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D3-5

Bio-Tech Pharmacal
4.7
★ ★ ★ ★ ★
(546 ratings)
Vitamin D 5000 IU
Product Image
Score83
Best suited to immunity, with the clearest benefits coming from the disclosed active ingredients. The dry format lacks a listed fat carrier, and the amount may be more than some users need for maintenance.
How scoring works
Quantity:250 Capsule(s) • (250 servings)
Goals:
Immunity
Anti-Aging
Testosterone Support
Anti-Inflammatory Support
General Health
Energy

Score 83

Best suited to immunity, with the clearest benefits coming from the disclosed active ingredients. The dry format lacks a listed fat carrier, and the amount may be more than some users need for maintenance.
How scoring works
$15.36($0.06 per serving)
Amazon
$ 15.95
iHerb
$ 15.36
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Analysis

A focused capsule supplies D3 at a substantial amount with strong serving value. The dry format lacks a listed fat carrier, and the amount may be more than some users need for maintenance.

Vitamin D3 directly regulates innate and adaptive immune signaling and is especially relevant when vitamin D status is low. The 5,000 IU amount is substantial and aligned with the supplied collection guidance. Cholecalciferol is the preferred vitamin D form, but the dry capsule includes no lipid carrier to aid absorption.

Vitamin D3 is a foundational nutrient for immune function, calcium absorption, and skeletal health, and the single-ingredient label is easy to assess. The dry capsule lacks an oil carrier, so taking it with a meal containing fat may improve practical delivery. The daily amount exceeds the usual adult upper intake level and is better suited to clinician-guided use based on vitamin D status.

Who is it for
  • People seeking immunity support
  • People seeking anti-aging support
  • People seeking testosterone support support
Best for
  • Immunity
  • Anti-Aging
  • Testosterone Support

Pros

  • A focused capsule supplies D3 at a substantial amount with strong serving value.
  • Vitamin D3 directly regulates innate and adaptive immune signaling and is especially relevant when vitamin D status is low.
  • The 5,000 IU amount is substantial and aligned with the supplied collection guidance.
  • Routine use at this amount is best matched to individual vitamin D needs rather than assumed for everyone.
  • Vitamin D3 provides foundational support for bone strength, muscle function, and immune regulation during aging.

Cons

  • The dry format lacks a listed fat carrier, and the amount may be more than some users need for maintenance.
  • Cholecalciferol is the preferred vitamin D form, but the dry capsule includes no lipid carrier to aid absorption.
  • Benefits depend strongly on baseline vitamin D status and the formula does not address other aging pathways.
  • Long-term use at this amount without checking vitamin D and calcium status may increase hypercalcemia risk.
  • Cholecalciferol is the preferred vitamin form, though the dry capsule lacks a lipid carrier.

Warnings

  • This daily amount can be excessive for some users over time, so blood testing and clinician-guided dosing are prudent.
  • The dose exceeds the usual adult daily upper intake level, so long-term use is better guided by blood testing and an identified need.
  • Excess vitamin D can raise blood calcium and may contribute to nausea, weakness, or kidney stones.
  • Long-term excessive intake can raise calcium levels and create kidney or other complications.

Nutrient quality

83 Highest impact

Cholecalciferol is a preferred form, but the dry capsule lacks a disclosed lipid carrier. The vitamin D3 amount is substantial when a high dose is needed.

.

Ingredient transparency

85 Highest impact

The single active ingredient has a specific amount. A complete inactive ingredient list was not supplied.

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Customer satisfaction

67 High impact

The available aggregate rating is strong for this category. No firsthand outcome details were supplied, so alignment with the intended use is uncertain.

.

Value for money

96 Highest impact

The preferred D3 form provides good quality despite the dry delivery format. The product is highly competitive on serving value among concentrated vitamin D capsules.

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Report analysis

Goals

Immunity
Immunity
Impact
Highest effect
A+ Goal FitA- Strength of SupportC- CoverageA Formula Quality
Vitamin D · 5000 IU

Vitamin D3 directly regulates innate and adaptive immune signaling and is especially relevant when vitamin D status is low. The 5,000 IU amount is substantial and aligned with the supplied collection guidance.

Cholecalciferol is the preferred vitamin D form, but the dry capsule includes no lipid carrier to aid absorption. Routine use at this amount is best matched to individual vitamin D needs rather than assumed for everyone.

