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Anxiety Control Plus

Metabolic Maintenance
4.7
★ ★ ★ ★ ★
(436 ratings)
GABA 400 mg
Glycine 100 mg
Product Image
Score72
GABA, magnesium, passionflower, and lemon balm create a well-aligned calming blend. Small secondary doses and additive drowsiness are important trade-offs.
How scoring works
Quantity:90 Capsule(s) • (45 servings)
Goals:
Stress Relief
Sleep Support
Mood Support

Score 72

GABA, magnesium, passionflower, and lemon balm create a well-aligned calming blend. Small secondary doses and additive drowsiness are important trade-offs.
How scoring works
$36.00($0.80 per serving)
Pure Formulas
$ 36.00
iHerb
$ 36.00
iHerb
$ 36.00
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Analysis

GABA at 400 mg provides the main calming dose, supported by 100 mg magnesium as bisglycinate. Passionflower and lemon balm each add 150 mg and strengthen the nighttime botanical theme.

Glycine and glutamine are far below focused standalone amounts, while vitamin B6 is listed at zero. The formula's depth comes mainly from GABA, magnesium, and the two calming botanicals.

Most active amounts are transparent and two capsules are convenient. The serving cost is premium, and combined sedative effects require care with alcohol and calming medicines.

Who is it for
  • Adults seeking nighttime calming support
  • People wanting GABA with magnesium
  • Users who prefer a botanical-amino acid blend
Best for
  • Stress relief
  • Bedtime relaxation
  • Calming mood support

Pros

  • Provides 400 mg GABA
  • Uses magnesium bisglycinate
  • Includes passionflower and lemon balm
  • No stimulant ingredients

Cons

  • Glycine and glutamine are lightly dosed
  • Vitamin B6 is listed at zero
  • High serving cost
  • GABA source is unbranded

Warnings

  • Combined calming ingredients may increase drowsiness with alcohol, benzodiazepines, sleep medicines, or other sedatives
  • Avoid driving until individual response is known
  • Passionflower is generally avoided during pregnancy

Nutrient quality

80 High impact

Magnesium bisglycinate is a strong form, while several botanicals lack standardization details. GABA is meaningful, but magnesium, glycine, glutamine, passionflower, and lemon balm are modest.

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Ingredient transparency

77 High impact

Active amounts are stated and no proprietary blend hides a core dose. Missing excipient details and complete use directions leave the supplied label information incomplete.

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Customer satisfaction

64 Moderate impact

The supplied aggregate satisfaction average provides a broad signal, while the response volume determines how stable it appears. No comment-level evidence is available to assess repeated complaints or confirm intended-use experiences.

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Value for money

64 Moderate impact

Quality, safety trade-offs, or serving economics materially weaken value. Most ingredients have plausible roles, while the zero-milligram vitamin B6 entry adds no value.

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Report analysis

Goals

Stress Relief
Stress Relief
Impact
Highest effect
B+ Goal FitA Strength of SupportA CoverageA Formula Quality
Magnesium · 100 mgGlycine · 100 mgGABA · 400 mgVitamin B6 · mg

Magnesium bisglycinate, GABA, passionflower, and lemon balm provide complementary support for physical and mental calm. The formula is strongly aligned with stress relief, although evidence for oral GABA and some botanicals is less certain.

Most core actives are supplied in meaningful disclosed amounts across mineral, inhibitory, and botanical pathways. The zero-listed vitamin B6 and smaller supporting amino acids add little, but they do not undermine the main formula.

Study evidence
GABA Supportive 6 studies
Magnesium Supportive 13 studies
Vitamin B6 Supportive 10 studies
Sleep Support
Sleep Support
Impact
High effect
B Goal FitB Strength of SupportB+ CoverageA- Formula Quality
Magnesium · 100 mgGlycine · 100 mg

GABA, magnesium bisglycinate, passionflower, and lemon balm create a coherent calming blend for nighttime use. The main GABA amount is meaningful, and the magnesium form is well suited to routine use.

Magnesium, glycine, and glutamine are present below typical standalone amounts, so much of the depth comes from GABA. The broad set of modest secondary ingredients may still complement relaxation without introducing stimulants.

Study evidence
GABA Supportive 4 studies
Glycine Supportive 3 studies
Magnesium Supportive 23 studies
Mood Support
Mood Support
Impact
High effect
B- Goal FitB Strength of SupportB+ CoverageA Formula Quality
Vitamin B6 · mgMagnesium · 100 mg

GABA, magnesium, glycine, passionflower, and lemon balm provide broad calming support for tension and anxious feelings. Evidence for oral GABA is mixed, so the formula depends on several modest pathways rather than one proven anchor.

The amounts are disclosed and magnesium uses a favorable bisglycinate form. The combined calming ingredients may increase drowsiness when used with alcohol, sedatives, or sleep medicines.

Study evidence
GABA Supportive 12 studies
Glycine Mixed 3 studies
Magnesium Supportive 60 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxine Hydrochloride)
 0 mg
Magnesium (Magnesium Bisglycinate)
 100 mg
GABA
400 mg
Glycine
100 mg
L-Glutamine
140 mg
Passion Flower powder
150 mg
Lemon Balm extract
150 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
GABA · 400 mg OverallScore75
B- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyD- Value

The disclosed 400 mg GABA dose fits a commonly useful range, though the source is not identified as a branded fermented form. A capsule format offers practical delivery, while the blend also includes magnesium, glycine, passionflower, and lemon balm for a broader calming focus. The relatively high cost per serving weakens its value compared with standard GABA options.

