Product Image

Sustained Release B-100

NOW
4.7
★ ★ ★ ★ ★
(5846 ratings)
Niacin 100 mg
Thiamin 100 mg
Riboflavin 100 mg
PABA 10 mg
Vitamin B6 100 mg
Vitamin B5 100 mg
Choline 35 mg
Product Image
Score75
Complete B-vitamin coverage and sustained release are useful, but conventional forms and 100 mg of vitamin B6 make it a poor fit for casual long-term use.
How scoring works
Quantity:100 Tablet(s) • (100 servings)
Goals:
Energy
Metabolism Boost
General Health

Score 75

Complete B-vitamin coverage and sustained release are useful, but conventional forms and 100 mg of vitamin B6 make it a poor fit for casual long-term use.
How scoring works
$18.50($0.18 per serving)
Vitacost
$ 20.97
iHerb
$ 19.59
Daily Vita
$ 18.50
Amazon
$ 19.33
Pure Formulas
$ 19.04
Report prices

Analysis

A complete, high-potency B-vitamin profile supports normal energy metabolism, with folate, B12, biotin, and pantothenic acid included alongside the core B vitamins. The sustained-release tablet may suit people who prefer gradual delivery rather than a standard capsule.

Most nutrients use conventional forms, including cyanocobalamin and pyridoxine hydrochloride, so the formula is less refined than active-form alternatives. Choline is present only in a modest amount and is not a meaningful reason to choose it.

Pyridoxine reaches 100 mg per serving, which is an aggressive amount for ongoing daily use. The large serving count improves convenience, but the safety trade-off matters more than the low serving cost.

Who is it for
  • Adults seeking a high-potency B-complex
  • People who prefer a sustained-release tablet
Best for
  • Broad B-vitamin coverage
  • Short-term use when a high-potency formula is appropriate

Pros

  • Complete core B-vitamin profile
  • Sustained-release tablet
  • Clearly listed nutrient amounts
  • Large serving count

Cons

  • Uses mostly conventional vitamin forms
  • Choline amount is modest
  • Potency is excessive for many routine users

Warnings

  • Vitamin B6 is supplied as 100 mg of pyridoxine hydrochloride; prolonged daily use at this level may cause tingling, numbness, or other nerve symptoms.

Nutrient quality

62 Moderate impact

The formula offers broad coverage, but standard forms and excessive pyridoxine weaken its quality. Most ingredients fit the intended purpose, although several minor additions are too small to add much.

Ingredient transparency

81 Highest impact

Active amounts are clearly disclosed and no proprietary blend is shown. Daily-use directions and the inactive ingredient list are missing from the supplied data.

Customer satisfaction

71 High impact

The average rating is strong and the large evidence base makes it more dependable. No specific feedback is supplied to judge repeated complaints or alignment with the intended use.

Value for money

87 Highest impact

Low serving cost supports good value for a broad B-complex. Conventional forms and several modest extras keep the formula from delivering premium quality.

Report analysis

Goals

Energy
Energy
Impact
Highest effect
A- Goal FitB+ Strength of SupportC+ CoverageA Formula Quality
Vitamin B5 · 100 mgRiboflavin · 100 mgThiamin · 100 mgVitamin B12 · 100 mcg

A full high-potency B-complex directly supports carbohydrate metabolism and the enzyme systems involved in cellular energy production. The focused design is most relevant when intake is inadequate and does not provide an immediate stimulant effect.

Amounts are clearly disclosed, although several vitamins use standard forms that require conversion in the body. Prolonged daily intake of the high vitamin B6 amount may cause tingling, numbness, or other nerve symptoms.

Metabolism Boost
Metabolism Boost
Impact
High effect
B- Goal FitB Strength of SupportD+ CoverageA- Formula Quality
Biotin · 100 mcgNiacin · 100 mgVitamin B12 · 100 mcgRiboflavin · 100 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 100 mg

Very high-potency B vitamins provide ample cofactors for normal cellular energy production. Sustained release may improve tolerance and distribution across the day.

The formula does not contain a thyroid nutrient, chromium, thermogenic, or carnitine. The very high B6 amount may cause tingling, numbness, or other nerve symptoms with ongoing use.

Study evidence
Vitamin B6 Supportive 16 studies
General Health
Daily Energy Vitality
General Health
Impact
High effect
B+ Goal FitD Strength of SupportC+ CoverageB+ Formula Quality
Folate · 667 mcg DFEVitamin B12 · 100 mcg

A complete B-vitamin panel can support energy metabolism and help address specific dietary gaps. Sustained release may spread delivery across the day, but it does not correct weak ingredient forms.

Vitamin B6 is supplied at a very high amount that may raise neuropathy risk with long-term daily use. Cyanocobalamin and standard pyridoxine are less preferred forms, making the formula better suited to a defined high-dose need than routine general use.

Study evidence
Folate Supportive 80 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
C+ Goal FitC Strength of SupportD+ CoverageB Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 667 mcg DFENiacin · 100 mg

A strongly dosed B-vitamin trio targets homocysteine metabolism. Evidence for direct cardiovascular outcomes is less convincing than the biochemical mechanism.

Older vitamin forms reduce formulation quality. Long-term high-dose vitamin B6 can cause neuropathy, which limits routine use.

Study evidence
Folate Supportive 93 studies
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies
Heart Health
Heart Health
Impact
Moderate effect
C+ Goal FitD+ Strength of SupportC- CoverageB Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 667 mcg DFE

Folate, vitamin B6, and vitamin B12 form a coherent homocysteine-support group. Sustained release may smooth delivery of the high-potency B-complex.

Folate and B12 use less preferred forms, niacinamide is not the lipid-modifying nicotinic-acid form, and no mineral or omega-3 pathway is included. The vitamin B6 amount reaches a level that may raise nerve-damage risk with prolonged daily use.

Study evidence
Folate Supportive 116 studies
Niacin Supportive 105 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Hydrochloride, Vitamin B1)
 100 mg
Riboflavin (Vitamin B2)
 100 mg
Niacin (Niacinamide, Vitamin B3)
 100 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 100 mg
Folate
667 mcg DFE
Vitamin B12 (Cyanocobalamin)
 100 mcg
Biotin
100 mcg
Pantothenic Acid (Calcium Pantothenate)
 100 mg
Choline (Choline Bitartrate)
 35 mg
Inositol
100 mg
PABA
10 mg
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
Niacin (Niacinamide, Vitamin B3) · 100 mg OverallScore91
A Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA- Value

Niacinamide supports general vitamin use, though it is not the form used for lipid-focused goals. The amount reaches an established general-use range, and sustained release may provide steadier delivery. Value is strong for the wider B-complex, but the supplied label details do not include a no-flush statement.

View ingredientView products
Thiamin (Thiamine Hydrochloride, Vitamin B1) · 100 mg OverallScore76
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value
Thiamine hydrochloride provides a clearly disclosed, high-potency B1 dose in a sustained-release B-complex. Its standard water-soluble form is less tissue-penetrating than premium thiamin derivatives, and the available data do not establish an especially clean excipient profile. Cost efficiency is weak when measured against the amount of this standard form.
View ingredientView products
Riboflavin (Vitamin B2) · 100 mg OverallScore74
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The 100 mg standard riboflavin dose provides high-potency metabolic support, though it requires conversion to the active coenzyme form. The hard-pressed tablet format may slow release, and no artificial colors, flavors, or synthetic sweeteners are listed. Cost efficiency is excellent for the potency supplied.

View ingredientView products
Loading alternative details
81 Performance

CellularActive Coenzyme B-Complex

Bluebonnet
<p>Cocarboxylase, riboflavin 5-phosphate, pyridoxal 5-phosphate, methylfolate, and methylcobalamin create a more balanced active-form profile than the original’s conventional 100 mg pattern. Vitamin B6 is held to 25 mg, though mixed methylfolate and folic acid plus only 10 mg choline remain trade-offs.</p>
81 Performance

Activated B-Complex High Bioavailability

Swanson
<p>Benfotiamine, riboflavin 5-phosphate, pyridoxal 5-phosphate, methylfolate, methylcobalamin, and pantethine improve form quality over the original’s conventional 100 mg pattern. The 25 mg B6 amount is more restrained than many high-potency complexes but still deserves care with long-term daily use.</p>
79 Performance

CoEnzyme B-Complex

KAL
<p>Active riboflavin, B6, methylfolate, and methylcobalamin provide broad coenzyme support with a more moderate 20 mg B6 amount than the original’s conventional 100 mg pattern. The chewable adds carbohydrate and also includes cyanocobalamin, while choline remains modest.</p>
77 Budget

B-50

NOW
<p>A much lower recurring cost still provides a complete B-complex with substantial core amounts. Compared with the original’s conventional 100 mg pattern, most forms remain basic and 50 mg of pyridoxine is still high for prolonged daily use.</p>
77 Budget

B-50 Complex 50 mg

Source Naturals
<p>A lower recurring cost preserves broad thiamine, riboflavin, niacin, B6, B12, pantothenic acid, choline, and inositol coverage. Compared with the original’s conventional 100 mg pattern, the formula uses basic forms, while high folate and 50 mg of pyridoxine reduce routine-use balance.</p>
76 Budget

Hi Potency B Complex

Natural Factors
<p>A lower recurring cost retains a complete high-potency B pattern with a long supply. Compared with the original’s conventional 100 mg pattern, the mostly conventional forms, very high folate, and 50 mg pyridoxine remain meaningful quality and long-term-use trade-offs.</p>
80 Value

B-Complex '100'

Solgar
<p>A very low recurring cost provides complete high-potency B coverage and a long supply. Compared with the original’s conventional 100 mg pattern, the value comes from quantity rather than form quality, and 100 mg pyridoxine creates a substantial long-term safety trade-off.</p>
75 Value

B-Complex 50

Bluebonnet
<p>A lower-cost 50 mg pattern retains the full set of B vitamins, choline, inositol, and PABA without moving into a 100 or 150 mg formula. Compared with the original’s conventional 100 mg pattern, form quality is basic and 50 mg pyridoxine remains high, so the value is mainly in broad coverage and supply.</p>
76 Value

Mega Vitamin B-Stress

Solaray
<p>A broad B-complex plus vitamin C provides substantial ingredient coverage and a larger supply for the cost. Compared with the original’s conventional 100 mg pattern, the formula adds antioxidant breadth but relies on basic forms, and 100 mg pyridoxine makes indefinite daily use difficult to justify.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  2. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  3. Vitamin B12 Supplementation: Is More Always Better?
    Yepes-Calderón M; Doorenbos CSE; Stegmann ME; Touw DJ; Harmsen HJM; Heiner-Fokkema MR; van Spronsen FJ; Corpeleijn E; Bakker SJL · Nutrients · 2026
    Narrative reviewEnergy forVitamin B12
  4. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.
    Duggal JK; Singh M; Attri N; Singh PP; Ahmed N; Pahwa S; Molnar J; Singh S; Khosla S; Arora R · Journal of cardiovascular pharmacology and therapeutics · 2010
    Meta-analysis5,137 participants7 studies pooledHeart Health forNiacin
  5. Role of Niacin in Current Clinical Practice: A Systematic Review.
    Garg A; Sharma A; Krishnamoorthy P; Garg J; Virmani D; Sharma T; Stefanini G; Kostis JB; Mukherjee D; Sikorskaya E · The American journal of medicine · 2017
    Meta-analysis35,206 participants13 studies pooledHeart Health forNiacin
  6. Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes).
    Guyton JR; Slee AE; Anderson T; Fleg JL; Goldberg RB; Kashyap ML; Marcovina SM; Nash SD; O'Brien KD; Weintraub WS; Xu P; Zhao XQ; Boden WE · Journal of the American College of Cardiology · 2013
    Randomized trial3,414 participantsHeart Health forNiacin
  7. Exploring the Cardiovascular Impacts of Oral Nicotinamide: A Comprehensive Narrative Review.
    Shoukfeh R; Tisack AM; Lim HW; Mohammad TF · Journal of drugs in dermatology : JDD · 2025
    Narrative reviewHeart Health forNiacin
  8. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
    Lavigne PM; Karas RH · Journal of the American College of Cardiology · 2013
    Meta-analysis9,959 participants11 studies pooledCardiovascular Support forNiacin
  9. Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.
    Saboori S; Yousefi Rad E; Tammam J; Thondre PS; Coe S · The British journal of nutrition · 2024
    Meta-analysis12 studies pooledCardiovascular Support forNiacin
  10. Effects of HDL-modifiers on cardiovascular outcomes: a meta-analysis of randomized trials.
    Verdoia M; Schaffer A; Suryapranata H; De Luca G · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2015
    Meta-analysis69,515 participants18 studies pooledCardiovascular Support forNiacin
  11. Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar.
    Jenkins DJA; Spence JD; Giovannucci EL; Kim YI; Josse RG; Vieth R; Sahye-Pudaruth S; Paquette M; Patel D; Blanco Mejia S; Viguiliouk E; Nishi SK; Kavanagh M; Tsirakis T; Kendall CWC; Pichika SC; Sievenpiper JL · Journal of the American College of Cardiology · 2021
    Meta-analysisCardiovascular Support forNiacin
  12. Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis.
    Mazur M; Ndokaj A; Salerno C; Vallone J; Ardan R; Bietolini S; Carrouel F; Wilk A; Sarig R; Ottolenghi L; Bourgeois D · Frontiers in pharmacology · 2026
    Meta-analysis6,098 participants16 studies pooledMetabolism Boost forVitamin B12
  13. First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders.
    Olivieri G; Bordugo A; Burnyte B; Costetti A; Couce ML; Diogo L; Feillet F; Froese DS; Greco B; Gueant JL; Hannibal L; Hörster F; Kožich V; La Marca G; Manoli I; Mochel F; Orazi L; Pérez B; Schiff M; Schwahn BC; Schwartz I; Stepien KM; Sykut-Cegielska J; Tangeraas T; Zetterström RH; Dionisi-Vici C; Huemer M · Journal of inherited metabolic disease · 2026
    Guideline / consensusMetabolism Boost forVitamin B12
  14. Vitamin B12 and Folate Concentrations in Recent-onset Type 2 Diabetes and the Effect of Metformin Treatment.
    Kanti G; Anadol-Schmitz E; Bobrov P; Strassburger K; Kahl S; Zaharia OP; Sarabhai T; Karusheva Y; Burkart V; Markgraf DF; Trenkamp S; Ziegler D; Szendroedi J; Roden M; GDS Group · The Journal of clinical endocrinology and metabolism · 2021
    Cross-sectional study249 participantsMetabolism Boost forVitamin B12
  15. Cross-Sectional Study of the Prevalence of Cobalamin Deficiency and Vitamin B12 Supplementation Habits among Vegetarian and Vegan Children in the Czech Republic.
    Světnička M; Sigal A; Selinger E; Heniková M; El-Lababidi E; Gojda J · Nutrients · 2022
    Cross-sectional study200 participantsMetabolism Boost forVitamin B12
  16. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  17. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  18. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  19. Optimum nutrition: thiamin, biotin and pantothenate.
    Bender DA · The Proceedings of the Nutrition Society · 1999
    Narrative reviewMetabolism Boost forVitamin B5
  20. Metabolic profiles of exercise in patients with McArdle disease or mitochondrial myopathy.
    Delaney NF; Sharma R; Tadvalkar L; Clish CB; Haller RG; Mootha VK · Proceedings of the National Academy of Sciences of the United States of America · 2018
    OtherMetabolism Boost forVitamin B5
  21. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  22. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  23. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  24. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  25. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  26. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  27. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  28. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  29. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  30. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  31. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  32. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  33. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  34. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  35. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  36. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  37. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  38. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  39. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  40. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  41. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  42. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  43. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  44. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate Heart Health forVitamin B6
  45. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  46. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  47. Differential effect of two nicotinic acid preparations on low-density lipoprotein subclass distribution in patients classified as low-density lipoprotein pattern A, B, or I.
    Superko HR; McGovern ME; Raul E; Garrett B · The American journal of cardiology · 2004
    Randomized trial180 participantsHeart Health forNiacin
  48. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration.
    Villines TC; Stanek EJ; Devine PJ; Turco M; Miller M; Weissman NJ; Griffen L; Taylor AJ · Journal of the American College of Cardiology · 2010
    Randomized trial315 participantsHeart Health forNiacin
  49. The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome.
    Thoenes M; Oguchi A; Nagamia S; Vaccari CS; Hammoud R; Umpierrez GE; Khan BV · International journal of clinical practice · 2008
    Randomized trial50 participantsHeart Health forNiacin
  50. Effect of niacin on endothelial function: a systematic review and meta-analysis of randomized controlled trials.
    Sahebkar A · Vascular medicine (London, England) · 2014
    Meta-analysis441 participants7 studies pooledHeart Health forNiacin
  51. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  52. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  53. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  54. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  55. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  56. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
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    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6
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    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
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    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  60. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
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    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
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    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6