Study evidence
Vitamin D Supportive 85 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
B+ Goal FitA- Strength of SupportC CoverageA+ Formula Quality
Vitamin D · 5000 IU

Vitamin D3 provides foundational support for bone strength, muscle function, and immune regulation during aging. The 5,000 IU amount is substantial, while the dry capsule offers no lipid carrier to support absorption.

Benefits depend strongly on baseline vitamin D status and the formula does not address other aging pathways. Long-term use at this amount without checking vitamin D and calcium status may increase hypercalcemia risk.

Study evidence
Vitamin D Supportive 50 studies
Testosterone Support
Testosterone Support
Impact
Highest effect
A- Goal FitA- Strength of SupportC- CoverageA Formula Quality
Vitamin D · 5000 IU

The 5,000 IU vitamin D3 dose directly supports a foundational hormone-related nutrient pathway and is most relevant when blood levels are low. Cholecalciferol is the preferred vitamin form, though the dry capsule lacks a lipid carrier.

The single-nutrient formula has strong depth but does not cover mineral or stress pathways. This daily amount can be excessive for some users over time, so blood testing and clinician-guided dosing are prudent.

Study evidence
Vitamin D Supportive 56 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Highest effect
B Goal FitA Strength of SupportD CoverageA+ Formula Quality
Vitamin D · 5000 IU

Vitamin D3 at 5,000 IU provides a strong immunomodulatory dose that may help when vitamin D status is low. Anti-inflammatory benefits are less predictable when vitamin D levels are already adequate.

The single-vitamin formula is clearly disclosed and uses cholecalciferol. Long-term use at this amount is best guided by vitamin D and calcium status rather than treated as general high-dose maintenance.

Study evidence
Vitamin D Supportive 101 studies
General Health
General Health
Impact
High effect
A Goal FitB- Strength of SupportC- CoverageA+ Formula Quality
Vitamin D · 5000 IU

Vitamin D3 is foundational for immune function, bone health, muscle function, and calcium regulation. The single-capsule amount is potent and clearly disclosed.

The dose exceeds the usual adult daily upper intake level, so long-term use is better guided by blood testing and an identified need. Excess vitamin D can raise blood calcium and may contribute to nausea, weakness, or kidney stones.

Study evidence
Vitamin D Supportive 115 studies
Energy
Energy
Impact
High effect
A Goal FitB- Strength of SupportC- CoverageA Formula Quality
Vitamin D · 5000 IU

Vitamin D3 is a foundational nutrient for immune function, calcium absorption, and skeletal health, and the single-ingredient label is easy to assess. The dry capsule lacks an oil carrier, so taking it with a meal containing fat may improve practical delivery.

The daily amount exceeds the usual adult upper intake level and is better suited to clinician-guided use based on vitamin D status. Long-term excessive intake can raise calcium levels and create kidney or other complications.

Study evidence
Vitamin D Supportive 32 studies

Ingredients

IngredientAmount per serving
Vitamin D3 (Cholecalciferol)
 5000 IU
Gluten Free Adults 18–50 Kosher Dairy Free Sugar Free Halal
Report overview
Vitamin D (Cholecalciferol) · 5000 IU OverallScore76
B- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyA+ Value

The D3 dose is well aligned with the collection's preferred daily range. A dry capsule lacks the lipid carrier that can aid absorption, and the raw source is not disclosed. The product is highly economical for the vitamin D delivered, though independent quality verification is not documented.

View ingredientView products
Loading alternative details
85 Performance

High Potency D3 5000 IU

Nature Made
<p>A focused formula supplies 5000 IU of cholecalciferol; the concentrated amount should be matched to measured vitamin D status. Compared with the original, the simple, clearly quantified vitamin D3 profile is easier to assess and closely matches the original’s listed vitamin D amount.</p>
82 Performance

Vitamin D-3 5000 IU

Source Naturals
<p>A focused formula supplies 5000 IU of cholecalciferol; the concentrated amount should be matched to measured vitamin D status. Compared with the original, the simple, clearly quantified vitamin D3 profile is easier to assess and closely matches the original’s listed vitamin D amount.</p>
78 Performance

Certified Vegan D3 5000 IU

Country Life
<p>A focused formula supplies 5000 IU of cholecalciferol; the concentrated amount should be matched to measured vitamin D status. Compared with the original, the simple, clearly quantified vitamin D3 profile is easier to assess and closely matches the original’s listed vitamin D amount.</p>
86 Budget

Liquid Vitamin D3 Drops 5000 IU Natural Citrus Flavor

Bluebonnet
<p>A liquid formula supplies 5000 IU of lanolin-derived vitamin D3; the concentrated amount should be matched to measured vitamin D status. It costs less per serving than the original and closely matches the original’s listed vitamin D amount.</p>
78 Budget

Vitamin D3 10000 IU

AN Amazing Nutrition Amazing Formulas
<p>A focused formula supplies 10000 IU of cholecalciferol; the very high amount calls for a clearly established need and monitoring. It costs less per serving than the original and uses a higher vitamin D amount, so suitability depends more heavily on measured status and professional guidance.</p>
88 Budget

Extra Strength Liquid Vitamin D3

Protocol For Life Balance
<p>A liquid formula supplies 2000 IU of lanolin-derived vitamin D3 without unrelated active ingredients. It costs less per serving than the original and uses a lower vitamin D amount that may suit routine maintenance better, but may not match a documented high-dose need.</p>
82 Value

Vitamin D-3 5000 IU

Source Naturals
<p>A focused formula supplies 5000 IU of cholecalciferol; the concentrated amount should be matched to measured vitamin D status. Its focused formula and dose alignment support practical value, although it does not undercut the original’s serving cost and closely matches the original’s listed vitamin D amount.</p>
88 Value

Liquid Vitamin D3 Drops 2000 IU Natural Citrus Flavor

Bluebonnet
<p>A liquid formula supplies 2000 IU of lanolin-derived vitamin D3 without unrelated active ingredients. The lower serving cost and focused ingredient list improve value, while the dose uses a lower vitamin D amount that may suit routine maintenance better, but may not match a documented high-dose need.</p>
88 Value

D3 2000 IU

Nature Made
<p>A focused formula supplies 2000 IU of cholecalciferol without unrelated active ingredients. The lower serving cost and focused ingredient list improve value, while the dose uses a lower vitamin D amount that may suit routine maintenance better, but may not match a documented high-dose need.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
    Zhu Z; Zhu X; Gu L; Zhan Y; Chen L; Li X · Frontiers in nutrition · 2022
    Meta-analysis4,859 participants10 studies pooledImmunity forVitamin D
  2. Effect of vitamin D status and vitamin D supplementation on immune function and prevention of acute respiratory tract infections in dark-skinned individuals: a systematic review and meta-analysis.
    Bournot AR; Darling AL; Givens ID; Lovegrove JA; Lanham-New SA; Hart KH · Public health nutrition · 2024
    Meta-analysis36,707 participants18 studies pooledImmunity forVitamin D
  3. Vitamin D supplementation and hospitalization for infection in older adults: A post-hoc analysis of data from the Australian D-Health Trial.
    Pham H; Waterhouse M; Baxter C; Romero BD; McLeod DS; Armstrong BK; Ebeling PR; English DR; Hartel G; O'Connell RL; van der Pols JC; Venn AJ; Webb PM; Whiteman DC; Neale RE · The American journal of clinical nutrition · 2023
    Randomized trial21,315 participantsImmunity forVitamin D
  4. Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging.
    Pan Z; Zeng J; Chen Z; Chen S; Yang J; Li H; Wang S; Wang J; Li N; Gong Y; Liu M; Li C · The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Cohort study389,217 participantsAnti-Aging forVitamin D
  5. Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong Associations With Age and All-Cause Mortality Independent From Telomere Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels.
    Schöttker B; Hagen L; Zhang Y; Gào X; Holleczek B; Gao X; Brenner H · The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Cohort study9,940 participantsAnti-Aging forVitamin D
  6. Sex-specific associations of serum 25-hydroxyvitamin D concentrations with incident sarcopenia in older adults: A 2-year follow-up study.
    Song S; Lim JY; Kim M; Won CW; Park HY · The journal of nutrition, health & aging · 2025
    Cohort study1,292 participantsAnti-Aging forVitamin D
  7. Vitamin D deficit is associated with accelerated brain aging in the general population.
    Terock J; Bonk S; Frenzel S; Wittfeld K; Garvert L; Hosten N; Nauck M; Völzke H; Van der Auwera S; Grabe HJ · Psychiatry research. Neuroimaging · 2022
    Cross-sectional study1,865 participantsAnti-Aging forVitamin D
  8. Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP).
    Zhao C; Tsapanou A; Manly J; Schupf N; Brickman AM; Gu Y · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Cohort study1,759 participantsAnti-Aging forVitamin D
  9. Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study.
    Zhou A; Hyppönen E · International journal of epidemiology · 2023
    Observational study294,970 participantsAnti-Inflammatory Support forVitamin D
  10. Vitamin D in Children With Inflammatory Bowel Disease: A Randomized Controlled Clinical Trial.
    El Amrousy D; El Ashry H; Hodeib H; Hassan S · Journal of clinical gastroenterology · 2021
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  11. Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers.
    Gao YQ; Gao YH; Xing JH · World journal of diabetes · 2025
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  12. Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES.
    Yang F; Sun M; Sun C; Li J; Yang X; Bi C; Wang M; Pu L; Wang J; Wang C; Xie M; Yao Y; Jin L · Scientific reports · 2020
    Cross-sectional study9,809 participantsAnti-Inflammatory Support forVitamin D
  13. Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.
    Zhang C; Cui J; Li S; Shen J; Luo X; Yao Y; Shi H · BMC geriatrics · 2024
    Cohort study3,072 participantsAnti-Inflammatory Support forVitamin D
  14. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  15. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  16. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  17. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  18. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D
  19. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  20. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  21. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  22. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  23. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  24. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
    Martineau AR; Jolliffe DA; Greenberg L; Aloia JF; Bergman P; Dubnov-Raz G; Esposito S; Ganmaa D; Ginde AA; Goodall EC; Grant CC; Janssens W; Jensen ME; Kerley CP; Laaksi I; Manaseki-Holland S; Mauger D; Murdoch DR; Neale R; Rees JR; Simpson S; Stelmach I; Trilok Kumar G; Urashima M; Camargo CA; Griffiths CJ; Hooper RL · Health technology assessment (Winchester, England) · 2020
    Meta-analysis11,321 participants25 studies pooledImmunity forVitamin D
  25. Vitamin D3 and deconvoluting a rash.
    Ernst MK; Evans ST; Techner JM; Rothbaum RM; Christensen LF; Onay UV; Biyashev D; Demczuk MM; Nguyen CV; Honda KS; McCormick TS; Tsoi LC; Gudjonsson JE; Cooper KD; Lu KQ · JCI insight · 2023
    Randomized trial28 participantsImmunity forVitamin D
  26. Effect of vitamin D3 supplementation on cellular immunity and inflammatory markers in COVID-19 patients admitted to the ICU.
    Bychinin MV; Klypa TV; Mandel IA; Yusubalieva GM; Baklaushev VP; Kolyshkina NA; Troitsky AV · Scientific reports · 2022
    Randomized trial110 participantsImmunity forVitamin D
  27. Current opinion on the role of vitamin D supplementation in respiratory infections and asthma/COPD exacerbations: A need to establish publication guidelines for overcoming the unpublished data.
    Anitua E; Tierno R; Alkhraisat MH · Clinical nutrition (Edinburgh, Scotland) · 2022
    Meta-analysis50,554 participants65 studies pooledImmunity forVitamin D
  28. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
    Jamilian M; Foroozanfard F; Rahmani E; Talebi M; Bahmani F; Asemi Z · Nutrients · 2018
    Randomized trial90 participantsTestosterone Support forVitamin D
  29. Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial.
    Al-Bayyari N; Al-Domi H; Zayed F; Hailat R; Eaton A · Clinical nutrition (Edinburgh, Scotland) · 2021
    Randomized trial60 participantsTestosterone Support forVitamin D
  30. Association between plasma 25-OH vitamin D and testosterone levels in men.
    Nimptsch K; Platz EA; Willett WC; Giovannucci E · Clinical endocrinology · 2012
    Case-control study1,362 participantsTestosterone Support forVitamin D
  31. Causal Link Between Vitamin D and Total Testosterone in Men: A Mendelian Randomization Analysis.
    Chen C; Zhai H; Cheng J; Weng P; Chen Y; Li Q; Wang C; Xia F; Wang N; Lu Y · The Journal of clinical endocrinology and metabolism · 2020
    Other4,254 participantsTestosterone Support forVitamin D
  32. Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men.
    Rafiq R; van Schoor NM; Sohl E; Zillikens MC; Oosterwerff MM; Schaap L; Lips P; de Jongh RT · The Journal of steroid biochemistry and molecular biology · 2017
    Cohort study643 participantsTestosterone Support forVitamin D