Histamine Block Plus

Histamine Block Plus

Seeking Health4.6 (735 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 30 servings
Goals
$69.00 $2.30 per serving
iHerbLowest$69.00Pure Formulas$69.00Amazon$69.00Vitacost$69.00

About this product

Riboflavin 5-phosphate and pyridoxal 5-phosphate are useful active B-vitamin forms, while magnesium malate, zinc, copper, vitamin C, and alpha-ketoglutarate add nutritional support. The design is broader and more deliberate than a standard B-complex.

Porcine kidney extract supplies the DAO-focused component, but the label gives only milligrams and no enzyme activity units. Without activity data, the ingredient cannot be compared reliably with standardized DAO products.

SAMe and PQQ extend the formula toward methylation and cellular-energy pathways, though both are below common focused amounts. The product fits a narrow histamine-support use better than general energy supplementation, and its complex formula carries weak value for people seeking only B vitamins.

Who is it for
  • Adults specifically seeking a multi-pathway histamine-support formula
  • People who value active B6 and riboflavin forms
  • Users who consume pork and have reviewed SAMe medicine interactions
Best for
  • Combining DAO-oriented support with nutritional cofactors
  • Active-form B vitamins in a specialized formula
  • Users who want SAMe and PQQ as secondary additions

Pros

  • Uses riboflavin 5-phosphate and pyridoxal 5-phosphate
  • Includes magnesium malate with zinc, copper, and vitamin C
  • Discloses the amounts of all named actives
  • Combines DAO-oriented and methylation-related ingredients

Cons

  • DAO activity units are not provided
  • SAMe and PQQ are modest for focused use
  • Porcine kidney extract excludes people avoiding pork
  • High serving cost weakens value

Warnings

  • SAMe can interact with serotonergic antidepressants, including SSRIs, SNRIs, and MAO inhibitors, and may contribute to serotonin excess.
  • People with bipolar disorder should avoid unsupervised SAMe because it may provoke mania or hypomania.
  • Porcine kidney extract makes the product unsuitable for people with a pork allergy or those avoiding pork for dietary or religious reasons.

Product analysis

69 out of 100
Good nutrient forms and a coherent histamine-support concept are limited by missing DAO activity data, modest specialty doses, and poor value.

AI assessment of the formula, label and price. How scoring works

Nutrient quality86

Favorable cofactor forms and a coherent ingredient pattern support histamine metabolism. Missing DAO activity and modest specialty amounts limit confidence in effective depth.

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Ingredient transparency77

Ingredient weights and most forms are clear without a hidden blend. Missing DAO activity, directions, and capsule excipients prevent complete assessment.

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Customer satisfaction68

The aggregate satisfaction signal is strong and supported by substantial volume. Missing review details prevent assessment of tolerance or histamine-related experience.

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Value for money39

Focused ingredients and strong forms provide meaningful formula quality. Very poor serving value and absent DAO activity units make competitors easier to justify.

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Format
Capsule
Container
60 Capsule(s)
Per serving
$2.30
Customer rating
4.6 · 735 ratings
Report analysis

Goals

Energy
Essential Energy Nutrients
Energy
Impact
High effect
B Ingredient FitF PathwaysB EvidenceA+ Formulation Logic
Vitamin B5 · 10 mgMagnesium · 50 mgRiboflavin · 10 mgThiamin · 20 mg

B vitamins and vitamin C may help tiredness when low levels of those nutrients are the cause. Their roles in normal metabolism don't mean extra amounts will make you more energetic when intake is adequate. The added PQQ doesn't provide a dependable separate fatigue benefit, and the magnesium malate form doesn't supply a specific reason to expect stronger relief.

How this product is rated for Energy

Ingredient fit77

B vitamins and vitamin C relate mainly to tiredness caused by low levels.
Goal fit
B vitamins and vitamin C relate mainly to tiredness caused by low levels.
Dose adequacy
The serving contains 10 mg riboflavin, 25 mg niacin, 7 mg B6 and 100 mg vitamin C; their comparison levels differ.

Pathways0

No particular direct energy pathway contribution is identified for these nutrient roles.
Depth
No particular direct energy pathway contribution is identified for these nutrient roles.
Breadth
No particular direct energy pathway contribution is identified for these nutrient roles.

Evidence78

B vitamins and vitamin C relate mainly to tiredness caused by low levels.
Evidence strength
B vitamins and vitamin C relate mainly to tiredness caused by low levels.
Studied preparation
The declared nutrient forms don't establish superior fatigue relief.

Formulation logic100

No particular ingredient conflict or missing required partner is identified. The ingredient amounts don't guarantee an energy benefit.
Partner coverage
No required ingredient partner is missing for the described roles.
Conflicts
No particular ingredient conflict is identified.
Effective doses
The serving contains 10 mg riboflavin, 25 mg niacin, 7 mg B6 and 100 mg vitamin C; their comparison levels differ.
Study evidence
Magnesium Supportive 4 studies
Riboflavin Mixed 6 studies

