Product Image

B-Complex '100'

Solgar
4.7
★ ★ ★ ★ ★
(30303 ratings)
Thiamin 100 mg
Niacin 100 mg
Riboflavin 100 mg
Vitamin B6 100 mg
Vitamin B5 100 mg
Choline 20 mg
Vitamin B12 100 mcg
Product Image
Score80

A large-supply B-100 capsule with complete coverage and basic forms. Very high vitamin B6 makes prolonged daily use the main concern.

How scoring works
Quantity:100 Capsule(s) • (100 servings)
Goals:
Energy
General Health
Heart Health

Score 80

A large-supply B-100 capsule with complete coverage and basic forms. Very high vitamin B6 makes prolonged daily use the main concern.

How scoring works

Also available as

4 options
50 mg • 250 Capsule(s) servings 50 mg • 250 Capsule(s) • 250 servings $25.87 ($0.10 per serving) 50 mg • 100 Capsule(s) servings 50 mg • 100 Capsule(s) • 100 servings $11.96 ($0.11 per serving) 250 servings 1 Vegetable Capsule(s) • 250 Capsule(s) • 250 servings $41.94 ($0.16 per serving) 50 servings 1 Vegetable Capsule(s) • 50 Capsule(s) • 50 servings $11.02 ($0.22 per serving)
$11.96($0.11 per serving)
Daily Vita
$ 22.27
iHerb
$ 18.92
Vitacost
$ 20.39
Amazon
$ 11.96
Report prices

Analysis

Thiamine, riboflavin, niacin, vitamin B6, and pantothenic acid are each supplied at 100 mg. Folate, cyanocobalamin, biotin, choline, and inositol add breadth.

The formula is straightforward, but most forms are conventional and choline is limited to 20 mg. The 100 mg pyridoxine amount is much more aggressive than needed for ordinary nutritional coverage.

A large capsule supply improves convenience for users who have a specific reason to choose a high-potency formula. Safety and dose fit matter more than bottle size for regular use.

Who is it for
  • Adults directed to use a high-potency B complex
  • People who prefer capsules
  • Users seeking a large serving supply
Best for
  • High-potency B-complex coverage
  • Normal energy metabolism
  • Short-term targeted supplementation

Pros

  • Broad B-vitamin profile
  • Clearly stated amounts
  • Includes inositol
  • Large serving supply

Cons

  • 100 mg vitamin B6 is excessive for many users
  • Uses conventional cyanocobalamin and pyridoxine
  • Choline amount is modest
  • High amounts may be unnecessary

Warnings

  • Long-term daily intake of 100 mg vitamin B6 may cause nerve symptoms
  • Avoid combining it with other high-dose vitamin B6 supplements
  • Seek advice if tingling, numbness, or balance changes develop

Nutrient quality

68 High impact

The complete B-vitamin profile provides substantial metabolic cofactors in a focused formula. Conventional forms and an excessive vitamin B6 amount make the design less suitable for routine long-term use.

Ingredient transparency

84 Highest impact

The major B vitamins have separate amounts and no hidden blend obscures the core formula. Complete usage directions and the inactive-ingredient list are not supplied here.

Customer satisfaction

78 High impact

The very strong average rating is supported by an exceptionally large review base. No review excerpts describe tolerance, effectiveness, or repeated complaints, so those experiences remain uncertain.

Value for money

90 Highest impact

A long supply and focused one-capsule formula provide strong economic value. The excessive vitamin B6 amount still limits value for routine long-term use.

Report analysis

Goals

Energy
Energy
Impact
High effect
A- Goal FitB Strength of SupportC CoverageB Formula Quality
Vitamin B5 · 100 mgRiboflavin · 100 mgThiamin · 100 mgVitamin B12 · 100 mcg

High amounts of the core B vitamins support energy metabolism when intake is insufficient. The formula is focused and clearly declares the main nutrient amounts.

Cyanocobalamin and pyridoxine are conventional forms, while several nutrients appear twice as a nutrient and source label. The 100 mg vitamin B6 amount is too high for casual long-term stacking with other B-complex products.

Study evidence
Vitamin B12 Disputed 14 studies
General Health
Daily Energy Vitality
General Health
Impact
High effect
A- Goal FitC Strength of SupportB- CoverageB- Formula Quality
Folate · 666 mcg DFEVitamin B12 · 100 mcg

A high-potency B-complex provides broad support for normal energy metabolism and nervous-system function. Most B vitamins are individually quantified, but B12 is cyanocobalamin rather than an active coenzyme form.

The formula is more intensive than routine nutritional maintenance requires. Vitamin B6 at 100 mg may cause nerve damage with sustained use, so long-term daily use deserves particular caution.

Heart Health
Heart Health
Impact
High effect
C+ Goal FitB- Strength of SupportC- CoverageB- Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 666 mcg DFE

Folate, Vitamin B6, and Vitamin B12 support homocysteine metabolism, giving the B-complex a narrow cardiovascular role. The formula does not directly address lipids, vascular tone, or cardiac energy.

Most amounts are clear, but folate is not identified as methylfolate and Vitamin B12 uses cyanocobalamin. The 100 mg Vitamin B6 amount is at a high chronic-use level and prolonged use may increase neuropathy risk.

Study evidence
Folate Supportive 116 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies
Metabolism Boost
Metabolism Boost
Impact
Moderate effect
D+ Goal FitC+ Strength of SupportD CoverageA- Formula Quality
Biotin · 100 mcgNiacin · 100 mgVitamin B12 · 100 mcgRiboflavin · 100 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 100 mg

High-dose B vitamins support normal energy-producing reactions but do not directly raise metabolic rate. The formula lacks thermogenic agents, mitochondrial transport compounds, thyroid minerals, and meaningful glycemic-control actives.

Several B vitamins reach substantial amounts, although most use standard precursor forms. The high vitamin B6 amount may raise the risk of tingling, numbness, or other nerve symptoms with prolonged daily use.

Study evidence
Vitamin B12 Supportive 10 studies
Vitamin B6 Supportive 16 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
C Goal FitD+ Strength of SupportD CoverageB Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 666 mcg DFENiacin · 100 mg

Folate, vitamin B6, and vitamin B12 support homocysteine metabolism, but this is a narrow cardiovascular pathway. Basic vitamin forms and an excessive B6 amount reduce suitability for long-term use.

The formula is focused and fully quantified, yet it omits lipids, cardiac-energy cofactors, and vascular minerals. Daily use at the listed B6 amount may increase peripheral neuropathy risk, especially with other B6 supplements.

Study evidence
Folate Supportive 93 studies
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Mononitrate, Vitamin B1)
 100 mg
Riboflavin (Vitamin B2)
 100 mg
Niacin (Niacinamide, Vitamin B3)
 100 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 100 mg
Folate
666 mcg DFE
Vitamin B12 (Cyanocobalamin)
 100 mcg
Biotin (D-Biotin)
 100 mcg
Pantothenic Acid (D-Calcium Pantothenate, Vitamin B5)
 100 mg
Choline (Choline Bitartrate)
 20 mg
Inositol
100 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Halal Vegetarian
Report overview
Thiamin (Thiamine Mononitrate, Vitamin B1) · 100 mg OverallScore92
B Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Thiamine mononitrate is a standard, clearly disclosed form supplied at a high-potency amount. The vegetable capsule and low serving cost make this an efficient B-complex choice, although it does not use a premium thiamin form. The high pyridoxine amount may cause nerve symptoms when used for long periods.

View ingredientView products
Niacin (Niacinamide, Vitamin B3) · 100 mg OverallScore88
B+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA Value

The capsule provides a meaningful niacinamide amount within a focused B-complex. Its standard immediate-release delivery is practical but does not include technology for slower or stabilized absorption. The low serving cost and broad B-vitamin profile create strong value for general supplementation.

View ingredientView products
Riboflavin (Vitamin B2) · 100 mg OverallScore77
D- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The 100 mg amount is in the high-potency range for metabolic support, although standard riboflavin requires conversion to its active coenzyme form. The capsule should dissolve quickly and support efficient release. The dose-for-cost balance is especially favorable.

View ingredientView products
Loading alternative details
85 Performance

BioCoenzymated Active B Complex

Natural Factors
Active thiamine, riboflavin, vitamin B6, folate, and vitamin B12 provide a more refined form profile than a mostly conventional B-complex. The formula remains potent, but its more moderate vitamin B6 amount improves routine-use balance.
83 Performance

Advanced B Complex

AOR Advanced Orthomolecular Research Advanced
Benfotiamine, active riboflavin, P-5-P, methylfolate, methylcobalamin, and pantethine create a substantially more refined B-complex. Several amounts are still high enough that stacking with fortified products should be deliberate, and the niacin form is unclear.
81 Performance

Coenzyme B-Complex Caps

Country Life
Multiple coenzyme forms improve ingredient quality while maintaining meaningful B-vitamin amounts. Vitamin B6 remains elevated for prolonged use and choline is modest, but the larger supply supports practical value.
76 Budget

B-100

NOW
Broad B-vitamin coverage keeps serving cost low for targeted high-potency use. Most forms are conventional, and very high pyridoxine may raise the risk of tingling, numbness, or other nerve symptoms with prolonged use.
79 Budget

B-100 Complex

21st Century
A broad high-potency profile provides economical energy-metabolism support with clearly stated amounts. Conventional forms and vitamin B6 at the chronic-use safety ceiling make unsupervised daily use a poor fit.
74 Budget

B-Complex '50'

Solgar
Broad B-vitamin coverage offers a lower-potency and inexpensive alternative to a B-100 formula. The forms remain conventional, and vitamin B6 is still unnecessarily high for prolonged daily use.
77 Value

B-50 Complex

Nature's Way
Active riboflavin improves a broad B-complex base while the lower-potency format supports favorable serving value. Vitamin B6 remains unnecessarily high for long-term daily use despite the more balanced direction.
76 Value

Megasorb B-Complex '50'

Solgar
Active riboflavin and vitamin B6 forms add quality within a more economical B-50 profile. The vitamin B6 amount is still aggressive, so prolonged daily use deserves caution.
75 Value

