Product Image

Bone Boost

California Gold Nutrition
4.7
★ ★ ★ ★ ★
(1891 ratings)
Calcium 600 mg
Copper 0.9 mg
Vitamin K 90 mcg
Boron 4 mg
Magnesium 250 mg
Silicon 5 mg
Product Image
Score77
Calcium, magnesium, vitamin D3, vitamin K2, boron, silicon, and balanced trace minerals create a comprehensive bone-support formula. The vitamin D3 amount is modest, and a few specialty additions are too lightly dosed to contribute much.
How scoring works
Quantity:120 Tablet(s) • (30 servings)
Goals:
Bone Health
General Health
Stress Relief
Heart Health
Energy
Testosterone Support
Cardiovascular Support

Score 77

Calcium, magnesium, vitamin D3, vitamin K2, boron, silicon, and balanced trace minerals create a comprehensive bone-support formula. The vitamin D3 amount is modest, and a few specialty additions are too lightly dosed to contribute much.
How scoring works
$21.91($0.73 per serving)
iHerb
$ 21.91
Amazon
$ 76.99
Walmart
$ 28.25
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Analysis

Calcium, magnesium, vitamin D3, vitamin K2, boron, silicon, and balanced trace minerals create a comprehensive bone-support formula. The vitamin D3 amount is modest, and a few specialty additions are too lightly dosed to contribute much.

Several well-absorbed forms, including calcium bisglycinate, citrate malate, and fructoborate, support strong calcium quality. The 600 mg serving is well sized, clearly disclosed, and paired with useful bone-health cofactors without listed artificial additives.

The formula closely matches bone-health needs with 600 mg calcium, 250 mg magnesium, vitamin D3, MK-7 vitamin K2, boron, trace minerals, and milk basic protein. Several well-absorbed mineral forms and clearly stated amounts support meaningful contribution across mineralization, calcium handling, and bone-matrix pathways.

Who is it for
  • Adults focused on bone health
  • Adults focused on general health
  • Adults focused on stress relief
Best for
  • Calcium supplementation
  • Copper supplementation
  • Vitamin K supplementation

Pros

  • Provides a disclosed 180.00mg of vitamin c
  • Provides a disclosed 250.00mg of magnesium
  • Provides a disclosed 90.00mcg of vitamin k2

Cons

  • Vitamin D3 is modest
  • Several specialty additions are lightly dosed
  • The broad formula can overlap other bone supplements

Warnings

  • Vitamin K can oppose warfarin and related medicines, so intake should remain consistent and medically coordinated.
  • Large supplemental calcium servings may be unsuitable with high blood calcium or a history of calcium kidney stones.
  • Calcium can reduce absorption of thyroid medicine and some antibiotics unless doses are separated.

Nutrient quality

88 Highest impact

Bisglycinate, citrate malate, malate, fructoborate, and MK-7 provide excellent form quality. Calcium, magnesium, boron, and vitamin K2 reach meaningful bone-support amounts.

.

Ingredient transparency

77 High impact

Most main amounts are shown, but some blend allocations remain unclear. The supplied data does not include a complete inactive ingredient list.

.

Customer satisfaction

70 High impact

The aggregate satisfaction measure is supported by adequate volume. Missing feedback themes leave recurring complaints and purpose fit uncertain.

.

Value for money

72 High impact

The price is reasonable for the formula quality and dose. Each serving provides only moderate cost efficiency.

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Report analysis

Goals

Bone Health
Bone Health
Impact
Highest effect
A Goal FitA Strength of SupportA CoverageA Formula Quality
Vitamin K · 90 mcgMagnesium · 250 mgCalcium · 600 mgVitamin D · 10 mcgCopper · 0.9 mgManganese · 1.15 mgBoron · 4 mgZinc · 5.5 mgVitamin C · 180 mg

The formula closely matches bone-health needs with 600 mg calcium, 250 mg magnesium, vitamin D3, MK-7 vitamin K2, boron, trace minerals, and milk basic protein. Several well-absorbed mineral forms and clearly stated amounts support meaningful contribution across mineralization, calcium handling, and bone-matrix pathways.

Vitamin D3 is modest and the small, unstandardized silica amount adds little, but most of the broader formula remains purposeful. Milk basic protein makes it unsuitable for people with milk-protein allergy, while 90 mcg of vitamin K2 can interfere with stable warfarin therapy.

Study evidence
Boron Supportive 5 studies
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Potassium Supportive 39 studies
Silicon Supportive 13 studies
Vitamin K Supportive 78 studies
General Health
General Health
Impact
Highest effect
A Goal FitA- Strength of SupportB+ CoverageA- Formula Quality
Vitamin D · 10 mcgMagnesium · 250 mgVitamin K · 90 mcgBoron · 4 mgZinc · 5.5 mgVitamin C · 180 mg

The broad bone-focused formula combines calcium, magnesium, vitamin D3, vitamin K2, and several trace minerals in generally favorable forms. Meaningful core amounts and logical nutrient pairing provide strong foundational structural support.

Several minor extras add complexity, and the vitamin D amount is modest relative to the mineral serving. Vitamin K2 can oppose warfarin, while calcium and magnesium should be separated from levothyroxine or tetracycline antibiotics because they can reduce medicine absorption.

Study evidence
Magnesium Supportive 114 studies
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Stress Relief
Calm and Tension Relief
Stress Relief
Impact
Highest effect
B+ Goal FitA- Strength of SupportC- CoverageA Formula Quality
Vitamin D · 10 mcgMagnesium · 250 mgVitamin C · 180 mg

Magnesium provides direct foundational support for relaxation and stress resilience. Magnesium has established nervous-system relevance when status is low.

The magnesium amount is well aligned. Magnesium malate is a useful, clearly disclosed form.

Study evidence
Magnesium Supportive 13 studies
Heart Health
Heart Health
Impact
Highest effect
B+ Goal FitB+ Strength of SupportB CoverageB+ Formula Quality
Vitamin K · 90 mcgMagnesium · 250 mgVitamin D · 10 mcg

Vitamin K2 as MK-7 and vitamin D3 form a logical pair for calcium management, while magnesium adds vascular and muscle support. The MK-7 amount is clearly disclosed and falls within a useful daily range.

The dry tablet lacks a lipid carrier for fat-soluble vitamins, and several bone-focused additions contribute little direct heart value. Vitamin K2 can interfere with warfarin control, while milk basic protein makes the formula unsuitable for people with a milk allergy.

Study evidence
Magnesium Supportive 158 studies
Vitamin K Mixed 62 studies
Energy
Energy
Impact
High effect
B- Goal FitA- Strength of SupportC- CoverageA- Formula Quality
Vitamin D · 10 mcgMagnesium · 250 mgPotassium · 94 mg

Magnesium malate at 250 mg meets the stated energy-support threshold in a favorable organic form. Vitamin D3, vitamin K2, boron, and trace minerals add a coherent bone-focused context.

Calcium is high relative to magnesium and may compete with its absorption, while the formula lacks alertness or stress-resilience ingredients. Vitamin K2 can counteract warfarin and similar vitamin K antagonists, so users of those medicines need consistent intake and medical guidance.

Study evidence
Magnesium Supportive 4 studies
Vitamin D Supportive 32 studies
Testosterone Support
Testosterone Support
Impact
High effect
B- Goal FitA- Strength of SupportC CoverageC Formula Quality
Magnesium · 250 mgZinc · 5.5 mgVitamin D · 10 mcgBoron · 4 mg

Boron provides the strongest testosterone-specific rationale and reaches a useful daily amount that may influence free-hormone markers. Magnesium, vitamin D3, and zinc add foundational support, although their amounts are mostly oriented toward bone nutrition.

The broad mineral formula covers several nutritional pathways but includes many ingredients unrelated to testosterone. Vitamin K2 can oppose warfarin and related vitamin K antagonists, so users of those medicines need prescriber guidance before changing intake.

Study evidence
Boron Disputed 3 studies
Magnesium Disputed 5 studies
Vitamin D Supportive 56 studies
Zinc Disputed 7 studies

Ingredients

IngredientAmount per serving
Vitamin C (Calcium Ascorbate)
 180 mg
Vitamin D (Cholecalciferol, Vitamin D3)
 10 mcg
Calcium (Calcium Ascorbate, Calcium Bisglycinate, Calcium Citrate Malate, Calcium Fructoborate)
 600 mg
Magnesium (Magnesium Malate)
 250 mg
Zinc (Zinc Bisglycinate)
 5.5 mg
Copper (Copper Bisglycinate)
 0.9 mg
Manganese (Manganese Bisglycinate)
 1.15 mg
Potassium (Potassium Glycinate)
 94 mg
MBP
40 mg
Betaine Hydrochloride
20 mg
Silica (Horsetail Aerial Part Extract)
 5 mg
Boron (Calcium Fructoborate)
 4 mg
Vitamin K2 (Menaquinone-7)
 90 mcg
Gluten Free Adults 18–50
Report overview
Calcium (Calcium Ascorbate, Calcium Bisglycinate, Calcium Citrate Malate, Calcium Fructoborate) · 600 mg OverallScore84
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Several well-absorbed forms, including calcium bisglycinate, citrate malate, and fructoborate, support strong calcium quality. The 600 mg serving is well sized, clearly disclosed, and paired with useful bone-health cofactors without listed artificial additives. Milk basic protein makes it unsuitable for people with milk-protein allergy, and vitamin K2 may interfere with warfarin.

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Copper (Copper Bisglycinate) · 0.9 mg OverallScore80
A+ Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD+ Value

The 0.9 mg copper serving covers the adult daily requirement without reaching the collection target. Copper bisglycinate is a premium amino acid chelate. The broader formula offers some added utility but does not make copper delivery inexpensive.

View ingredientView products
Vitamin K (Menaquinone-7) · 90 mcg OverallScore77
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

The 90 mcg MK-7 dose is clearly disclosed and fits the targeted range for bone and cardiovascular support. The broad bone-support formula and added vitamin D3 partly justify the high serving cost, but the MK-7 source is not premium. The MK-7 dose can affect warfarin control, while milk basic protein makes the formula unsuitable for people with milk allergy.

View ingredientView products
Loading alternative details
83 Performance

Cal/Mag Citrate

NaturesPlus
<p>It provides 500 mg of calcium citrate, 250 mg of magnesium citrate, and 3 mg of boron. The provided analysis shows stronger calcium, mineral, or overall formulation performance than the original in at least one central area, though the exact nutrient balance differs.</p>
83 Performance

Calcium Bone Maker Complex with MCH-Cal and VitaMK7

Doctor's Best
<p>It combines MCH-Cal with 300 mg of calcium, 150 mg of magnesium, 40 mcg of K2, 23 mcg of D3, and 2 mg of boron. The provided analysis shows stronger calcium, mineral, or overall formulation performance than the original in at least one central area, though the exact nutrient balance differs.</p>
81 Performance

Bone Restore with Vitamin K2

Life Extension
<p>It provides 700 mg of calcium from three sources, 300 mg of magnesium, 200 mcg of K2, 25 mcg of D3, 3 mg of boron, and silicon. The provided analysis shows stronger calcium, mineral, or overall formulation performance than the original in at least one central area, though the exact nutrient balance differs.</p>
77 Budget

Calcium Magnesium plus Boron

Solgar
<p>It provides 1,000 mg of calcium, 400 mg of magnesium, and 3 mg of boron. It lowers the serving cost while retaining substantial coverage of the original’s calcium, magnesium, vitamin K, silicon, or boron collections.</p>
82 Budget

Ultra BoneUp

Jarrow Formulas
<p>It combines 400 mg of microcrystalline hydroxyapatite calcium, 166.7 mg of magnesium, 40 mcg of K2, 1 mg of boron, silicon, and type II collagen. It lowers the serving cost while retaining substantial coverage of the original’s calcium, magnesium, vitamin K, silicon, or boron collections.</p>
77 Budget

Calcium Citrate Magnesium and Zinc

Kirkland Signature
<p>It provides 500 mg of calcium, 80 mg of magnesium, 10 mg of zinc, 20 mcg of D3, and 1 mg of boron. It lowers the serving cost while retaining substantial coverage of the original’s calcium, magnesium, vitamin K, silicon, or boron collections.</p>
81 Value

Bone Restore

Life Extension
<p>It provides 700 mg of calcium from three sources, 300 mg of magnesium, 25 mcg of D3, 3 mg of boron, and 5 mg of silicon. It balances broad bone-support coverage with a lower or moderate serving cost compared with the original. The trade-off is a lower amount or omission of at least one nutrient emphasized by the original.</p>
79 Value

Cal-Mag Citrate with Vitamin D-3 & K-2 2:1 Ratio

Solaray
<p>It provides 1,000 mg of calcium citrate, 500 mg of magnesium, 25 mcg of D3, and 50 mcg of K2. It balances broad bone-support coverage with a lower or moderate serving cost compared with the original. The trade-off is a lower amount or omission of at least one nutrient emphasized by the original.</p>
82 Value

Advanced Calcium Complex

Solgar
<p>It provides 1,000 mg of calcium from three forms, 500 mg of magnesium from four forms, 65 mcg of K2, 25 mcg of D3, and 2 mg of boron. It balances broad bone-support coverage with a lower or moderate serving cost compared with the original. The trade-off is a lower amount or omission of at least one nutrient emphasized by the original.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis.
    Chen HG; Sheng LT; Zhang YB; Cao AL; Lai YW; Kunutsor SK; Jiang L; Pan A · European journal of nutrition · 2020
    Meta-analysis222,592 participants21 studies pooledHeart Health Cardiovascular Support forVitamin K
  2. Comparison of concurrent treatment with vitamin K2 and risedronate compared with treatment with risedronate alone in patients with osteoporosis: Japanese Osteoporosis Intervention Trial-03.
    Tanaka S; Miyazaki T; Uemura Y; Miyakawa N; Gorai I; Nakamura T; Fukunaga M; Ohashi Y; Ohta H; Mori S; Hagino H; Hosoi T; Sugimoto T; Itoi E; Orimo H; Shiraki M · Journal of bone and mineral metabolism · 2018
    Randomized trial1,874 participantsBone Health forVitamin K
  3. Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta-analysis.
    Tihtonen K; Korhonen P; Isojärvi J; Ojala R; Ashorn U; Ashorn P; Tammela O · Annals of the New York Academy of Sciences · 2022
    Meta-analysis1,566 participants7 studies pooledBone Health forCalcium
  4. Interventions to Attenuate Cardiovascular Calcification Progression: A Systematic Review of Randomized Clinical Trials.
    Murali S; Smith ER; Tiong MK; Tan SJ; Toussaint ND · Journal of the American Heart Association · 2024
    Systematic review9,901 participants49 studies pooledCardiovascular Support forVitamin K
  5. Association between magnesium deficiency scores and hip bone health in adults: a population-based study.
    Li S; Chang W; Wu G; Wang K; Sun X; Sun H; Zhou J · Magnesium research · 2025
    Cross-sectional study13,259 participantsBone Health forMagnesium
  6. Effects of total gastrectomy on plasma silicon and amino acid concentrations in men.
    Tatara MR; Krupski W; Szpetnar M; Dąbrowski A; Bury P; Szabelska A; Charuta A; Boguszewska-Czubara A; Maciejewski R; Wallner G · Experimental biology and medicine (Maywood, N.J.) · 2016
    Cohort study14 participantsBone Health forSilicon
  7. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes.
    Meacham SL; Taper LJ; Volpe SL · Environmental health perspectives · 1995
    Randomized trial28 participantsBone Health forBoron
  8. Vitamin K Supplementation to Improve Vascular Stiffness in CKD: The K4Kidneys Randomized Controlled Trial.
    Witham MD; Lees JS; White M; Band M; Bell S; Chantler DJ; Ford I; Fulton RL; Kennedy G; Littleford RC; McCrea IV; McGlynn D; Panarelli M; Ralston MR; Rutherford E; Severn A; Thomson N; Traynor JP; Struthers AD; Wetherall K; Mark PB · Journal of the American Society of Nephrology : JASN · 2021
    Randomized trial159 participantsHeart Health forVitamin K
  9. The relationship between vitamin K and peripheral arterial disease.
    Vissers LET; Dalmeijer GW; Boer JMA; Verschuren WMM; van der Schouw YT; Beulens JWJ · Atherosclerosis · 2017
    Cohort study36,629 participantsCardiovascular Support forVitamin K
  10. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.
    Orchard TS; Larson JC; Alghothani N; Bout-Tabaku S; Cauley JA; Chen Z; LaCroix AZ; Wactawski-Wende J; Jackson RD · The American journal of clinical nutrition · 2014
    Cohort study73,684 participantsBone Health forMagnesium
  11. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  12. Calcium supplementation and bone mineral density in postmenopausal women using estrogen replacement therapy.
    Haines CJ; Chung TK; Leung PC; Hsu SY; Leung DH · Bone · 1995
    Randomized trialBone Health forCalcium
  13. Absorption of silicon from artesian aquifer water and its impact on bone health in postmenopausal women: a 12 week pilot study.
    Li Z; Karp H; Zerlin A; Lee TY; Carpenter C; Heber D · Nutrition journal · 2011
    Randomized trial17 participantsBone Health forSilicon
  14. [Comparative study of the urinary excretion of boron, calcium, magnesium and phosphorus in postmenopausal women with and without osteoporosis].
    José Ramón V; Mora Mora M; Marino Alarcón O; Hernández G; Josefina Linares L; Urdaneta Romero H; Arévalo González E · Investigacion clinica · 2013
    Case-control study45 participantsBone Health forBoron
  15. Six weeks phylloquinone supplementation produces undesirable effects on blood lipids with no changes in inflammatory and fibrinolytic markers in postmenopausal women.
    Kristensen M; Kudsk J; Bügel S · European journal of nutrition · 2008
    Randomized trial31 participantsHeart Health forVitamin K
  16. Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease.
    van den Heuvel EG; van Schoor NM; Lips P; Magdeleyns EJ; Deeg DJ; Vermeer C; den Heijer M · Maturitas · 2014
    Cohort study577 participantsCardiovascular Support forVitamin K
  17. Dialysate Magnesium and Coronary Artery Calcification, Bone Mineral Density, and Cramping in Maintenance Hemodialysis: A Quasi-experimental Study.
    Srisuwarn P; Sethakarun S; Nongnuch A; Jongjirasiri S; Sritara C; Klyprayong P; Disthabanchong S · Kidney medicine · 2022
    Non-randomized trial40 participantsBone Health forMagnesium
  18. Bone turnover and the response to alendronate treatment in postmenopausal osteoporosis.
    Gonnelli S; Cepollaro C; Pondrelli C; Martini S; Montagnani A; Monaco R; Gennari C · Calcified tissue international · 1999
    Randomized trial100 participantsBone Health forCalcium
  19. Urinary Silicon Excretion in Relation to Lactation and Bone Mineral Density - a Longitudinal Study Post-partum.
    Magnusson C; Augustin H; Jugdaohsingh R; Powell JJ; Hulthén L; Ransjö M · Biological trace element research · 2025
    Cohort study81 participantsBone Health forSilicon
  20. Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.
    Cheung AM; Tile L; Lee Y; Tomlinson G; Hawker G; Scher J; Hu H; Vieth R; Thompson L; Jamal S; Josse R · PLoS medicine · 2009
    Randomized trial440 participantsBone Health forVitamin K
  21. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.
    Nielsen FH; Hunt CD; Mullen LM; Hunt JR · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 1987
    Single-arm trial12 participantsBone Health forBoron
  22. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  23. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  24. Associations of dietary calcium intake with metabolic syndrome and bone mineral density among the Korean population: KNHANES 2008-2011.
    Kim MK; Chon SJ; Noe EB; Roh YH; Yun BH; Cho S; Choi YS; Lee BS; Seo SK · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Cross-sectional study14,705 participantsBone Health forCalcium
  25. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  26. The effect of choline-stabilized orthosilicic acid in patients with peri-implantitis: an exploratory randomized, double-blind, placebo controlled study.
    Teughels W; Celik GU; Tarce M; De Cock I; Persyn SM; Haytac MC · BMC oral health · 2021
    Randomized trial21 participantsBone Health forSilicon
  27. The relationship between boron and magnesium status and bone mineral density in the human: a review.
    Volpe SL; Taper LJ; Meacham S · Magnesium research · 1994
    Narrative reviewBone Health forBoron
  28. Vitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials.
    Vlasschaert C; Goss CJ; Pilkey NG; McKeown S; Holden RM · Nutrients · 2021
    Systematic review9 studies pooledHeart Health forVitamin K
  29. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.
    Huang ZB; Wan SL; Lu YJ; Ning L; Liu C; Fan SW · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Meta-analysis6,759 participants19 studies pooledBone Health forVitamin K
  30. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsHeart Health Cardiovascular Support forVitamin K
  31. Treatment with alendronate plus calcium, alendronate alone, or calcium alone for postmenopausal low bone mineral density.
    Bonnick S; Broy S; Kaiser F; Teutsch C; Rosenberg E; DeLucca P; Melton M · Current medical research and opinion · 2007
    Randomized trial701 participantsBone Health forCalcium
  32. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  33. Calcium Phosphate Modified with Silicon vs. Bovine Hydroxyapatite for Alveolar Ridge Preservation: Densitometric Evaluation, Morphological Changes and Histomorphometric Study.
    Cadenas-Vacas G; Martínez-Rodríguez N; Barona-Dorado C; Sánchez-Labrador L; Cortés-Bretón Brinkmann J; Meniz-García C; Martínez-González JM · Materials (Basel, Switzerland) · 2021
    Non-randomized trialBone Health forSilicon
  34. Vitamin K intake and all-cause and cause specific mortality.
    Zwakenberg SR; den Braver NR; Engelen AIP; Feskens EJM; Vermeer C; Boer JMA; Verschuren WMM; van der Schouw YT; Beulens JWJ · Clinical nutrition (Edinburgh, Scotland) · 2018
    Cohort study33,289 participantsHeart Health forVitamin K
  35. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  36. Intake of dietary phylloquinone and menaquinones and risk of stroke.
    Vissers LE; Dalmeijer GW; Boer JM; Monique Verschuren WM; van der Schouw YT; Beulens JW · Journal of the American Heart Association · 2014
    Cohort study35,476 participantsCardiovascular Support forVitamin K
  37. Calcium and osteoporosis.
    Nordin BE · Nutrition (Burbank, Los Angeles County, Calif.) · 1998
    Meta-analysis20 studies pooledBone Health forCalcium
  38. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects.
    Ryder KM; Shorr RI; Bush AJ; Kritchevsky SB; Harris T; Stone K; Cauley J; Tylavsky FA · Journal of the American Geriatrics Society · 2006
    Cross-sectional study2,038 participantsBone Health forMagnesium
  39. Silicon: a review of its potential role in the prevention and treatment of postmenopausal osteoporosis.
    Price CT; Koval KJ; Langford JR · International journal of endocrinology · 2013
    Narrative reviewBone Health forSilicon
  40. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  41. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  42. Dietary calcium intake protects women consuming oral contraceptives from spine and hip bone loss.
    Teegarden D; Legowski P; Gunther CW; McCabe GP; Peacock M; Lyle RM · The Journal of clinical endocrinology and metabolism · 2005
    Randomized trial154 participantsBone Health forCalcium
  43. Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort.
    Welch AA; Skinner J; Hickson M · Nutrients · 2018
    Cross-sectional study156,575 participantsBone Health forMagnesium
  44. Osteogenic Effect of a Bioactive Calcium Alkali Phosphate Bone Substitute in Humans.
    Knabe C; Adel-Khattab D; Rezk M; Cheng J; Berger G; Gildenhaar R; Wilbig J; Günster J; Rack A; Heiland M; Knauf T; Stiller M · Bioengineering (Basel, Switzerland) · 2023
    Clinical trial38 participantsBone Health forSilicon
  45. Vitamin K2 (menaquinone-7) prevents age-related deterioration of trabecular bone microarchitecture at the tibia in postmenopausal women.
    Rønn SH; Harsløf T; Pedersen SB; Langdahl BL · European journal of endocrinology · 2017
    Randomized trial148 participantsBone Health forVitamin K
  46. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsHeart Health Cardiovascular Support forVitamin K
  47. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  48. Relationship between bone mineral density changes and risk of fractures among patients receiving calcium with or without vitamin D supplementation: a meta-regression.
