D3 + K2
Nature Made
D3 + K2
4.6
★ ★ ★ ★ ★
(138 ratings)
Vitamin K 100 mcg
Score 88.0
A high-quality D3 and K2 MK-7 combination from a reputable brand, featuring the superior 'all-trans' K2 form. It offers excellent synergistic support for bone and cardiovascular health at a competitive price, but has fewer reviews than some competitors.
Quantity: 30 Softgel(s)Servings size: 1 Softgel(s) (30 servings)
Selected goals:
Other goals:
Bone Health
Heart Health
Cardiovascular Support
General Health
leaderboard Score 88.0
A high-quality D3 and K2 MK-7 combination from a reputable brand, featuring the superior 'all-trans' K2 form. It offers excellent synergistic support for bone and cardiovascular health at a competitive price, but has fewer reviews than some competitors.
insights Analysis
Nature Made D3 + K2 is a well-formulated supplement that provides 100mcg of all-trans-Menaquinone-7 (MK-7), indicating a high-purity and effective form of Vitamin K2. While the D3 quantity is not specified in the ingredients list, its inclusion in the product name strongly suggests a beneficial synergistic dose with K2. This combination is highly favored by nutritionists for its crucial roles in directing calcium to bones and preventing its accumulation in arteries. Nature Made is a widely recognized and trusted brand. The price per serving (41 cents) is quite competitive for a combined D3+K2 product of this quality, making it an accessible option. The main area for improvement is its relatively lower review count (133) compared to some established market leaders in this category, which might affect consumer perception of its popularity or efficacy.
- Contains the highly bioavailable 'all-trans-Menaquinone-7' form of Vitamin K2.
- Combines Vitamin D3 with K2, offering crucial synergistic benefits for calcium utilization, bone density, and arterial health.
- Provides an effective 100mcg dosage of K2 MK-7.
- From Nature Made, a widely recognized and trusted supplement brand.
- Competitive price per serving for a combined D3+K2 product.
- The specific dosage of Vitamin D3 is not detailed in the provided ingredient list, which might be a consideration for users tracking their D3 intake precisely.
- Relatively lower review count compared to some leading D3+K2 supplements, potentially impacting perceived market adoption.
$12.59($0.41 per serving)
 Vitacost | $ 12.59 | |
 Walmart | $ 16.21 |
bolt Effectiveness for goals
Vitamin K is essential for proper blood clotting and plays a significant role in bone metabolism. It helps the body produce proteins necessary for these vital bodily functions.
Vitamin K activates proteins such as osteocalcin, which are crucial for incorporating calcium into the bone matrix. This mechanism supports bone mineralization and helps maintain bone density.
Vitamin K1 (phylloquinone) is primarily effective for blood coagulation and is abundant in green leafy vegetables. Vitamin K2 (menaquinones) is more involved in bone and cardiovascular health, found in fermented foods and animal products, and has different bioavailabilities.
Emerging research suggests that Vitamin K, particularly K2, may help prevent arterial calcification by activating matrix Gla protein. This protein helps inhibit calcium deposition in soft tissues, supporting arterial flexibility.
Vitamin K works synergistically with calcium by helping to direct calcium to the bones and away from soft tissues like arteries. It activates proteins like osteocalcin for bone binding and matrix Gla protein to inhibit soft tissue calcification.
schedule Dosage, timing & forms
Recommended dosages for Vitamin K vary by age and form (K1 vs K2). For adults, the Adequate Intake (AI) for Vitamin K is 120 mcg per day for men and 90 mcg per day for women. Specific supplemental dosages may differ depending on individual needs and health goals.
Yes, dosages can differ between Vitamin K1 and K2 due to their varying potencies and half-lives. While K1 is measured in micrograms (mcg) for general intake, K2 (especially MK-7) may be effective at lower microgram doses due to its longer half-life. It's important to check the specific form and dosage on the supplement label.
Yes, Vitamin K is a fat-soluble vitamin, meaning it is best absorbed when taken with a meal containing some dietary fat. This helps facilitate its absorption into the body.
The two main forms of Vitamin K found in supplements are Vitamin K1 (phylloquinone) and Vitamin K2 (menaquinone). Vitamin K2 further has various subtypes, with MK-4 and MK-7 being the most common in supplements. Each form may have distinct roles and bioavailability.
There is no established Upper Limit (UL) for Vitamin K from food or supplements, as toxicity is rare. However, high doses of synthetic Vitamin K (menadione, K3) can be toxic, though this form is not typically found in supplements. Always adhere to recommended dosages and consult a healthcare provider if you have concerns.
health_and_safety Safety & interactions
Vitamin K plays a crucial role in blood clotting, which is the opposite effect of anticoagulant medications such as warfarin. Consuming inconsistent amounts of Vitamin K can alter warfarin's effectiveness, potentially making the blood thinner less effective or increasing bleeding risk. Individuals taking warfarin should maintain a consistent intake of Vitamin K and consult their healthcare provider.
Individuals taking anticoagulant medications like warfarin should consult their doctor before taking Vitamin K supplements due to potential interactions. People with certain liver conditions or those with a G6PD deficiency should also seek medical advice before supplementation. Always discuss new supplements with a healthcare provider.
Vitamin K supplements are generally considered safe for most healthy individuals when taken at recommended dosages. Side effects are uncommon but can include upset stomach, diarrhea, or allergic reactions in sensitive individuals. High doses of synthetic Vitamin K (menadione, K3) can be toxic, but this form is rarely used in supplements.
Vitamin K is essential during pregnancy and breastfeeding, and adequate intake is important for both mother and child. However, supplementation during these periods should only be undertaken under the guidance of a healthcare professional. High doses are generally not recommended without specific medical advice.
There is currently no established Tolerable Upper Intake Level (UL) for Vitamin K from food or supplements due to its low potential for toxicity. However, excessive intake, especially of synthetic forms, could potentially have adverse effects. It is always best to adhere to recommended dosages on supplement labels or as advised by a healthcare professional.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin D3 | 125 mcg |
Vitamin K2 | 100 mcg |
Categories
Vitamin K 92.0
Within the Vitamin K category, this product offers the superior all-trans MK-7 form in an effective dose, crucially combined with Vitamin D3, making it an excellent and comprehensive choice for those seeking the full benefits of Vitamin K.
Goals
Bone Health 95.0
The D3 and K2 MK-7 combination is exceptional for bone health, as D3 enhances calcium absorption, and K2 ensures this calcium is effectively integrated into the bone matrix. This synergistic action is foundational for strong bones.
Heart Health 93.0
K2 is critical for preventing arterial calcification, a major factor in heart health, while D3 also contributes to cardiovascular wellness. This combination actively supports arterial elasticity and overall heart function, as recommended by health experts.
By preventing calcium deposition in soft tissues and arteries, this D3+K2 product offers robust cardiovascular support. It's a proactive approach to maintaining arterial health and reducing calcification risk, a key benefit recognized by nutritionists.
Recommended Alternatives
95 Value 
Vitamin D3 50 mcg (2000 IU) + K2 90 mcg
Carlson
4.9
★★★★★
(1290 ratings)
While slightly higher in price per serving (56 cents vs 41 cents), this alternative provides a clearly defined and optimal D3 dose along with K2 MK-7 from a highly trusted brand, offering superior proven value for comprehensive bone and heart health.
97 Value 
ADK Vitamins
Codeage
4.8
★★★★★
(1294 ratings)
Offering an exceptionally high 1800mcg of K2 MK-7 and including Vitamins A and D at a remarkably low price per serving (19 cents), this product offers outstanding value for a comprehensive fat-soluble vitamin complex, especially for high-dose K2 needs.
90 Value 
Vitamins D and K with Sea-lodine
Life Extension
4.8
★★★★★
(20811 ratings)
This alternative offers the valuable D+K combination along with Iodine at a very competitive price per serving (25 cents), providing excellent overall value for a multi-nutrient formula focused on bone, heart, and thyroid health.