Sustained Release B-100

NOW
Broad high-potency coverage and strong serving value make this a practical option when a B-100 dose is specifically wanted. Most forms are conventional, and very high pyridoxine may raise nerve-symptom risk with prolonged daily use.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes).
    Guyton JR; Slee AE; Anderson T; Fleg JL; Goldberg RB; Kashyap ML; Marcovina SM; Nash SD; O'Brien KD; Weintraub WS; Xu P; Zhao XQ; Boden WE · Journal of the American College of Cardiology · 2013
    Randomized trial3,414 participantsCardiovascular Support forNiacin
  2. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  3. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  4. Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis.
    D'Andrea E; Hey SP; Ramirez CL; Kesselheim AS · JAMA network open · 2020
    Meta-analysis35,760 participants17 studies pooledCardiovascular Support forNiacin
  5. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  6. Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline.
    González-Domínguez R; Castellano-Escuder P; Lefèvre-Arbogast S; Low DY; Du Preez A; Ruigrok SR; Lee H; Helmer C; Pallàs M; Urpi-Sarda M; Sánchez-Pla A; Korosi A; Lucassen PJ; Aigner L; Manach C; Thuret S; Samieri C; Andres-Lacueva C · Alzheimer's research & therapy · 2022
    Observational studyMetabolism Boost forVitamin B5
  7. Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar.
    Jenkins DJA; Spence JD; Giovannucci EL; Kim YI; Josse RG; Vieth R; Sahye-Pudaruth S; Paquette M; Patel D; Blanco Mejia S; Viguiliouk E; Nishi SK; Kavanagh M; Tsirakis T; Kendall CWC; Pichika SC; Sievenpiper JL · Journal of the American College of Cardiology · 2021
    Meta-analysisCardiovascular Support forNiacin
  8. Exploring auxotrophy and engineering vitamin B6 prototrophy in the acetogen Clostridium sp. AWRP.
    Kwon SJ; Lee J; Lee HS · Applied and environmental microbiology · 2024
    Clinical trialMetabolism Boost forVitamin B5
  9. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  10. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
    Lavigne PM; Karas RH · Journal of the American College of Cardiology · 2013
    Meta-analysis9,959 participants11 studies pooledCardiovascular Support forNiacin
  11. Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy.
    Spry C; van Schalkwyk DA; Strauss E; Saliba KJ · Infectious disorders drug targets · 2010
    Narrative reviewMetabolism Boost forVitamin B5
  12. Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.
    Saboori S; Yousefi Rad E; Tammam J; Thondre PS; Coe S · The British journal of nutrition · 2024
    Meta-analysis12 studies pooledCardiovascular Support forNiacin
  13. Pantothenate synthetase is essential but not limiting for pantothenate biosynthesis in Arabidopsis.
    Jonczyk R; Ronconi S; Rychlik M; Genschel U · Plant molecular biology · 2008
    OtherMetabolism Boost forVitamin B5
  14. Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials.
    Xie S; Galimberti F; Olmastroni E; Carugo S; Catapano AL; Casula M; META-LIPID Group · Atherosclerosis · 2025
    Meta-analysis145,314 participants147 studies pooledCardiovascular Support forNiacin
  15. Optimum nutrition: thiamin, biotin and pantothenate.
    Bender DA · The Proceedings of the Nutrition Society · 1999
    Narrative reviewMetabolism Boost forVitamin B5
  16. Effectiveness of niacin supplementation for patients with type 2 diabetes: A meta-analysis of randomized controlled trials.
    Xiang D; Zhang Q; Wang YT · Medicine · 2020
    Meta-analysis2,110 participants8 studies pooledCardiovascular Support forNiacin
  17. Serum metabolites of hypertension among Chinese adolescents aged 12-17 years.
    Sun J; Ding W; Liu X; Zhao M; Xi B · Journal of human hypertension · 2022
    Other77 participantsMetabolism Boost forVitamin B5
  18. Niacin improves lipid profile but not endothelial function in patients with coronary artery disease on high dose statin therapy.
    Philpott AC; Hubacek J; Sun YC; Hillard D; Anderson TJ · Atherosclerosis · 2013
    Randomized trial66 participantsCardiovascular Support forNiacin
  19. Metabolic profiles of exercise in patients with McArdle disease or mitochondrial myopathy.
    Delaney NF; Sharma R; Tadvalkar L; Clish CB; Haller RG; Mootha VK · Proceedings of the National Academy of Sciences of the United States of America · 2018
    OtherMetabolism Boost forVitamin B5
  20. Effects of HDL-modifiers on cardiovascular outcomes: a meta-analysis of randomized trials.
    Verdoia M; Schaffer A; Suryapranata H; De Luca G · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2015
    Meta-analysis69,515 participants18 studies pooledCardiovascular Support forNiacin
  21. Dual-omics analysis reveals B vitamin regulation and metabolism in Areca Catechu inflorescence.
    Jiang W; Liu X; Li W; Yang J; Li P; Xie M; Zhou G · BMC genomics · 2026
    OtherMetabolism Boost forVitamin B5
  22. Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial.
    Elam MB; Hunninghake DB; Davis KB; Garg R; Johnson C; Egan D; Kostis JB; Sheps DS; Brinton EA · JAMA · 2000
    Randomized trial468 participantsCardiovascular Support forNiacin
  23. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  24. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  25. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  26. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  27. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  28. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  29. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  30. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  31. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  32. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  33. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  34. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  35. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  36. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  37. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  38. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  39. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  40. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  41. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  42. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  43. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  44. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  45. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate Heart Health forVitamin B6
  46. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  47. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  48. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  49. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  50. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  51. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  52. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  53. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  54. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6
  55. Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes: a prospective UK cohort study (PRiDE study).
    Saravanan P; Sukumar N; Adaikalakoteswari A; Goljan I; Venkataraman H; Gopinath A; Bagias C; Yajnik CS; Stallard N; Ghebremichael-Weldeselassie Y; Fall CHD · Diabetologia · 2022
    Cohort study4,746 participantsMetabolism Boost forVitamin B12
  56. First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders.
    Olivieri G; Bordugo A; Burnyte B; Costetti A; Couce ML; Diogo L; Feillet F; Froese DS; Greco B; Gueant JL; Hannibal L; Hörster F; Kožich V; La Marca G; Manoli I; Mochel F; Orazi L; Pérez B; Schiff M; Schwahn BC; Schwartz I; Stepien KM; Sykut-Cegielska J; Tangeraas T; Zetterström RH; Dionisi-Vici C; Huemer M · Journal of inherited metabolic disease · 2026
    Guideline / consensusMetabolism Boost forVitamin B12
  57. Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
    Carmel R; Melnyk S; James SJ · Blood · 2003
    Observational study39 participantsMetabolism Boost forVitamin B12
  58. Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis.
    Mazur M; Ndokaj A; Salerno C; Vallone J; Ardan R; Bietolini S; Carrouel F; Wilk A; Sarig R; Ottolenghi L; Bourgeois D · Frontiers in pharmacology · 2026
    Meta-analysis6,098 participants16 studies pooledMetabolism Boost forVitamin B12
  59. Diagnosis and treatment of vitamin B12 deficiency in children.
    Kanvinde P; Khurana R; Mudaliar S · Frontiers in nutrition · 2026
    Narrative reviewMetabolism Boost forVitamin B12
  60. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  61. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  62. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  63. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  64. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6