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NightRest With Melatonin

Source Naturals
4.5
★ ★ ★ ★ ★
(5467 ratings)
GABA 500 mg
Magnesium 300 mg
Melatonin 5 mg
Glycine 250 mg
Taurine 300 mg
Product Image
Score74
A broad, economical sleep formula with strong melatonin, GABA, and magnesium. It may work well but is more likely than low-dose options to cause next-day drowsiness.
How scoring works
Quantity:50 Tablet(s) • (25 servings)
Goals:
Sleep Support
Stress Relief
General Health

Score 74

A broad, economical sleep formula with strong melatonin, GABA, and magnesium. It may work well but is more likely than low-dose options to cause next-day drowsiness.
How scoring works
$7.35($0.29 per serving)
Pure Formulas
$ 13.65
iHerb
$ 7.35
Vitacost
$ 7.35
Report prices

Analysis

Five milligrams of melatonin provides a strong sleep-timing signal, while 500 mg GABA and 300 mg magnesium support relaxation. Chamomile and lemon balm reinforce the evening focus.

Taurine is moderate, while glycine and skullcap are comparatively small. The crowded combination makes it harder to identify which ingredient helps or causes unwanted effects.

Twenty-five servings are inexpensive and convenient. Users sensitive to melatonin may prefer a lower-dose, simpler product to reduce morning grogginess.

Who is it for
  • Adults seeking a strong multi-ingredient sleep tablet
  • Users who tolerate 5 mg melatonin
  • Value-focused evening users
Best for
  • Sleep-onset support
  • Nighttime relaxation
  • Low-cost short-term use

Pros

  • Substantial GABA and magnesium
  • Includes chamomile and lemon balm
  • Strong serving value
  • Clear melatonin amount

Cons

  • Melatonin amount is high for sensitive users
  • Crowded blend is hard to troubleshoot
  • Glycine and some botanicals are modest
  • Only twenty-five servings

Warnings

  • Five milligrams of melatonin with other calming agents can cause next-day drowsiness
  • Do not combine with alcohol, sleep medicines, or sedatives without guidance
  • Avoid driving after taking it
  • Magnesium may cause loose stools

Nutrient quality

69 High impact

The magnesium chelate is not fully identified, and several botanicals lack extract-strength details. Magnesium and GABA have useful amounts, while glycine, taurine, and some herbs are modest.

.

Ingredient transparency

76 High impact

Every listed active ingredient has a specific amount. The supplied data does not include a complete inactive ingredient list.

.

Customer satisfaction

70 High impact

The aggregate satisfaction measure and review volume support a favorable first impression. Missing firsthand feedback leaves repeat complaints and real-world purpose fit uncertain.

.

Value for money

81 Highest impact

The broad sleep blend reasonably supports the low product cost despite quality gaps. Each serving offers good value across several calming actives.

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Report analysis

Goals

Sleep Support
Sleep Support
Impact
Highest effect
A Goal FitB+ Strength of SupportA CoverageB- Formula Quality
Magnesium · 300 mgMelatonin · 5 mgGlycine · 250 mg

Melatonin, magnesium, GABA, glycine, and calming botanicals cover circadian timing, nervous-system relaxation, and physical settling. GABA and magnesium are meaningfully dosed, while melatonin provides a direct sleep signal.

Glycine, taurine, skullcap, and some botanical amounts are modest compared with typical stand-alone use, making the formula broader than it is deep. The 5 mg melatonin combined with several calming agents may cause next-day drowsiness, so driving or other alertness-sensitive activity after use is unsafe.

Study evidence
GABA Supportive 4 studies
Glycine Supportive 3 studies
Magnesium Supportive 23 studies
Melatonin Supportive 181 studies
Taurine Not classified

No linked studies yet.

Stress Relief
Stress Relief
Impact
High effect
B Goal FitB Strength of SupportB+ CoverageB- Formula Quality
Magnesium · 300 mgGlycine · 250 mgGABA · 500 mg

Magnesium, GABA, taurine, glycine, chamomile, lemon balm, skullcap, and melatonin cover physical relaxation, inhibitory signaling, botanical calming, and sleep support. GABA and magnesium receive meaningful amounts, while several supporting actives are more modest.

The wide sedating blend may cause next-day drowsiness, especially with alcohol or other sedatives, and 5 mg melatonin is higher than many users need. Multiple overlapping calming ingredients create breadth but make the formula less precise for daytime stress relief.

Study evidence
GABA Supportive 6 studies
Glycine Supportive 1 study
Magnesium Supportive 13 studies
Melatonin Supportive 21 studies
Taurine Supportive 5 studies
General Health
Stress Resilience
General Health
Impact
High effect
B Goal FitC Strength of SupportB- CoverageB Formula Quality
Magnesium · 300 mgGlycine · 250 mgTaurine · 300 mg

Magnesium, taurine, and glycine offer foundational support, while the formula mainly targets nighttime use. Several actives have relevant evidence for sleep or cellular function, though oral GABA and some herbs have more variable support.

Magnesium is substantial, but glycine and taurine are modest and the 5 mg melatonin amount exceeds typical low-dose use. Amounts are clear, yet the magnesium chelate ligand and several botanical standardizations are not identified. The 5 mg melatonin amount combined with chamomile, lemon balm, and skullcap may cause next-day drowsiness and is unsuitable before driving.

Study evidence
Glycine Supportive 4 studies
Magnesium Supportive 114 studies
Melatonin Supportive 69 studies
Taurine No effect 3 studies
Energy
Energy
Impact
Moderate effect
D- Goal FitB- Strength of SupportD+ CoverageB Formula Quality
Magnesium · 300 mg

Magnesium supports energy metabolism, but the formula is designed to promote sleep with melatonin, GABA, glycine, and calming herbs. It may indirectly support daytime energy through better sleep rather than providing an energy-enhancing effect.

The magnesium amount is meaningful, though the exact chelate ligand is not identified. Sedating ingredients make the product unsuitable for daytime alertness.

Study evidence
Magnesium Supportive 4 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
C Goal FitC+ Strength of SupportC- CoverageD+ Formula Quality
Magnesium · 300 mgTaurine · 300 mg

Magnesium and taurine provide some rhythm and vascular-tone support within a sleep formula. The remaining GABA, glycine, melatonin, and calming herbs primarily target sedation rather than cardiovascular health.

Magnesium reaches a meaningful amount, while taurine remains modest and the exact chelate is unknown. Melatonin with chamomile, lemon balm, and skullcap may cause drowsiness, making use before driving unsafe.

Study evidence
Magnesium Supportive 123 studies
Taurine Supportive 24 studies
Heart Health
Healthy Blood Pressure
Heart Health
Impact
Moderate effect
C Goal FitC Strength of SupportC- CoverageD+ Formula Quality
Magnesium · 300 mgTaurine · 300 mg

A meaningful magnesium amount and a modest taurine dose provide some cardiovascular relevance, particularly for mineral balance and normal muscle function. The formula is primarily designed for sleep, so its heart-health contribution is secondary rather than comprehensive.

The magnesium chelate is not chemically specified, and taurine remains below commonly used targeted amounts. Melatonin and several calming herbs can increase drowsiness, so the formula is unsuitable before driving or other alertness-dependent activities.

Study evidence
Magnesium Supportive 158 studies
Taurine Supportive 25 studies
Bone Health
Bone Health
Impact
Moderate effect
C- Goal FitC+ Strength of SupportD CoverageF Formula Quality
Magnesium · 300 mgGlycine · 250 mg

Magnesium supplies one relevant structural mineral at a meaningful amount and in a chelated form. Glycine adds limited support for the protein matrix but is present well below typical standalone use.

Most of the formula is designed for sleep rather than skeletal nutrition. Melatonin and sedating botanicals do not expand bone pathway coverage, so this is a weak choice for focused bone support.

Study evidence
Glycine Disputed 6 studies
Magnesium Supportive 48 studies

Ingredients

IngredientAmount per serving
Calories
5 Calorie(s)
Magnesium (Magnesium Chelate)
 300 mg
Sodium
5 mg
GABA
500 mg
Taurine
300 mg
Glycine
250 mg
Chamomile flower extract
220 mg
Lemon Balm aerial parts extract
140 mg
Skullcap
70 mg
Melatonin
5 mg
Adults 18–50 Women
Report overview
GABA · 500 mg OverallScore77
C+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyB- Value
The formula provides a full standalone-range dose of clearly stated GABA at a moderate serving cost. Standard GABA and tablet delivery are functional but lack the quality and absorption advantages of fermented or dissolving forms. Melatonin at 5 mg plus several calming ingredients may cause next-day drowsiness, so it is poorly suited to driving or other alertness-sensitive activity after use.
View ingredientView products
Magnesium (Magnesium Chelate) · 300 mg OverallScore68
D Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyB- Value

A generic magnesium chelate suggests better absorption than oxide, but the chelating ligand is not identified. The 300 mg elemental dose sits within the standard therapeutic range. Value is good because a chelated form is priced below the collection median.