98 Performance
Vitamin D3 50 mcg (2000 IU) + K2 90 mcg
Carlson
4.9
★★★★★
(1290 ratings)
This alternative is arguably superior due to its explicitly stated 2000 IU Vitamin D3 alongside a comparable K2 MK-7 dose, coupled with a significantly higher number of positive reviews, indicating widespread consumer trust and proven efficacy.
96 Performance
ADK Vitamins
Codeage
4.8
★★★★★
(1294 ratings)
This alternative provides a remarkably higher dose of K2 MK-7 (1800mcg) and additionally includes Vitamin A, offering a more potent and comprehensive blend of fat-soluble vitamins for those seeking enhanced support.
90 Performance 
Super K
Life Extension
4.7
★★★★★
(11302 ratings)
This product provides a high-dose blend of various Vitamin K forms (K1, MK-4, and MK-7), which might be considered 'better' for a broader spectrum of Vitamin K benefits and enhanced total absorption than a single form.
92 Budget
ADK Vitamins
Codeage
4.8
★★★★★
(1294 ratings)
Offers an exceptionally high 1800mcg of K2 MK-7 along with Vitamins A and D at a significantly lower price per serving (19 cents vs 41 cents), providing a much more economical option for high-potency K2 and comprehensive fat-soluble vitamin support.
88 Budget
Vitamins D and K with Sea-lodine
Life Extension
4.8
★★★★★
(20811 ratings)
At a more affordable price per serving (25 cents), this alternative provides a D+K combination, plus beneficial iodine, making it a cost-effective option for synergistic benefits, though the K form is unspecified.
85 Budget 
Vitamin K2 MK-7 (Menaquinone-7) 90 mcg
Carlson
4.8
★★★★★
(366 ratings)
While it's a K2-only product, it provides a quality MK-7 dose at a very competitive price per serving (30 cents), making it a cheaper option if one prefers to source D3 separately.
95 Value
Vitamin D3 50 mcg (2000 IU) + K2 90 mcg
Carlson
4.9
★★★★★
(1290 ratings)
While slightly higher in price per serving (56 cents vs 41 cents), this alternative provides a clearly defined and optimal D3 dose along with K2 MK-7 from a highly trusted brand, offering superior proven value for comprehensive bone and heart health.
97 Value
ADK Vitamins
Codeage
4.8
★★★★★
(1294 ratings)
Offering an exceptionally high 1800mcg of K2 MK-7 and including Vitamins A and D at a remarkably low price per serving (19 cents), this product offers outstanding value for a comprehensive fat-soluble vitamin complex, especially for high-dose K2 needs.
90 Value
Vitamins D and K with Sea-lodine
Life Extension
4.8
★★★★★
(20811 ratings)
This alternative offers the valuable D+K combination along with Iodine at a very competitive price per serving (25 cents), providing excellent overall value for a multi-nutrient formula focused on bone, heart, and thyroid health.
98 Performance
Vitamin D3 50 mcg (2000 IU) + K2 90 mcg
Carlson
4.9
★★★★★
(1290 ratings)
This alternative is arguably superior due to its explicitly stated 2000 IU Vitamin D3 alongside a comparable K2 MK-7 dose, coupled with a significantly higher number of positive reviews, indicating widespread consumer trust and proven efficacy.
96 Performance
ADK Vitamins
Codeage
4.8
★★★★★
(1294 ratings)
This alternative provides a remarkably higher dose of K2 MK-7 (1800mcg) and additionally includes Vitamin A, offering a more potent and comprehensive blend of fat-soluble vitamins for those seeking enhanced support.
90 Performance
Super K
Life Extension
4.7
★★★★★
(11302 ratings)
This product provides a high-dose blend of various Vitamin K forms (K1, MK-4, and MK-7), which might be considered 'better' for a broader spectrum of Vitamin K benefits and enhanced total absorption than a single form.