studies
Glycine Supportive 1 study
Magnesium Supportive 13 studies
Taurine Supportive 5 studies
Mood Support
Mood Support
Impact
Moderate effect
D Goal FitC Strength of SupportD CoverageC+ Formula Quality
Magnesium · 5 mg

The lozenge combines several calming ingredients, but oral GABA has limited access to the brain. Glycine, magnesium, tyrosine, and taurine are present only in small supporting amounts.

The exact active amounts are disclosed and the lozenge offers a practical delivery format. The broad-looking blend is less convincing than its ingredient count suggests because most secondary actives are lightly dosed.

Study evidence
GABA Supportive 12 studies
Glycine Mixed 3 studies
Magnesium Supportive 60 studies
Sleep Support
Sleep Support
Impact
Moderate effect
C Goal FitD+ Strength of SupportD+ CoverageD Formula Quality
Magnesium · 5 mgGlycine · 50 mg

GABA provides the main calming contribution, while glycine, taurine, and magnesium add related sleep pathways. The lozenge clearly discloses each amount and may be convenient near bedtime.

Glycine, taurine, and magnesium are far below commonly useful standalone amounts, while N-acetyl tyrosine is more often used for alertness. The broad label therefore offers little functional depth beyond GABA.

Study evidence
GABA Supportive 4 studies
Glycine Supportive 3 studies
Magnesium Supportive 23 studies
Taurine Not classified

No linked studies yet.

Ingredients

IngredientAmount per serving
Magnesium (Magnesium Chelate)
 5 mg
GABA
125 mg
Glycine
50 mg
N-Acetyl L-Tyrosine
25 mg
Taurine
20 mg
Adults 18–50
Report overview
GABA · 125 mg OverallScore83
B+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyA- Value
The lozenge format supports convenient mouth dissolution and may aid delivery, while the GABA itself is a standard unbranded form. Its clearly stated dose is appropriate for a calming combination rather than a high-dose standalone product. A low serving cost supports good value despite incomplete excipient details.
View ingredientView products
Glycine · 50 mg OverallScore52
F Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyB- Value

The lozenge clearly discloses glycine, but no source or purity standard is provided. The 50 mg amount is only a supporting dose within a broader calming blend led by GABA. Value depends on wanting the complete blend because it is inefficient as a dedicated glycine source.

View ingredientView products
Loading alternative details
85 Performance

Pharma GABA 250 mg

Natural Factors Stress-Relax
Pharma GABA supplies a clearly named 200 to 250 mg form in a focused calming formula. Its formulation quality and curcumin focus compare favorably with the original, although the formula does not retain the original product’s glycine component.
83 Performance

GABA 500 mg

Swanson
A focused 500 mg GABA serving provides a clearly disclosed and practical amount of the main calming ingredient. Its formulation quality and curcumin focus compare favorably with the original, although the formula does not retain the original product’s glycine component.
83 Performance

GABA 750 mg

NOW
A focused 750 mg GABA serving provides substantially more of the main calming ingredient than the original. Its formulation quality and curcumin focus compare favorably with the original, although the formula does not retain the original product’s glycine component.
84 Budget

GABA

NOW
A focused 500 mg GABA serving provides a clearly disclosed and practical amount of the main calming ingredient. A lower serving cost improves everyday value, although the formula does not retain the original product’s glycine component.
81 Budget

GABA Powder

Source Naturals Serene Science
A focused 750 mg GABA serving provides substantially more of the main calming ingredient than the original. A lower serving cost improves everyday value, although the formula does not retain the original product’s glycine component.
83 Budget

GABA 500 mg

Nutricost
Curcumin remains the main active, but the supplied label does not clearly state its active curcuminoid yield. A lower serving cost improves everyday value, although some active-form details remain incomplete.
84 Value

GABA 500 mg

NOW
A focused 500 mg GABA serving provides a clearly disclosed and practical amount of the main calming ingredient. Useful formulation quality and efficient serving economics create a favorable quality-to-cost balance, although the formula does not retain the original product’s glycine component.
81 Value

GABA 750 mg

Source Naturals Serene Science
A focused 750 mg GABA serving provides substantially more of the main calming ingredient than the original. Useful formulation quality and efficient serving economics create a favorable quality-to-cost balance, although the formula does not retain the original product’s glycine component.
82 Value

GABA 750 mg

AN Amazing Nutrition Amazing Formulas
A focused 750 mg GABA serving provides substantially more of the main calming ingredient than the original. Useful formulation quality and efficient serving economics create a favorable quality-to-cost balance, although the formula does not retain the original product’s glycine component.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  2. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief Mood Support forGABA
  3. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure.
    Díaz-Flores M; Cruz M; Duran-Reyes G; Munguia-Miranda C; Loza-Rodríguez H; Pulido-Casas E; Torres-Ramírez N; Gaja-Rodriguez O; Kumate J; Baiza-Gutman LA; Hernández-Saavedra D · Canadian journal of physiology and pharmacology · 2014
    Randomized trial60 participantsStress Relief forGlycine
  4. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  5. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  6. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  7. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  8. [Augmentation of antipsychotics with glycine may ameliorate depressive and extrapyramidal symptoms in schizophrenic patients--a preliminary 10-week open-label study].
    Strzelecki D; Kropiwnicki P; Rabe-Jabłońska J · Psychiatria polska · 2014
    Single-arm trial29 participantsMood Support forGlycine
  9. Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls.
    Pålsson E; Jakobsson J; Södersten K; Fujita Y; Sellgren C; Ekman CJ; Ågren H; Hashimoto K; Landén M · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015
    Cross-sectional study327 participantsMood Support forGlycine
  10. Erythrocyte glycine in depressed, hypomanic, and euthymic bipolar patients treated with lithium carbonate.
    Peselow ED; Deutsch SI; Stanley M; Banay-Schwartz M; Virgilio J; Fieve RR · Psychopharmacology · 1983
    Cross-sectional study27 participantsMood Support forGlycine
  11. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  12. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support Stress Relief forMagnesium
  13. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  14. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  15. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  16. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  17. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  18. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsSleep Support Stress Relief forGABA
  19. The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review.
    Soh J; Raventhiran S; Lee JH; Lim ZX; Goh J; Kennedy BK; Maier AB · GeroScience · 2024
    Systematic reviewSleep Support forGlycine
  20. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.
    Bannai M; Kawai N · Journal of pharmacological sciences · 2012
    Narrative reviewSleep Support forGlycine
  21. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.
    Bannai M; Kawai N; Ono K; Nakahara K; Murakami N · Frontiers in neurology · 2012
    Clinical trial7 participantsSleep Support forGlycine
  22. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  23. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  24. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  25. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  26. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  27. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  28. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  29. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsStress Relief forGABA
  30. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  31. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  32. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  33. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  34. Protective and therapeutic effectiveness of taurine supplementation plus low calorie diet on metabolic parameters and endothelial markers in patients with diabetes mellitus: a randomized, clinical trial.
    Moludi J; Qaisar SA; Kadhim MM; Ahmadi Y; Davari M · Nutrition & metabolism · 2022
    Randomized trial120 participantsStress Relief forTaurine
  35. Effects of taurine supplementation on VDT work induced visual stress.
    Zhang M; Bi LF; Ai YD; Yang LP; Wang HB; Liu ZY; Sekine M; Kagamimori S · Amino acids · 2005
    Randomized trial25 participantsStress Relief forTaurine
  36. Taurine supplementation attenuates delayed increase in exercise-induced arterial stiffness.
    Ra SG; Choi Y; Akazawa N; Ohmori H; Maeda S · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2017
    Randomized trial29 participantsStress Relief forTaurine
  37. Correlations between dietary taurine intake and life stress in Korean college students.
    Sung MJ; Chang KJ · Advances in experimental medicine and biology · 2009
    Observational studyStress Relief forTaurine
  38. Profiling inflammatory and oxidative stress biomarkers following taurine supplementation: a systematic review and dose-response meta-analysis of controlled trials.
    Faghfouri AH; Seyyed Shoura SM; Fathollahi P; Shadbad MA; Papi S; Ostadrahimi A; Faghfuri E · European journal of clinical nutrition · 2022
    Meta-analysisStress Relief forTaurine