B-Supreme

B-Supreme

Designs for Health4.8 (333 ratings)
Format:Capsule Quantity: 120 Capsule(s) · 120 servings
Goals
$52.99 $0.44 per serving

Product analysis

63 out of 100

B-Supreme supports normal use of food for energy when B-vitamin intake is low. Its broad B-vitamin coverage is more relevant to filling dietary gaps than providing an extra boost when needs are already met.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality48

Several B vitamins have clearly identified sources, including niacinamide and calcium D-pantothenate. Folate and choline remain less clearly described, and some preparation details are unresolved.

Ingredient Transparency89

The listed ingredient amounts are disclosed. Most forms are named, but B6, choline and betaine have incomplete preparation details.

Value For Money48

B6 and riboflavin compare favorably for cost. Niacin, folate and B5 compare less favorably, leaving mixed value across the formula.

Customer Satisfaction77

Customer ratings indicate very favorable satisfaction. Several hundred ratings provide a useful but still limited picture of buyer opinion.

Product Focus63

B vitamins give the formula a shared nutritional purpose across energy, mood and concentration. Expected benefits mainly concern low intake rather than added performance in well-nourished adults.

Format
Capsule
Container
120 Capsule(s)
Per serving
$0.44
Customer rating
4.8 · 333 ratings
Report analysis

Goals

Impact
High effect
B+ Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Vitamin B5 · 100 mgRiboflavin · 50 mgThiamin · 100 mgVitamin B12 · 250 mcg
Study evidence
Thiamin Disputed 12 studies
Impact
Moderate effect
B- Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Biotin · 2 mg
Study evidence
Biotin Supportive 4 studies
Folate Mixed 15 studies
Niacin Disputed 2 studies
Impact
High effect
B+ Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 2 mgNiacin · 50 mgVitamin B12 · 250 mcgRiboflavin · 50 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 50 mg
Study evidence
Biotin Supportive 5 studies
Niacin Supportive 17 studies
Thiamin Supportive 11 studies
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per servingScore
Thiamine (Thiamine Hydrochloride)
100 mg 76
Riboflavin (Vitamin B2)
50 mg 84
Niacin (Niacinamide)
50 mg 65
Vitamin B6
50 mg 73
NatureFolate Blend
200 mcg 4
Vitamin B12 (Methylcobalamin)
250 mcg 67
Biotin (D-Biotin)
2 mg
Pantothenic Acid (D-Calcium Pantothenate)
100 mg 70
Choline
200 mg 51
Trimethylglycine
200 mg
Gluten Free Adults 18–50
Report overview
A- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value
Each serving provides 50 mg of niacin, and the whole product has a high cost per serving. It uses Niacinamide. No no-flush claim is recorded.
How this ingredient is rated

Active Ingredient Quality & Bioavailability86

It uses Niacinamide.
Niacin Form & Goal Alignment
It uses Niacinamide.
Precursor Source Quality
Niacinamide is the named source.

Dose, Safety & Label Transparency67

The amount is 50 mg per serving. No no-flush claim is recorded.
Clarity of Chemical Form
The form is disclosed as Niacinamide.
Form-Specific Dosage Efficacy
The serving contains 50 mg of niacin.
Flush Risk & Safety Labeling
No no-flush claim is recorded.

Value20

The whole product has a high cost per serving; the price covers more than niacin.
Price Per Effective Serving
The whole product has a high cost per serving; the price covers more than niacin.
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value
The serving provides 100 mg of thiamin, a high-potency amount, but its cost for that amount is high. It uses Thiamine Hydrochloride. The listed ingredients do not trigger the specified artificial color or sweetener concerns.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

Thiamine Hydrochloride is a standard water-soluble form. The listed ingredients do not trigger the specified artificial color or sweetener concerns.
Thiamin Chemical Form
Thiamine Hydrochloride is a standard water-soluble form.
Excipient Purity
The listed ingredients do not trigger the specified artificial color or sweetener concerns.

Dose, Safety & Label Transparency100

The serving provides 100 mg of thiamin, a high-potency amount.
Thiamin Dosage Potency
The serving provides 100 mg of thiamin, a high-potency amount.
Label Transparency & Proprietary Blends
The thiamin amount is stated as 100 mg per serving.

Value40

The cost is high relative to the declared thiamin amount.
Price per Declared Dose
The cost is high relative to the declared thiamin amount.
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value
Each serving supplies 50 mg of riboflavin, a high amount, at a moderate cost per serving. It uses Riboflavin Hydrochloride and Riboflavin 5-Phosphate, which includes the bioactive coenzyme form. No artificial colors, flavors or synthetic sweeteners are indicated.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

It uses Riboflavin Hydrochloride and Riboflavin 5-Phosphate, which includes the bioactive coenzyme form.
Riboflavin Form Quality
It uses Riboflavin Hydrochloride and Riboflavin 5-Phosphate, which includes the bioactive coenzyme form.

Dose, Safety & Label Transparency100

Each serving supplies 50 mg of riboflavin. No artificial colors, flavors or synthetic sweeteners are indicated.
Dosage for Energy & Metabolism
A serving provides 50 mg, a high amount.
R5P Elemental Yield Transparency
The riboflavin amount is stated for the phosphate source.
Additive Purity
No artificial colors, flavors or synthetic sweeteners are indicated.

Value80

The product has a moderate cost per serving.
Price per Serving Value
The product has a moderate cost per serving.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Support forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
  17. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  18. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  19. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  20. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate