B-Supreme

B-Supreme

Designs for Health4.8 (287 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals
$29.99 $0.49 per serving

Product analysis

61 out of 100

B-Supreme supplies B vitamins that support normal energy use and blood formation when intake falls short. Its folate form and usable amount remain unclear, limiting comparison with other B complexes.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality45

Some B-vitamin preparations are clearly identified, while folate, choline and betaine are less specific. B6 details are inconsistent, limiting a complete comparison of the vitamin forms.

Ingredient Transparency89

The listed amounts are stated, making the combination easier to compare. Several forms remain unclear, including information needed to interpret folate more precisely.

Value For Money44

B6 compares favorably for the serving cost, while niacin, folate and B5 offer less value. Some other ingredients lack enough information for a reliable value judgment.

Customer Satisfaction77

Customer ratings are very positive across an established set of feedback. They describe satisfaction rather than establishing health benefits.

Product Focus63

The main purpose is filling B-vitamin gaps relevant to normal metabolism and blood formation. Its broader mood, hair and cognitive uses remain conditional on nutritional need.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.49
Customer rating
4.8 · 287 ratings
Report analysis

Goals

Impact
High effect
B Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Vitamin B5 · 100 mgRiboflavin · 50 mgThiamin · 100 mgVitamin B12 · 250 mcg

B vitamins help the body use food for energy, while folate and B12 support normal blood formation. Their contribution to tiredness is most relevant when intake is low or a deficiency is corrected; larger amounts do not establish extra energy when intake is adequate. Folate is present, but its usable amount remains unresolved; the methylcobalamin form does not establish superior fatigue relief.

How this product is rated for Energy

Ingredient fit79

The relevant connection comes from Vitamin B2 (Riboflavin), Vitamin B1 (Thiamin), Vitamin B5, Vitamin B12, Vitamin B6, Niacin. Folate amount uncertainty limits that contribution.
Goal fit
Relevant energy ingredients appear alongside ingredients aimed at other purposes, so the formulation has a broader focus.
Dose adequacy
Most included amounts support the saved findings, but folate has no usable amount and contributes no amount support.

Pathways0

The saved findings concern nutrient sufficiency rather than coverage of the configured alertness, muscle-energy, cellular-energy, stress-fatigue or blood-flow pathways.
Depth
No configured energy pathway receives coverage; nutrient-related contributions are considered separately.
Breadth
No configured pathway reaches the saved coverage requirement.

Evidence81

The strongest included evidence contribution comes from Vitamin B12. Studied-preparation matching does not remove the ingredient-specific limits on fatigue benefits.
Evidence strength
Vitamin B12 provides the strongest included evidence contribution; its population and deficiency limitations still determine the benefit that can be expected.
Studied preparation
The included amounts meet the saved studied-preparation check, without establishing that the finished product itself was tested.

Formulation logic96

The included ingredients need no missing partner and have no matched conflict, but folate fails the amount requirement.
Partner coverage
The included ingredients do not lack a required partner in the saved findings; this does not imply an added combination benefit.
Conflicts
No configured ingredient conflict was matched in the supplied facts.
Effective doses
Six included ingredients meet the saved amount requirement; folate does not because its usable amount is unresolved.
Study evidence
Thiamin Disputed 12 studies
Impact
Moderate effect
B- Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Biotin · 2 mg

Biotin may help if a shortage is contributing to diffuse hair shedding. This means the benefit depends on the cause of the hair loss, rather than simply taking a larger amount. When you already get enough, extra amounts aren't known to promote regrowth.

How this product is rated for Hair Health

Ingredient fit71

biotin may help with shedding caused by a deficiency, rather than reliably regrowing hair when intake is adequate.
Goal fit
biotin may help with shedding caused by a deficiency, rather than reliably regrowing hair when intake is adequate.
Dose adequacy
One serving provides Vitamin B12 250 mcg; Vitamin B7 (Biotin) 2000 mcg. These serving amounts don't establish an effective hair-loss regimen.

Pathways0

Normal nutrient functions or proposed biological pathways don't by themselves establish improved hair growth. The practical benefit depends on the ingredient, preparation and cause of hair loss.
Depth
The ingredients relate to normal nutrient or antioxidant functions; those roles alone don't demonstrate hair regrowth.
Breadth
Several biological connections don't establish several independent hair benefits or a combined regrowth effect.

Evidence80

Declared nutrient identities don't demonstrate superior hair outcomes or an independent regrowth benefit.
Evidence strength
biotin may help with shedding caused by a deficiency, rather than reliably regrowing hair when intake is adequate.
Studied preparation
Declared nutrient identities don't demonstrate superior hair outcomes or an independent regrowth benefit.

Formulation logic100

No required ingredient partner or particular conflict is identified. Serving amounts alone don't establish an individual hair response.
Partner coverage
No required partner is missing for the relevant ingredients.
Conflicts
No particular conflict between the listed ingredients is identified.
Effective doses
One serving provides Vitamin B12 250 mcg; Vitamin B7 (Biotin) 2000 mcg. These serving amounts don't establish an effective hair-loss regimen.
Study evidence
Biotin Supportive 4 studies
Folate Mixed 15 studies
Niacin Disputed 2 studies
Impact
High effect
B+ Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 2 mgNiacin · 50 mgVitamin B12 · 250 mcgRiboflavin · 50 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 50 mg

B vitamins help the body use carbohydrate, fat and protein through their normal roles in energy metabolism. Filling a nutritional gap supports those essential processes, but extra B vitamins have not been shown here to make the body burn more energy when intake is adequate. Their normal metabolic roles should therefore be distinguished from a faster metabolic rate or lasting weight loss.

How this product is rated for Metabolism Support

Ingredient fit82

B vitamins supply the main metabolic connection; the saved amount comparison describes the declared serving rather than a proven boost.
Goal fit
B vitamins provide the main metabolic connection alongside ingredients serving other purposes.
Dose adequacy
The declared amounts reach the reference ranges unevenly, without establishing that increasing them would increase energy expenditure.

Pathways0

No tracked route to increased energy expenditure is covered by the included nutrients.
Depth
No tracked pathway for increasing energy expenditure receives coverage.
Breadth
None of the tracked pathways reaches the coverage threshold.

Evidence100

B vitamins receive evidence and preparation findings, while the supplied scientific context limits claims about a faster metabolic rate.
Evidence strength
Thiamin leads the saved evidence finding, but normal carbohydrate metabolism does not demonstrate an extra increase in energy expenditure.
Studied preparation
The counted preparations receive study matches in the saved findings; this does not establish a direct metabolism boost from each form.

Formulation logic100

No required companion or configured conflict is identified, and the counted amounts clear the minimum comparison threshold.
Partner coverage
No required companion is missing for the counted ingredients; this does not establish an extra benefit from their combination.
Conflicts
No configured ingredient conflict is identified in the saved findings.
Effective doses
All counted ingredients clear the saved minimum amount threshold, which is a comparison cutoff rather than a proven metabolism-boosting dose.
Study evidence
Biotin Supportive 5 studies
Niacin Supportive 17 studies
Thiamin Supportive 11 studies
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per servingScore
Thiamine (Thiamine Hydrochloride)
100 mg 76
Riboflavin (Vitamin B2)
50 mg 78
Niacin (Niacinamide)
50 mg 65
Vitamin B6
50 mg 73
NatureFolate Blend
200 mcg 4
Vitamin B12 (Methylcobalamin)
250 mcg 67
Biotin (D-Biotin)
2 mg
Pantothenic Acid
100 mg 54
Choline
200 mg 51
Trimethylglycine
200 mg
Gluten Free Adults 18–50
Report overview
A- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value
Each serving provides 50 mg of niacin as niacinamide. Niacinamide is treated as a lower-flush form in the evaluation.
How this ingredient is rated

Active Ingredient Quality & Bioavailability86

Niacinamide is the identified niacin form.
Niacin Form & Goal Alignment
Niacinamide is the identified form, evaluated in a general context.
Precursor Source Quality
Niacinamide is a standard form; no separate NR or NMN source is identified in the saved facts.

Dose, Safety & Label Transparency67

The serving lists 50 mg of niacin as niacinamide, a lower-flush form.
Clarity of Chemical Form
Niacinamide is identified as the niacin source.
Form-Specific Dosage Efficacy
Each serving lists 50 mg of niacin as niacinamide.
Flush Risk & Safety Labeling
Niacinamide is treated as a lower-flush form; no no-flush claim is recorded in the saved facts.

Value20

The whole-product serving costs about $0.50; that price includes everything in the product, not just niacin.
Price Per Effective Serving
The whole-product serving costs about $0.50; that price includes everything in the product, not just niacin.
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value
The serving provides 100 mg of thiamin as thiamine hydrochloride. The whole-product price works out to about $0.50 per 100 mg of thiamin, which the evaluation considers high.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

Thiamine Hydrochloride is a standard water-soluble form of thiamin. No configured sweetener or color concern was flagged.
Thiamin Chemical Form
Thiamine Hydrochloride is a standard water-soluble form of thiamin.
Excipient Purity
No configured sweetener or color concern was flagged, and no minimal-additive claim is recorded; this does not establish that the product contains no additives.

Dose, Safety & Label Transparency100

The label gives 100 mg of thiamin per serving, making the amount clear for comparison.
Thiamin Dosage Potency
The serving declares 100 mg of thiamin, a high-potency amount in this evaluation.
Label Transparency & Proprietary Blends
The label specifies 100 mg of thiamin per serving.

Value40

The whole-product price corresponds to about $0.50 per 100 mg of thiamin, which is high in this evaluation.
Price per Declared Dose
The whole-product price corresponds to about $0.50 per 100 mg of thiamin, which is high in this evaluation.
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value
Each serving lists 50 mg of riboflavin from riboflavin hydrochloride and riboflavin 5-phosphate. The whole-product serving costs about $0.50.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The listed forms are riboflavin hydrochloride and riboflavin 5-phosphate.
Riboflavin Form Quality
The listed forms are riboflavin hydrochloride and riboflavin 5-phosphate.

Dose, Safety & Label Transparency100

The serving lists 50 mg of riboflavin, a comparatively large amount. The 50 mg of riboflavin is stated for the combined sources. The available ingredient list has no artificial dyes or synthetic sweeteners flagged in the evaluation.
Dosage for Energy & Metabolism
A serving contains 50 mg of riboflavin, a comparatively large amount.
R5P Elemental Yield Transparency
The 50 mg of riboflavin is stated for the combined sources.
Additive Purity
The available ingredient list has no artificial dyes or synthetic sweeteners flagged in the evaluation.

Value50

The whole-product serving costs about $0.50, near the middle of the comparison.
Price per Serving Value
The whole-product serving costs about $0.50, near the middle of the comparison.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Support forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
  17. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  18. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  19. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  20. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate