Ashwagandha

botanical

Ashwagandha (Withania somnifera) is an herb used in Ayurvedic medicine as an adaptogen that helps the body maintain balance and resilience when facing physical or psychological stressors. Its principal active compounds, known as withanolides, are considered responsible for its wide-ranging biological effects. The herb is frequently utilized for its calming properties, which may reduce feelings of stress and anxiety and encourage a sense of tranquility. It is commonly used to support restful sleep during occasional sleeplessness and may also support physical performance and recovery. Ashwagandha has also been studied for its potential to support memory and focus. These uses reflect its traditional role in supporting vitality and mental clarity.

Natural sources
Roots and berries of the Ashwagandha plant (Withania somnifera)

Ingredient forms

No public comparison lists found.

Timing & Intake
AnytimeWith foodTake with A meal
Taking Ashwagandha in the evening often supports relaxation and sleep, or it may be taken with meals at any time to help manage stress during the day.
Optimal Dosage
Minimum300 mg
Maximum600 mg
Safety & Toxicity
4 safety notes
  • Pregnant or breastfeeding individuals should avoid use.
  • Individuals with autoimmune diseases (e.g., rheumatoid arthritis, lupus, Hashimoto's thyroiditis) should consult a healthcare professional before use, as Ashwagandha may stimulate the immune system.
  • Those with thyroid disorders should consult a healthcare professional, as Ashwagandha may increase thyroid hormone levels.
  • Avoid use if scheduled for surgery, as it may slow the central nervous system.
Goals
Stress Relief
Impact
Highest effect
Typical dose:300–1000 mg
Ashwagandha is one of the most well-researched adaptogens for stress. It directly modulates the HPA axis, significantly reducing serum cortisol levels. This leads to a tangible and felt sense of calm, improved resilience to daily stressors, and better sleep quality, making it a foundational tool for managing chronic stress.

Study evidence

47 studies

Ashwagandha may ease stress in adults who already feel stressed, with several trials reporting improvements. Reductions in cortisol are more consistent than improvements in perceived stress, and results vary across extracts and studies; lasting benefits and long-term safety remain uncertain.

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Brain Health
Impact
High effect
Typical dose:300–1000 mg
Ashwagandha significantly reduces cortisol levels and the perception of stress, which protects the brain from the damaging effects of chronic stress. By calming the nervous system, it has been shown to improve memory, executive function, and attention while promoting resilience against mental fatigue.

Study evidence

12 studies

Ashwagandha extracts may improve memory, attention and some other thinking skills, with encouraging findings in controlled human research. Benefits vary across cognitive tasks and populations, and the available evidence does not establish protection against dementia or lasting improvements in overall brain health.

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Cognitive Support
Impact
High effect
Typical dose:300–900 mg
As a powerful adaptogen, Ashwagandha's main cognitive benefit comes from its ability to mitigate the negative effects of chronic stress. By lowering cortisol, it can clear 'brain fog,' improve executive function, and enhance attention and information processing speed.

Study evidence

17 studies

Ashwagandha extracts may improve some aspects of memory, attention and thinking in adults, including people with stress or cognitive complaints. Results are promising but vary across tasks and preparations, and they do not establish prevention of dementia or lasting cognitive protection.

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Fitness
Impact
High effect
Typical dose:300–600 mg
Intense training is a physical stressor that elevates cortisol. Ashwagandha helps the body adapt to this stress, leading to better hormonal balance, reduced feelings of fatigue, and improved sleep quality, which are all fundamental for optimal physical recovery and progress.

Study evidence

23 studies

Ashwagandha may improve strength gains alongside resistance training and may support aerobic fitness. Benefits vary across studies, however, and some controlled research finds no added improvement in endurance beyond training alone; effects on body fat are also inconsistent.

View goal
General Health
Impact
High effect
Typical dose:300–600 mg
Ashwagandha is one of the most well-researched adaptogens. It helps the body manage stress by lowering levels of the stress hormone cortisol, leading to tangible benefits like reduced anxiety, improved sleep quality, and increased energy levels without being a stimulant.

