Product Image

Double Strength 5-HTP 200 mg

NOW
4.8
★ ★ ★ ★ ★
(17043 ratings)
5-HTP 200 mg
Niacin 20 mg
Glycine 100 mg
Product Image
Score81
A convenient high-strength 5-HTP capsule with useful companion nutrients, but weak source detail and serious serotonin-related interaction concerns require caution.
How scoring works
Quantity:60 Capsule(s) • (60 servings)
Goals:
Mood Support
Sleep Support
Weight Loss
Stress Relief

Score 81

A convenient high-strength 5-HTP capsule with useful companion nutrients, but weak source detail and serious serotonin-related interaction concerns require caution.
How scoring works

Also available as

1 option
120 servings 5-HTP 200 mg, Glycine 100 mg • 120 Capsule(s) • 120 servings $29.20 ($0.24 per serving)
$13.60($0.22 per serving)
Amazon
$ 17.40
iHerb
$ 18.36
Vitacost
$ 19.65
Daily Vita
$ 17.40
Pure Formulas
$ 13.60
iHerb
$ 18.36
Report prices

Analysis

The 200 mg 5-HTP amount is the clear center of the formula and may suit experienced users looking for stronger mood or sleep support. Niacinamide and low-dose B6 support related nutrient pathways without adding flushing niacin.

Glycine, taurine, and inositol broaden the calming profile, but 100 mg of each is modest compared with focused standalone use. The Griffonia source also lacks a stated standardization percentage or controlled-release feature.

The single-capsule serving is convenient, though a high-strength starting amount may be harder to tolerate than a lower-dose option. Medication compatibility should be checked carefully because 5-HTP directly increases serotonergic load.

Who is it for
  • Experienced 5-HTP users seeking a higher amount
  • Adults prioritizing mood or sleep support in one capsule
Best for
  • High-strength 5-HTP supplementation
  • Serotonin-related sleep and mood support

Pros

  • Provides 200 mg of 5-HTP per serving
  • Includes glycine, taurine, and inositol
  • Convenient one-capsule format

Cons

  • Griffonia standardization is not stated
  • Companion amino acids are lightly dosed
  • High-strength amount may be more than a new user needs

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonin-raising agents because serious serotonin-related effects may occur
  • The 200 mg 5-HTP amount may cause nausea or digestive discomfort
  • 5-HTP may cause drowsiness, so assess tolerance before driving or operating machinery

Nutrient quality

83 Highest impact

The 5-HTP source and niacinamide form are identified, while the amino acids use standard names. The 5-HTP amount is substantial, though the supporting amino acids are modest.

Ingredient transparency

81 Highest impact

Every listed active has a specific amount. Inactive capsule ingredients are not included in the supplied label data.

Customer satisfaction

73 High impact

The supplied average and volume indicate strong aggregate satisfaction. No detailed experience reports are available to identify repeated complaints or confirm perceived benefits.

Value for money

87 Highest impact

The substantial 5-HTP amount supports the moderate cost. The serving cost appears reasonable for the disclosed active dose.

Report analysis

Goals

Mood Support
Mood Support
Impact
High effect
B+ Goal FitA Strength of SupportC- CoverageB+ Formula Quality
Vitamin B6 · 2 mg5-HTP · 200 mg

5-HTP at 200 mg directly supplies a serotonin precursor and is clearly aligned with mood support. Human evidence suggests possible benefit for depressive symptoms, but the research base is smaller and less consistent than for established therapies.

The high amount provides strong pathway depth but may increase nausea and other serotonergic effects. Combining 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonergic agents can raise the risk of serotonin toxicity.

Study evidence
5-HTP Supportive 9 studies
Glycine Mixed 3 studies
Vitamin B6 Supportive 19 studies
Sleep Support
Sleep Support
Impact
High effect
B Goal FitB+ Strength of SupportB- CoverageB- Formula Quality
Glycine · 100 mg

A substantial 5-HTP amount anchors a sleep-focused serotonin and melatonin precursor formula. Glycine, taurine, and inositol add calming concepts, although their small amounts are unlikely to work as standalone sleep doses.

Every active amount is stated, but Griffonia standardization and preferred cofactor forms are not shown. The 5-HTP may dangerously add to the effects of SSRIs, SNRIs, MAO inhibitors, or other serotonin-raising medicines.

Study evidence
5-HTP Supportive 1 study
Glycine Supportive 3 studies
Taurine Not classified

No linked studies yet.

Vitamin B6 Disputed 7 studies
Weight Loss
Weight Loss
Impact
High effect
C+ Goal FitB+ Strength of SupportC CoverageB- Formula Quality

High-strength 5-HTP may help appetite and carbohydrate cravings, with vitamin B6 supporting serotonin synthesis. Glycine, taurine, and inositol add calming support but little direct fat-loss action.

The formula is situational rather than a broad weight-management solution. Combining 5-HTP with SSRIs, MAO inhibitors, or other serotonin-raising drugs can create dangerous excess serotonin.

