Product Image

Blood Pressure Wellness

Bio Nutrition
4.7
★ ★ ★ ★ ★
(77 ratings)
Calcium 400 mg
Magnesium 200 mg
Rosemary
Coenzyme Q-10 50 mg
Hawthorn 300 mg
Vitamin D 400 IU
Product Image
Score69
A broad cardiovascular blend with useful magnesium and hawthorn, but uneven forms and additive blood-pressure effects require careful use.
How scoring works
Quantity:60 Tablet(s) • (30 servings)
Goals:
Heart Health
Bone Health
Energy
Cardiovascular Support

Score 69

A broad cardiovascular blend with useful magnesium and hawthorn, but uneven forms and additive blood-pressure effects require careful use.
How scoring works
$20.97($0.69 per serving)
Pure Formulas
$ 20.97
iHerb
$ 20.97
Vitacost
$ 20.97
Report prices

Analysis

Cardiovascular support is the best fit. Hawthorn, magnesium, CoQ10, garlic, celery seed, potassium, and arginine address vascular tone, mineral balance, and cardiac energy, although several secondary ingredients are modest.

Calcium citrate and a substantial magnesium amount also provide some bone relevance. Half of the magnesium comes from oxide, vitamin D is modest, and the dry tablet offers little help with absorption of fat-soluble CoQ10.

The blend may suit someone seeking broad heart support rather than a single high-dose active. It is less suitable for users taking blood-pressure medicines or for anyone seeking dedicated stress, digestive, energy, or testosterone support.

Who is it for
  • Adults seeking multi-ingredient cardiovascular support
  • People who want minerals and botanicals in one formula
  • Users not relying on it as a dedicated CoQ10 product
Best for
  • Heart and vascular support
  • Magnesium plus hawthorn coverage
  • Users who also want incidental calcium support

Pros

  • Substantial magnesium and calcium amounts
  • Hawthorn is present at a meaningful extract amount
  • Includes CoQ10, garlic, and potassium
  • Calcium citrate offers a useful absorbed form

Cons

  • Magnesium is partly lower-absorption oxide
  • CoQ10 amount and dry-tablet delivery are modest
  • Botanical standardization is largely missing
  • Vitamin D amount is low for focused bone support

Warnings

  • Hawthorn, garlic, celery seed, and forskohlii may add to antihypertensive medicines and increase the chance of low blood pressure.
  • Calcium can reduce absorption of levothyroxine and tetracycline or quinolone antibiotics, so those doses should be separated.
  • Garlic may increase bleeding tendency with anticoagulant or antiplatelet medicines.

Nutrient quality

72 High impact

The main minerals and hawthorn provide a credible cardiovascular base. Mixed magnesium quality and small amounts of several supporting actives limit formula strength.

.

Ingredient transparency

63 Moderate impact

Most active amounts are disclosed, but duplicated mineral entries and a vague natural-base heading create uncertainty. Full directions and non-active ingredients are also missing.

.

Customer satisfaction

64 Moderate impact

The supplied average is very strong, but the rating count is only moderately developed. Without detailed feedback, repeated tolerability issues or purpose-aligned experiences cannot be judged.

.

Value for money

80 Highest impact

A credible mineral and botanical base supports good value at an accessible cost. Small secondary doses modestly reduce the efficiency of the blend.

.
Report analysis

Goals

Heart Health
Healthy Blood Pressure
Heart Health
Impact
High effect
A Goal FitB- Strength of SupportB+ CoverageC+ Formula Quality
Magnesium · 200 mgCoenzyme Q-10 · 50 mgVitamin D · 400 IU

Hawthorn, magnesium, CoQ10, garlic, and potassium create a clearly cardiovascular formula. The combination addresses vascular tone, cardiac energy, and mineral support, although several secondary botanicals are modestly dosed.

Magnesium citrate is mixed with oxide, CoQ10 uses a dry tablet, and Vitamin D remains low. People using blood-pressure medicines should be alert to additive effects from hawthorn, garlic, celery seed, and coleus.

Study evidence
Coenzyme Q-10 Supportive 114 studies
Hawthorn Supportive 27 studies
Magnesium Supportive 158 studies
Potassium Supportive 182 studies
Vitamin D Mixed 164 studies
Bone Health
Bone Mineral Density
Bone Health
Impact
High effect
A- Goal FitB- Strength of SupportB- CoverageC- Formula Quality
Magnesium · 200 mgCalcium · 400 mgVitamin D · 400 IU

Calcium citrate, magnesium, and vitamin D3 provide a meaningful mineralization base. The calcium amount is well aligned, while magnesium uses a mixed-quality blend and vitamin D is modest.

Most companion botanicals target blood pressure rather than bone tissue, so the formula loses skeletal focus. Calcium should be separated from levothyroxine and tetracycline or quinolone antibiotics because it can reduce their absorption.

Study evidence
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Vitamin D Supportive 202 studies
Energy
Physical Stamina
Energy
Impact
High effect
B Goal FitC Strength of SupportB- CoverageB- Formula Quality
Vitamin D · 400 IUMagnesium · 200 mgPotassium · 99 mgCoenzyme Q-10 · 50 mg

Vitamin D, Magnesium, and Coenzyme Q-10 provide relevant support for energy. Magnesium is a mandatory cofactor for ATP-dependent enzymes; deficiency directly causes lethargy.

Vitamin D is supplied as D3, the form generally preferred for maintaining vitamin D status. The 400 IU serving falls below the preferred daily range.

Study evidence
Coenzyme Q-10 Supportive 32 studies
Magnesium Supportive 4 studies
Vitamin D Supportive 32 studies
Cardiovascular Support
Blood Flow and CirculationHeart Muscle and Rhythm
Cardiovascular Support
Impact
High effect
B+ Goal FitC- Strength of SupportB CoverageC- Formula Quality
Arginine · 75 mgPotassium · 99 mgMagnesium · 200 mgVitamin D · 400 IUCoenzyme Q-10 · 50 mgHawthorn · 300 mg

Magnesium, hawthorn, CoQ10, garlic, potassium, and arginine give the formula direct blood-pressure and cardiac relevance. Several ingredients are too modest or insufficiently standardized to support the broad positioning.

Magnesium and hawthorn carry most of the meaningful contribution, while dry tablets offer weak CoQ10 delivery. The combined blood-pressure actives may add to antihypertensive medicines and increase the chance of low blood pressure.

Study evidence
Arginine Supportive 47 studies
Coenzyme Q-10 Supportive 89 studies
Hawthorn Supportive 28 studies
Magnesium Supportive 123 studies
Potassium Supportive 117 studies
General Health
Stress Resilience
General Health
Impact
Moderate effect
B- Goal FitC Strength of SupportC+ CoverageC- Formula Quality
Vitamin D · 400 IUMagnesium · 200 mg

Magnesium, calcium, potassium, vitamin D3, CoQ10, and several botanicals create broad cardiovascular and foundational support. Magnesium reaches a substantial amount, but half comes from lower-absorption oxide and vitamin D is modest.

Many secondary botanicals and amino acids are supplied below common focused-use amounts. The formula may suit users seeking breadth, but it lacks the dose consistency and streamlined design of a stronger daily-health product.

Study evidence
Magnesium Supportive 114 studies
Vitamin D Supportive 115 studies
Stress Relief
Calm and Tension Relief
Stress Relief
Impact
Moderate effect
C+ Goal FitC+ Strength of SupportD+ CoverageD- Formula Quality
Vitamin D · 400 IUMagnesium · 200 mg

Magnesium and vitamin D provide some foundational nervous-system and mood support, while rosemary has only a mild and situational calming role. The formula is primarily designed for cardiovascular support, so most botanicals and CoQ10 do not create a focused stress-relief strategy.

The magnesium amount is useful, but oxide reduces absorption quality and the calcium-heavy formula may compete during uptake. Hawthorn, garlic, celery, and forskohlii may add to the effects of blood-pressure medicines, making the cardiovascular blend a product-specific consideration for medicated users.

Study evidence
Magnesium Supportive 13 studies
Rosemary Supportive 11 studies
Vitamin D Supportive 41 studies

Ingredients

IngredientAmount per serving
Calcium (Calcium Citrate, Calcium Orotate)
 400 mg
Magnesium (Magnesium Citrate, Magnesium Oxide)
 200 mg
Potassium (Potassium Aspartate)
 99 mg
Hawthorne extract
300 mg
Co-Enzyme-Q-10 (Ubiquinone)
 50 mg
Vitamin D3 (Cholecalciferol)
 400 IU
Garlic extract
125 mg
Celery seed extract
75 mg
Rosemary extract
50 mg
Grape seed extract
20 mg
Forskohlii
10 mg
L-Arginine
75 mg
In a natural base of
0 NP
Adults 18–50 Dairy Free Sugar Free
Report overview
Calcium (Calcium Citrate, Calcium Orotate) · 400 mg OverallScore84
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

Calcium citrate supports reliable absorption, while orotate adds no clear premium advantage. The 400 mg serving fits the absorption-efficient range for a single dose. Calcium can reduce absorption of levothyroxine and tetracycline or quinolone antibiotics, so doses should be separated.

View ingredientView products
Magnesium (Magnesium Citrate, Magnesium Oxide) · 200 mg OverallScore60
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

A substantial magnesium amount combines citrate with lower-absorption oxide, producing mixed absorption quality. Vitamin D adds a useful bone-health cofactor, while calcium remains at the highest ratio allowed without a competition penalty. The serving cost is above the collection midpoint and the broad cardiovascular blend weakens value as a focused magnesium supplement.

View ingredientView products
Rosemary · 50 mg OverallScore59
F Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyB- Value

The 50 mg rosemary extract reaches a meaningful amount within this multi-ingredient formula. Missing marker standardization, plant-part details, and extraction information limit confidence in active quality. Tablet delivery may offer less protection for rosemary compounds, while the serving cost remains moderate.

View ingredientView products
Loading alternative details
86 Performance

Calcium & Magnesium Citrate Powder with Vitamin D3

NOW
The ingredient profile offers a potentially clearer fit for part of the original product’s purpose, but the supplied data do not establish an across-the-board improvement. Calcium citrate and magnesium citrate are each supplied at 400 mg with vitamin D3, giving clearer mineral forms than the original mixed citrate-and-oxide formula.
80 Performance

Liquid Calcium Magnesium Citrate with Vitamin D3 Natural Strawberry Flavor

Solgar
The ingredient profile offers a potentially clearer fit for part of the original product’s purpose, but the supplied data do not establish an across-the-board improvement. The liquid supplies 600 mg calcium citrate and 300 mg magnesium citrate with vitamin D3, but duplicate vitamin D entries reduce label clarity.
83 Performance

Liquid Calcium Magnesium Citrate & Vitamin D3 Strawberry Flavor

Bluebonnet
The ingredient profile offers a potentially clearer fit for part of the original product’s purpose, but the supplied data do not establish an across-the-board improvement. Calcium citrate with magnesium citrate and aspartate provides well-specified mineral forms, while the flavored liquid omits the original hawthorn, garlic, and CoQ10.
77 Budget

Calcium Magnesium Zinc + Vitamin D3

AN Amazing Nutrition Amazing Formulas
The supplied serving-cost data indicates a less expensive option than the original. Calcium, magnesium, zinc, and vitamin D3 provide broad mineral coverage at low cost, though repeated source entries obscure form contributions and the zinc amount is high.
80 Budget

Natural Calcium Magnesium & Zinc with Vitamin D3

Spring Valley
The supplied serving-cost data indicates a less expensive option than the original. The substantial calcium, magnesium, zinc, and vitamin D3 amounts are economical, but the supplied label does not identify the mineral forms.
85 Budget

Cal/Mag 500 mg/250 mg

NaturesPlus
The supplied serving-cost data indicates a less expensive option than the original. Chelated calcium and magnesium provide a simple 500 mg to 250 mg mineral balance, although vitamin D and the original cardiovascular botanicals are absent.
80 Value

Calcium Mag & D Complex

Nature's Way
The serving format or ingredient focus may offer practical value, but it should be weighed against how closely it matches the original use. Useful calcium and magnesium amounts combine citrate, malate, and aspartate with weaker carbonate and oxide forms, while the vitamin D amount is small.
82 Value

Calcium Magnesium Citrate Plus Vitamin D-3 Strawberry

LifeTIME
The serving format or ingredient focus may offer practical value, but it should be weighed against how closely it matches the original use. The liquid provides 600 mg calcium citrate, 300 mg magnesium citrate, and vitamin D3 in a concise formula without the original blood-pressure-focused botanicals.
75 Value

