Coenzyme B-Complex Advanced

Coenzyme B-Complex Advanced

Country Life4.8 (3,249 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 30 servings
Goals
$26.79 $0.89 per serving

Product analysis

67 out of 100

Coenzyme B-Complex Advanced combines several well-identified B-vitamin preparations, though value is uneven. Undisclosed source proportions make the mixtures harder to compare closely.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality70

Several B-vitamin preparations work in its favor, including the B5 combination and identified d-biotin. Unstated source proportions and limited information about some extras prevent a firm judgment of the whole mixture.

Ingredient Transparency77

The amounts and nearly all sources are identified, helping compare the main nutrients. Several source mixtures lack individual proportions, and differing declarations should not be added into larger totals.

Value For Money40

B6 compares reasonably and biotin offers moderate value, while riboflavin, niacin and B5 are costly for their contributions. Uncertain comparisons for the remaining ingredients leave value uneven across the complete mixture.

Customer Satisfaction89

Customer ratings are strongly favorable across a substantial number of buyers. The feedback gives a useful view of satisfaction without establishing extra benefit from the coenzyme preparations.

Product Focus62

B-vitamin nutrition is the central theme despite a wider set of associated aims. The multiple nutrient forms and extra compounds make it broader than a supplement for one B vitamin.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.89
Customer rating
4.8 · 3,249 ratings
Report analysis

Goals

Impact
High effect
A- Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Vitamin B5 · 76 mgRiboflavin · 37 mgThiamin · 25 mgVitamin B12 · 400 mcg
Study evidence
Thiamin Disputed 12 studies
Impact
High effect
B+ Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 300 mcgNiacin · 53 mgVitamin B12 · 400 mcgRiboflavin · 37 mgThiamin · 25 mgVitamin B5 · 76 mgVitamin B6 · 50 mg
Study evidence
Biotin Supportive 5 studies
Niacin Supportive 17 studies
Thiamin Supportive 11 studies
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per servingScore
Vitamin C (Ascorbic Acid, Calcium Ascorbate, Chromium Ascorbate, Copper Ascorbate, Magnesium Ascorbate, Manganese Ascorbate, Potassium Ascorbate, Zinc Ascorbate)
60 mg
Thiamin (Thiamine Cocarboxylase Chloride, Thiamine Hydrochloride)
26 mg 67
Riboflavin (Riboflavin 5-Phosphate)
37 mg 65
Niacin (Inositol Hexaniacinate, Nicotinamide Adenine Dinucleotide)
53 mg 52
Vitamin B6 (Pyridoxal 5-Phosphate, Pyridoxine Alpha-Ketoglutarate Hydrochloride, Pyridoxine Hydrochloride)
50 mg 70
Folate ((6S)-5-Methyltetrahydrofolate-Glucosamine Salt)
360 mcg DFE
Vitamin B12 (Methylcobalamin)
400 mcg 67
Biotin (D-Biotin)
300 mcg 66
Pantothenic Acid (Calcium D-Pantothenate, Pantethine)
76 mg 70
Benfotiamine
25 mg 67
BioPQQ (Pyrroloquinoline Quinone Disodium Salt)
5 mg
Nicotinamide Adenine Dinucleotide
500 mcg
Gluten Free Adults 18–50 Vegan Dairy Free Sugar Free Women Vegetarian
Report overview
A+ Ingredient Form & Label QualityF Dose, Safety & Label TransparencyB Value
The 50 mg of vitamin B6 per serving comes at a moderate cost per amount of B6. It uses pyridoxal 5-phosphate, pyridoxine alpha-ketoglutarate hydrochloride and pyridoxine hydrochloride, in unknown proportions. The amount exceeds the European adult daily upper limit, before food or other supplements are counted.
How this ingredient is rated

Ingredient Form & Label Quality100

The B6 comes from pyridoxal 5-phosphate, pyridoxine alpha-ketoglutarate hydrochloride and pyridoxine hydrochloride, but the proportions are unknown. The listed ingredients show no artificial dyes, titanium dioxide, hydrogenated oils or talc.
Vitamin B6 Form Identification
The B6 comes from pyridoxal 5-phosphate, pyridoxine alpha-ketoglutarate hydrochloride and pyridoxine hydrochloride, but the proportions are unknown.
Clean Label and Excipient Purity
The listed ingredients show no artificial dyes, titanium dioxide, hydrogenated oils or talc.

Dose, Safety & Label Transparency37

The serving provides 50 mg of B6, above the European adult daily upper limit; total intake can also include food and other supplements.
Vitamin B6 Dose & Safety Policy
The serving provides 50 mg of B6, above the European adult daily upper limit; total intake can also include food and other supplements.
Label Transparency
The B6 source is named as pyridoxal 5-phosphate, pyridoxine alpha-ketoglutarate hydrochloride and pyridoxine hydrochloride, with proportions unspecified.

Value76

The cost per amount of B6 is moderate.
Vitamin B6 Price Efficiency
The cost per amount of B6 is moderate.
B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value
Each serving provides 26 mg of thiamin, a moderate amount, at a high cost relative to that amount. The proportions of the forms are unknown.
How this ingredient is rated

Active Ingredient Quality & Bioavailability74

Thiamine Cocarboxylase Chloride, Thiamine Hydrochloride and Benfotiamine are included, but their proportions are unknown. The listed ingredients include none of the specified artificial colors or sweeteners.
Thiamin Chemical Form
Thiamine Cocarboxylase Chloride, Thiamine Hydrochloride and Benfotiamine are included, but their proportions are unknown.
Excipient Purity
The listed ingredients include none of the specified artificial colors or sweeteners.

Dose, Safety & Label Transparency72

The label states 26 mg of thiamin per serving, a moderate amount.
Thiamin Dosage Potency
The serving provides 26 mg of thiamin, a moderate amount.
Label Transparency & Proprietary Blends
The thiamin amount per serving is stated on the label.

Value40

The cost is high relative to the declared thiamin amount.
Price per Declared Dose
The cost is high relative to the declared thiamin amount.
A Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyF Value
A serving provides 76 mg of B5, though the cost is high for that amount. It includes calcium D-pantothenate and pantethine, but their proportions are unknown.
How this ingredient is rated

Active Ingredient Quality & Bioavailability92

It combines calcium D-pantothenate and pantethine.
Vitamin B5 Chemical Form
It combines calcium D-pantothenate and pantethine.

Dose, Safety & Label Transparency74

A serving provides 76 mg of vitamin B5, an amount suited to general maintenance. The B5 amount and both forms are named, but their proportions are unknown.
Dosage Potency and Efficacy
A serving provides 76 mg of vitamin B5, an amount suited to general maintenance.
Label Transparency & Source Clarity
The B5 amount and both forms are named, but their proportions are unknown.

Value20

The cost is high for the stated amount of B5.
Price per 500mg Vitamin B5
The cost is high for the stated amount of B5.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Support forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. Biotin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusMetabolism Support forBiotin
  17. Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
    Perry CA; West AA; Gayle A; Lucas LK; Yan J; Jiang X; Malysheva O; Caudill MA · The Journal of nutrition · 2015
    Clinical trial75 participantsMetabolism Support forBiotin
  18. Survey of the effect of biotin on glycemic control and plasma lipid concentrations in type 1 diabetic patients in kermanshah in iran (2008-2009)
    Hemmati M, Babaei H, Abdolsalehei M · Oman Medical Journal · 2013
    Randomized trial70 participantsMetabolism Support forBiotin
  19. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes
    César A Albarracin, Bobby C Fuqua, James L Evans, Ira D Goldfine · Diabetes/Metabolism Research and Reviews · 2008
    Randomized trial348 participantsMetabolism Support forBiotin
  20. Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia
    Cristina Revilla-Monsalve, Iván Zendejas-Ruiz, Sergio Islas-Andrade, Armida Báez-Saldaña, Miguel Angel Palomino-Garibay, Pedro Martín Hernández-Quiróz, Cristina Fernandez-Mejia · Biomedicine & Pharmacotherapy · 2006
    Randomized trial33 participantsMetabolism Support forBiotin