B-Complex #12
Thorne
B-Complex #12
4.8
★ ★ ★ ★ ★
(10542 ratings)
Vitamin B6 23.4 mg
Vitamin B5 45 mg
Niacin 80 mg
Choline 14 mg
Vitamin B12 600 mcg
Riboflavin 28.6 mg
Thiamin 40 mg
Score 90.0
A premium B-complex from Thorne, distinguished by its use of highly bioavailable forms of B12 (Methylcobalamin) and Folate (L-Methylfolate), ensuring optimal absorption and efficacy.
Quantity: 60 Capsule(s)Servings size: 1 Capsule(s) (60 servings)
Selected goals:
Other goals:
Energy
Brain Health
Mood Support
General Health
Skin Health
leaderboard Score 90.0
A premium B-complex from Thorne, distinguished by its use of highly bioavailable forms of B12 (Methylcobalamin) and Folate (L-Methylfolate), ensuring optimal absorption and efficacy.
insights Analysis
Thorne's B-Complex #12 is an excellent, professional-grade supplement due to its commitment to using active and well-absorbed forms of B vitamins. It features Methylcobalamin for B12, a directly usable form, and L-Methylfolate for Folate, bypassing common genetic conversion issues. While the B6 form is unspecified (but given Thorne's quality, likely an active form or highly pure Pyridoxine), the overall profile is robust. The dosages are generally well-balanced for daily support without being excessively high. It includes Choline for added cognitive benefits. Its higher price per serving reflects the superior quality of ingredients and formulations.
- Contains highly bioavailable and active forms of B12 (Methylcobalamin) and Folate (L-Methylfolate), crucial for individuals with MTHFR mutations or absorption issues.
- From Thorne, a highly respected brand known for rigorous testing and pure, high-quality ingredients.
- Well-balanced dosages for comprehensive daily B vitamin support.
- Includes Choline for enhanced cognitive and liver support.
- Higher price per serving compared to many standard B-complex products.
- The specific form of Vitamin B6 is not explicitly stated as P-5-P, though Thorne generally uses high-quality ingredients.
- Individuals new to activated B vitamins might experience a temporary increase in energy or subtle detoxification effects, which are generally harmless but can be noticeable.
- As with any supplement, consult a healthcare professional, especially if pregnant, nursing, or taking other medications, given the potency.
$22.50($0.37 per serving)
 iHerb | $ 22.50 | |
 Pure Formulas | $ 25.00 | |
 Walmart | $ 25.00 | |
 Vitacost | $ 25.00 | |
 Amazon | $ 25.00 |
bolt Effectiveness for goals
B vitamins are crucial coenzymes that play a direct role in cellular metabolic pathways. They help convert carbohydrates, fats, and proteins from food into usable energy. This process is essential for maintaining overall vitality and supporting various bodily functions.
Folate, Vitamin B6, and Vitamin B12 work synergistically to support homocysteine metabolism. This process is important for cardiovascular health, nerve function, and red blood cell formation. These vitamins are vital for the body's methylation cycle.
Methylcobalamin is an active and bioavailable form of Vitamin B12. Unlike cyanocobalamin, it does not require an additional methylation step in the body, which may allow for more direct utilization. It directly participates in metabolic processes such as homocysteine metabolism and nerve health.
Niacinamide is a non-flushing form of Niacin (Vitamin B3). It provides the essential benefits of Niacin without causing the common 'niacin flush,' which is a temporary redness and itching sensation. This form is often preferred for its comfortable tolerability.
Pantothenic Acid is essential for the synthesis of coenzyme A (CoA), a molecule critical for fatty acid metabolism and energy production. It supports various metabolic reactions, including the breakdown of carbohydrates and proteins. This vitamin also contributes to the synthesis of hormones and cholesterol.
schedule Dosage, timing & forms
B vitamins are often recommended to be taken in the morning or early afternoon. This is because they can provide an energy boost, and taking them late in the day might interfere with sleep for some individuals. Consistent daily intake is generally more important than the exact time.