View ingredientView products
Melatonin · 5 mg OverallScore54
F Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyC Value

The hard tablet may act more slowly and provides no sustained-release technology. A single tablet gives 5 mg, which is above the preferred physiological range but clearly labeled. Cost is moderately above the collection median, though the multi-ingredient sleep blend adds formulation breadth.

View ingredientView products
Loading alternative details
87 Performance

NightRest with Melatonin

Source Naturals
The formula closely matches the original across magnesium, GABA, taurine, glycine, calming herbs, and melatonin while providing more servings at a lower recurring cost. The melatonin amount remains high enough to cause next-day drowsiness or vivid dreams in sensitive users.
88 Performance

Theanine Serene

Source Naturals Serene Science
Chelated magnesium, GABA, taurine, L-theanine, and holy basil provide a focused relaxation blend without the original’s high melatonin amount. It may better suit users seeking calm without direct sleep-hormone support, though exact chelate and botanical details are limited.
80 Performance

Anxiety Control Plus

Metabolic Maintenance
Magnesium bisglycinate, GABA, glycine, passionflower, and lemon balm create a coherent calming formula without a high melatonin dose. Several supporting amounts are modest and the zero-milligram vitamin B6 entry is confusing, but the blend is well aligned with relaxation.
88 Budget

Melatonin 2 mg

Metabolic Maintenance
A more moderate melatonin amount offers direct sleep-timing support with less risk of excessive dosing than the original, and the serving is substantially more economical. Glycine is present only at a small supporting amount, so it does not match the original’s broad calming blend.
82 Budget

Advanced Magnesium Complex

AOR Advanced Orthomolecular Research Advanced
Several named magnesium forms and a substantial glycine contribution provide a strong mineral foundation at a lower serving cost. Melatonin, GABA, and calming herbs are absent, making it more suitable for foundational support than direct sleep onset.
65 Budget

GABA Calm Orange Flavor

Source Naturals
GABA, glycine, taurine, and a small amount of chelated magnesium preserve part of the original calming profile at a lower serving cost. All supporting amounts are small and melatonin is absent, so sleep support is likely gentler.
72 Value

GABA Calm

Source Naturals Serene Science
A very low serving cost and convenient GABA lozenge format support value for mild situational calming. Glycine, taurine, magnesium, and tyrosine are all small, and the formula does not provide the original’s direct melatonin support.
86 Value

Theanine Serene With Relora

Source Naturals
Chelated magnesium, GABA, taurine, L-theanine, Relora botanicals, and holy basil provide broad calming support at a reasonable recurring cost. The formula avoids high-dose melatonin, though generic sourcing and limited botanical standardization reduce certainty.
60 Value

Full Spectrum Curcumin Sleep Ease

Solgar
Melatonin, GABA, and Apocynum preserve direct sleep and calming intent in a simpler formula. The high melatonin amount, unusable curcumin quantity, and costly serving weaken quality-adjusted value compared with the original.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  2. Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
    Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Meta-analysis516 participants8 studies pooledSleep Support forMelatonin
  3. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.
    Bannai M; Kawai N · Journal of pharmacological sciences · 2012
    Narrative reviewSleep Support forGlycine
  4. The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review.
    Soh J; Raventhiran S; Lee JH; Lim ZX; Goh J; Kennedy BK; Maier AB · GeroScience · 2024
    Systematic reviewSleep Support forGlycine
  5. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  6. Effects of zinc and magnesium supplements on postpartum depression and anxiety: A randomized controlled clinical trial.
    Fard FE; Mirghafourvand M; Mohammad-Alizadeh Charandabi S; Farshbaf-Khalili A; Javadzadeh Y; Asgharian H · Women & health · 2017
    Randomized trial99 participantsStress Relief forMagnesium
  7. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief forGABA
  8. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsStress Relief Sleep Support forGABA
  9. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  10. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  11. Implantoplasty Versus Glycine Air Abrasion for the Surgical Treatment of Peri-implantitis: A Randomized Clinical Trial.
    Lasserre JF; Brecx MC; Toma S · The International journal of oral & maxillofacial implants · 2020
    Randomized trial31 participantsBone Health forGlycine
  12. Amino Acid Intakes Are Associated With Bone Mineral Density and Prevalence of Low Bone Mass in Women: Evidence From Discordant Monozygotic Twins.
    Jennings A; MacGregor A; Spector T; Cassidy A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Cross-sectional study135 participantsBone Health forGlycine
  13. Type V osteogenesis imperfecta: a new form of brittle bone disease.
    Glorieux FH; Rauch F; Plotkin H; Ward L; Travers R; Roughley P; Lalic L; Glorieux DF; Fassier F; Bishop NJ · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2001
    Other3 participantsBone Health forGlycine
  14. Associations of Dietary and Circulating Choline and Glycine With Bone Mineral Density: UK Biobank Analyses With Mendelian Randomization.
    Chen S; Lu R; Zhang Y; Li Y; Cao X; Yang H; Lin J · International journal of endocrinology · 2026
    Cross-sectional study18,769 participantsBone Health forGlycine
  15. Metabolomic insights into amino acid signatures and pathways associated with osteoporosis in Iranian elderly population.
    Dehghanbanadaki H; Soltani A; Majidi Z; Rezaei-Tavirani M; Shafiee G; Ostovar A; Bandarian F; Najjar N; Larijani B; Nabipour I; Khashayar P; Fahimfar N; Razi F · Frontiers in medicine · 2025
    Cross-sectional study1,916 participantsBone Health forGlycine
  16. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  17. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  18. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  19. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  20. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  21. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  22. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  23. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  24. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  25. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  26. Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study.
    Sun Q; Wang B; Li Y; Sun F; Li P; Xia W; Zhou X; Li Q; Wang X; Chen J; Zeng X; Zhao Z; He H; Liu D; Zhu Z · Hypertension (Dallas, Tex. : 1979) · 2016
    Randomized trial120 participantsCardiovascular Support Heart Health forTaurine
  27. Taurine ameliorates blood pressure and vascular function in patients with type 2 diabetes: Randomized, double-blind, placebo-controlled trial.
    Li Y; Wang Q; Liu Y; Li Q; Xia W; Lin S; Yang Q; Scholze A; Zhao Z; He H; Zhang H; Yan Z; Tepel M; Mu H; Zhu Z; Liu D · iScience · 2025
    Randomized trial165 participantsCardiovascular Support Heart Health forTaurine
  28. Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.
    Tzang CC; Chi LY; Lin LH; Lin TY; Chang KV; Wu WT; Özçakar L · Nutrition & diabetes · 2024
    Meta-analysis1,024 participants25 studies pooledCardiovascular Support forTaurine
  29. Effects of Oral Taurine Supplementation on Cardiometabolic Risk Factors: A Meta-analysis and Systematic Review of Randomized Clinical Trials.
    Nie Z; Liu Y; Zhang M; Wu C; Cao Q; Xu J; Zheng Y; Min Z; Zhang W; Han S · Nutrition reviews · 2025
    Meta-analysis34 studies pooledCardiovascular Support General Health forTaurine
  30. The effects of taurine supplementation on glycemic control and serum lipid profile in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.
    Maleki V; Alizadeh M; Esmaeili F; Mahdavi R · Amino acids · 2021
    Randomized trial45 participantsCardiovascular Support forTaurine
  31. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  32. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  33. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  34. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  35. Air-abrasive debridement with glycine powder versus manual debridement and chlorhexidine administration for the maintenance of peri-implant health status: a six-month randomized clinical trial.
    Lupi SM; Granati M; Butera A; Collesano V; Rodriguez Y Baena R · International journal of dental hygiene · 2018
    Randomized trial46 participantsGeneral Health forGlycine
  36. The effects of glycine on auditory mismatch negativity in schizophrenia.
    Greenwood LM; Leung S; Michie PT; Green A; Nathan PJ; Fitzgerald P; Johnston P; Solowij N; Kulkarni J; Croft RJ · Schizophrenia research · 2018
    Randomized trial22 participantsGeneral Health forGlycine
  37. Dietary glycine improves urine storage symptoms in urology outpatients.
    Sugaya K; Oh-Oka H; Yamada T; Miyata M; Ashitomi K; Kadekawa K; Nishijima S · Journal of complementary & integrative medicine · 2021
    Non-randomized trial20 participantsGeneral Health forGlycine
  38. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure.
    Díaz-Flores M; Cruz M; Duran-Reyes G; Munguia-Miranda C; Loza-Rodríguez H; Pulido-Casas E; Torres-Ramírez N; Gaja-Rodriguez O; Kumate J; Baiza-Gutman LA; Hernández-Saavedra D · Canadian journal of physiology and pharmacology · 2014
    Randomized trial60 participantsGeneral Health Stress Relief forGlycine
  39. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  40. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  41. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  42. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  43. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  44. Melatonin for preventing and treating jet lag.
    Herxheimer A; Petrie KJ · The Cochrane database of systematic reviews · 2001
    Systematic review10 studies pooledGeneral Health forMelatonin
  45. Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life.
    Schroder CM; Malow BA; Maras A; Melmed RD; Findling RL; Breddy J; Nir T; Shahmoon S; Zisapel N; Gringras P · Journal of autism and developmental disorders · 2019
    Randomized trial125 participantsGeneral Health forMelatonin
  46. Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.
    Fatemeh G; Sajjad M; Niloufar R; Neda S; Leila S; Khadijeh M · Journal of neurology · 2022
    Meta-analysis23 studies pooledGeneral Health forMelatonin
  47. Efficacy of melatonin for chronic insomnia: Systematic reviews and meta-analyses.
    Choi K; Lee YJ; Park S; Je NK; Suh HS · Sleep medicine reviews · 2022
    Meta-analysis24 studies pooledGeneral Health forMelatonin
  48. Effectiveness of melatonin for the treatment of nocturia: a randomized controlled trial.
    Leerasiri P; Pariyaeksut P; Hengrasmee P; Asumpinwong C · International urogynecology journal · 2023
    Randomized trial60 participantsGeneral Health forMelatonin
  49. Cognitive Effects of Taurine and Related Sulphur-Containing Amino Acids: A Systematic Review of Human Trials and Considerations for Plant-Based Dietary Transitions.
    Moore JA; Cousins AL; Taylor RMJ; Griffiths AR; Young HA · Foods (Basel, Switzerland) · 2026
    Systematic review244 participants8 studies pooledGeneral Health forTaurine
  50. Association between habitual dietary taurine intake and the risk of metabolic dysfunction-associated steatotic liver disease: a prospective cohort study.
    Zhang S; Xu X; Wang D; Gu Y; Wu H; Meng G; Zhang Q; Liu L; Borné Y; Niu K; Bai L · Food & function · 2026
    Cohort study16,699 participantsGeneral Health forTaurine
  51. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  52. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  53. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  54. Seafood diets: hypolipidemic and antiatherogenic effects of taurine and n-3 fatty acids.
    Elvevoll EO; Eilertsen KE; Brox J; Dragnes BT; Falkenberg P; Olsen JO; Kirkhus B; Lamglait A; Østerud B · Atherosclerosis · 2009
    Randomized trial80 participantsHeart Health forTaurine
  55. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials.
    Guan L; Miao P · European journal of pharmacology · 2021
    Meta-analysis12 studies pooledHeart Health forTaurine
  56. The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis.
    Waldron M; Patterson SD; Tallent J; Jeffries O · Current hypertension reports · 2019
    Meta-analysis103 participants7 studies pooledHeart Health forTaurine
  57. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  58. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  59. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
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    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
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  65. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
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    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
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  67. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
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    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
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    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
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    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
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  72. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
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    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
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  74. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
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  76. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
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  78. Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial.
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    Demirhan Kayacik A; İlcioglu K · Archives of women's mental health · 2024
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  81. Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial.
    Norouzi A; Fateh S; Modir H; Kamali A; Akrami L · Medical gas research · 2020
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  82. Protective and therapeutic effectiveness of taurine supplementation plus low calorie diet on metabolic parameters and endothelial markers in patients with diabetes mellitus: a randomized, clinical trial.
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    Ra SG; Choi Y; Akazawa N; Ohmori H; Maeda S · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2017
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    Sung MJ; Chang KJ · Advances in experimental medicine and biology · 2009
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