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R.E.M. Maintenance

Metabolic Maintenance
4.3
★ ★ ★ ★ ★
(46 ratings)
Glycine 3500 mg
5-HTP 100 mg
Product Image
Score77
Strong glycine and magnesium anchor a focused sleep powder, with premium cost and serotonergic interaction risk as key limitations.
How scoring works
Quantity:360 Gram(s) • (60 servings)
Goals:
Sleep Support
Mood Support
Stress Relief
Anti-Aging
Detoxification
Weight Loss

Score 77

Strong glycine and magnesium anchor a focused sleep powder, with premium cost and serotonergic interaction risk as key limitations.
How scoring works
$56.00($0.93 per serving)
Pure Formulas
$ 56.00
iHerb
$ 56.00
iHerb
$ 56.00
Report prices

Analysis

Three and a half grams of glycine and 250 mg of magnesium glycinate provide meaningful physical-relaxation and sleep-recovery support. Inositol, 5-HTP, and low-dose melatonin add calming, serotonin-related, and circadian pathways.

Principal active amounts are fully disclosed, and the magnesium form is well suited to a nighttime powder. Five-HTP lacks botanical-source or standardization details, while potassium plays only a small supporting role.

Adjustable powder dosing suits users who want a comprehensive bedtime formula. The daily cost is premium, and the 5-HTP plus melatonin combination requires careful attention to medicines and next-day alertness.

Who is it for
  • Adults seeking a comprehensive nighttime powder
  • Users wanting glycine and magnesium together
Best for
  • Sleep recovery and physical relaxation
  • Multi-pathway bedtime support

Pros

  • High glycine amount
  • Substantial magnesium glycinate
  • Low-dose melatonin

Cons

  • Premium daily cost
  • 5-HTP source is unspecified
  • Not suited to daytime use

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, triptans, or other serotonin-raising medicines without medical guidance.
  • Melatonin and other calming actives may cause next-day drowsiness; do not drive after use.
  • Magnesium may cause loose stools and requires caution with significant kidney impairment.

Nutrient quality

91 Highest impact

Strong glycine and magnesium amounts anchor a coherent nighttime formula. Missing 5-HTP sourcing and combined serotonergic and sedating effects are the key limitations.

Ingredient transparency

81 Highest impact

Every listed active has a specific amount, and no proprietary blend hides key doses. The serving count is clear, but intake directions and non-active ingredients are not supplied.

Customer satisfaction

57 Moderate impact

Customer sentiment is positive but not exceptional, and the small review volume limits confidence. No review excerpts are supplied, so repeated complaints and purpose fit cannot be verified.

Value for money

74 High impact

Meaningful amounts across several relevant actives support good formula-level value. Premium serving economics reduce category competitiveness.

Report analysis

Goals

Sleep Support
Sleep Support
Impact
Highest effect
A+ Goal FitA+ Strength of SupportA+ CoverageA Formula Quality
Magnesium · 250 mgMelatonin · 1 mgGlycine · 3500 mg

Glycine, magnesium glycinate, melatonin, 5-HTP, and inositol cover circadian timing, physical relaxation, and neurotransmitter support. Glycine and magnesium are supplied at strong amounts with excellent form disclosure.

The formula is highly sleep focused and avoids a crowded botanical blend. People using serotonergic antidepressants or other serotonin-raising medicines should avoid 5-HTP unless medically supervised.

Study evidence
5-HTP Supportive 1 study
Glycine Supportive 3 studies
Magnesium Supportive 23 studies
Melatonin Supportive 181 studies
Mood Support
Mood Support
Impact
Highest effect
B Goal FitA Strength of SupportA- CoverageA Formula Quality
Magnesium · 250 mg5-HTP · 100 mg

5-HTP supports serotonin production, while magnesium, glycine, inositol, and melatonin promote nighttime recovery. The formula may help mood when poor sleep is a major contributor but is less suited to daytime emotional resilience.

Glycine and magnesium are well dosed, and all principal actives are transparent. 5-HTP should not be combined with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines, and melatonin may cause next-day drowsiness.

Study evidence
5-HTP Supportive 9 studies
Glycine Mixed 3 studies
Magnesium Supportive 60 studies
Stress Relief
Calm and Tension Relief
Stress Relief
Impact
Highest effect
B Goal FitA Strength of SupportB+ CoverageA Formula Quality
Magnesium · 250 mgGlycine · 3500 mgVitamin C · 250 mg

Glycine, magnesium glycinate, 5-HTP, inositol, and melatonin create a focused sleep-recovery formula that may help when stress disrupts rest. The design supports nighttime recovery more directly than daytime resilience or acute calm.