Study evidence

31 studies

Ashwagandha may support wellbeing by improving sleep and reducing perceived stress in some adults. Evidence for broader health benefits is less consistent, particularly for exercise performance, and favorable tolerability in limited clinical studies does not establish long-term safety.

View goal
Mood Support
Impact
High effect
Typical dose:300–1000 mg
Ashwagandha helps to modulate the body's stress-response system (HPA axis), leading to tangible reductions in anxiety and improved resilience to stressors. Standardized extracts like KSM-66 or Sensoril ensure a consistent dose of active withanolides.

Study evidence

29 studies

Ashwagandha may support mood by reducing stress and anxiety, particularly in adults already experiencing these symptoms. Results are encouraging but inconsistent, and evidence for a broader antidepressant effect is less secure than evidence for stress relief.

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Showing 6 of 17 goals

Studies

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Sources

Up to five highest-ranked published examples per goal. Study counts and charts include all published studies for the connection.

  1. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study.
    Lopresti AL; Smith SJ; Malvi H; Kodgule R · Medicine · 2019
    Randomized trial60 participantsStress Relief
  2. Shoden promotes Relief from stress and anxiety: A randomized, double-blind, placebo-controlled study on healthy subjects with high stress levels.
    Mishra DN; Kumar M · Heliyon · 2024
    Randomized trial60 participantsStress Relief
  3. Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study.
    Gopukumar K; Thanawala S; Somepalli V; Rao TSS; Thamatam VB; Chauhan S · Evidence-based complementary and alternative medicine : eCAM · 2022
    Randomized trial130 participantsStress ReliefSleep SupportBrain Health
  4. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.
    Chandrasekhar K; Kapoor J; Anishetty S · Indian journal of psychological medicine · 2013
    Randomized trial64 participantsStress ReliefMood Support
  5. Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study.
    Salve J; Pate S; Debnath K; Langade D · Cureus · 2020
    Randomized trial60 participantsStress Relief
  6. Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood.
    Leonard M; Dickerson B; Estes L; Gonzalez DE; Jenkins V; Johnson S; Xing D; Yoo C; Ko J; Purpura M; Jäger R; Faries M; Kephart W; Sowinski R; Rasmussen CJ; Kreider RB · Nutrients · 2024
    Randomized trial59 participantsCognitive SupportBrain HealthEnergy
  7. Effect of ashwagandha (Withania somnifera) extract with Sominone (Somin-On™) to improve memory in adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study.
    Rai HP; Mishra DN · Journal of psychopharmacology (Oxford, England) · 2025
    Randomized trial40 participantsCognitive SupportBrain HealthMental Focus
  8. Efficacy of Withania somnifera supplementation on adult's cognition and mood.
    Remenapp A; Coyle K; Orange T; Lynch T; Hooper D; Hooper S; Conway K; Hausenblas HA · Journal of Ayurveda and integrative medicine · 2022
    Randomized trial60 participantsCognitive SupportProductivity BoostBrain Health
  9. A clinical assessment of the therapeutic effects of Ashwagandha root extract on cognitive performance, sleep, and fatigue in children aged 6-12 years.
    Saxena A; Lopresti A; Sharif M; Elon N; Suri R; Langade DK · Frontiers in nutrition · 2026
    Randomized trial85 participantsBrain HealthMental Focus
  10. A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study.
    Majeed M; Nagabhushanam K; Mundkur L · Medicine · 2023
    Randomized trial54 participantsCognitive SupportMental Focus
  11. Efficacy and safety of ashwagandha root extract in children and adolescents with mild attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled trial.
    Naik S; Muralidhar G; Rao BS; Agarwal S; Jain M · Journal of medicine and life · 2026
    Randomized trial58 participantsMental FocusCognitive Support
  12. Effects of an Aqueous Extract of Withania somnifera on Strength Training Adaptations and Recovery: The STAR Trial.
    Ziegenfuss TN; Kedia AW; Sandrock JE; Raub BJ; Kerksick CM; Lopez HL · Nutrients · 2019
    Randomized trial38 participantsFitnessWeight Gain
  13. Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults.
    Choudhary B; Shetty A; Langade DG · Ayu · 2016
    Randomized trial50 participantsFitnessGeneral Health
  14. Effects of Ashwagandha ( Withania somnifera) standardized root extract on physical endurance and VO 2max in healthy adults performing resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study.
    Verma N; Gupta SK; Patil S; Tiwari S; Mishra AK · F1000Research · 2024
    Randomized trial80 participantsGeneral HealthFitnessMuscle Gain
  15. Effects of Withania somnifera (L.) Dunal (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis.
    Zhu X; Zeng Q; Lei Y; Xu D · Frontiers in pharmacology · 2026
    Meta-analysis1,249 participants20 studies pooledTestosterone SupportFitnessMuscle Gain
  16. Effects of eight-week supplementation of Ashwagandha on cardiorespiratory endurance in elite Indian cyclists.
    Shenoy S; Chaskar U; Sandhu JS; Paadhi MM · Journal of Ayurveda and integrative medicine · 2013
    Randomized trial40 participantsFitness
  17. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.
    Deshpande A; Irani N; Balkrishnan R; Benny IR · Sleep medicine · 2021
    Randomized trial150 participantsGeneral HealthSleep Support
  18. Withania somnifera (L.) Dunal as Add-On Therapy for COPD Patients: A Randomized, Placebo-Controlled, Double-Blind Study.
    Singh P; Salman KA; Shameem M; Warsi MS · Frontiers in pharmacology · 2022
    Randomized trial150 participantsGeneral Health
  19. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.
    Cheah KL; Norhayati MN; Husniati Yaacob L; Abdul Rahman R · PloS one · 2021
    Meta-analysis400 participants5 studies pooledProductivity BoostGeneral Health
  20. A proprietary herbal extract of ashwagandha root for stress and anxiety in healthy adults: a randomized, double-blind, three-arm, placebo-controlled efficacy and safety study.
    West RE; Biswas A; Rao R; Tayade H; Ademola J · Journal of medicine and life · 2026
    Randomized trial141 participantsMood Support
  21. Safety and efficacy of Withania somnifera for anxiety and insomnia: Systematic review and meta-analysis.
    Fatima K; Malik J; Muskan F; Raza G; Waseem A; Shahid H; Jaffery SF; Khan U; Zaheer MK; Shaikh Y; Rashid AM · Human psychopharmacology · 2024
    Meta-analysis254 participants5 studies pooledMood Support
  22. Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study.
    McKinney E; Stewart J; Kewalramani R; Singh S · Trials · 2026
    Randomized trial186 participantsMood SupportEnergy
  23. Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
    Zhang W; Yan Y; Wu Y; Yang H; Zhu P; Yan F; Zhao R; Tian P; Wang T; Fan Q; Su Z · Pharmacological research · 2022
    Meta-analysis29 participants29 studies pooledMood Support
  24. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: A randomized controlled trial.
    Chauhan S; Srivastava MK; Pathak AK · Health science reports · 2024
    Randomized trial50 participantsTestosterone Support
  25. Examining the Effects of Herbs on Testosterone Concentrations in Men: A Systematic Review.
    Smith SJ; Lopresti AL; Teo SYM; Fairchild TJ · Advances in nutrition (Bethesda, Md.) · 2021
    Systematic review32 studies pooledTestosterone Support
  26. Do "testosterone boosters" really increase serum total testosterone? A systematic review.
    Morgado A; Tsampoukas G; Sokolakis I; Schoentgen N; Urkmez A; Sarikaya S · International journal of impotence research · 2024
    Systematic review3 studies pooledTestosterone Support
  27. Safety and Tolerability of Withania somnifera Root Extract in Healthy Male Participants: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
    Vaidya N; Agarwal R; Kshirsagar P; Ganu G; Nagore D; Mehta A; Vora A; Nair S · Food science & nutrition · 2025
    Randomized trial40 participantsTestosterone Support
  28. Efficacy and safety of Ashwagandha (Withania somnifera) root extract on stress and weight management in adults: a prospective, randomized, double-blind, placebo-controlled study.
    Pakhale K; Pakhale R; Srivathsan M; Langade J; Langade D · Journal of medicine and life · 2026
    Randomized trial100 participantsWeight Loss
  29. Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial.
    Choudhary D; Bhattacharyya S; Joshi K · Journal of evidence-based complementary & alternative medicine · 2017
    Randomized trial52 participantsWeight Loss
  30. Impact of ashwagandha (Withania somnifera L.) supplementation on serum lipid concentrations and anthropometric parameters in adults with overweight and obesity: a double-blind, placebo-controlled pilot study.
    Ballesteros-Torres JM; Vázquez-Aguilar A; Luzardo-Ocampo I; Escalante-Aburto A; Caballero-Prado CJ · Nutrition & metabolism · 2025
    Randomized trial43 participantsWeight Loss
  31. Adjunctive Ashwagandha (Withania somnifera) Supplementation and Resistance-Training Adaptations in Healthy Adults: A Systematic Review and Random-Effects Meta-Analysis of Muscular Strength, Chest Circumference, and Body Composition.
    Lee JC; Heo AS · Nutrients · 2026
    Meta-analysis161 participants4 studies pooledWeight Loss
  32. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions.
    Choudhary D; Bhattacharyya S; Bose S · Journal of dietary supplements · 2018
    Randomized trial50 participantsMental Focus
  33. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial.
    Wankhede S; Langade D; Joshi K; Sinha SR; Bhattacharyya S · Journal of the International Society of Sports Nutrition · 2016
    Randomized trial57 participantsWeight GainMuscle Gain
  34. A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males.
    Lopresti AL; Drummond PD; Smith SJ · American journal of men's health · 2020
    Randomized trial57 participantsAnti-Aging
  35. Efficacy and Safety of Low-Dose Ashwagandha Supplementation on Exercise Endurance: A Randomized, Placebo-Controlled, Double-Blind, Clinical Trial.
    Prajapati H; Satia M; Shah D; Basera I; Shah T · Phytotherapy research : PTR · 2026
    Randomized trialEnergy
  36. Enhancing healthspan with Ashwagandha (Withania somnifera): a comprehensive review of its multifaceted geroprotective benefits.
    Vittal M; Vinciguerra M · Biogerontology · 2025
    Narrative reviewEnergy
  37. Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study.
    Kale S; Lopresti A; Suri R; Garg N; Langade D · Journal of psychoactive drugs · 2026
    Randomized trial120 participantsProductivity BoostEnergy
  38. Effects of Withania somnifera root extract serum application on hair health in healthy adults: A prospective, double-blind, randomized, parallel, placebo-controlled study.
    Yerram C; Jillella A; Reddy V · Journal of Ayurveda and integrative medicine · 2023
    Randomized trial61 participantsHair Health
  39. A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Study of Efficacy and Safety of Ashwagandha Root Extract Capsule on Skin and Hair Health in Healthy Adults.
    Jillella A; Keerthi N; Venkateswar Reddy J · Phytotherapy research : PTR · 2026
    Randomized trialHair Health
  40. Ashwagandha Root Extract Stabilises Physiological Stress Responses in Male and Female Team Sports Athletes During Pre-Season Training.
    Coope OC; Otaegui E; Suárez M; Levington A; Abad-Sangrà M; Lloyd B; Spurr TJ; Roman-Viñas B · Nutrients · 2026
    Randomized trial56 participantsMuscle Gain
  41. Evaluation of Withania somnifera (L.) Dunal (Ashwagandha) on Physical Performance, Biomarkers of Inflammation, and Muscle Status in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Study.
    Raut A; Tripathi R; Marathe PA; Uchil DA; Agashe S; Rege N; Vaidya AB · Cureus · 2024
    Randomized trialMuscle Gain
  42. Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study.
    Langade D; Thakare V; Kanchi S; Kelgane S · Journal of ethnopharmacology · 2021
    Randomized trial80 participantsProductivity BoostSleep Support
  43. Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants.
    Pingali U; Pilli R; Fatima N · Pharmacognosy research · 2014
    Randomized trial20 participantsProductivity Boost
  44. Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial.
    Thanawala S; Shah R; Alluri KV; Bhupathiraju K; Desomayanandanam P; Bhuvenendran A · Medicine · 2026
    Randomized trial135 participantsSleep Support
  45. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study.
    Langade D; Kanchi S; Salve J; Debnath K; Ambegaokar D · Cureus · 2020
    Randomized trial60 participantsSleep Support