Product Image

EPA-DHA Balance

Jarrow Formulas
4.8
★ ★ ★ ★ ★
(17353 ratings)
EPA (Eicosapentaenoic Acid) 800 mg
Omega-3 1200 mg
Fish Oil 2000 mg
DHA 400 mg
Product Image
Score81
A potent and clearly dosed EPA-DHA blend, held back by missing oil-quality details and middling value in this package size.
How scoring works
Quantity:120 Softgel(s) • (60 servings)
Goals:
Heart Health
Cardiovascular Support
Anti-Inflammatory Support
Skin Health
Joint Health
Metabolism Boost
Mental Focus

Score 81

A potent and clearly dosed EPA-DHA blend, held back by missing oil-quality details and middling value in this package size.
How scoring works
$48.99($0.81 per serving)
iHerb
$ 56.30
Vitacost
$ 57.63
Vitacost
$ 57.63
Daily Vita
$ 48.99
Walmart
$ 60.80
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Analysis

Two softgels deliver 1,200 mg omega-3s from 2,000 mg fish-oil concentrate. The 800 mg EPA and 400 mg DHA split gives useful depth for cardiovascular goals and some broader skin or joint support.

Separate EPA, DHA, total omega-3, and fish-oil amounts make the concentration easy to judge. The supplied label details omit molecular form, source species, antioxidant protection, purification information, and inactive ingredients.

The smaller bottle provides 60 servings and carries only moderate serving value compared with the larger version. It makes more sense for a trial period than for an established daily routine.

Who is it for
  • Adults seeking a balanced but EPA-forward omega-3 dose
  • People who prefer trying a smaller package first
Best for
  • Heart and cardiovascular support
  • Meaningful EPA and DHA intake

Pros

  • 1,200 mg combined omega-3s per serving
  • EPA and DHA are fully disclosed
  • Active fats make up a solid share of the fish oil

Cons

  • Requires two softgels per serving
  • Molecular form and fish source are missing
  • Smaller package is less economical than its companion size

Warnings

  • Avoid with a fish allergy because the concentrate is fish-derived
  • The substantial EPA and DHA dose can add to anticoagulant or antiplatelet effects
  • Stop using capsules that develop a strong rancid odor because oxidation protection is not stated

Nutrient quality

88 Highest impact

Strong EPA and DHA concentration provides meaningful dose quality. Missing molecular-form, purification, and oxidation details reduce ingredient confidence.

Ingredient transparency

81 Highest impact

Active fatty-acid quantities are clearly disclosed without a hidden blend. Missing full directions, excipients, and some oil-quality details reduce completeness.

Customer satisfaction

72 High impact

The supplied average rating is very strong and the rating volume is substantial. No specific experience details were provided to judge repeated complaints or purpose alignment.

Value for money

82 Highest impact

The formula offers fair value for its cost. It remains moderately competitive but does not clearly lead the category.

Report analysis

Goals

Heart Health
Impact
Highest effect
A+ Goal FitA+ Strength of SupportB CoverageA+ Formula Quality
EPA (Eicosapentaenoic Acid) · 800 mg

A fully disclosed 800 mg of EPA and 400 mg of DHA provides a concentrated omega-3 serving with strong cardiovascular relevance. The EPA-forward profile directly supports triglyceride management and also contributes to inflammatory balance.

Two softgels deliver the full active amount without relying on a vague fish-oil total. EPA and DHA may modestly increase bleeding tendency with anticoagulant or antiplatelet medicines, especially alongside other products that affect clotting.

Study evidence
Cardiovascular Support
Impact
Highest effect
A+ Goal FitB Strength of SupportB- CoverageA+ Formula Quality
Fish Oil · 2000 mg

The fish oil supplies a substantial combined amount of EPA and DHA for triglyceride and endothelial support. These fatty acids have strong human evidence for lowering elevated triglycerides, while broader cardiovascular effects depend on dose and user context.

EPA and DHA are listed separately and make up a high share of the oil. Molecular form, purification, independent testing, fish source, and antioxidant protection are not disclosed.

Study evidence
Fish Oil Supportive 185 studies
Anti-Inflammatory Support
Impact
Highest effect
A Goal FitB+ Strength of SupportB- CoverageA Formula Quality
Fish Oil · 2000 mg

The 1,200 mg combined EPA and DHA dose provides strong support for inflammation-resolution pathways. Individual active amounts are clearly disclosed and make up a substantial share of the fish oil.

Unknown molecular form, purification, independent testing, fish source, and oxidation protection limit confidence in quality. The focused formula still provides meaningful pathway depth because the active dose is substantial.

Study evidence
Fish Oil Supportive 68 studies
Skin Health
Impact
Highest effect
B Goal FitB+ Strength of SupportB- CoverageA Formula Quality
Omega-3 · 1200 mg

EPA and DHA may support the skin's lipid barrier and help regulate inflammatory stress. Human evidence for skin hydration and resilience is useful but less direct than evidence for collagen or ceramides.

The combined active amount is substantial and each fatty acid is clearly disclosed. A generic concentrate form with no fish source, antioxidant protection, or purity testing limits quality confidence.

Study evidence
Omega-3 Supportive 35 studies
Joint Health
Impact
High effect
C+ Goal FitB+ Strength of SupportD+ CoverageA+ Formula Quality
Omega-3 · 1200 mg

Clearly disclosed EPA and DHA amounts provide a meaningful omega-3 dose that may support inflammatory balance and joint comfort. The product remains a focused lipid supplement rather than a complete joint formula.

It offers strong depth for one pathway but no cartilage building blocks or direct lubrication support. Transparent fatty-acid amounts and a streamlined design strengthen confidence in the intended use.

Study evidence
Omega-3 Supportive 40 studies
Metabolism Boost
Impact
High effect
C Goal FitA- Strength of SupportD+ CoverageA- Formula Quality
Omega-3 · 1200 mg

EPA and DHA may support insulin sensitivity and metabolic health indirectly. Human evidence is useful for cardiometabolic markers, but omega-3 fats do not directly stimulate thermogenesis.

The 1200 mg total omega-3 amount, including 800 mg EPA and 400 mg DHA, provides a substantial dose. EPA, DHA, and total omega-3 amounts are clearly disclosed, though the oil form is not specified. The oil comes from fish and may not be suitable for people with a fish allergy.

Study evidence
Omega-3 Supportive 42 studies
Mental Focus
Impact
High effect
D+ Goal FitB Strength of SupportD+ CoverageA Formula Quality

EPA and DHA support long-term neuronal structure but are not dependable acute focus enhancers. The formula is EPA-heavy and lacks an alertness, precursor, or adaptogen component.

The fatty-acid amounts are fully disclosed and substantial. Missing oil form, antioxidant protection, and independent contaminant testing reduce quality confidence.

Study evidence

Ingredients

IngredientAmount per serving
Calories
20 Calorie(s)
Total Fat
2 Gram(s)
Fish Oil concentrate
2000 mg
Omega-3 Fatty Acids
1200 mg
Eicosapentaenoic Acid
800 mg
Docosahexaenoic Acid
400 mg
Gluten Free Adults 18–50
Report overview
D Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD+ Value

The EPA-focused profile is strong, with 800 mg of EPA and half as much DHA per serving. The label does not state triglyceride form, antioxidant protection, or third-party contaminant testing, leaving quality safeguards uncertain. Value is moderate for the amount of EPA delivered.

Omega-3 · 1200 mg OverallScore58
D- Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyB+ Value

Separate EPA and DHA amounts make the active dose easy to understand, and they form a solid share of the total oil. The concentrate form, generic fish source, and lack of listed antioxidant protection limit confidence in absorption and freshness. Cost per active gram remains favorable despite these quality gaps.

Fish Oil · 2000 mg OverallScore44
F Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyD+ Value

The serving supplies a standard effective amount of EPA and DHA, with both fats clearly disclosed. Active fats make up a high share of the oil, but its molecular form, purification method, testing, and antioxidant protection are not stated. Cost per gram of EPA and DHA is moderate rather than especially low.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Dietetic intervention in psoriatic arthritis: the DIETA trial.
    Leite BF; Morimoto MA; Gomes CMF; Klemz BNC; Genaro PS; Shivappa N; Hébert JR; Damasceno NRT; Pinheiro MM · Advances in rheumatology (London, England) · 2022
    Randomized trial97 participantsSkin Health forOmega-3
  2. Omega-3 fatty acid supplement skin cancer prophylaxis in lung transplant recipients: A randomized, controlled pilot trial.
    Miura K; Vail A; Chambers D; Hopkins PM; Ferguson L; Grant M; Rhodes LE; Green AC · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019
    Randomized trial49 participantsSkin Health forOmega-3
  3. Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation.
    Furuhjelm C; Warstedt K; Fagerås M; Fälth-Magnusson K; Larsson J; Fredriksson M; Duchén K · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2011
    Randomized trial145 participantsSkin Health forOmega-3
  4. Dietary supplementation with very long-chain n-3 fatty acids in patients with atopic dermatitis. A double-blind, multicentre study.
    Søyland E; Funk J; Rajka G; Sandberg M; Thune P; Rustad L; Helland S; Middelfart K; Odu S; Falk ES · The British journal of dermatology · 1994
    Randomized trial145 participantsSkin Health forOmega-3
  5. Prenatal Omega-3 Supplementation and Eczema Risk among Offspring at Age 36 Months.
    Berman D; Clinton C; Limb R; Somers EC; Romero V; Mozurkewich E · Insights in allergy, asthma & bronchitis · 2020
    Randomized trial84 participantsSkin Health forOmega-3
  6. A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
    Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
    Meta-analysis1,524 participants17 studies pooledCardiovascular Support forFish Oil
  7. Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
    Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
    Randomized trial309 participantsCardiovascular Support forFish Oil
  8. Vitamin D, Marine n-3 Fatty Acids, and Primary Prevention of Cardiovascular Disease Current Evidence.
    Manson JE; Bassuk SS; Cook NR; Lee IM; Mora S; Albert CM; Buring JE; VITAL Research Group · Circulation research · 2020
    Randomized trial25,871 participantsCardiovascular Support forFish Oil
  9. Marine n-3 fatty acid treatment for carotid plaques in patients with type 2 diabetes.
    Zhuang P; Liu X; Jia W; Zheng W; Wan X; Chen W; Gu J; Li Y; Lan X; Li H; Tong W; Wu Y; Wu X; Ao Y; Ye H; Wu F; Zhu L; Zhang L; Li Y; Meng D; Tian Y; Wang A; Wu S; Zhu F; Zhang Y; Shi H; Yu X; Zhang F; Zhang Y; Jiao J · Cardiovascular diabetology · 2026
    Randomized trial415 participantsCardiovascular Support forFish Oil
  10. Fish oil, enriched with polyunsaturated fatty acids of the omega-3-type accelerates the nucleation time in healthy subjects.
    Janowitz P; Swobodnik W; Wechsler JG; Janowitz A; Saal D; Ditschuneit H · Klinische Wochenschrift · 1991
    Non-randomized trial24 participantsCardiovascular Support forFish Oil
  11. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial.
    Stonehouse W; Benassi-Evans B; Bednarz J; Vincent AD; Hall S; Hill CL · The American journal of clinical nutrition · 2022
    Randomized trial235 participantsJoint Health forOmega-3
  12. Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis.
    Sigaux J; Mathieu S; Nguyen Y; Sanchez P; Letarouilly JG; Soubrier M; Czernichow S; Flipo RM; Sellam J; Daïen C · Arthritis research & therapy · 2022
    Meta-analysis1,420 participants30 studies pooledJoint Health forOmega-3
  13. Omega-3 polyunsaturated fatty acids and the treatment of rheumatoid arthritis: a meta-analysis.
    Lee YH; Bae SC; Song GG · Archives of medical research · 2013
    Meta-analysis10 studies pooledJoint Health forOmega-3
  14. Dietary Long-Chain n-3 Fatty Acid Intake and Arthritis Risk in the Women's Health Initiative.
    Krok-Schoen JL; Brasky TM; Hunt RP; Rohan TE; Baker TA; Li W; Carbone L; Mackey RH; Snetselaar L; Lustberg MB; Neuhouser ML · Journal of the Academy of Nutrition and Dietetics · 2019
    Cohort study80,551 participantsJoint Health forOmega-3
  15. Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial.
    Song J; Hu M; Li C; Yang B; Ding Q; Wang C; Mao L · Food & function · 2018
    Randomized trial201 participantsAnti-Inflammatory Support forFish Oil
  16. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients.
    Lin YL; Wang CL; Chiang TI · Frontiers in nephrology · 2024
    Randomized trial60 participantsAnti-Inflammatory Support forFish Oil
  17. Lowering effects of fish oil supplementation on proinflammatory markers in hypertension: results from a randomized controlled trial.
    Yang B; Ren XL; Li ZH; Shi MQ; Ding F; Su KP; Guo XJ; Li D · Food & function · 2020
    Randomized trial77 participantsAnti-Inflammatory Support forFish Oil
  18. The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning.
    Meng Z; Dong Y; Gao H; Yao D; Gong Y; Meng Q; Zheng T; Cui X; Su X; Tian Y · The Journal of international medical research · 2019
    Randomized trial174 participantsAnti-Inflammatory Support forFish Oil
  19. Effects of Omega-3 Fatty Acid Intake in Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Liu R; Jiang J; Fu Z; Liu C; Yao L; Quan H · Journal of the American Nutrition Association · 2022
    Meta-analysis49 studies pooledAnti-Inflammatory Support forFish Oil
  20. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
    Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
    Meta-analysis127,477 participants13 studies pooledCardiovascular Support forFish Oil
  21. Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
    Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial422 participantsCardiovascular Support forFish Oil
  22. Effect of High-Dose Marine Omega-3 Fatty Acids on Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
    Sekikawa A; Cui C; Sugiyama D; Fabio A; Harris WS; Zhang X · Nutrients · 2020
    Meta-analysis6 studies pooledCardiovascular Support forFish Oil
  23. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.
    Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Saito Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Japan EPA lipid intervention study (JELIS) Investigators · Lancet (London, England) · 2007
    Randomized trial18,645 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  24. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS).
    Saito Y; Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; JELIS Investigators, Japan · Atherosclerosis · 2008
    Randomized trial14,981 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  25. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis.
    Dinu M; Sofi F; Lotti S; Colombini B; Mattioli AV; Catapano AL; Casula M; Baragetti A; Wong ND; Steg PG; Ambrosio G · European journal of preventive cardiology · 2024
    Meta-analysis134,144 participants18 studies pooledHeart Health forEPA (Eicosapentaenoic Acid)
  26. Incremental effects of eicosapentaenoic acid on cardiovascular events in statin-treated patients with coronary artery disease.
    Matsuzaki M; Yokoyama M; Saito Y; Origasa H; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Matsuzawa Y; JELIS Investigators · Circulation journal : official journal of the Japanese Circulation Society · 2009
    Randomized trialHeart Health forEPA (Eicosapentaenoic Acid)
  27. Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association.
    Skulas-Ray AC; Wilson PWF; Harris WS; Brinton EA; Kris-Etherton PM; Richter CK; Jacobson TA; Engler MB; Miller M; Robinson JG; Blum CB; Rodriguez-Leyva D; de Ferranti SD; Welty FK; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology · Circulation · 2020
    OtherHeart Health forEPA (Eicosapentaenoic Acid)
  28. Supplementation of fish oil and olive oil in patients with rheumatoid arthritis.
    Berbert AA; Kondo CR; Almendra CL; Matsuo T; Dichi I · Nutrition (Burbank, Los Angeles County, Calif.) · 2005
    Randomized trial43 participantsJoint Health forOmega-3
  29. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
    Wang W; Xu Y; Zhou J; Zang Y · Clinical rheumatology · 2024
    Meta-analysis1,018 participants18 studies pooledJoint Health forOmega-3
  30. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain.
    Goldberg RJ; Katz J · Pain · 2007
    Meta-analysis17 studies pooledJoint Health forOmega-3
  31. The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose-response meta-analysis.
    Suh SW; Lim E; Burm SY; Lee H; Bae JB; Han JW; Kim KW · BMC medicine · 2024
    Meta-analysis9,660 participants24 studies pooledMental Focus forEPA (Eicosapentaenoic Acid)
  32. EPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHD.
    Gustafsson PA; Birberg-Thornberg U; Duchén K; Landgren M; Malmberg K; Pelling H; Strandvik B; Karlsson T · Acta paediatrica (Oslo, Norway : 1992) · 2011
    Randomized trial92 participantsMental Focus forEPA (Eicosapentaenoic Acid)
  33. Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA)-Should They Be Mandatory Supplements in Pregnancy?
    Amza M; Haj Hamoud B; Sima RM; Dinu MD; Gorecki GP; Popescu M; Gică N; Poenaru MO; Pleș L · Biomedicines · 2024
    Narrative reviewMental Focus forEPA (Eicosapentaenoic Acid)
  34. Supplementation with oil rich in eicosapentaenoic acid, but not in docosahexaenoic acid, improves global cognitive function in healthy, young adults: results from randomized controlled trials.
    Patan MJ; Kennedy DO; Husberg C; Hustvedt SO; Calder PC; Khan J; Forster J; Jackson PA · The American journal of clinical nutrition · 2021
    Randomized trial310 participantsMental Focus forEPA (Eicosapentaenoic Acid)
  35. Effects of omega-3 supplementation on glucose and lipid metabolism in patients with gestational diabetes: A meta-analysis of randomized controlled trials.
    Liu W; Gao M; Yang S; Sun C; Bi Y; Li Y; Wang J; Yuan X · Journal of diabetes and its complications · 2023
    Meta-analysis331 participants6 studies pooledMetabolism Boost forOmega-3
  36. Hepatic de novo lipogenesis is suppressed and fat oxidation is increased by omega-3 fatty acids at the expense of glucose metabolism.
    Green CJ; Pramfalk C; Charlton CA; Gunn PJ; Cornfield T; Pavlides M; Karpe F; Hodson L · BMJ open diabetes research & care · 2021
    Randomized trial38 participantsMetabolism Boost forOmega-3
  37. Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
    Soleimani Z; Hashemdokht F; Bahmani F; Taghizadeh M; Memarzadeh MR; Asemi Z · Journal of diabetes and its complications · 2018
    Randomized trial60 participantsMetabolism Boost Skin Health forOmega-3
  38. The Effects of Flaxseed Oil Omega-3 Fatty Acids Supplementation on Metabolic Status of Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Mirmasoumi G; Fazilati M; Foroozanfard F; Vahedpoor Z; Mahmoodi S; Taghizadeh M; Esfeh NK; Mohseni M; Karbassizadeh H; Asemi Z · Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2018
    Randomized trial60 participantsMetabolism Boost forOmega-3
  39. A combination of omega-3 and plant sterols regulate glucose and lipid metabolism in individuals with impaired glucose regulation: a randomized and controlled clinical trial.
    Wang JF; Zhang HM; Li YY; Xia S; Wei Y; Yang L; Wang D; Ye JJ; Li HX; Yuan J; Pan RR · Lipids in health and disease · 2019
    Randomized trial200 participantsMetabolism Boost forOmega-3
  40. Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix.
    Lee YJ; Han HJ; Shim HS · Journal of wound care · 2024
    Randomized trial50 participantsSkin Health forOmega-3
  41. Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers.
    Rhodes LE; Shahbakhti H; Azurdia RM; Moison RM; Steenwinkel MJ; Homburg MI; Dean MP; McArdle F; Beijersbergen van Henegouwen GM; Epe B; Vink AA · Carcinogenesis · 2003
    Randomized trial42 participantsSkin Health forOmega-3