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Stress B-Complex

Thorne
4.8
★ ★ ★ ★ ★
(216 ratings)
Niacin 80 mg
Thiamin 50 mg
Vitamin B5 250 mg
Vitamin B6 28.4 mg
Riboflavin 28.6 mg
Choline 14 mg
Product Image
Score74
A focused high-potency complex with methylcobalamin and substantial pantothenic acid. Moderate-high B6 plus missing B6 and folate form details reduce its long-term appeal.
How scoring works
Quantity:60 Capsule(s) • (60 servings)
Goals:
Energy
Metabolism Boost

Score 74

A focused high-potency complex with methylcobalamin and substantial pantothenic acid. Moderate-high B6 plus missing B6 and folate form details reduce its long-term appeal.
How scoring works
$26.00($0.43 per serving)
Pure Formulas
$ 26.00
Vitacost
$ 26.00
Vitacost
$ 26.00
Walmart
$ 26.00
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Analysis

The formula emphasizes pantothenic acid at 250 mg alongside thiamine, riboflavin, niacinamide, B6, folate, methylcobalamin, and biotin. That profile is coherent for broad metabolic support during periods of increased demand.

Methylcobalamin is a favorable B12 form, but the B6 and folate forms are not identified. Choline citrate contributes only 14 mg, so it adds little beyond the main B-vitamin profile.

Vitamin B6 at 28.4 mg is lower than a B-50 product but still more than needed for open-ended maintenance. The capsule best suits limited-duration use when the high pantothenic acid emphasis is specifically desired.

Who is it for
  • Adults seeking a pantothenic-acid-heavy B complex
  • Users who prefer methylcobalamin
  • People planning limited-duration high-potency use
Best for
  • Stress-period B-vitamin coverage
  • Pantothenic acid supplementation
  • Short-term energy-metabolism support

Pros

  • Uses methylcobalamin
  • Provides substantial pantothenic acid
  • Includes all core B vitamins
  • Requires one capsule daily

Cons

  • B6 form is not disclosed
  • Folate form is not disclosed
  • B6 is high for indefinite daily use
  • Choline is only 14 mg

Warnings

  • The 28.4 mg vitamin B6 amount may contribute to nerve symptoms with prolonged use, especially when combined with other B6 sources.
  • The 80 mg niacinamide amount may cause nausea or stomach upset in sensitive users.

Nutrient quality

74 High impact

Methylcobalamin and choline citrate are useful, while several vitamin forms are not identified. Vitamin B6 and niacin are high enough to make routine long-term use less appealing.

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Ingredient transparency

84 Highest impact

Specific amounts are supplied for every listed active ingredient. No proprietary blend hides the listed doses.

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Customer satisfaction

70 High impact

The supplied aggregate rating is very strong. No complaint themes or purpose-specific experience details are supplied.

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Value for money

63 Moderate impact

Quality or dose limitations weaken the premium position. The compact formula contains few obvious low-value additions.

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Goals

Energy
Energy
Impact
Highest effect
A- Goal FitB+ Strength of SupportC+ CoverageA Formula Quality
Vitamin B5 · 250 mgRiboflavin · 28.6 mgThiamin · 50 mgVitamin B12 · 100 mcg

A high-dose B-complex provides strong metabolic support, with pantothenic acid especially prominent. The formula remains focused on nutrient-based energy rather than immediate alertness.

Amounts are clearly stated, but undisclosed riboflavin form and standard thiamin limit part of the quality profile. High vitamin B6 intake warrants attention during prolonged daily use if nerve symptoms develop.

Study evidence
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
C- Goal FitB- Strength of SupportD+ CoverageB+ Formula Quality
Biotin · 80 mcgNiacin · 80 mgVitamin B12 · 100 mcgRiboflavin · 28.6 mgThiamin · 50 mgVitamin B5 · 250 mgVitamin B6 · 28.4 mg

B vitamins, led by a substantial pantothenic acid amount, support coenzyme reactions used in cellular energy production. The formula lacks chromium, magnesium, carnitine, CoQ10, or a thermogenic ingredient.

Methylcobalamin and transparent individual amounts strengthen its foundational use. The streamlined design remains narrow outside B-vitamin metabolism.

Study evidence
Vitamin B5 Supportive 12 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Hydrochloride)
 50 mg
Riboflavin
28.6 mg
Niacin (Niacinamide)
 80 mg
Vitamin B6
28.4 mg
Folate
334 mcg DFE
Vitamin B12 (Methylcobalamin)
 100 mcg
Biotin
80 mcg
Pantothenic Acid (Calcium Pantothenate)
 250 mg
Choline (Choline Citrate)
 14 mg
Gluten Free Adults 18–50
Report overview
Niacin (Niacinamide) · 80 mg OverallScore77
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD+ Value

Niacinamide is clearly identified at 80 mg and is suitable for general B-vitamin support rather than lipid-focused use. The capsule is easy to use but has no specified release technology. A focused B-complex supports the formula, although the standard niacin form offers only moderate value.

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Thiamin (Thiamine Hydrochloride) · 50 mg OverallScore76
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value
Thiamine hydrochloride is clearly supplied at the entry point of the high-potency range. The standard capsule does not establish premium tissue penetration or an especially clean excipient system. Its cost per active dose is high for a conventional B1 form.
View ingredientView products
Vitamin B5 (Calcium Pantothenate) · 250 mg OverallScore74
A- Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value

The 250 mg calcium pantothenate dose provides strong support for energy metabolism and stress response. Its stable, well-absorbed form is clearly identified, though the full capsule excipient profile is unavailable. Value is limited because the cost per active amount remains high.