Taking B-complex vitamins with food is generally recommended to minimize potential stomach upset. Food can also aid in the absorption of certain nutrients, even though most B vitamins are water-soluble. Following the product label instructions is always advisable.
Yes, it is common for urine to appear bright yellow after taking a B-complex supplement. This is primarily due to Riboflavin (Vitamin B2), which has a natural yellow pigment. Excess Riboflavin is safely excreted in the urine, indicating normal processing.
B-complex supplements are commonly formulated for daily intake to ensure consistent support for metabolic functions. Since B vitamins are water-soluble, the body does not store large amounts, so regular replenishment is beneficial. Always adhere to the serving size indicated on the product label.
Methylcobalamin is an active form of Vitamin B12, readily utilized by the body without needing conversion. Folate DFE (Dietary Folate Equivalents) accounts for differences in absorption between dietary folate and folic acid, aiming for more accurate dosage. These forms are often chosen for their bioavailability and efficacy.
health_and_safety Safety & interactions
While generally considered safe due to their water-soluble nature, very high intakes of certain B vitamins can cause side effects. For example, prolonged excessive Vitamin B6 may contribute to nerve damage, and high doses of Niacin can cause flushing or gastrointestinal upset. It is advisable to adhere to recommended dosages and consult a healthcare professional with any concerns.
Yes, certain B vitamins can interact with prescription drugs. For instance, Folate may affect the efficacy of methotrexate, and Vitamin B6 can influence medications for conditions like Parkinson's disease. Always inform your healthcare provider about any supplements you are taking to assess potential interactions.
High doses of biotin, an ingredient in this complex, have been shown to interfere with certain laboratory tests. This can lead to inaccurate results for thyroid hormones and cardiac markers. It is recommended to inform your doctor and temporarily stop biotin supplementation several days before scheduled blood tests.
Yes, a concern exists that very high doses of Folate can mask the symptoms of a Vitamin B12 deficiency. This can delay diagnosis and potentially allow neurological damage from the B12 deficiency to progress undetected. It is important to ensure adequate intake of both vitamins, particularly if you have risk factors for B12 deficiency.
Niacinamide is a specific form of Niacin that typically causes significantly less flushing compared to nicotinic acid, another form of Niacin. While generally well-tolerated, very large doses might still cause mild skin redness or warmth in sensitive individuals. Gastrointestinal upset is also possible at high intakes.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Thiamine | 40 mg |
Riboflavin | 28.6 mg |
Niacin | 80 mg |
Vitamin B6 | 23.4 mg |
Folate | 667 mcg DFE |
Vitamin B12 | 600 mcg |
Biotin | 80 mcg |
Pantothenic Acid | 45 mg |
Choline | 14 mg |
Categories
Vitamin B12 95.0
Uses Methylcobalamin, the highly active and bioavailable form of B12, which is superior to Cyanocobalamin for direct utilization in the body.
Niacin 85.0
Provides 80mg of Niacinamide, a non-flushing form of B3. This is a very good, effective dose that avoids the uncomfortable 'niacin flush' while supporting various bodily functions.
Thiamin 85.0
Contains 40mg of Thiamine Hydrochloride. While not Benfotiamine, it is a very good and effective dose of B1, supporting carbohydrate metabolism and nervous system function.
Goals
Brain Health 95.0
Methylated B12 and L-Methylfolate are critical for neurological function and neurotransmitter synthesis, directly supporting superior brain health and cognitive performance.
Heart Health 95.0
Optimal levels of active B6, B9, and B12 are crucial for healthy homocysteine metabolism, directly contributing to superior cardiovascular health and reducing related risks.
Cognitive Support 95.0
The inclusion of methylated B12 and L-Methylfolate directly supports neurotransmitter production and neuronal health, providing excellent benefits for cognitive functions like memory and focus.
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