Ingredients

IngredientAmount per servingScore
Vitamin C (Ascorbic Acid)
 100 mg
Thiamine (Thiamine Hydrochloride)
 20 mg 65
Riboflavin (Riboflavin 5-Phosphate Sodium)
 10 mg 68
Niacin
25 mg 33
Vitamin B6 (Pyridoxal 5-Phosphate)
 7 mg
Pantothenic Acid (D-Calcium Pantothenate)
 10 mg
Magnesium (Albion Dimagnesium Malate)
 50 mg
Zinc (Zinc Gluconate)
 5 mg
Copper (Copper Gluconate)
 0.5 mg
Alpha-Ketoglutaric Acid
150 mg
SAMe (Disulfate Ptoluensulfonate)
 100 mg 52
LifePQQ (Pyrroloquinoline Quinone Disodium Salt)
 7 mg
DAO2 (Porcine Kidney Extract)
 2.1 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Thiamin (Thiamine Hydrochloride) · 20 mg OverallScore65
B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value
Histamine Block Plus lists 20 mg of thiamine hydrochloride per serving, clearly identifying the B5 source and amount. The dose is below the collection median, and the saved facts show no sweetener, color, or liposomal markers. The cost per 100 mg of the declared hydrochloride amount is high.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The label names thiamine hydrochloride as the B5 source form, with no saved sweetener, color, or liposomal markers.
Thiamin Chemical Form
The listed B5 form is thiamine hydrochloride.
Excipient Purity
The saved details show no configured sweetener or color markers and no liposomal claim.

Dose, Safety & Label Transparency72

The serving provides 20 mg, below the collection median. Its source and amount are clearly stated.
Thiamin Dosage Potency
The serving provides 20 mg of thiamin, below the 30 mg collection median.
Label Transparency & Proprietary Blends
The label names thiamine hydrochloride and clearly states its amount.

Value40

The cost is high relative to the declared hydrochloride amount.
Price per Declared Dose
The cost per 100 mg of declared thiamine hydrochloride is high.
View ingredientView products
Riboflavin (Riboflavin 5-Phosphate Sodium) · 10 mg OverallScore68
A+ Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyF Value
The serving lists 10 mg of riboflavin from Riboflavin 5-Phosphate Sodium, with its form and B2 yield specified. No covered artificial additives are reported, but the per-serving cost is very high.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The label names Riboflavin 5-Phosphate Sodium as the source form.
Riboflavin Form Quality
The listed form is Riboflavin 5-Phosphate Sodium.

Dose, Safety & Label Transparency64

A riboflavin amount is given for the named phosphate form, with no covered additives reported.
Dosage for Energy & Metabolism
The selected serving lists 10 mg of Riboflavin.
R5P Elemental Yield Transparency
The saved details specify the riboflavin amount from the phosphate source.
Additive Purity
The available ingredient details list no artificial colors, flavors, or synthetic sweeteners.

Value10

The serving price is far above the lower-cost products.
Price per Serving Value
The per-serving cost is in a very high price range.
View ingredientView products
Niacin · 25 mg OverallScore33
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value
Histamine Block Plus lists 25 mg of niacin, but the saved facts leave its chemical form unknown. That makes its form-specific dose context unclear, and no flush warning or No-Flush label is recorded. Its cost per serving is high.
How this ingredient is rated

Active Ingredient Quality & Bioavailability36

The saved facts don't identify the niacin form or a specific B3 goal.
Niacin Form & Goal Alignment
The chemical form remains unknown in the saved information.
Precursor Source Quality
No specific niacin precursor source can be identified.

Dose, Safety & Label Transparency37

The amount is listed, but the form isn't specified and no flushing label is recorded.
Clarity of Chemical Form
The saved facts list the form as unknown.
Form-Specific Dosage Efficacy
It gives 25 mg, but no chemical form can be matched to that amount.
Flush Risk & Safety Labeling
No flush warning or No-Flush statement is recorded for the unknown form.

Value20

Its cost per serving is high.
Price Per Effective Serving
The cost per serving is high for the amount listed.
View ingredientView products
Loading alternative details
78 Performance

B-50 Complex

21st Century

Its label clearly provides 50 mg of Thiamine as Vitamin B1, making it a more clearly defined niacin and thiamin and riboflavin option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s same coverage.

73 Performance

B-50 Gels

Carlson

Its label clearly provides 1 g of Total Fat, making it a more clearly defined niacin and thiamin and riboflavin option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s same coverage.

78 Performance

Vitamins Only

Solgar

Its label clearly provides 1531 mcg of Vitamin A as Beta-Carotene, making it a more clearly defined niacin and thiamin and riboflavin option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s same coverage.

73 Budget

B-50 Gels

Carlson

Its label clearly provides 1 g of Total Fat, preserving relevant niacin and thiamin and riboflavin coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s same coverage.

79 Budget

Super Vitamin B-Complex

Spring Valley

Its label clearly provides 150 mg of Vitamin C, preserving relevant niacin and thiamin and riboflavin coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s same coverage.

81 Budget

Super B-Complex

Nature Made

Its label clearly provides 150 mg of Vitamin C as Ascorbic Acid, preserving relevant niacin and thiamin and riboflavin coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s same coverage.

80 Value

B-Complex plus Vitamin C

21st Century

Its label clearly provides 300 mg of Vitamin C as Ascorbic Acid, keeping the formula relevant to niacin and thiamin and riboflavin. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s same coverage.

80 Value

Super Vitamin B-Complex

Spring Valley

Its label clearly provides 25 mg of Niacin, keeping the formula relevant to niacin and thiamin and riboflavin. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s same coverage.

84 Value

Super B-Complex with Folic Acid plus Vitamin C

Nature's Bounty

Its label clearly provides 60 mg of Vitamin C as Ascorbic Acid, keeping the formula relevant to niacin and thiamin and riboflavin. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s same coverage.

Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  2. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  3. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  4. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  5. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  6. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  7. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  8. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  9. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin