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Vitamin K2 100 mcg

4.8
★ ★ ★ ★ ★
(8941 ratings)
Vitamin K 100 mcg
Product Image
Score82
A clear, well-dosed natto-derived MK-7 capsule with good value, limited mainly by dry delivery and generic source quality.
How scoring works
Capsule
Quantity:60 Capsule(s) • (60 servings)
Goals:
Anti-Aging
Cardiovascular Support
Bone Health
Heart Health
General Health

Score 82

A clear, well-dosed natto-derived MK-7 capsule with good value, limited mainly by dry delivery and generic source quality.
How scoring works
$13.97($0.23 per serving)
iHerb
$ 13.97
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Analysis

Natto-derived MK-7 supports vitamin K-dependent proteins that direct calcium toward bone and away from soft tissue. The subtype and practical daily amount are clearly disclosed.

The focused capsule makes it easy to combine with separately chosen vitamin D and minerals. No lipid carrier, branded source, or all-trans purity statement is provided.

The product fits adults seeking straightforward natto-derived K2 at a reasonable cost. It provides strong depth in calcium handling but does not constitute broad bone or cardiovascular support alone.

Who is it for
  • Adults seeking natto-derived MK-7
  • Users wanting a practical daily K2 amount
  • People building a separate bone-support routine
Best for
  • Vitamin K-dependent calcium handling
  • Bone-protein activation
  • Focused arterial-support nutrition

Pros

  • Natto-derived MK-7
  • Well-aligned daily amount
  • Focused and clearly disclosed formula

Cons

  • No lipid carrier
  • No branded or all-trans guarantee
  • No vitamin D companion

Warnings

  • MK-7 can oppose warfarin and related vitamin K antagonist medicines
  • Keep vitamin K intake consistent if an anticoagulation prescriber approves use
  • Take the dry capsule with a meal containing fat unless directed otherwise

Nutrient quality

94 Highest impact

Natto-derived menaquinone-7 is a well-regarded, long-acting vitamin K2 form, and the vitamin K2 amount is meaningful for routine standalone support. The amount is not unnecessarily aggressive for a focused supplement, while the focused formula is not padded with low-value active extras.

Ingredient transparency

77 High impact

The amount is listed, but duplicate vitamin K2 source entries make the total presentation slightly ambiguous. No proprietary blend hides active doses, while capsule materials and inactive ingredients are not provided.

Customer satisfaction

73 High impact

The supplied aggregate satisfaction metric is very strong, and the large amount of aggregate feedback makes the metric highly stable. No review excerpts were provided, so recurring complaints and purpose-specific experiences cannot be checked.

Value for money

83 Highest impact

A well-regarded form and moderate serving cost support good value. Each serving provides meaningful vitamin K2 with little burden, while the formula avoids unnecessary active extras.

Report analysis

Goals

Anti-Aging
Impact
Highest effect
A- Goal FitA+ Strength of SupportC CoverageA+ Formula Quality
Vitamin K · 100 mcg

Natto-derived vitamin K2 as MK-7 supports bone mineral placement and helps keep calcium out of arteries. The 100 mcg amount is fully disclosed and well aligned with common daily use.

The formula has strong depth in one healthy-aging pathway but lacks mitochondrial, inflammatory, or structural breadth. Vitamin K can oppose warfarin-type anticoagulants, so intake should remain consistent under prescriber guidance.

Study evidence
Vitamin K Supportive 27 studies
Cardiovascular Support
Impact
Highest effect
B+ Goal FitA+ Strength of SupportC- CoverageA+ Formula Quality
Vitamin K · 100 mcg

Vitamin K2 in the MK-7 form supports proteins that help keep calcium directed away from arteries. The mechanism is relevant to vascular health, although evidence for major cardiovascular outcomes is less developed than for lipid or blood-pressure interventions.

The natto-derived amount fits a practical daily range and is clearly disclosed. Vitamin K2 can counteract warfarin and related vitamin K antagonists, so dose changes require prescriber oversight.

Study evidence
Vitamin K Supportive 40 studies
Bone Health
Impact
Highest effect
A- Goal FitA Strength of SupportC CoverageB+ Formula Quality
Vitamin K · 100 mcg

Natto-derived vitamin K2 as MK-7 is directly relevant to activating proteins that guide calcium into bone. The disclosed amount fits a commonly used daily range and the long-acting form is appropriate.

The focused capsule provides strong depth for calcium-routing support but no calcium or vitamin D. Vitamin K2 can alter warfarin control, so users of vitamin K antagonist anticoagulants need clinician-guided consistency.

Study evidence
Vitamin K Supportive 78 studies
Heart Health
Impact
Highest effect
B Goal FitA+ Strength of SupportC- CoverageA+ Formula Quality
Vitamin K · 100 mcg

Vitamin K2 as menaquinone-7 supports activation of proteins that help direct calcium away from arteries and into bone. Human evidence is encouraging for arterial-calcium biology, although direct cardiovascular outcome evidence is less established than for EPA and DHA.

The 100 mcg amount and natto-derived MK-7 form are clearly disclosed in a focused formula. Vitamin K2 can oppose warfarin and other vitamin-K-antagonist anticoagulants, making stable intake and prescriber guidance essential for those users.

Study evidence
Vitamin K Mixed 62 studies
General Health
Impact
Highest effect
B+ Goal FitA Strength of SupportC- CoverageA Formula Quality
Vitamin K · 100 mcg

Natto-derived MK-7 provides a well-disclosed vitamin K2 form that supports normal blood clotting and calcium handling. The 100 mcg amount fits the collection's preferred range.

The dry capsule has no listed fat carrier, which may limit absorption unless taken with a meal containing fat. MK-7 can counteract warfarin and related vitamin K antagonist medicines, so users of those drugs need consistent intake and prescriber guidance.

Study evidence
Vitamin K Supportive 34 studies

Ingredients

IngredientAmount per serving
Vitamin K2 (Menaquinone-7, Natto)
100 mcg
Gluten Free Adults 18–50 Vegan Dairy Free Sugar Free Vegetarian
Report overview
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The natto-derived MK-7 amount fits the preferred daily range at a very low cost. Clear form and dose disclosure make the label easy to assess. The dry capsule has no stated lipid carrier or meal direction, and the source lacks a branded or all-trans guarantee.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  2. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  3. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  4. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  5. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  6. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  7. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  8. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  9. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  10. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  11. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  12. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  13. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  14. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  15. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  16. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  17. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  18. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  19. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  20. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  21. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K