View ingredientView products
Glycine · 100 mg OverallScore56
F Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyB- Value

The capsule blend uses glycine as one of several calming ingredients rather than as the main active. Its glycine amount is far below a stand-alone sleep dose, while GABA, magnesium, passionflower, and lemon balm provide the broader rationale. The formula can still offer reasonable blended value, but it is inefficient for someone primarily seeking glycine.

View ingredientView products
Loading alternative details
85 Performance

Pharma GABA 250 mg

Natural Factors Stress-Relax
Pharma GABA supplies a clearly named 200 to 250 mg form in a focused calming formula. Its formulation quality and curcumin focus compare favorably with the original, although the formula does not retain the original product’s glycine component.
83 Performance

GABA 500 mg

Swanson
A focused 500 mg GABA serving provides a clearly disclosed and practical amount of the main calming ingredient. Its formulation quality and curcumin focus compare favorably with the original, although the formula does not retain the original product’s glycine component.
83 Performance

GABA 750 mg

NOW
A focused 750 mg GABA serving provides substantially more of the main calming ingredient than the original. Its formulation quality and curcumin focus compare favorably with the original, although the formula does not retain the original product’s glycine component.
84 Budget

GABA

NOW
A focused 500 mg GABA serving provides a clearly disclosed and practical amount of the main calming ingredient. A lower serving cost improves everyday value, although the formula does not retain the original product’s glycine component.
81 Budget

GABA Powder

Source Naturals Serene Science
A focused 750 mg GABA serving provides substantially more of the main calming ingredient than the original. A lower serving cost improves everyday value, although the formula does not retain the original product’s glycine component.
83 Budget

GABA 500 mg

Nutricost
Curcumin remains the main active, but the supplied label does not clearly state its active curcuminoid yield. A lower serving cost improves everyday value, although some active-form details remain incomplete.
84 Value

GABA 500 mg

NOW
A focused 500 mg GABA serving provides a clearly disclosed and practical amount of the main calming ingredient. Useful formulation quality and efficient serving economics create a favorable quality-to-cost balance, although the formula does not retain the original product’s glycine component.
81 Value

GABA 750 mg

Source Naturals Serene Science
A focused 750 mg GABA serving provides substantially more of the main calming ingredient than the original. Useful formulation quality and efficient serving economics create a favorable quality-to-cost balance, although the formula does not retain the original product’s glycine component.
82 Value

GABA 750 mg

AN Amazing Nutrition Amazing Formulas
A focused 750 mg GABA serving provides substantially more of the main calming ingredient than the original. Useful formulation quality and efficient serving economics create a favorable quality-to-cost balance, although the formula does not retain the original product’s glycine component.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  2. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.
    Bannai M; Kawai N · Journal of pharmacological sciences · 2012
    Narrative reviewSleep Support forGlycine
  3. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief Mood Support forGABA
  4. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure.
    Díaz-Flores M; Cruz M; Duran-Reyes G; Munguia-Miranda C; Loza-Rodríguez H; Pulido-Casas E; Torres-Ramírez N; Gaja-Rodriguez O; Kumate J; Baiza-Gutman LA; Hernández-Saavedra D · Canadian journal of physiology and pharmacology · 2014
    Randomized trial60 participantsStress Relief forGlycine
  5. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  6. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  7. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  8. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  9. [Augmentation of antipsychotics with glycine may ameliorate depressive and extrapyramidal symptoms in schizophrenic patients--a preliminary 10-week open-label study].
    Strzelecki D; Kropiwnicki P; Rabe-Jabłońska J · Psychiatria polska · 2014
    Single-arm trial29 participantsMood Support forGlycine
  10. Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls.
    Pålsson E; Jakobsson J; Södersten K; Fujita Y; Sellgren C; Ekman CJ; Ågren H; Hashimoto K; Landén M · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015
    Cross-sectional study327 participantsMood Support forGlycine
  11. Erythrocyte glycine in depressed, hypomanic, and euthymic bipolar patients treated with lithium carbonate.
    Peselow ED; Deutsch SI; Stanley M; Banay-Schwartz M; Virgilio J; Fieve RR · Psychopharmacology · 1983
    Cross-sectional study27 participantsMood Support forGlycine
  12. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  13. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support Stress Relief forMagnesium
  14. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  15. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  16. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  17. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  18. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  19. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsSleep Support Stress Relief forGABA
  20. The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review.
    Soh J; Raventhiran S; Lee JH; Lim ZX; Goh J; Kennedy BK; Maier AB · GeroScience · 2024
    Systematic reviewSleep Support forGlycine
  21. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.
    Bannai M; Kawai N; Ono K; Nakahara K; Murakami N · Frontiers in neurology · 2012
    Clinical trial7 participantsSleep Support forGlycine
  22. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  23. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  24. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  25. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  26. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  27. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  28. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  29. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsStress Relief forGABA
  30. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  31. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  32. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  33. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium Stress Relief forVitamin B6
  34. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsStress Relief forVitamin B6
  35. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  36. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  37. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6