Study evidence
5-HTP Supportive 5 studies
Stress Relief
Stress Relief
Impact
High effect
B- Goal FitB Strength of SupportC CoverageC+ Formula Quality
Glycine · 100 mgVitamin B6 · 2 mg

The formula centers on a high-strength 200 mg 5-HTP serving for serotonin-related mood and sleep support. Glycine, taurine, and inositol add conceptually relevant calming pathways, but each is present at only 100 mg.

The broad concept is weakened by token supporting amounts and missing source standardization. Combining 5-HTP with SSRIs, SNRIs, MAO inhibitors, or other serotonin-raising medicines can increase the risk of serotonin toxicity.

Study evidence
5-HTP Supportive 18 studies
Glycine Supportive 1 study
Taurine Supportive 5 studies

Ingredients

IngredientAmount per serving
Niacin (Niacinamide, Vitamin B3)
 20 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 2 mg
5-HTP (Griffonia simplicifolia Seed Extract)
 200 mg
Glycine
100 mg
Taurine
100 mg
Inositol
100 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Vegetarian
Report overview
5-HTP (Griffonia simplicifolia Seed Extract) · 200 mg OverallScore75
B- Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyA+ Value

The 200 mg amount provides a high-strength serving in a vegetable capsule. Griffonia simplicifolia seed extract is named without standardization details, and no controlled-release feature is stated. Cost efficiency is excellent, but the supplied label data lacks a serotonin-medication warning.

View ingredientView products
Niacin (Niacinamide, Vitamin B3) · 20 mg OverallScore62
B Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value

The combination formula clearly includes niacinamide, but vitamin B3 is secondary to its 5-HTP focus. The amount is modest for targeted niacin use, and the standard capsule has no specialized release feature. Its serving cost is high if evaluated mainly as a niacin source.

View ingredientView products
Glycine · 100 mg OverallScore55
F Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyB- Value
Free-form glycine is clearly listed in a practical capsule, but its amount is far below a standalone sleep dose. The formula centers on a substantial 5-HTP amount, which partly explains the high cost per gram of glycine. Because 5-HTP can add to serotonergic effects, combining it with SSRIs, SNRIs, MAO inhibitors, or other serotonin-raising medicines may increase the risk of serotonin toxicity.
View ingredientView products
Loading alternative details
83 Performance

Sleep Nighttime Powder

youtheory
<p>Full-dose glycine with magnesium citrate, L-theanine, melatonin, tryptophan, and 5-HTP creates a well-targeted nighttime formula. The ingredient focus improves on the original’s modest supporting nutrients around a high 5-HTP amount, although combining tryptophan and 5-HTP can intensify serotonin effects with serotonergic medicines.</p>
77 Performance

R.E.M. Maintenance

Metabolic Maintenance
<p>Glycine, magnesium glycinate, inositol, 5-HTP, and melatonin create a coherent and well-dosed nighttime blend. The ingredient focus improves on the original’s modest supporting nutrients around a high 5-HTP amount, although serotonergic medicines are a concern, and melatonin may increase next-day drowsiness.</p>
74 Performance

5-HTP (5-Hydroxytryptophan) 200 mg

Protocol For Life Balance
<p>High-strength Griffonia-derived 5-HTP provides direct sleep and mood support. The ingredient focus improves on the original’s modest supporting nutrients around a high 5-HTP amount, although glycine, taurine, and inositol are modest, while serotonergic medicines create a specific interaction concern.</p>
77 Budget

True Calm

NOW
<p>A higher serving cost means this is not a true cheaper option, although gABA, glycine, taurine, inositol, and valerian create a coherent calming blend. Most amounts are modest and only GABA makes a notable contribution at the stated serving.</p>
72 Budget

5-HTP 50 mg

Metabolic Maintenance
<p>A higher serving cost means this is not a true cheaper option, although a cautious 5-HTP amount offers a lower-intensity starting point for sleep and mood support. Glycine is far below common sleep-focused use, source details are sparse, and serotonergic medicines remain a concern.</p>
68 Budget

GABA Relaxer

Country Life
<p>A higher serving cost means this is not a true cheaper option, although gABA, glycine, taurine, inositol, and supportive B vitamins create a broad calming blend. Several amino-acid amounts are modest, while niacinamide and vitamin B6 are aggressive for routine long-term use.</p>
78 Value

Double Strength 5-HTP 200 mg

NOW
<p>A high 5-HTP amount provides direct sleep and mood support at a higher serving cost. The quality-to-cost balance may improve on the original’s modest supporting nutrients around a high 5-HTP amount, although glycine, taurine, and inositol add little depth, while serotonergic medicines create a specific interaction concern.</p>
77 Value

5-HTP 100 mg

Metabolic Maintenance
<p>A practical 5-HTP amount and vitamin cofactors create a coherent serotonin-support formula at a higher serving cost. The quality-to-cost balance may improve on the original’s modest supporting nutrients around a high 5-HTP amount, although glycine remains modest and serotonergic medicines create a specific interaction concern.</p>
82 Value

Sleep Nighttime Powder

youtheory
<p>Glycine, L-theanine, magnesium citrate, tryptophan, 5-HTP, and low-dose melatonin create a well-dosed nighttime formula at a higher serving cost. The quality-to-cost balance may improve on the original’s modest supporting nutrients around a high 5-HTP amount, although tryptophan and 5-HTP can interact with serotonergic medicines, while melatonin may increase drowsiness.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  2. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  3. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure.
    Díaz-Flores M; Cruz M; Duran-Reyes G; Munguia-Miranda C; Loza-Rodríguez H; Pulido-Casas E; Torres-Ramírez N; Gaja-Rodriguez O; Kumate J; Baiza-Gutman LA; Hernández-Saavedra D · Canadian journal of physiology and pharmacology · 2014
    Randomized trial60 participantsStress Relief forGlycine
  4. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  5. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  6. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  7. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  8. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  9. Symptomatic treatment of interferon-α-induced depression in hepatitis C: a systematic review.
    Baraldi S; Hepgul N; Mondelli V; Pariante CM · Journal of clinical psychopharmacology · 2012
    Systematic review64 studies pooledMood Support for5-HTP
  10. Serotonin precursors in the treatment of depression.
    van Praag HM · Advances in biochemical psychopharmacology · 1982
    Narrative reviewMood Support for5-HTP
  11. Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
    Takahashi S; Takahashi R; Masumura I; Miike A · Folia psychiatrica et neurologica japonica · 1977
    Single-arm trial14 participantsMood Support for5-HTP
  12. [Augmentation of antipsychotics with glycine may ameliorate depressive and extrapyramidal symptoms in schizophrenic patients--a preliminary 10-week open-label study].
    Strzelecki D; Kropiwnicki P; Rabe-Jabłońska J · Psychiatria polska · 2014
    Single-arm trial29 participantsMood Support forGlycine
  13. Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls.
    Pålsson E; Jakobsson J; Södersten K; Fujita Y; Sellgren C; Ekman CJ; Ågren H; Hashimoto K; Landén M · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015
    Cross-sectional study327 participantsMood Support forGlycine
  14. Erythrocyte glycine in depressed, hypomanic, and euthymic bipolar patients treated with lithium carbonate.
    Peselow ED; Deutsch SI; Stanley M; Banay-Schwartz M; Virgilio J; Fieve RR · Psychopharmacology · 1983
    Cross-sectional study27 participantsMood Support forGlycine
  15. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  16. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support forVitamin B6
  17. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  18. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  19. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  20. The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review.
    Soh J; Raventhiran S; Lee JH; Lim ZX; Goh J; Kennedy BK; Maier AB · GeroScience · 2024
    Systematic reviewSleep Support forGlycine
  21. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.
    Bannai M; Kawai N · Journal of pharmacological sciences · 2012
    Narrative reviewSleep Support forGlycine
  22. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.
    Bannai M; Kawai N; Ono K; Nakahara K; Murakami N · Frontiers in neurology · 2012
    Clinical trial7 participantsSleep Support forGlycine
  23. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  24. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  25. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  26. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  27. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  28. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  29. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  30. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  31. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  32. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  33. Protective and therapeutic effectiveness of taurine supplementation plus low calorie diet on metabolic parameters and endothelial markers in patients with diabetes mellitus: a randomized, clinical trial.
    Moludi J; Qaisar SA; Kadhim MM; Ahmadi Y; Davari M · Nutrition & metabolism · 2022
    Randomized trial120 participantsStress Relief forTaurine
  34. Effects of taurine supplementation on VDT work induced visual stress.
    Zhang M; Bi LF; Ai YD; Yang LP; Wang HB; Liu ZY; Sekine M; Kagamimori S · Amino acids · 2005
    Randomized trial25 participantsStress Relief forTaurine
  35. Taurine supplementation attenuates delayed increase in exercise-induced arterial stiffness.
    Ra SG; Choi Y; Akazawa N; Ohmori H; Maeda S · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2017
    Randomized trial29 participantsStress Relief forTaurine
  36. Correlations between dietary taurine intake and life stress in Korean college students.
    Sung MJ; Chang KJ · Advances in experimental medicine and biology · 2009
    Observational studyStress Relief forTaurine
  37. Profiling inflammatory and oxidative stress biomarkers following taurine supplementation: a systematic review and dose-response meta-analysis of controlled trials.
    Faghfouri AH; Seyyed Shoura SM; Fathollahi P; Shadbad MA; Papi S; Ostadrahimi A; Faghfuri E · European journal of clinical nutrition · 2022
    Meta-analysisStress Relief forTaurine
  38. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  39. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  40. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  41. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  42. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP