Product Image

Complete B 100 mg

Natural Factors
4.7
★ ★ ★ ★ ★
(1311 ratings)
PABA 100 mg
Thiamin 100 mg
Niacin 100 mg
Riboflavin 100 mg
Vitamin B6 100 mg
Choline 84 mg
Vitamin B5 100 mg
Product Image
Score72
Best suited to general health, with the clearest benefits coming from the disclosed active ingredients. Complete B-vitamin coverage fits energy metabolism well, but basic forms and very high B6, niacin, and related doses are unnecessarily aggressive.
How scoring works
Quantity:90 Tablet(s) • (90 servings)
Goals:
General Health
Energy
Cardiovascular Support

Score 72

Best suited to general health, with the clearest benefits coming from the disclosed active ingredients. Complete B-vitamin coverage fits energy metabolism well, but basic forms and very high B6, niacin, and related doses are unnecessarily aggressive.
How scoring works
$18.87($0.20 per serving)
Amazon
$ 18.87
iHerb
$ 18.87
Vitacost
$ 18.87
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Analysis

Complete B-vitamin coverage fits energy metabolism well, but basic forms and very high B6, niacin, and related doses are unnecessarily aggressive. Active ingredients and amounts are clearly listed with no hidden blend, while non-active ingredients are not supplied.

A complete B-complex supports energy metabolism and several foundational cellular processes. The amounts are substantial, but conventional forms such as cyanocobalamin and pyridoxine hydrochloride are less refined than active alternatives. The formula is focused and clearly dosed, with inositol and choline adding modest breadth.

Biotin, B12, folate, and other B vitamins can help cover nutrient gaps that occasionally contribute to shedding. The label clearly states a high-potency B-complex profile. Hair benefit is unlikely when B-vitamin status is already adequate, and the formula lacks zinc, iron, structural amino acids, or hormonal support.

Who is it for
  • People seeking general health support
  • People seeking energy support
  • People seeking cardiovascular support support
Best for
  • General Health
  • Energy
  • Cardiovascular Support

Pros

  • A complete B-complex supports energy metabolism and several foundational cellular processes.
  • The large pyridoxine amount may raise neuropathy risk with prolonged daily use, making it less suitable as an unrestricted maintenance formula.
  • A complete high-dose B-complex supports the reactions needed for normal energy metabolism.
  • The vitamin B6 amount reaches the adult upper intake level, and prolonged use may increase the risk of nerve damage.
  • B vitamins support homocysteine metabolism, giving this formula a plausible cardiovascular role.

Cons

  • Complete B-vitamin coverage fits energy metabolism well, but basic forms and very high B6, niacin, and related doses are unnecessarily aggressive.
  • Active ingredients and amounts are clearly listed with no hidden blend, while non-active ingredients are not supplied.
  • The amounts are substantial, but conventional forms such as cyanocobalamin and pyridoxine hydrochloride are less refined than active alternatives.
  • The formula is focused and clearly dosed, with inositol and choline adding modest breadth.
  • Vitamin B12 remains below the stated focused benchmark and uses cyanocobalamin, while several other B vitamins are supplied at very high amounts.

Warnings

  • The large pyridoxine amount may raise neuropathy risk with prolonged daily use, making it less suitable as an unrestricted maintenance formula.
  • The product also lacks thermogenic agents, thyroid minerals, chromium, magnesium, carnitine, and other direct metabolic actives.
  • The formula has useful depth within one metabolic pathway but does not address lipids, minerals, or cardiac energy.
  • Long-term use of this B6 amount may raise the risk of peripheral nerve symptoms.
  • Long-term daily use of the high vitamin B6 amount may increase the risk of tingling, numbness, or other nerve symptoms.

Nutrient quality

63 Moderate impact

Cyanocobalamin and pyridoxine hydrochloride are conventional forms, while the folate form is not identified. The vitamin B6 amount is excessive for routine long-term use and raises neuropathy concern.

Ingredient transparency

79 High impact

Listed active amounts are clear without a hidden proprietary dose. Complete directions and inactive-ingredient details remain incomplete.

Customer satisfaction

72 High impact

The aggregate rating and its volume provide a favorable top-level signal. Missing experience details prevent assessment of repeated complaints or purpose-specific satisfaction.

Value for money

72 High impact

The low serving cost supports value, but conventional forms and excessive vitamin B6 reduce quality. Form quality and routine-use safety keep the value conclusion mixed.

Report analysis

Goals

General Health
Daily Energy Vitality
General Health
Impact
High effect
A- Goal FitC Strength of SupportB- CoverageB+ Formula Quality
Folate · 680 mcg DFEVitamin B12 · 100 mcg

A complete B-complex supports energy metabolism and several foundational cellular processes. The amounts are substantial, but conventional forms such as cyanocobalamin and pyridoxine hydrochloride are less refined than active alternatives.

The formula is focused and clearly dosed, with inositol and choline adding modest breadth. The large pyridoxine amount may raise neuropathy risk with prolonged daily use, making it less suitable as an unrestricted maintenance formula.

Study evidence
Vitamin B12 Adverse 66 studies
Energy
Energy
Impact
High effect
B- Goal FitC- Strength of SupportC- CoverageB Formula Quality
Vitamin B5 · 100 mgRiboflavin · 100 mgThiamin · 100 mgVitamin B12 · 100 mcg

A complete high-dose B-complex supports the reactions needed for normal energy metabolism. Vitamin B12 remains below the stated focused benchmark and uses cyanocobalamin, while several other B vitamins are supplied at very high amounts.

The formula is streamlined but offers no acute alertness, mitochondrial specialty active, or adaptogen pathway. The vitamin B6 amount reaches the adult upper intake level, and prolonged use may increase the risk of nerve damage.

Study evidence
Vitamin B12 Disputed 14 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
C Goal FitC+ Strength of SupportD+ CoverageB+ Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 680 mcg DFENiacin · 100 mg

B vitamins support homocysteine metabolism, giving this formula a plausible cardiovascular role. The design is still a general high-potency B complex rather than a focused heart-support product.

Folate, vitamin B12, and vitamin B6 are present in meaningful amounts, but the forms are mostly conventional. The high vitamin B6 amount may increase nerve-symptom risk with long-term daily use.

Study evidence
Folate Supportive 93 studies
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies
Metabolism Boost
Metabolism Boost
Impact
Moderate effect
D+ Goal FitC- Strength of SupportD CoverageB Formula Quality
Biotin · 300 mcgNiacin · 100 mgVitamin B12 · 100 mcgRiboflavin · 100 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 100 mg

A broad set of high-dose B vitamins supports normal cellular energy reactions. The label is transparent and the formula stays focused on related cofactors.

Standard forms and a very high pyridoxine amount reduce the quality and balance of the approach. The product also lacks thermogenic agents, thyroid minerals, chromium, magnesium, carnitine, and other direct metabolic actives.

Study evidence
Riboflavin Mixed 5 studies
Vitamin B12 Supportive 10 studies
Vitamin B6 Supportive 16 studies
Heart Health
Heart Health
Impact
Moderate effect
C- Goal FitD+ Strength of SupportD CoverageC Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 680 mcg DFE

A full B-complex supports homocysteine metabolism through B6, folate, and B12. Pyridoxine and cyanocobalamin are less preferred forms, while the 100 mg B6 amount is unusually high for daily use.

The formula has useful depth within one metabolic pathway but does not address lipids, minerals, or cardiac energy. Long-term use of this B6 amount may raise the risk of peripheral nerve symptoms.

Study evidence
Folate Supportive 116 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Hydrochloride)
 100 mg
Riboflavin (Vitamin B2)
 100 mg
Niacin (Niacinamide)
 100 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 100 mg
Folate
680 mcg DFE
Vitamin B12 (Cyanocobalamin)
 100 mcg
Biotin (Vitamin B7)
 300 mcg
Pantothenic Acid (Calcium Pantothenate)
 100 mg
Choline (Choline Bitartrate)
 84 mg
Calcium (Calcium Pantothenate, Dicalcium Phosphate)
 80 mg
Inositol
100 mg
Para-Aminobenzoic Acid
100 mg
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
PABA · 100 mg OverallScore93
A Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA- Value

The clearly identified PABA amount is well aligned with a robust standalone dose. Standard immediate release is appropriate at this amount. The serving cost compares favorably with the active amount delivered.

View ingredientView products
Thiamin (Thiamine Hydrochloride) · 100 mg OverallScore88
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Thiamine hydrochloride is a standard water-soluble form, and the 100 mg amount reaches a high-potency range. The exact thiamin amount is clear, but the standard tablet has no advanced delivery feature. The 100 mg vitamin B6 amount may raise the risk of nerve symptoms with prolonged daily use.

View ingredientView products
Niacin (Niacinamide) · 100 mg OverallScore77
B- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyC Value

A clear 100 mg niacinamide dose supports general niacin needs without the usual nicotinic-acid flush. The hard tablet lacks a release feature, but the serving remains reasonably priced for a high-potency B complex. Long-term daily use deserves caution because the 100 mg vitamin B6 amount may increase the risk of nerve symptoms.

View ingredientView products
Loading alternative details
92 Performance

BioCoenzymated Active B Complex

Natural Factors
<p>Benfotiamine, riboflavin 5-phosphate, P-5-P, methylfolate, and methylcobalamin provide a focused active-form profile with a more moderate vitamin B6 amount than many high-potency formulas. Niacin remains substantial, but the formula avoids the original’s more aggressive combination of duplicate high-dose entries.</p>
90 Performance

B-Complex Plus

Pure Encapsulations
<p>Methylfolate, methylcobalamin, P-5-P, and activated riboflavin create a focused formula with a comparatively restrained vitamin B6 amount. Niacin remains elevated, but the shorter ingredient list avoids token extras and keeps the purpose clear.</p>
87 Performance

High Potency Vitamin B Complex

Lake Avenue Nutrition
<p>Active riboflavin, P-5-P, methylfolate, and methylcobalamin provide strong form quality with a modest vitamin B6 amount. The niacin declaration combines niacinamide and nicotinic acid without a clear split, so flushing, redness, or stomach upset remain possible.</p>
68 Budget

B-Complex '100'

Solgar
<p>A much lower serving cost provides a complete high-potency B-vitamin panel with useful biotin and inositol. Most forms are conventional, and 100 mg of pyridoxine reaches the chronic-use safety ceiling, so the savings do not make it a good unsupervised daily option.</p>
66 Budget

B-100

NOW
<p>A substantially lower serving cost retains broad B-vitamin coverage in a simple one-serving formula. Conventional forms and 100 mg of pyridoxine make it less refined than the original and raise concern about nerve symptoms with prolonged use.</p>
73 Budget

B-100 Complex with B2 Coenzyme

Nature's Way
<p>A lower serving cost adds active riboflavin and partial P-5-P while preserving broad B-100 coverage. The total vitamin B6 listing remains very high, and cyanocobalamin and several conventional forms make it less balanced for routine long-term use.</p>
88 Value

CellularActive Coenzyme B-Complex

Bluebonnet
<p>Coenzyme thiamine, riboflavin 5-phosphate, P-5-P, methylfolate, and methylcobalamin provide strong form quality at a modest serving cost. Mixed methylfolate and folic-acid entries plus elevated vitamin B6 reduce clarity, while small PABA and inositol amounts add little.</p>
85 Value

Coenzyme B-Complex Caps

Country Life
<p>Multiple coenzyme forms, methylfolate, two active vitamin B12 forms, and pantethine provide substantial formulation depth for the serving cost. Vitamin B6 remains elevated and choline is modest, so the value is strongest for selective rather than continuous high-dose use.</p>
83 Value

B-Complex

Paradise Earth's Blend
<p>Benfotiamine, riboflavin 5-phosphate, P-5-P, methylfolate, and methylcobalamin provide broad active-form coverage at a low serving cost. The vitamin B6 amount is high for prolonged unsupervised use, while the small greens, probiotic, and adaptogen blends add little measurable value.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid function tests, zinc, copper, biotin, and selenium levels.
    Durusu Turkoglu IN; Turkoglu AK; Soylu S; Gencer G; Duman R · Journal of cosmetic dermatology · 2024
    Case-control study180 participantsHair Health forVitamin B12
  2. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  3. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  4. Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single-Center Experience.
    Karakoyun Ö; Ayhan E; Yıldız İ · Journal of cosmetic dermatology · 2025
    Cohort study2,851 participantsHair Health forVitamin B12
  5. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  6. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  7. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forVitamin B12
  8. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  9. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  10. Micronutrient levels and thyroid functions in scarring alopecias: Do they play a role in disease pathogenesis?
    Gönülal Bak R; Çetin C; Kılınç F; Akbaş A; Aksoy Saraç G · Cutaneous and ocular toxicology · 2025
    Case-control study136 participantsHair Health forVitamin B12
  11. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
  12. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  13. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  14. Dermatological findings of vitamin B12 deficiency and resolving time of these symptoms.
    Demir N; Doğan M; Koç A; Kaba S; Bulan K; Ozkol HU; Doğan SZ · Cutaneous and ocular toxicology · 2014
    Single-arm trial57 participantsHair Health forVitamin B12
  15. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  16. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  17. Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in a Tertiary Medical Center.
    Arslan H; Gündüz Ö · Dermatology practical & conceptual · 2023
    Observational study973 participantsHair Health forVitamin B12
  18. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  19. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  20. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  21. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  22. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  23. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  24. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  25. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  26. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  27. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  28. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  29. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  30. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  31. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  32. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  33. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  34. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  35. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  36. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  37. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  38. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  39. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  40. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  41. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  42. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  43. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  44. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  45. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate Heart Health forVitamin B6
  46. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  47. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  48. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  49. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  50. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  51. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  52. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  53. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  54. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6
  55. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  56. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  57. Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects.
    Chuang CZ; Boyles A; Legardeur B; Su J; Japa S; Lopez-S A · The American journal of the medical sciences · 2006
    Non-randomized trial34 participantsMetabolism Boost forRiboflavin
  58. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  59. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledMetabolism Boost forRiboflavin
  60. Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes: a prospective UK cohort study (PRiDE study).
    Saravanan P; Sukumar N; Adaikalakoteswari A; Goljan I; Venkataraman H; Gopinath A; Bagias C; Yajnik CS; Stallard N; Ghebremichael-Weldeselassie Y; Fall CHD · Diabetologia · 2022
    Cohort study4,746 participantsMetabolism Boost forVitamin B12
  61. First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders.
    Olivieri G; Bordugo A; Burnyte B; Costetti A; Couce ML; Diogo L; Feillet F; Froese DS; Greco B; Gueant JL; Hannibal L; Hörster F; Kožich V; La Marca G; Manoli I; Mochel F; Orazi L; Pérez B; Schiff M; Schwahn BC; Schwartz I; Stepien KM; Sykut-Cegielska J; Tangeraas T; Zetterström RH; Dionisi-Vici C; Huemer M · Journal of inherited metabolic disease · 2026
    Guideline / consensusMetabolism Boost forVitamin B12
  62. Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
    Carmel R; Melnyk S; James SJ · Blood · 2003
    Observational study39 participantsMetabolism Boost forVitamin B12
  63. Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis.
    Mazur M; Ndokaj A; Salerno C; Vallone J; Ardan R; Bietolini S; Carrouel F; Wilk A; Sarig R; Ottolenghi L; Bourgeois D · Frontiers in pharmacology · 2026
    Meta-analysis6,098 participants16 studies pooledMetabolism Boost forVitamin B12
  64. Diagnosis and treatment of vitamin B12 deficiency in children.
    Kanvinde P; Khurana R; Mudaliar S · Frontiers in nutrition · 2026
    Narrative reviewMetabolism Boost forVitamin B12
  65. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  66. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  67. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  68. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  69. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6