Product Image

Emotional Balance Support

Thorne
4.8
★ ★ ★ ★ ★
(376 ratings)
Vitamin B12 550 mcg
Vitamin B5 130 mg
Tyrosine 200 mg
Eleuthero 50 mg
5-HTP 50 mg
Rhodiola
Product Image
Score74
A coherent and transparent emotional-support blend, limited by modest specialty doses, premium cost, and an important 5-HTP interaction.
How scoring works
Quantity:120 Capsule(s) • (60 servings)
Goals:
Energy
Mood Support
Stress Relief

Score 74

A coherent and transparent emotional-support blend, limited by modest specialty doses, premium cost, and an important 5-HTP interaction.
How scoring works
$63.00($1.05 per serving)
Pure Formulas
$ 63.00
Vitacost
$ 63.00
iHerb
$ 63.00
Report prices

Analysis

P-5-P, methylcobalamin, tyrosine, 5-HTP, GABA, rhodiola, and eleuthero cover several mood, stress, and energy pathways. The formula is logically assembled and lists each active amount rather than using a proprietary blend.

Tyrosine, rhodiola, eleuthero, and GABA are modest for strong stand-alone effects, while rhodiola lacks species and marker standardization. The 5-HTP amount is a standard starting level but its source and standardization are not given.

The formula costs more than its specialty doses justify for many users. Its main suitability limit is 5-HTP, which should not be combined casually with medicines that increase serotonin.

Who is it for
  • Adults seeking broad emotional-support ingredients
  • Users not taking serotonergic medicines
  • People who value active B-vitamin forms
Best for
  • Multi-pathway mood and stress support
  • Combining 5-HTP with active B vitamins
  • Users who prefer clearly disclosed amounts

Pros

  • Uses P-5-P and methylcobalamin
  • Clearly states every active amount
  • Coherent mood and stress ingredient selection

Cons

  • Tyrosine and adaptogens are modestly dosed
  • Rhodiola standardization is missing
  • Weak value for the specialty ingredients

Warnings

  • 5-HTP can interact with SSRIs, SNRIs, MAO inhibitors, triptans, and other serotonin-raising medicines.

Nutrient quality

79 High impact

The combination fits mood, stress-resilience, and neurotransmitter support. B vitamins and 5-HTP are meaningful, but tyrosine, rhodiola, eleuthero, and GABA are modest.

Ingredient transparency

84 Highest impact

Every active ingredient has a stated amount. The supplied data omit a complete inactive-ingredient list.

Customer satisfaction

69 High impact

The aggregate satisfaction metric is strong. No complaint text is supplied, so repeated negative themes cannot be assessed.

Value for money

58 Moderate impact

Most additions are relevant despite several low amounts. The serving is costly relative to the dose depth.

Report analysis

Goals

Energy
Energy
Impact
Highest effect
B+ Goal FitB+ Strength of SupportB+ CoverageB+ Formula Quality
Iodine · 68 mcgVitamin B5 · 130 mgVitamin B12 · 550 mcg

Methylcobalamin, active B6, pantothenic acid, and tyrosine support metabolic and neurotransmitter pathways relevant to energy and focus. Rhodiola and eleuthero add a stress-resilience angle, although their amounts are modest.

The formula is better aligned with mood and stress-related fatigue than with acute physical stamina. Combining 5-HTP and GABA with energizing ingredients may feel balancing for some users but also makes the net effect less predictable.

Study evidence
Eleuthero Disputed 3 studies
Rhodiola Supportive 18 studies
Vitamin B12 Disputed 14 studies
Mood Support
Mood Support
Impact
High effect
B+ Goal FitC- Strength of SupportC+ CoverageA- Formula Quality
Folate · 667 mcg DFEVitamin B6 · 5 mgVitamin B12 · 550 mcg5-HTP · 50 mg

5-HTP directly supports serotonin production, while P-5-P vitamin B6 supplies a relevant conversion cofactor. Rhodiola, GABA, active folate, and methylcobalamin broaden stress and neurotransmitter support.

The 5-HTP amount is a reasonable starting level, but rhodiola and GABA are too low for strong standalone effects. 5-HTP may interact with antidepressants and other medicines or supplements that raise serotonin.

Study evidence
5-HTP Supportive 9 studies
Folate Supportive 84 studies
GABA Supportive 12 studies
Rhodiola Supportive 15 studies
Vitamin B12 Supportive 29 studies
Vitamin B6 Supportive 19 studies
Stress Relief
Stress Relief
Impact
High effect
B+ Goal FitD Strength of SupportC+ CoverageB Formula Quality
Folate · 667 mcg DFEVitamin B12 · 550 mcgGABA · 50 mgVitamin B6 · 5 mgVitamin C · 250 mgEleuthero · 50 mg

GABA, 5-HTP, rhodiola, eleuthero, and B vitamins directly target mood, inhibitory signaling, and stress resilience. The combination has good conceptual breadth, but nearly every primary stress active is supplied below common standalone amounts.

Rhodiola and eleuthero also lack standardization details, limiting potency confidence. The 5-HTP can raise serotonin and should not be combined with SSRIs, SNRIs, MAO inhibitors, or other serotonin-raising medicines without clinical guidance.

Study evidence
5-HTP Supportive 18 studies
Eleuthero No effect 1 study
GABA Supportive 6 studies
Rhodiola Supportive 16 studies
Vitamin B12 Mixed 6 studies
General Health
General Health
Impact
Moderate effect
D+ Goal FitC Strength of SupportD CoverageB+ Formula Quality
Folate · 667 mcg DFEVitamin B12 · 550 mcgVitamin C · 250 mg

Active B vitamins and several neuroactive compounds create a focused emotional-support formula with some relevance to energy and nervous-system function. Methylcobalamin and pyridoxal phosphate are clearly identified preferred forms.

Most specialty ingredients are below commonly studied amounts, and evidence is mixed for broad daily wellness. The included 5-HTP can raise serotonin and may interact with SSRIs, SNRIs, MAO inhibitors, and other serotonergic medicines.

Study evidence
Rhodiola Supportive 7 studies
Vitamin B12 Adverse 66 studies
Sleep Support
Sleep Support
Impact
Moderate effect
C Goal FitC Strength of SupportC- CoverageC- Formula Quality

Five-hydroxytryptophan and GABA provide modest support for serotonin and inhibitory signaling. The formula is designed for daytime emotional balance and includes tyrosine, rhodiola, and eleuthero that may feel activating.

Coverage reaches serotonin and GABA pathways but lacks circadian, mineral, and dedicated bedtime support. Calming and activating ingredients are combined for mood balance rather than a unified sleep strategy.

Study evidence
5-HTP Supportive 1 study
GABA Supportive 4 studies
Productivity Boost
Productivity Boost
Impact
Moderate effect
C+ Goal FitD+ Strength of SupportC- CoverageC Formula Quality
Vitamin B12 · 550 mcgVitamin B12 · 550 mcgVitamin B6 · 5 mgEleuthero · 50 mgEleuthero · 50 mg

Rhodiola, eleuthero, L-tyrosine, and methylcobalamin create a plausible stress-related productivity concept. The direct adaptogens and precursor are all too small to match the breadth suggested by the label.

The included 5-HTP can interact with antidepressants and other serotonergic medicines, increasing the risk of excessive serotonin effects. The mix is better viewed as low-dose emotional support than a dependable focus formula.

Study evidence
Eleuthero No effect 1 study
Eleuthero Not classified

No linked studies yet.

Rhodiola Supportive 7 studies
Vitamin B12 Supportive 15 studies
Vitamin B12 No effect 17 studies
Cognitive Support
Cognitive Support
Impact
Moderate effect
C Goal FitD- Strength of SupportC CoverageC- Formula Quality
Vitamin B6 · 5 mgFolate · 667 mcg DFEVitamin B12 · 550 mcg

Rhodiola, Eleuthero, tyrosine, active B6, methylfolate, and methylcobalamin create a plausible stress-and-neurotransmitter support formula. The combination may suit people whose mental performance declines under emotional strain.

Rhodiola, Eleuthero, and tyrosine are all below typical targeted amounts, and the herbal extracts lack standardization. The added 5-HTP can raise serotonin and may interact with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines.

Study evidence
Eleuthero No effect 1 study
Rhodiola Supportive 7 studies
Vitamin B12 Disputed 84 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 250 mg
Vitamin B6 (Pyridoxal 5-Phosphate)
 5 mg
Folate
667 mcg DFE
Vitamin B12 (Methylcobalamin)
 550 mcg
Pantothenic Acid (Calcium Pantothenate)
 130 mg
Iodine (Potassium Iodide)
 68 mcg
L-Tyrosine
200 mg
5-HTP
50 mg
Eleuthero Root Extract
50 mg
Gamma-Aminobutyric Acid
50 mg
Rhodiola extract
50 mg
Gluten Free Adults 18–50 Women
Report overview
Vitamin B12 (Methylcobalamin) · 550 mcg OverallScore71
A- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

Methylcobalamin supplies a bioactive form, but the 550 mcg amount is below the level aimed at higher B12 needs. Swallowed capsules may be less useful for people with absorption difficulties, and the cost efficiency is poor for the B12 delivered. The added 5-HTP can increase serotonin and may pose a risk with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines.

View ingredientView products
Vitamin B5 (Calcium Pantothenate) · 130 mg OverallScore66
B Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

A clearly identified calcium pantothenate form offers stable, well-absorbed vitamin B5 for general metabolic support. The disclosed dose is adequate for maintenance but below stronger targeted levels. Missing excipient details and a high cost per active amount limit confidence in purity and value.

View ingredientView products
Tyrosine · 200 mg OverallScore50
B- Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyF Value

The preferred L-tyrosine form and exact amount are disclosed, but the 200 mg serving is too low for meaningful acute cognitive support for most users. No raw-material sourcing or purity standard is provided, and the cost per gram is high. The included 50 mg 5-HTP may add to serotonin effects from SSRIs, MAO inhibitors, or triptans, creating a risk of serotonin excess.

View ingredientView products
Loading alternative details
89 Performance

HPA Adapt

Integrative Therapeutics
<p>Substantial rhodiola, eleuthero, Sensoril ashwagandha, holy basil, and maca provide deeper stress, energy, focus, and mood coverage than the original modest adaptogen doses. The premium serving cost and missing marker percentages are trade-offs, but the formula avoids 5-HTP-related serotonergic interactions.</p>
88 Performance

Daily Stress Formula

Pure Encapsulations
<p>Active B vitamins, tyrosine, eleuthero, marker-defined rhodiola, and several calming botanicals align closely with the original goals while supplying greater botanical depth. Some duplicated nutrient entries and a high serving cost reduce practicality, but 5-HTP is absent for users avoiding serotonergic combinations.</p>
87 Performance

AdrenaSense

Natural Factors WS WomenSense
<p>Meaningful marker-identified rhodiola and eleuthero amounts create stronger adaptogen support for stress, mood, and energy than the original small doses. The concise formula is clearly disclosed and avoids 5-HTP, although it does not provide the original active B vitamins or tyrosine.</p>
78 Budget

Sublingual Liquid B Complex

Nature's Bounty
<p>A low-cost liquid provides B12 and pantothenic acid alongside several related B vitamins. It omits 5-HTP, tyrosine, rhodiola, and eleuthero, while cyanocobalamin and pyridoxine are less-preferred forms than those in the original.</p>
79 Budget

Sublingual Liquid B-12 2000 mcg with B-Complex

Solgar
<p>Broad B-vitamin coverage in a liquid format costs much less per serving and may be easier to take. Cyanocobalamin, pyridoxine, and unspecified folate are weaker choices than the original active forms, and the mood-focused botanicals are absent.</p>
67 Budget

Anti-Fatigue

Kroeger Herb Products Co.
<p>Vitamin C and several B vitamins provide inexpensive energy-oriented coverage with the same B5 collection fit. Very high pantothenic acid, an unspecified licorice amount, conventional vitamin forms, and no 5-HTP or adaptogens make it a less balanced mood option.</p>
88 Value

Energy Xtra

Pure Encapsulations
<p>Named adaptogens with marker compounds provide rhodiola and eleuthero support at a much lower serving cost. The formula is narrower and omits B vitamins, tyrosine, and 5-HTP, but its adaptogen amounts and disclosure make the energy-stress core easier to assess.</p>
89 Value

Adrenal Serenity

Natural Factors Stress-Relax
<p>Sensoril ashwagandha with eleuthero, lavender, and rhodiola offers focused stress support at favorable serving value. It lacks the original B vitamins, tyrosine, and 5-HTP, but the concise blend avoids the original serotonergic interaction concern.</p>
72 Value

PureBalance Seratonin

Quality Of Life
<p>Five-HTP, theanine, and rhodiola retain the closest mood-oriented ingredient theme at a lower serving cost. The 5-HTP amount is smaller and a proprietary blend hides important detail, while the same caution with antidepressants and other serotonergic medicines remains relevant.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial.
    Mao JJ; Xie SX; Zee J; Soeller I; Li QS; Rockwell K; Amsterdam JD · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2015
    Randomized trial57 participantsMood Support forRhodiola
  2. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  3. Rhodiola rosea for mental and physical fatigue in nursing students: a randomized controlled trial.
    Punja S; Shamseer L; Olson K; Vohra S · PloS one · 2015
    Randomized trial48 participantsEnergy forRhodiola
  4. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  5. Association of Vitamin B12 and Polymorphism of TCN2 with Early-Onset Post-Stroke Depression.
    Zhang J; Liao Q; Chen H; Liu F; Sun D; Luo S; Xiao Y; Xu W; Tian F; Song M · Neuropsychiatric disease and treatment · 2024
    Cohort study173 participantsMood Support forVitamin B12
  6. Effects of vitamin B12 supplementation on oxidative stress markers and pro-inflammatory cytokines during pregnancy and postpartum among Bangladeshi mother-child pairs.
    Siddiqua TJ; Akhtar E; Haq MA; Shahab-Ferdows S; Hampel D; Islam S; Ahmed T; Allen LH; Raqib R · BMC nutrition · 2024
    Randomized trial68 participantsStress Relief forVitamin B12
  7. Randomized controlled trial of Siberian ginseng for chronic fatigue.
    Hartz AJ; Bentler S; Noyes R; Hoehns J; Logemann C; Sinift S; Butani Y; Wang W; Brake K; Ernst M; Kautzman H · Psychological medicine · 2004
    Randomized trial96 participantsEnergy forEleuthero
  8. Scientific Opinion on the substantiation of a health claim related to Rhodiola rosea L. extract and reduction of mental fatigue pursuant to Article 13(5) of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy Stress Relief forRhodiola
  9. Sex-linked differences in cortisol, ACTH and prolactin responses to 5-hydroxy-tryptophan in healthy controls and minor and major depressed patients.
    Maes M; Vandewoude M; Schotte C; Maes L; Martin M; Blockx P · Acta psychiatrica Scandinavica · 1990
    Clinical trial120 participantsStress Relief for5-HTP
  10. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B12 Mood Support forVitamin B6
  11. Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients With Fibromyalgia.
    Munipalli B; Strothers S; Rivera F; Malavet P; Mitri G; Abu Dabrh AM; Dawson NL · Mayo Clinic proceedings. Innovations, quality & outcomes · 2022
    Observational study2,142 participantsEnergy forVitamin B12
  12. [Effects of rhodiola rosea on oxidative stress and negative emotional states in patients with obstructive sleep apnea].
    Yu HL; Zhang PP; Zhang C; Zhang X; Li ZZ; Li WQ; Fu AS · Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2019
    Randomized trial90 participantsStress Relief Mood Support forRhodiola
  13. Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study.
    Bjelland I; Tell GS; Vollset SE; Refsum H; Ueland PM · Archives of general psychiatry · 2003
    Cross-sectional study5,948 participantsStress Relief forVitamin B12
  14. Gastrointestinal distress to serotonergic challenge: a risk marker for emotional disorder?
    Campo JV; Dahl RE; Williamson DE; Birmaher B; Perel JM; Ryan ND · Journal of the American Academy of Child and Adolescent Psychiatry · 2003
    Cohort study23 participantsStress Relief for5-HTP
  15. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  16. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.
    Panossian A; Wikman G · Current clinical pharmacology · 2009
    Narrative reviewEnergy forEleuthero Cognitive Support forRhodiola
  17. Rhodiola rosea for physical and mental fatigue: a systematic review.
    Ishaque S; Shamseer L; Bukutu C; Vohra S · BMC complementary and alternative medicine · 2013
    Systematic review11 studies pooledEnergy forRhodiola
  18. Systematic review and meta-analysis of randomized placebo-controlled trials of folate and vitamin B12 for depression.
    Almeida OP; Ford AH; Flicker L · International psychogeriatrics · 2016
    Meta-analysis11 studies pooledMood Support forVitamin B12
  19. Vitamin B12 deficiency and neuropsychiatric symptoms in Lebanon: A cross-sectional study of vegans, vegetarians, and omnivores.
    Al Jassem O; Kheir K; Ismail A; Abou-Abbas L; Masri A; Haddad C; Nasrallah K; El Masry J · PloS one · 2024
    Cross-sectional study483 participantsStress Relief forVitamin B12
  20. Association between serum vitamin B12 level and frailty in older adults.
    Dokuzlar O; Soysal P; Isik AT · Northern clinics of Istanbul · 2022
    Cross-sectional study335 participantsEnergy forVitamin B12
  21. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  22. Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.
    Urata M; Sakurai H; Ueno F; Maruki T; Tada T; Uchida T; Matsumoto Y; Murao M; Tomita M; Baba H; Kato M; Tsuboi T; Watanabe K · Neuropsychopharmacology reports · 2025
    Meta-analysis1,049 participants2 studies pooledMood Support forRhodiola
  23. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  24. Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes.
    Łuszczak J; Kocki J · Annals of agricultural and environmental medicine : AAEM · 2026
    Systematic review19 studies pooledStress Relief Cognitive Support forRhodiola
  25. Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials.
    Borges-Vieira JG; Cardoso CKS · Nutritional neuroscience · 2023
    Systematic review2,256 participants20 studies pooledMood Support forVitamin B12 Mood Support forFolate
  26. The Effect of Short-Term Rhodiola rosea Supplementation on Simulated Game Time, Perceived Fatigue, and Performance in Basketball Players.
    Wang J; Zhao H; Yu L; Zhao K; Jiang W; Liu S; Dai J; Xu L; Sun P; Yun H; Liu C · Nutrients · 2025
    Randomized trial48 participantsEnergy forRhodiola
  27. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  28. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
    Olsson EM; von Schéele B; Panossian AG · Planta medica · 2009
    Randomized trial60 participantsMood Support Cognitive Support Productivity Boost forRhodiola
  29. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  30. Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial.
    Lekomtseva Y; Zhukova I; Wacker A · Complementary medicine research · 2019
    Single-arm trial100 participantsEnergy Stress Relief General Health forRhodiola
  31. A cross-sectional study of nutritional status in healthy, young, physically-active German omnivores, vegetarians and vegans reveals adequate vitamin B12 status in supplemented vegans.
    Storz MA; Müller A; Niederreiter L; Zimmermann-Klemd AM; Suarez-Alvarez M; Kowarschik S; Strittmatter M; Schlachter E; Pasluosta C; Huber R; Hannibal L · Annals of medicine · 2023
    Cross-sectional study115 participantsEnergy forVitamin B12
  32. Effects of Rhodiola rosea on Physical and Decision-Making Performance in Football Players: A Randomised Controlled Trial.
    Dou Y; Wang Y; Zhang W; Jiang Y; Zhang J; Yang T; Han Z; Li Y; Liu C; Ren D · Nutrients · 2026
    Randomized trial24 participantsEnergy forRhodiola
  33. Low vitamin B12 but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4-year longitudinal study.
    Laird EJ; O'Halloran AM; Molloy AM; Healy M; Hernandez B; O'Connor DMA; Kenny RA; Briggs R · The British journal of nutrition · 2023
    Cohort study3,849 participantsMood Support forVitamin B12
  34. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  35. The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate, Substrate Utilisation, Mood State, and Perceptions of Exertion, Arousal, and Pleasure/Displeasure in Active Men.
    Duncan MJ; Clarke ND · Journal of sports medicine (Hindawi Publishing Corporation) · 2015
    Clinical trial10 participantsMood Support Energy forRhodiola
  36. Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD).
    Bertolini F; Robertson L; Bisson JI; Meader N; Churchill R; Ostuzzi G; Stein DJ; Williams T; Barbui C · The Cochrane database of systematic reviews · 2022
    Systematic review2,023 participants13 studies pooledStress Relief for5-HTP
  37. The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence.
    Ivanova Stojcheva E; Quintela JC · Molecules (Basel, Switzerland) · 2022
    Narrative reviewStress Relief Productivity Boost forRhodiola
  38. Megaloblastic anaemia: prevalence and causative factors.
    Khanduri U; Sharma A · The National medical journal of India · 2008
    Observational study175 participantsEnergy forVitamin B12
  39. Subjective well-being in older adults: folate and vitamin B12 independently predict positive affect.
    Edney LC; Burns NR; Danthiir V · The British journal of nutrition · 2016
    Cohort study391 participantsMood Support forVitamin B12
  40. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence.
    Sarris J; Panossian A; Schweitzer I; Stough C; Scholey A · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2012
    Systematic review66 studies pooledMood Support forRhodiola
  41. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  42. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  43. The influence of adaptogens on ultraweak biophoton emission: a pilot-experiment.
    Schutgens FW; Neogi P; van Wijk EP; van Wijk R; Wikman G; Wiegant FA · Phytotherapy research : PTR · 2009
    Randomized trial30 participantsStress Relief forRhodiola
  44. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  45. Association between suicide attempts and anemia in late-life depression inpatients.
    Li J; Wang L; Wang Z; Zhao F; Sun Y; Lu Y; Yang L · BMC geriatrics · 2024
    Case-control study113 participantsMood Support forVitamin B12
  46. Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms.
    Kasper S; Dienel A · Neuropsychiatric disease and treatment · 2020
    Single-arm trial118 participantsMood Support forRhodiola
  47. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  48. Symptomatic treatment of interferon-α-induced depression in hepatitis C: a systematic review.
    Baraldi S; Hepgul N; Mondelli V; Pariante CM · Journal of clinical psychopharmacology · 2012
    Systematic review64 studies pooledMood Support for5-HTP
  49. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce.
    Sarris J; Ravindran A; Yatham LN; Marx W; Rucklidge JJ; McIntyre RS; Akhondzadeh S; Benedetti F; Caneo C; Cramer H; Cribb L; de Manincor M; Dean O; Deslandes AC; Freeman MP; Gangadhar B; Harvey BH; Kasper S; Lake J; Lopresti A; Lu L; Metri NJ; Mischoulon D; Ng CH; Nishi D; Rahimi R; Seedat S; Sinclair J; Su KP; Zhang ZJ; Berk M · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2022
    Guideline / consensusStress Relief forRhodiola
  50. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  51. Association between of vitamin B12 status during pregnancy and probable postpartum depression: the ECLIPSES study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Arija V · Journal of reproductive and infant psychology · 2025
    Cohort study336 participantsMood Support forVitamin B12
  52. Combined Rhodiola rosea and eccentric training boost endurance performance and lower-limb reactive strength in recreationally active women.
    Wang IL; Su Y; Zhang L; Tang M; Chen YM · Frontiers in physiology · 2025
    Randomized trial30 participantsEnergy forRhodiola
  53. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD).
    Bystritsky A; Kerwin L; Feusner JD · Journal of alternative and complementary medicine (New York, N.Y.) · 2008
    Single-arm trial10 participantsMood Support Stress Relief forRhodiola
  54. Serotonergic dysregulation in bipolar disorders: a literature review of serotonergic challenge studies.
    Sobczak S; Honig A; van Duinen MA; Riedel WJ · Bipolar disorders · 2003
    Systematic review15 studies pooledStress Relief for5-HTP
  55. Stress management and the role of Rhodiola rosea: a review.
    Anghelescu IG; Edwards D; Seifritz E; Kasper S · International journal of psychiatry in clinical practice · 2019
    Narrative reviewStress Relief forRhodiola
  56. Vitamin B12 Supplementation: Is More Always Better?
    Yepes-Calderón M; Doorenbos CSE; Stegmann ME; Touw DJ; Harmsen HJM; Heiner-Fokkema MR; van Spronsen FJ; Corpeleijn E; Bakker SJL · Nutrients · 2026
    Narrative reviewEnergy forVitamin B12
  57. Serotonin precursors in the treatment of depression.
    van Praag HM · Advances in biochemical psychopharmacology · 1982
    Narrative reviewMood Support for5-HTP
  58. The biological relationship among depression, vitamins B9, B12, and D, and genetic variants: a systematic review.
    Soriano-Gonzalez R; Ramirez-Olea H; Gonzalez-Soltero R; Chavez-Santoscoy RA · Frontiers in nutrition · 2025
    Systematic review24 studies pooledMood Support forVitamin B12
  59. The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises Under Resting and Mental Fatigue Conditions: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial.
    Marcos-Frutos D; Leban Ž; Li Z; Zhang X; Lara PM; Alix-Fages C; Jiménez-Martínez P; Zebboudji N; Caillet A; Redondo B; Vera J; Janicijevic D; García-Ramos A · Nutrients · 2025
    Randomized trial18 participantsEnergy forRhodiola
  60. Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials.
    Moragrega I; Ríos JL · Planta medica · 2022
    Systematic reviewMood Support forRhodiola
  61. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
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    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  63. Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
    Takahashi S; Takahashi R; Masumura I; Miike A · Folia psychiatrica et neurologica japonica · 1977
    Single-arm trial14 participantsMood Support for5-HTP
  64. Association between vitamin b12 levels and melancholic depressive symptoms: a Finnish population-based study.
    Seppälä J; Koponen H; Kautiainen H; Eriksson JG; Kampman O; Leiviskä J; Männistö S; Mäntyselkä P; Oksa H; Ovaskainen Y; Viikki M; Vanhala M; Seppälä J · BMC psychiatry · 2015
    Cross-sectional study2,806 participantsMood Support forVitamin B12
  65. Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study.
    Edwards D; Heufelder A; Zimmermann A · Phytotherapy research : PTR · 2012
    Single-arm trial101 participantsEnergy forRhodiola
  66. Antidepressants effects of Rhodiola capsule combined with sertraline for major depressive disorder: A randomized double-blind placebo-controlled clinical trial.
    Gao L; Wu C; Liao Y; Wang J · Journal of affective disorders · 2021
    Methods validation study100 participantsMood Support forRhodiola
  67. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.
    Sarris J; McIntyre E; Camfield DA · CNS drugs · 2013
    Narrative reviewStress Relief forRhodiola
  68. Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study.
    Sarzi Puttini P; Caruso I · The Journal of international medical research · 1992
    Single-arm trial50 participantsStress Relief for5-HTP
  69. Trends in energy and nutrient intake and risk of inadequate intakes in Catalonia, Spain (1992-2003).
    Serra-Majem L; Ribas-Barba L; Salvador G; Jover L; Raidó B; Ngo J; Plasencia A · Public health nutrition · 2008
    Cross-sectional study4,701 participantsEnergy forVitamin B12
  70. No benefit adding eleutherococcus senticosus to stress management training in stress-related fatigue/weakness, impaired work or concentration, a randomized controlled study.
    Schaffler K; Wolf OT; Burkart M · Pharmacopsychiatry · 2014
    Randomized trial144 participantsCognitive Support Productivity Boost Stress Relief forEleuthero
  71. Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event-related potential dual task study.
    Koop T; Dienel A; Heldmann M; Münte TF · Phytotherapy research : PTR · 2021
    Single-arm trial50 participantsCognitive Support forRhodiola
  72. Central additive effect of Ginkgo biloba and Rhodiola rosea on psychomotor vigilance task and short-term working memory accuracy.
    Al-Kuraishy HM · Journal of intercultural ethnopharmacology · 2016
    Clinical trial112 participantsCognitive Support forRhodiola
  73. Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India.
    Behere RV; Deshmukh AS; Otiv S; Gupte MD; Yajnik CS · Frontiers in endocrinology · 2021
    Systematic review46 studies pooledCognitive Support forVitamin B12
  74. Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial.
    Thomas S; Thomas T; Bosch RJ; Ramthal A; Bellinger DC; Kurpad AV; Duggan CP; Srinivasan K · Maternal and child health journal · 2019
    Randomized trial218 participantsCognitive Support forVitamin B12
  75. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsCognitive Support Productivity Boost forVitamin B12
  76. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsCognitive Support forVitamin B12
  77. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsCognitive Support Productivity Boost forVitamin B12
  78. The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human
    J Kuo, K W Chen, I S Cheng, P H Tsai, Y J Lu, N Y Lee · Chinese Journal of Physiology · 2010
    Randomized trial9 participantsEnergy forEleuthero
  79. Combined Effects of Rhodiola Rosea and Caffeine Supplementation on Straight Punch Explosive Power in Untrained and Trained Boxing Volunteers: A Synergistic Approach.
    Tao B; Sun H; Li H; Xu Z; Xu Y; Chen L; Ma C; Zhang X; Yu L; Bao S; Liu C · Metabolites · 2025
    Randomized trial96 participantsEnergy forRhodiola
  80. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  81. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.
    Darbinyan V; Kteyan A; Panossian A; Gabrielian E; Wikman G; Wagner H · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2001
    Randomized trial56 participantsGeneral Health Productivity Boost forRhodiola
  82. Actaea racemosa L. Is More Effective in Combination with Rhodiola rosea L. for Relief of Menopausal Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study.
    Pkhaladze L; Davidova N; Khomasuridze A; Shengelia R; Panossian AG · Pharmaceuticals (Basel, Switzerland) · 2024
    Randomized trial220 participantsGeneral Health forRhodiola
  83. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.
    Spasov AA; Wikman GK; Mandrikov VB; Mironova IA; Neumoin VV · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2000
    Randomized trialGeneral Health Productivity Boost forRhodiola
  84. [The effect of the preparation rodakson on the psychophysiological and physical adaptation of students to an academic load].
    Spasov AA; Mandrikov VB; Mironova IA · Eksperimental'naia i klinicheskaia farmakologiia · 2000
    Clinical trialGeneral Health forRhodiola
  85. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  86. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  87. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  88. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  89. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  90. The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials.
    Firth J; Teasdale SB; Allott K; Siskind D; Marx W; Cotter J; Veronese N; Schuch F; Smith L; Solmi M; Carvalho AF; Vancampfort D; Berk M; Stubbs B; Sarris J · World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025
    Systematic review10,951 participants33 studies pooledMood Support forFolate
  91. Continuous supplementation of folic acid in pregnancy and the risk of perinatal depression-A meta-analysis.
    Jin X; Cheng Z; Yu X; Tao Q; Huang R; Wang S · Journal of affective disorders · 2022
    Meta-analysis26,275 participants15 studies pooledMood Support forFolate
  92. Folate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses.
    Gao S; Khalid A; Amini-Salehi E; Radkhah N; Jamilian P; Badpeyma M; Zarezadeh M · Food science & nutrition · 2024
    Meta-analysis11 studies pooledMood Support forFolate
  93. Oral 5'-methyltetrahydrofolic acid in senile organic mental disorders with depression: results of a double-blind multicenter study.
    Passeri M; Cucinotta D; Abate G; Senin U; Ventura A; Stramba Badiale M; Diana R; La Greca P; Le Grazie C · Aging (Milan, Italy) · 1993
    Randomized trial96 participantsMood Support forFolate
  94. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsMood Support Stress Relief forGABA
  95. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  96. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  97. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  98. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  99. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B12 Mood Support forVitamin B6
  100. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support forVitamin B6
  101. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  102. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  103. Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men.
    Jówko E; Sadowski J; Długołęcka B; Gierczuk D; Opaszowski B; Cieśliński I · Journal of sport and health science · 2022
    Randomized trial26 participantsProductivity Boost forRhodiola
  104. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forVitamin B12
  105. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsProductivity Boost forVitamin B12
  106. Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
    Balatacı U; Ay B · Frontiers in pediatrics · 2026
    Case-control study108 participantsProductivity Boost forVitamin B12
  107. Association between vitamin B12 levels and cognitive impairment in older adults.
    Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
    Cross-sectional study241 participantsProductivity Boost forVitamin B12
  108. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsProductivity Boost forVitamin B12
  109. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
    An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
    Cohort study2,533 participantsProductivity Boost forVitamin B12
  110. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.
    Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
    Cross-sectional study812 participantsProductivity Boost forVitamin B12
  111. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  112. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  113. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  114. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  115. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsSleep Support Stress Relief forGABA
  116. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  117. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  118. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsStress Relief forGABA
  119. A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and 'At-Risk' Individuals
    Lauren M. Young, Andrew Pipingas, David J. White, Sarah Gauci, Andrew Scholey · Nutrients · 2019
    Meta-analysis12 studies pooledStress Relief forVitamin B12
  120. Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: a meta-analysis
    Stephen J. Long, David Benton · Psychosomatic Medicine · 2013
    Meta-analysis8 studies pooledStress Relief forVitamin B12