Calcium Citrate Chewable Natural Mixed Fruit Flavor

KAL
The serving format or ingredient focus may offer practical value, but it should be weighed against how closely it matches the original use. The chewable provides 500 mg calcium citrate but relies on magnesium oxide and only a modest vitamin D3 amount, with carbohydrates added by the format.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of monthly high-dose vitamin D on bone density in community-dwelling older adults substudy of a randomized controlled trial.
    Reid IR; Horne AM; Mihov B; Gamble GD; Al-Abuwsi F; Singh M; Taylor L; Fenwick S; Camargo CA; Stewart AW; Scragg R · Journal of internal medicine · 2017
    Randomized trial452 participantsBone Health forVitamin D
  2. Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta-analysis.
    Tihtonen K; Korhonen P; Isojärvi J; Ojala R; Ashorn U; Ashorn P; Tammela O · Annals of the New York Academy of Sciences · 2022
    Meta-analysis1,566 participants7 studies pooledBone Health forCalcium
  3. Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults.
    Joris PJ; Plat J; Bakker SJ; Mensink RP · Scientific reports · 2018
    Randomized trial52 participantsCardiovascular Support forMagnesium
  4. Coenzyme Q10 for heart failure.
    Madmani ME; Yusuf Solaiman A; Tamr Agha K; Madmani Y; Shahrour Y; Essali A; Kadro W · The Cochrane database of systematic reviews · 2015
    Systematic review914 participants7 studies pooledCardiovascular Support forCoenzyme Q-10
  5. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer.
    Lesser GJ; Case D; Stark N; Williford S; Giguere J; Garino LA; Naughton MJ; Vitolins MZ; Lively MO; Shaw EG; Wake Forest University Community Clinical Oncology Program Research Base · The journal of supportive oncology · 2013
    Randomized trial236 participantsEnergy forCoenzyme Q-10
  6. Association between magnesium deficiency scores and hip bone health in adults: a population-based study.
    Li S; Chang W; Wu G; Wang K; Sun X; Sun H; Zhou J · Magnesium research · 2025
    Cross-sectional study13,259 participantsBone Health forMagnesium
  7. Effects of Hawthorn Fruit Extract Drink in Chinese Patients With Mild Hypertension and/or Hyperlipidaemia: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.
    Zeng W; Chu TTW; Fok BSP; Ho WKK; Chan JCN; Tomlinson B · Dose-response : a publication of International Hormesis Society · 2024
    Randomized trial61 participantsCardiovascular Support forHawthorn
  8. Vitamin D and HRT: no benefit additional to that of HRT alone in prevention of bone loss in early postmenopausal women. A 2.5-year randomized placebo-controlled study.
    Komulainen M; Tuppurainen MT; Kröger H; Heikkinen AM; Puntila E; Alhava E; Honkanen R; Saarikoski S · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1997
    Randomized trial464 participantsBone Health forVitamin D
  9. Impact of oral magnesium supplementation on glycemic and cardiometabolic outcomes in prediabetic adults: a systematic review and meta-analysis.
    Basit A; Kumar S; Ahmed H; Babar R; Saeed SS; Siddiqui TA; Khan S; Saeed A; Khan M; Hanif H; Fasih A; Shabbir S; Kumar H; Kumar L; Raja A; Kumar S; Chander S · Journal of diabetes and metabolic disorders · 2026
    Meta-analysis384 participants5 studies pooledCardiovascular Support forMagnesium
  10. Supplementation with coenzyme Q10 reduces plasma lipoprotein(a) concentrations but not other lipid indices: A systematic review and meta-analysis.
    Sahebkar A; Simental-Mendía LE; Stefanutti C; Pirro M · Pharmacological research · 2016
    Meta-analysis409 participants7 studies pooledCardiovascular Support forCoenzyme Q-10
  11. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.
    Orchard TS; Larson JC; Alghothani N; Bout-Tabaku S; Cauley JA; Chen Z; LaCroix AZ; Wactawski-Wende J; Jackson RD · The American journal of clinical nutrition · 2014
    Cohort study73,684 participantsBone Health forMagnesium
  12. Coenzyme Q10 supplementation increases blood concentrations but shows limited and inconsistent effects on exercise performance: a systematic review and meta-analysis.
    Deng H; Song T; Yin M; Xu K; Zhong Y; Mohd NB; Naharudin MNB; Yusof A; Fan X · The British journal of nutrition · 2026
    Meta-analysis24 studies pooledEnergy forCoenzyme Q-10
  13. Calcium supplementation and bone mineral density in postmenopausal women using estrogen replacement therapy.
    Haines CJ; Chung TK; Leung PC; Hsu SY; Leung DH · Bone · 1995
    Randomized trialBone Health forCalcium
  14. Hawthorn Herb Increases the Risk of Bleeding after Cardiac Surgery: An Evidence-Based Approach.
    Rababa'h AM; Altarabsheh SE; Haddad O; Deo SV; Obeidat Y; Al-Azzam S · The heart surgery forum · 2017
    Observational study116 participantsCardiovascular Support forHawthorn
  15. Serum magnesium and outcomes in heart failure with reduced ejection fraction: the GALACTIC-HF trial.
    Chimura M; Docherty KF; Jhund PS; Yang M; Ono R; Henderson AD; Metra M; Liu G; Divanji PH; Heitner SB; Kupfer S; Malik FI; Felker GM; Solomon SD; Teerlink JR; McMurray JJV · European heart journal · 2026
    Randomized trial6,147 participantsCardiovascular Support forMagnesium
  16. Impact of serum 25-hydroxyvitamin D levels on fragility fractures in patients undergoing chronic hemodialysis.
    Hori M; Takahashi H; Kondo C; Tokoroyama S; Kanda A; Furuhashi K; Mori Y; Shirasawa Y; Takeda A; Morozumi K; Maruyama S · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Cohort study292 participantsBone Health forVitamin D
  17. Dialysate Magnesium and Coronary Artery Calcification, Bone Mineral Density, and Cramping in Maintenance Hemodialysis: A Quasi-experimental Study.
    Srisuwarn P; Sethakarun S; Nongnuch A; Jongjirasiri S; Sritara C; Klyprayong P; Disthabanchong S · Kidney medicine · 2022
    Non-randomized trial40 participantsBone Health forMagnesium
  18. Bone turnover and the response to alendronate treatment in postmenopausal osteoporosis.
    Gonnelli S; Cepollaro C; Pondrelli C; Martini S; Montagnani A; Monaco R; Gennari C · Calcified tissue international · 1999
    Randomized trial100 participantsBone Health forCalcium
  19. Platelet mitochondrial function and endogenous coenzyme Q10 levels are reduced in patients after COVID-19.
    Sumbalova Z; Kucharska J; Palacka P; Rausova Z; Langsjoen PH; Langsjoen AM; Gvozdjakova A · Bratislavske lekarske listy · 2022
    Cross-sectional study25 participantsEnergy forCoenzyme Q-10
  20. Promising hypotensive effect of hawthorn extract: a randomized double-blind pilot study of mild, essential hypertension.
    Walker AF; Marakis G; Morris AP; Robinson PA · Phytotherapy research : PTR · 2002
    Randomized trial36 participantsCardiovascular Support forHawthorn
  21. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.
    Liu Z; Tian Z; Zhao D; Liang Y; Dai S; Liu M; Hou S; Dong X; Zhaxinima; Yang Y · The Journal of clinical endocrinology and metabolism · 2022
    Meta-analysis2,794 participants50 studies pooledCardiovascular Support Heart Health forCoenzyme Q-10
  22. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  23. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  24. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial.
    Mortensen SA; Rosenfeldt F; Kumar A; Dolliner P; Filipiak KJ; Pella D; Alehagen U; Steurer G; Littarru GP; Q-SYMBIO Study Investigators · JACC. Heart failure · 2015
    Randomized trial420 participantsCardiovascular Support forCoenzyme Q-10
  25. Real world effectiveness of Hawthorn special extract WS 1442 in a retrospective cohort study from Germany.
    Wyss C; Gündling PW; Kostev K · Scientific reports · 2024
    Cohort study9,100 participantsCardiovascular Support forHawthorn
  26. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
    Qu H; Guo M; Chai H; Wang WT; Gao ZY; Shi DZ · Journal of the American Heart Association · 2019
    Meta-analysis575 participants12 studies pooledEnergy forCoenzyme Q-10
  27. Associations of dietary calcium intake with metabolic syndrome and bone mineral density among the Korean population: KNHANES 2008-2011.
    Kim MK; Chon SJ; Noe EB; Roh YH; Yun BH; Cho S; Choi YS; Lee BS; Seo SK · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Cross-sectional study14,705 participantsBone Health forCalcium
  28. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  29. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  30. [Coenzyme Q-10 in the treatment of patients with chronic heart failure and reduced left ventricular ejection fraction: systematic review and meta-analysis].
    Mareev VY; Mareev YV; Begrambekova YL · Kardiologiia · 2022
    Meta-analysis1,139 participants6 studies pooledCardiovascular Support forCoenzyme Q-10
  31. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  32. Coenzyme Q10 Supplementation in Athletes: A Systematic Review.
    Fernandes MSS; Fidelis DEDS; Aidar FJ; Badicu G; Greco G; Cataldi S; Santos GCJ; de Souza RF; Ardigò LP · Nutrients · 2026
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  33. Hawthorn (Crataegus spp.) Clinically Significantly Reduces Blood Pressure in Hypertension: A Meta-Analysis of Randomized Placebo-Controlled Clinical Trials.
    Szikora Z; Mátyus RO; Szabó BV; Csupor D; Tóth B · Pharmaceuticals (Basel, Switzerland) · 2025
    Meta-analysis428 participants6 studies pooledCardiovascular Support Heart Health forHawthorn
  34. Treatment with alendronate plus calcium, alendronate alone, or calcium alone for postmenopausal low bone mineral density.
    Bonnick S; Broy S; Kaiser F; Teutsch C; Rosenberg E; DeLucca P; Melton M · Current medical research and opinion · 2007
    Randomized trial701 participantsBone Health forCalcium
  35. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  36. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  37. Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial.
    Mortensen AL; Rosenfeldt F; Filipiak KJ · Cardiology journal · 2020
    Randomized trialCardiovascular Support forCoenzyme Q-10
  38. The effect of calcium and vitamin D compounds on bone mineral density in patients undergoing glucocorticoid therapies: a network meta-analysis.
    Deng J; Silver Z; Huang E; Zheng E; Kavanagh K; Panicker J · Clinical rheumatology · 2021
    Meta-analysis1,073 participants16 studies pooledBone Health forVitamin D
  39. Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia?
    Cordero MD; Alcocer-Gómez E; de Miguel M; Culic O; Carrión AM; Alvarez-Suarez JM; Bullón P; Battino M; Fernández-Rodríguez A; Sánchez-Alcazar JA · Antioxidants & redox signaling · 2014
    Randomized trial20 participantsEnergy forCoenzyme Q-10
  40. Calcium and osteoporosis.
    Nordin BE · Nutrition (Burbank, Los Angeles County, Calif.) · 1998
    Meta-analysis20 studies pooledBone Health forCalcium
  41. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects.
    Ryder KM; Shorr RI; Bush AJ; Kritchevsky SB; Harris T; Stone K; Cauley J; Tylavsky FA · Journal of the American Geriatrics Society · 2006
    Cross-sectional study2,038 participantsBone Health forMagnesium
  42. A randomised double blind placebo controlled clinical trial of a standardised extract of fresh Crataegus berries (Crataegisan) in the treatment of patients with congestive heart failure NYHA II.
    Degenring FH; Suter A; Weber M; Saller R · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2003
    Randomized trial143 participantsCardiovascular Support forHawthorn
  43. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  44. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.
    Vrentzos E; Ikonomidis I; Pavlidis G; Katogiannis K; Korakas E; Kountouri A; Pliouta L; Michalopoulou E; Pelekanou E; Boumpas D; Lambadiari V · Cardiovascular diabetology · 2024
    Randomized trial60 participantsCardiovascular Support forCoenzyme Q-10
  45. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  46. Dietary calcium intake protects women consuming oral contraceptives from spine and hip bone loss.
    Teegarden D; Legowski P; Gunther CW; McCabe GP; Peacock M; Lyle RM · The Journal of clinical endocrinology and metabolism · 2005
    Randomized trial154 participantsBone Health forCalcium
  47. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies.
    Mehrabani S; Askari G; Miraghajani M; Tavakoly R; Arab A · Complementary therapies in medicine · 2019
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  48. Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort.