Glycine and magnesium are well dosed, and all principal actives are individually disclosed. Melatonin may cause next-day drowsiness, and 5-HTP should not be combined with SSRIs, SNRIs, MAO inhibitors, or other serotonergic medicines.

Study evidence
5-HTP Supportive 18 studies
Glycine Supportive 1 study
Magnesium Supportive 13 studies
Melatonin Supportive 21 studies
Anti-Aging
Antioxidant DefenseSkin, Joint, & Bone Health
Anti-Aging
Impact
High effect
C+ Goal FitA- Strength of SupportB CoverageA Formula Quality
Magnesium · 250 mgGlycine · 3500 mg

Glycine, magnesium, vitamin C, and sleep-support ingredients may aid healthy aging through restorative sleep, antioxidant building blocks, and structural support. The goal connection is useful but less direct than a targeted mitochondrial or vascular formula.

Glycine reaches a meaningful amount and the main active doses are clearly disclosed. The 5-HTP may interact with serotonergic medicines, while melatonin can add to drowsiness and impair alertness after use.

Study evidence
Glycine Mixed 14 studies
Magnesium Supportive 12 studies
Melatonin Supportive 6 studies
Vitamin C Supportive 30 studies
Detoxification
Glutathione Support
Detoxification
Impact
High effect
C- Goal FitA- Strength of SupportD+ CoverageB+ Formula Quality
Magnesium · 250 mgVitamin C · 250 mgGlycine · 3500 mg

The included 5-HTP can interact with serotonergic medicines, and melatonin can increase drowsiness of glycine provides a direct substrate for Phase II glycine conjugation. The formula is designed for sleep, so detoxification remains a secondary use.

The glycine amount is clearly disclosed and forms the dominant active component. undefined.

Study evidence
Glycine Supportive 5 studies
Weight Loss
Appetite and Craving Control
Weight Loss
Impact
High effect
C- Goal FitB+ Strength of SupportD+ CoverageA Formula Quality
Magnesium · 250 mg

Glycine, magnesium, inositol, 5-HTP, and melatonin create a focused nighttime formula. Improved sleep may indirectly support appetite control and adherence to healthy routines.

Direct body-composition evidence is limited and the product does not address thermogenesis or muscle preservation. 5-HTP can interact with serotonergic antidepressants and other serotonin-raising drugs.

Study evidence
5-HTP Supportive 5 studies
Magnesium Supportive 17 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Moderate effect
D+ Goal FitB- Strength of SupportD CoverageC+ Formula Quality
Glycine · 3500 mgVitamin C · 250 mg

Glycine at 3,500 mg provides a meaningful amount of an amino acid with immunomodulatory and antioxidant roles. Vitamin C adds antioxidant support, but the remaining ingredients are aimed mainly at sleep.

The transparent powder format makes the principal dose easy to assess. Included 5-HTP can interact with serotonergic medicines, and melatonin may add drowsiness.

Study evidence
Glycine Supportive 7 studies
Vitamin C Supportive 50 studies

Ingredients

IngredientAmount per serving
Calories
10 Calorie(s)
Vitamin C (Ascorbic Acid)
 250 mg
Magnesium (Magnesium Glycinate)
 250 mg
Potassium (Potassium Citrate)
 75 mg
Glycine
3500 mg
Inositol
500 mg
5-Hydroxytryptophan
100 mg
Melatonin
1 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Glycine · 3500 mg OverallScore76
B- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyC Value

The powder supplies a clinically relevant glycine amount and allows easy dose adjustment. Source purity is not independently verified, but the exact amount is clear. Its cost per gram falls in a moderate value tier. Included 5-HTP may conflict with serotonergic medicines, while melatonin can increase drowsiness.

View ingredientView products
5-HTP · 100 mg OverallScore44
D- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyF Value

The label identifies 5-HTP but gives no botanical source or active standardization. The mixed powder lacks sustained or enteric delivery support; the serving matches the main target, although the supplied label data include no specific serotonin-medication warning. The normalized cost is poor for the disclosed active amount.