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Loading alternative details
79 Performance

B Complex Plus

Seeking Health
<p>It improves ingredient-form quality through active riboflavin, vitamin B6, and vitamin B12 forms at meaningful amounts. The niacin declaration is ambiguous and may carry flushing potential.</p>
80 Performance

B-Complex #12

Thorne
<p>It improves ingredient-form quality through a focused B-complex with methylcobalamin and substantial energy-metabolism coverage. Several forms are not identified, and vitamin B6 and niacin warrant attention alongside fortified foods or other supplements.</p>
80 Performance

B-100 Complex with B2 Coenzyme

Nature's Way
<p>It improves ingredient-form quality through active riboflavin and partial P-5-P within broad B-vitamin coverage. The total vitamin B6 amount is very high and may raise nerve-symptom risk with prolonged use.</p>
77 Budget

B-50

NOW
<p>It lowers the recurring cost while providing broad B-vitamin dosing and a large supply. Basic forms and high vitamin B6 reduce suitability for indefinite daily use.</p>
74 Budget

B-Complex '50'

Solgar
<p>It lowers the recurring cost while providing complete B-vitamin coverage aligned with energy metabolism. Conventional forms, high vitamin B6, and a tiny herbal blend limit the quality case.</p>
77 Budget

B-50 Complex 50 mg

Source Naturals
<p>It lowers the recurring cost while providing broad metabolic coverage with clearly stated amounts and substantial pantothenic acid. High folic acid and vitamin B6 reduce dose balance for routine use.</p>
77 Value

B-50 Complex

Nature's Way
<p>It balances formulation quality and cost through active riboflavin and a broad, clearly dosed B-complex base. Vitamin B6 remains unnecessarily high for routine long-term use.</p>
76 Value

Hi Potency B Complex

Natural Factors
<p>It balances formulation quality and cost through a complete high-potency B-vitamin pattern with coherent energy support. High folate and vitamin B6 make the formula unnecessarily aggressive for unsupervised daily use.</p>
75 Value

B-Complex 50

Bluebonnet
<p>It balances formulation quality and cost through a complete B-vitamin pattern with clear amounts and reasonable serving value. The formula still relies on basic forms and a high vitamin B6 amount.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. [Niacin in therapy].
    Nagalski A; Bryła J · Postepy higieny i medycyny doswiadczalnej (Online) · 2007
    Narrative reviewMetabolism Boost forNiacin
  2. Lipid-lowering therapies, glucose control and incident diabetes: evidence, mechanisms and clinical implications.
    Zafrir B; Jain M · Cardiovascular drugs and therapy · 2015
    Narrative reviewMetabolism Boost forNiacin
  3. Insights Into Thiamine Supplementation in Patients With Septic Shock.
    Costa NA; Pereira AG; Sugizaki CSA; Vieira NM; Garcia LR; de Paiva SAR; Zornoff LAM; Azevedo PS; Polegato BF; Minicucci MF · Frontiers in medicine · 2022
    Narrative reviewMetabolism Boost forThiamin
  4. Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials.
    Nakanishi N; Abe Y; Matsuo M; Tampo A; Yamada K; Hatakeyama J; Yoshida M; Yamamoto R; Higashibeppu N; Nakamura K; Kotani J · Clinical nutrition (Edinburgh, Scotland) · 2024
    Meta-analysis3,494 participants35 studies pooledMetabolism Boost forThiamin
  5. Pyridoxine challenge reflects pediatric hypophosphatasia severity and thereby examines tissue-nonspecific alkaline phosphatase's role in vitamin B6 metabolism.
    Whyte MP; Zhang F; Mack KE; Wenkert D; Gottesman GS; Ericson KL; Cole JT; Coburn SP · Bone · 2024
    Non-randomized trial149 participantsMetabolism Boost forVitamin B6
  6. Vitamin B6 requirements of women using oral contraceptives.
    Leklem JE; Brown RR; Rose DP; Linkswiler HM · The American journal of clinical nutrition · 1975
    Non-randomized trial24 participantsMetabolism Boost forVitamin B6
  7. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  8. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  9. Optimum nutrition: thiamin, biotin and pantothenate.
    Bender DA · The Proceedings of the Nutrition Society · 1999
    Narrative reviewMetabolism Boost forVitamin B5
  10. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  11. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  12. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  13. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  14. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  15. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  16. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  17. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  18. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  19. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  20. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  21. Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline.
    González-Domínguez R; Castellano-Escuder P; Lefèvre-Arbogast S; Low DY; Du Preez A; Ruigrok SR; Lee H; Helmer C; Pallàs M; Urpi-Sarda M; Sánchez-Pla A; Korosi A; Lucassen PJ; Aigner L; Manach C; Thuret S; Samieri C; Andres-Lacueva C · Alzheimer's research & therapy · 2022
    Observational studyMetabolism Boost forVitamin B5
  22. Exploring auxotrophy and engineering vitamin B6 prototrophy in the acetogen Clostridium sp. AWRP.
    Kwon SJ; Lee J; Lee HS · Applied and environmental microbiology · 2024
    Clinical trialMetabolism Boost forVitamin B5
  23. Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy.
    Spry C; van Schalkwyk DA; Strauss E; Saliba KJ · Infectious disorders drug targets · 2010
    Narrative reviewMetabolism Boost forVitamin B5
  24. Serum metabolites of hypertension among Chinese adolescents aged 12-17 years.
    Sun J; Ding W; Liu X; Zhao M; Xi B · Journal of human hypertension · 2022
    Other77 participantsMetabolism Boost forVitamin B5