    Welch AA; Skinner J; Hickson M · Nutrients · 2018
    Cross-sectional study156,575 participantsBone Health forMagnesium
  49. [Crataegus Special Extract WS 1442. Assessment of objective effectiveness in patients with heart failure (NYHA II)].
    Weikl A; Assmus KD; Neukum-Schmidt A; Schmitz J; Zapfe G; Noh HS; Siegrist J · Fortschritte der Medizin · 1996
    Randomized trial136 participantsCardiovascular Support forHawthorn
  50. Dose-response relationship between dietary magnesium intake and cardiovascular mortality: A systematic review and dose-based meta-regression analysis of prospective studies.
    Fang X; Liang C; Li M; Montgomery S; Fall K; Aaseth J; Cao Y · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2017
    Meta-analysis449,748 participants8 studies pooledCardiovascular Support forMagnesium
  51. Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Zhao D; Liang Y; Dai S; Hou S; Liu Z; Liu M; Dong X; Zhan Y; Tian Z; Yang Y · Advances in nutrition (Bethesda, Md.) · 2022
    Meta-analysis1,831 participants26 studies pooledCardiovascular Support Heart Health forCoenzyme Q-10
  52. Effects of vitamin D and high dairy protein intake on bone mineralization and linear growth in 6- to 8-year-old children: the D-pro randomized trial.
    Stounbjerg NG; Thams L; Hansen M; Larnkjær A; Clerico JW; Cashman KD; Mølgaard C; Damsgaard CT · The American journal of clinical nutrition · 2022
    Randomized trial200 participantsBone Health forVitamin D
  53. Relationship between bone mineral density changes and risk of fractures among patients receiving calcium with or without vitamin D supplementation: a meta-regression.
    Rabenda V; Bruyère O; Reginster JY · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011
    Meta-analysis47,365 participants15 studies pooledBone Health forCalcium
  54. Coenzyme Q10 supplementation in rheumatic diseases: A systematic review.
    Freire de Carvalho J; Skare T · Clinical nutrition ESPEN · 2024
    Systematic review483 participants20 studies pooledEnergy forCoenzyme Q-10
  55. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  56. Prospective, comparative cohort studies and their contribution to the benefit assessments of therapeutic options: heart failure treatment with and without Hawthorn special extract WS 1442.
    Habs M · Forschende Komplementarmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine · 2005
    Cohort study952 participantsCardiovascular Support forHawthorn
  57. The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis.
    Leenders NHJ; Vermeulen EA; van Ballegooijen AJ; Hoekstra T; de Vries R; Beulens JW; Vervloet MG · Clinical nutrition (Edinburgh, Scotland) · 2021
    Meta-analysis348,059 participants33 studies pooledCardiovascular Support forMagnesium
  58. Micronutrient Supplementation to Reduce Cardiovascular Risk.
    An P; Wan S; Luo Y; Luo J; Zhang X; Zhou S; Xu T; He J; Mechanick JI; Wu WC; Ren F; Liu S · Journal of the American College of Cardiology · 2022
    Meta-analysis883,627 participants884 studies pooledCardiovascular Support forCoenzyme Q-10
  59. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  60. Calcium supplementation provides an extended window of opportunity for bone mass accretion after menarche.
    Rozen GS; Rennert G; Dodiuk-Gad RP; Rennert HS; Ish-Shalom N; Diab G; Raz B; Ish-Shalom S · The American journal of clinical nutrition · 2003
    Randomized trial100 participantsBone Health forCalcium
  61. Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome.
    Fukuda S; Nojima J; Kajimoto O; Yamaguti K; Nakatomi Y; Kuratsune H; Watanabe Y · BioFactors (Oxford, England) · 2017
    Randomized trial63 participantsEnergy forCoenzyme Q-10
  62. Antihypertensive effect of Iranian Crataegus curvisepala Lind.: a randomized, double-blind study.
    Asgary S; Naderi GH; Sadeghi M; Kelishadi R; Amiri M · Drugs under experimental and clinical research · 2005
    Randomized trial92 participantsCardiovascular Support forHawthorn
  63. Serum magnesium is associated with osteoporosis risk in postmenopausal women: a retrospective study and risk-prediction model.
    Shi D; Li X; Men N; Ren B; Ma Y; Wang L; Zhang Z; He K; Du X; Wang J · Frontiers in medicine · 2026
    Observational study496 participantsBone Health forMagnesium
  64. Effect of magnesium supplementation on endothelial function: A systematic review and meta-analysis of randomized controlled trials.
    Darooghegi Mofrad M; Djafarian K; Mozaffari H; Shab-Bidar S · Atherosclerosis · 2019
    Meta-analysis306 participants7 studies pooledCardiovascular Support forMagnesium
  65. Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study.
    Tiano L; Belardinelli R; Carnevali P; Principi F; Seddaiu G; Littarru GP · European heart journal · 2008
    Randomized trial38 participantsCardiovascular Support forCoenzyme Q-10
  66. Effects of Vitamin D Supplementation on Bone Turnover and Bone Mineral Density in Healthy Men: A Post-Hoc Analysis of a Randomized Controlled Trial.
    Lerchbaum E; Trummer C; Theiler-Schwetz V; Kollmann M; Wölfler M; Pilz S; Obermayer-Pietsch B · Nutrients · 2019
    Randomized trial200 participantsBone Health forVitamin D
  67. Effect of milk and calcium supplementation on bone density and bone turnover in pregnant Chinese women: a randomized controlled trail.
    Liu Z; Qiu L; Chen YM; Su YX · Archives of gynecology and obstetrics · 2011
    Randomized trial36 participantsBone Health forCalcium
  68. Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals.
    Mizuno K; Sasaki AT; Watanabe K; Watanabe Y · Nutrients · 2021
    Clinical trial62 participantsEnergy forCoenzyme Q-10
  69. Clinical efficacy of crataegus extract WS 1442 in congestive heart failure NYHA class II.
    Zapfe jun G · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2002
    Randomized trial40 participantsCardiovascular Support Heart Health forHawthorn
  70. Associations of Dietary Intakes of Calcium, Magnesium, and Soy Isoflavones With Bone Fracture Risk in Men: A Prospective Study.
    Cui Y; Cai H; Zheng W; Shu XO · JBMR plus · 2026
    Cohort study61,025 participantsBone Health forMagnesium
  71. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  72. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  73. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  74. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  75. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  76. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  77. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  78. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  79. Reassessment of the effect of oral l-arginine on blood pressure: A systematic review and meta-analysis based on ambulatory blood pressure monitoring.
    Shi Y; Liu Y; Zhou Z; Xu S; Luo P · Nitric oxide : biology and chemistry · 2026
    Meta-analysis202 participants5 studies pooledCardiovascular Support forArginine
  80. Effect of Long-Term L-Arginine Supplementation on Arterial Compliance and Metabolic Parameters in Patients with Multiple Cardiovascular risk Factors: Randomized, Placebo-Controlled Study.
    Guttman H; Zimlichman R; Boaz M; Matas Z; Shargorodsky M · Journal of cardiovascular pharmacology · 2024
    Randomized trial90 participantsCardiovascular Support forArginine
  81. Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials.
    Bai Y; Sun L; Yang T; Sun K; Chen J; Hui R · The American journal of clinical nutrition · 2009
    Meta-analysis492 participants13 studies pooledCardiovascular Support forArginine
  82. L-arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease.
    Yin WH; Chen JW; Tsai C; Chiang MC; Young MS; Lin SJ · Clinical nutrition (Edinburgh, Scotland) · 2006
    Randomized trial31 participantsCardiovascular Support forArginine
  83. Oral L-Arginine Administration Improves Anthropometric and Biochemical Indices Associated With Cardiovascular Diseases in Obese Patients: A Randomized, Single Blind Placebo Controlled Clinical Trial.
    Dashtabi A; Mazloom Z; Fararouei M; Hejazi N · Research in cardiovascular medicine · 2016
    Randomized trial90 participantsCardiovascular Support forArginine
  84. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium Heart Health forVitamin D
  85. Sex-specific associations between sodium and potassium intake and overall and cause-specific mortality: a large prospective U.S. cohort study, systematic review, and updated meta-analysis of cohort studies.
    Gan L; Zhao B; Inoue-Choi M; Liao LM; Graubard BI; Weinstein SJ; Albanes D; Huang J · BMC medicine · 2024
    Meta-analysis416,104 participantsCardiovascular Support forPotassium
  86. Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies.
    D'Elia L; Barba G; Cappuccio FP; Strazzullo P · Journal of the American College of Cardiology · 2011
    Meta-analysis247,510 participants11 studies pooledCardiovascular Support Heart Health forPotassium
  87. Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials.
    Geleijnse JM; Kok FJ; Grobbee DE · Journal of human hypertension · 2003
    Meta-analysis27 studies pooledCardiovascular Support forPotassium
  88. Twenty-Four-Hour Urinary Sodium and Potassium Excretion and Their Associations With Blood Pressure Among Adults in China: Baseline Survey of Action on Salt China.
    Li Y; Zhang P; Wu J; Ma J; Xu J; Zhang X; Luo R; Liu M; Sun Y; Li X; Tan M; He FJ; MacGregor GA; Li X · Hypertension (Dallas, Tex. : 1979) · 2021
    Cross-sectional study5,353 participantsCardiovascular Support forPotassium
  89. Dietary Sodium and Potassium Intake and Risk of Non-Fatal Cardiovascular Diseases: The Million Veteran Program.
    Wang DD; Li Y; Nguyen XT; Song RJ; Ho YL; Hu FB; Willett WC; Wilson PWF; Cho K; Gaziano JM; Djoussé L; On Behalf Of The Va Million Veteran Program · Nutrients · 2022
    Cohort study180,156 participantsCardiovascular Support forPotassium
  90. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Tsai IC; Hsu CW; Chang CH; Tseng PT; Chang KV · Frontiers in pharmacology · 2024
    Meta-analysis1,126 participants13 studies pooledEnergy forCoenzyme Q-10
  91. Antifatigue effects of coenzyme Q10 during physical fatigue.
    Mizuno K; Tanaka M; Nozaki S; Mizuma H; Ataka S; Tahara T; Sugino T; Shirai T; Kajimoto Y; Kuratsune H; Kajimoto O; Watanabe Y · Nutrition (Burbank, Los Angeles County, Calif.) · 2008
    Randomized trial17 participantsEnergy forCoenzyme Q-10
  92. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  93. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  94. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  95. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  96. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  97. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  98. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  99. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  100. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D
  101. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  102. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  103. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  104. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  105. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  106. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  107. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  108. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  109. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  110. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  111. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial.
    Sabbatinelli J; Orlando P; Galeazzi R; Silvestri S; Cirilli I; Marcheggiani F; Dludla PV; Giuliani A; Bonfigli AR; Mazzanti L; Olivieri F; Antonicelli R; Tiano L · Nutrients · 2021
    Randomized trial51 participantsHeart Health forCoenzyme Q-10
  112. Effects of Coenzyme Q10 on Lipid, Glycemic, and Inflammatory Markers in Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Zhang Z; Liu Z; Geng Y; Huang Y; Hu R; Li F; Song Y; Zhang M · Journal of diabetes research · 2026
    Meta-analysis3,422 participants64 studies pooledHeart Health forCoenzyme Q-10
  113. Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals.
    Zhang P; Yang C; Guo H; Wang J; Lin S; Li H; Yang Y; Ling W · Journal of clinical lipidology · 2019
    Randomized trial101 participantsHeart Health forCoenzyme Q-10
  114. [Actions of standardized extracts of Crataegus berries on exercise tolerance and quality of life in patients with congestive heart failure].
    Rietbrock N; Hamel M; Hempel B; Mitrovic V; Schmidt T; Wolf GK · Arzneimittel-Forschung · 2001
    Randomized trial88 participantsHeart Health forHawthorn
  115. Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials.
    Pittler MH; Schmidt K; Ernst E · The American journal of medicine · 2003
    Meta-analysis632 participants13 studies pooledHeart Health forHawthorn
  116. Baseline severity but not gender modulates quantified Crataegus extract effects in early heart failure--a pooled analysis of clinical trials.
    Eggeling T; Regitz-Zagrosek V; Zimmermann A; Burkart M · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012
    Meta-analysis687 participants10 studies pooledHeart Health forHawthorn
  117. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  118. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  119. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  120. Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trials.
    Poorolajal J; Zeraati F; Soltanian AR; Sheikh V; Hooshmand E; Maleki A · PloS one · 2017
    Meta-analysis1,213 participants23 studies pooledHeart Health forPotassium
  121. Joint association of urinary sodium and potassium excretion with cardiovascular events and mortality: prospective cohort study.
    O'Donnell M; Mente A; Rangarajan S; McQueen MJ; O'Leary N; Yin L; Liu X; Swaminathan S; Khatib R; Rosengren A; Ferguson J; Smyth A; Lopez-Jaramillo P; Diaz R; Avezum A; Lanas F; Ismail N; Yusoff K; Dans A; Iqbal R; Szuba A; Mohammadifard N; Oguz A; Yusufali AH; Alhabib KF; Kruger IM; Yusuf R; Chifamba J; Yeates K; Dagenais G; Wielgosz A; Lear SA; Teo K; Yusuf S; PURE Investigators · BMJ (Clinical research ed.) · 2019
    Cohort study103,570 participantsHeart Health forPotassium
  122. Effect of Potassium Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis of Intervention Studies.
    D'Elia L; Cappuccio FP; Masulli M; La Fata E; Rendina D; Galletti F · Nutrients · 2023
    Meta-analysis332 participants5 studies pooledHeart Health forPotassium
  123. Effects of potassium supplementation on office, home, and 24-h blood pressure in patients with essential hypertension.
    Kawano Y; Minami J; Takishita S; Omae T · American journal of hypertension · 1999
    Randomized trial55 participantsHeart Health forPotassium
  124. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  125. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsHeart Health forVitamin D
  126. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  127. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  128. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  129. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  130. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  131. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  132. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  133. Safety and stress-reducing effects of rosemary extract: an open-label trial and randomized double-blind crossover study.
    Kuwata H; Ookoshi K; Shimazu K; Fukumitsu S; Aida K · Journal of clinical biochemistry and nutrition · 2025
    Randomized trial40 participantsStress Relief forRosemary
  134. Comparing the effects of rosemary aromatherapy and music therapy on anxiety levels in patients undergoing general surgery: A randomized controlled clinical trial.
    Sayadi Mank-Halati M; Rezaei M; Farzaei MH; Khatony A · Explore (New York, N.Y.) · 2024
    Randomized trial236 participantsStress Relief forRosemary
  135. Effects of Continuous Intake of Rosemary Extracts on Mental Health in Working Generation Healthy Japanese Men: Post-Hoc Testing of a Randomized Controlled Trial.
    Araki R; Sasaki K; Onda H; Nakamura S; Kassai M; Kaneko T; Isoda H; Hashimoto K · Nutrients · 2021
    Randomized trial21 participantsStress Relief forRosemary
  136. Effects of Olfactory Stimulation with Aroma Oils on Psychophysiological Responses of Female Adults.
    Choi NY; Wu YT; Park SA · International journal of environmental research and public health · 2022
    Observational study23 participantsStress Relief forRosemary
  137. Effects of visual and aromatic stimulations on the perception of five fundamental tastes.
    Itoh M; Kitagawa A; Ouchi H; Yamaguchi M; Watanabe R; Sone H; Kamiyama S · Bioscience, biotechnology, and biochemistry · 2022
    Non-randomized trial14 participantsStress Relief forRosemary
  138. Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study.
    Zaromytidou E; Koufakis T; Dimakopoulos G; Drivakou D; Konstantinidou S; Rakitzi P; Grammatiki M; Manthou E; Notopoulos A; Iakovou I; Gotzamani-Psarrakou A; Kotsa K · Metabolites · 2023
    Randomized trial90 participantsStress Relief forVitamin D
  139. Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial.
    Charoenporn V; Tungsukruthai P; Teacharushatakit P; Hanvivattanakul S; Sriyakul K; Sukprasert S; Kamalashiran C; Tungsukruthai S; Charernboon T · Psychiatry and clinical neurosciences · 2024
    Randomized trial80 participantsStress Relief forVitamin D
  140. The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review.
    Głąbska D; Kołota A; Lachowicz K; Skolmowska D; Stachoń M; Guzek D · Nutrients · 2021
    Systematic review24 studies pooledStress Relief forVitamin D
  141. Vitamin D3 enhances mood in healthy subjects during winter.
    Lansdowne AT; Provost SC · Psychopharmacology · 1998
    Randomized trial44 participantsStress Relief forVitamin D
  142. Comparative Effects of Etelcalcetide and Maxacalcitol on Serum Calcification Propensity in Secondary Hyperparathyroidism: A Randomized Clinical Trial.
    Shoji T; Nakatani S; Kabata D; Mori K; Shintani A; Yoshida H; Takahashi K; Ota K; Fujii H; Ueda S; Nishi S; Nakatani T; Yoshiyama M; Goto K; Hamada T; Imanishi M; Ishimura E; Kagitani S; Kato Y; Kumeda Y; Maekawa K; Matsumura T; Nagayama H; Obi Y; Ohno Y; Sai Y; Sakurai M; Sasaki S; Shidara K; Shoji S; Tsujimoto Y; Yamakawa K; Yasuda H; Yodoi S; Inaba M; Emoto M · Clinical journal of the American Society of Nephrology : CJASN · 2021
    Randomized trial326 participantsStress Relief forVitamin D