View ingredientView products
Loading alternative details
82 Performance

Sleep Nighttime Powder

youtheory
A coherent nighttime blend retains glycine, magnesium, 5-HTP, and melatonin while adding tryptophan and theanine. The melatonin amount is lower than in the original, though the combined serotonergic ingredients still warrant medication caution.
85 Performance

5-HTP 100 mg

NOW
A clearly disclosed Griffonia-derived 5-HTP serving provides a focused alternative with stronger supplied quality and value measures. It is not a complete nighttime blend and omits glycine, magnesium, inositol, and melatonin.
85 Performance

Glycine Powder

Metabolic Maintenance
The single-ingredient powder is easy to assess and can be scaled toward a multi-gram glycine intake. It avoids 5-HTP and melatonin exposure but does not provide the original's multi-ingredient sleep support.
84 Budget

5-HTP 50 mg

NOW
The lower-dose single active is far less costly and allows a more cautious approach to 5-HTP. It does not replace the original's glycine, magnesium, inositol, or melatonin, and serotonergic medicine interactions still matter.
85 Budget

5-HTP 100 mg

Doctor's Best
A focused Griffonia-derived 5-HTP serving matches the original's 5-HTP amount at a much lower cost. The simpler formula loses the original's broader nighttime ingredients and still requires caution with serotonergic medicines.
84 Budget

Glycine 1000 mg

Life Extension
The inexpensive single-ingredient capsule supports a simpler glycine-centered routine without melatonin or 5-HTP. Its glycine amount is lower than the original, so multiple capsules may be needed for a comparable intake.
83 Value

5-HTP 200mg

Best Naturals
The focused 5-HTP product offers strong supplied value and a clearly stated active amount. Its higher 5-HTP amount may not suit everyone, and it omits the original's glycine, magnesium, inositol, and melatonin.
83 Value

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best
A disclosed 5-HTP serving with vitamins B6 and C offers favorable value and keeps the formula relatively focused. It cannot fully replace the original's glycine-centered nighttime blend and retains the same serotonergic interaction concern.
83 Value

5-HTP 100 mg Extra Strength

Swanson
The matching 5-HTP amount and strong supplied value measures make this an economical option for that single pathway. It provides none of the original's glycine, magnesium, inositol, or melatonin, so the coverage is much narrower.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.
    Bannai M; Kawai N; Ono K; Nakahara K; Murakami N · Frontiers in neurology · 2012
    Clinical trial7 participantsSleep Support forGlycine
  2. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  3. Accelerated biological aging, mediating amino acids, and risk of incident type 2 diabetes: a prospective cohort study.
    Zhang Z; Wang J; Yu B; Sun Y; Chen Y; Lu Y; Wang N; Xia F · Journal of endocrinological investigation · 2025
    Cohort study95,773 participantsAnti-Aging forGlycine
  4. Dietary protein and amino acid intakes for mitigating sarcopenia in humans.
    He W; Connolly ED; Cross HR; Wu G · Critical reviews in food science and nutrition · 2025
    Narrative reviewAnti-Aging forGlycine
  5. Age-Related Neurochemical Changes in the Vestibular Nuclei.
    Smith PF · Frontiers in neurology · 2016
    Narrative reviewAnti-Aging forGlycine
  6. SHMT2 regulates CD8+ T cell senescence via the reactive oxygen species axis in HIV-1 infected patients on antiretroviral therapy.
    Zhang QS; Wang JN; Yang TL; Li SY; Li JQ; Liu DN; Shang H; Zhang ZN · EBioMedicine · 2025
    Observational studyAnti-Aging forGlycine
  7. Metabolomics and incident dementia in older Chinese adults: The Shanghai Aging Study.
    Cui M; Jiang Y; Zhao Q; Zhu Z; Liang X; Zhang K; Wu W; Dong Q; An Y; Tang H; Ding D; Chen X · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Cohort studyAnti-Aging forGlycine
  8. Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort.
    Welch AA; Skinner J; Hickson M · Nutrients · 2018
    Cross-sectional study156,575 participantsAnti-Aging forMagnesium
  9. Higher Magnesium Intake Is Associated with a Lower Risk of Frailty in Older Adults.
    Dominguez LJ; Mérida DM; Donat-Vargas C; Banegas JR; Veronese N; Barbagallo M; Rodríguez-Artalejo F; Guallar-Castillón P · Journal of the American Medical Directors Association · 2024
    Cohort study1,900 participantsAnti-Aging forMagnesium
  10. Ca:Mg Ratio, APOE Cytosine Modifications, and Cognitive Function: Results from a Randomized Trial.
    Zhu X; Borenstein AR; Zheng Y; Zhang W; Seidner DL; Ness R; Murff HJ; Li B; Shrubsole MJ; Yu C; Hou L; Dai Q · Journal of Alzheimer's disease : JAD · 2021
    Randomized trial250 participantsAnti-Aging forMagnesium
  11. The Association between Dietary Nutrient Intake and Acceleration of Aging: Evidence from NHANES.
    Ma J; Li P; Jiang Y; Yang X; Luo Y; Tao L; Guo X; Gao B · Nutrients · 2024
    Cross-sectional study4,692 participantsAnti-Aging forMagnesium
  12. Interpretable machine learning with SHAP analysis identifies redox-modulating dietary antioxidants for predicting accelerated biological aging.
    Zhang B; Zhang X; Ma L; Li D; Li Y; Lin S; Peng L; He L · Experimental gerontology · 2026
    Cross-sectional study8,125 participantsAnti-Aging forMagnesium
  13. Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis.
    Shang Y; Song N; He R; Wu M · Advances in nutrition (Bethesda, Md.) · 2024
    Meta-analysis2,617 participants20 studies pooledAnti-Aging forMelatonin
  14. Lipidomic and Instrumental Evaluation of a Melatonin-Based In & Out Strategy Versus Topical Treatment in Skin Aging: A Randomized Prospective Trial.
    Colombo F; Alfano S; Milani M · Metabolites · 2025
    Randomized trial39 participantsAnti-Aging forMelatonin
  15. Melatonin supplementation attenuates cuproptosis and ferroptosis in aging cumulus and granulosa cells: potential for improving IVF outcomes in advanced maternal age.
    Tsui KH; Li CJ; Lin LT · Reproductive biology and endocrinology : RB&E · 2024
    Cohort study161 participantsAnti-Aging forMelatonin
  16. Melatonin and healthy aging.
    Cardinali DP · Vitamins and hormones · 2021
    Narrative reviewAnti-Aging forMelatonin
  17. Clinical Studies Using Topical Melatonin.
    Greco G; Di Lorenzo R; Ricci L; Di Serio T; Vardaro E; Laneri S · International journal of molecular sciences · 2024
    Narrative reviewAnti-Aging forMelatonin
  18. Study on the Multiple Efficacies of Vitamin C Serum in Anti-Glycation, Anti-Carbonylation, Antioxidation, and Anti-Inflammation of Human Skin Based on In Vivo Tests.
    Zi Y; Liu J; Liu Q; Pan Y; Jiang X · Journal of cosmetic dermatology · 2026
    Randomized trial66 participantsAnti-Aging forVitamin C
  19. Evaluation of the anti-wrinkle effect of a lipophilic pro-vitamin C derivative, tetra-isopalmitoyl ascorbic acid.
    Yokota M; Yahagi S · Journal of cosmetic dermatology · 2022
    Randomized trial69 participantsAnti-Aging forVitamin C
  20. The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach.
    Crisan D; Roman I; Crisan M; Scharffetter-Kochanek K; Badea R · Clinical, cosmetic and investigational dermatology · 2015
    Clinical trial60 participantsAnti-Aging forVitamin C
  21. In vivo evaluation of topical ascorbic acid application on skin aging by 50 MHz ultrasound.
    Vergilio MM; Aiello LM; Furlan AS; Caritá AC; Azevedo JR; Bolzinger MA; Chevalier Y; Leonardi GR · Journal of cosmetic dermatology · 2022
    Randomized trial25 participantsAnti-Aging forVitamin C
  22. Clinical Applications of Vitamin C in Dermatology: A Systematic Review.
    Boghosian T; Mendez H; Boghosian N; Sayegh M; Beer J; Tosti A · The Journal of clinical and aesthetic dermatology · 2026
    Systematic review44 studies pooledAnti-Aging forVitamin C
  23. Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes.
    Cruz M; Maldonado-Bernal C; Mondragón-Gonzalez R; Sanchez-Barrera R; Wacher NH; Carvajal-Sandoval G; Kumate J · Journal of endocrinological investigation · 2009
    Randomized trial74 participantsAnti-Inflammatory Support forGlycine
  24. Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial.
    Vargas MH; Del-Razo-Rodríguez R; López-García A; Lezana-Fernández JL; Chávez J; Furuya MEY; Marín-Santana JC · BMC pulmonary medicine · 2018
    Randomized trial13 participantsAnti-Inflammatory Support forGlycine
  25. Subgingival air polishing (glycine powder) versus minocycline hydrochloride: efficacy in residual periodontal pockets following endoscope-assisted scaling and root planing.
    Guo X; Bai H; Lu X; Guo J; Qi Y; Huo X; Li S · Clinical oral investigations · 2026
    Randomized trial80 participantsAnti-Inflammatory Support forGlycine
  26. Long-term Implant Maintenance: A Systematic Review of Home and Professional Care Strategies in Supportive Implant Therapy.
    Araújo TG; Moreira CS; Neme RA; Luan H; Bertolini M · Brazilian dental journal · 2024
    Systematic review13 studies pooledAnti-Inflammatory Support forGlycine
  27. Analysis of the factors influencing the occurrence of peri-implantitis in patients with implant-supported restoration and study on the maintenance effect of subgingival sandblasting.
    Pan T; Meng W; Zhang M; Xie Y; Chen Z; Zhou M; Yin L; Xie H · BMC oral health · 2026
    Randomized trial198 participantsAnti-Inflammatory Support forGlycine
  28. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  29. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  30. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  31. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  32. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  33. The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
    Tan HC; Hsu JW; Tai ES; Chacko S; Kovalik JP; Jahoor F · Frontiers in endocrinology · 2024
    Cohort study42 participantsDetoxification forGlycine
  34. Metabolic impact of dietary glycine supplementation in individuals with severe obesity.
    Tan HC; Hsu JW; Tai ES; Chacko S; Wu V; Yen PM; Kovalik JP; Jahoor F · Scientific reports · 2025
    Single-arm trial19 participantsDetoxification forGlycine
  35. Contribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study.
    Irwin C; van Reenen M; Mason S; Mienie LJ; Westerhuis JA; Reinecke CJ · PloS one · 2017
    Non-randomized trial21 participantsDetoxification forGlycine
  36. Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function.
    Furuya KN; Durie PR; Roberts EA; Soldin SJ; Verjee Z; Yung-Jato L; Giesbrecht E; Ellis L · Clinical biochemistry · 1996
    Methods validation study74 participantsDetoxification forGlycine
  37. The treatment of isovaleric acidemia with glycine supplement
    M Naglak, R Salvo, K Madsen, P Dembure, L Elsas · Pediatric research · 1988
    Non-randomized trial2 participantsDetoxification forGlycine
  38. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  39. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  40. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  41. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  42. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  43. [Augmentation of antipsychotics with glycine may ameliorate depressive and extrapyramidal symptoms in schizophrenic patients--a preliminary 10-week open-label study].
    Strzelecki D; Kropiwnicki P; Rabe-Jabłońska J · Psychiatria polska · 2014
    Single-arm trial29 participantsMood Support forGlycine
  44. Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls.
    Pålsson E; Jakobsson J; Södersten K; Fujita Y; Sellgren C; Ekman CJ; Ågren H; Hashimoto K; Landén M · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015
    Cross-sectional study327 participantsMood Support forGlycine
  45. Erythrocyte glycine in depressed, hypomanic, and euthymic bipolar patients treated with lithium carbonate.
    Peselow ED; Deutsch SI; Stanley M; Banay-Schwartz M; Virgilio J; Fieve RR · Psychopharmacology · 1983
    Cross-sectional study27 participantsMood Support forGlycine
  46. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  47. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support Stress Relief forMagnesium
  48. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  49. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  50. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  51. The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review.
    Soh J; Raventhiran S; Lee JH; Lim ZX; Goh J; Kennedy BK; Maier AB · GeroScience · 2024
    Systematic reviewSleep Support forGlycine
  52. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.
    Bannai M; Kawai N · Journal of pharmacological sciences · 2012
    Narrative reviewSleep Support forGlycine
  53. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  54. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  55. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  56. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  57. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  58. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  59. Melatonin treatment for age-related insomnia.
    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
    Randomized trial30 participantsSleep Support forMelatonin
  60. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
    Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
    Meta-analysis409 participants8 studies pooledSleep Support forMelatonin
  61. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
    Randomized trial791 participantsSleep Support forMelatonin
  62. Effects of exogenous melatonin on sleep: a meta-analysis.
    Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
    Meta-analysis284 participants8 studies pooledSleep Support forMelatonin
  63. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
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