    Rabenda V; Bruyère O; Reginster JY · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011
    Meta-analysis47,365 participants15 studies pooledBone Health forCalcium
  49. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  50. Silicon and bone health.
    Jugdaohsingh R · The journal of nutrition, health & aging · 2007
    Narrative reviewBone Health forSilicon
  51. Dietary vitamin K intakes and atherosclerotic cardiovascular disease incidence: Findings from the UK biobank.
    Dupuy M; Li C; Pokharel P; Zhong L; Parmenter BH; Radavelli-Bagatini S; Dalla Via J; Linneberg A; Jakobsen J; Kühn T; Cassidy A; Hodgson JM; Lewis JR; Sim M; Bondonno NP · Atherosclerosis · 2026
    Cohort study112,111 participantsHeart Health forVitamin K
  52. Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women.
    Bolton-Smith C; McMurdo ME; Paterson CR; Mole PA; Harvey JM; Fenton ST; Prynne CJ; Mishra GD; Shearer MJ · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2007
    Randomized trial244 participantsBone Health forVitamin K
  53. Calcium supplementation provides an extended window of opportunity for bone mass accretion after menarche.
    Rozen GS; Rennert G; Dodiuk-Gad RP; Rennert HS; Ish-Shalom N; Diab G; Raz B; Ish-Shalom S · The American journal of clinical nutrition · 2003
    Randomized trial100 participantsBone Health forCalcium
  54. Serum magnesium is associated with osteoporosis risk in postmenopausal women: a retrospective study and risk-prediction model.
    Shi D; Li X; Men N; Ren B; Ma Y; Wang L; Zhang Z; He K; Du X; Wang J · Frontiers in medicine · 2026
    Observational study496 participantsBone Health forMagnesium
  55. Biosilica-based strategies for treatment of osteoporosis and other bone diseases.
    Schröder HC; Wiens M; Wang X; Schloßmacher U; Müller WE · Progress in molecular and subcellular biology · 2016
    Narrative reviewBone Health forSilicon
  56. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  57. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K
  58. Vitamin K1 and progression of cardiovascular calcifications in hemodialysis patients: the VitaVasK randomized controlled trial.
    Saritas T; Reinartz S; Krüger T; Ketteler M; Liangos O; Labriola L; Stenvinkel P; Kopp C; Westenfeld R; Evenepoel P; Siepmann R; Wied S; Hilgers RD; Schurgers L; Floege J; VitaVasK Investigators · Clinical kidney journal · 2026
    Randomized trial60 participantsCardiovascular Support forVitamin K
  59. Effect of milk and calcium supplementation on bone density and bone turnover in pregnant Chinese women: a randomized controlled trail.
    Liu Z; Qiu L; Chen YM; Su YX · Archives of gynecology and obstetrics · 2011
    Randomized trial36 participantsBone Health forCalcium
  60. Associations of Dietary Intakes of Calcium, Magnesium, and Soy Isoflavones With Bone Fracture Risk in Men: A Prospective Study.
    Cui Y; Cai H; Zheng W; Shu XO · JBMR plus · 2026
    Cohort study61,025 participantsBone Health forMagnesium
  61. Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial.
    Spector TD; Calomme MR; Anderson SH; Clement G; Bevan L; Demeester N; Swaminathan R; Jugdaohsingh R; Berghe DA; Powell JJ · BMC musculoskeletal disorders · 2008
    Randomized trial136 participantsBone Health forSilicon
  62. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations
    C D Hunt, J L Herbel, F H Nielsen · The American Journal of Clinical Nutrition · 1997
    Non-randomized trial11 participantsBone Health forBoron
  63. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  64. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  65. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  66. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  67. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  68. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  69. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  70. Effect of potassium citrate on bone density, microarchitecture, and fracture risk in healthy older adults without osteoporosis: a randomized controlled trial.
    Jehle S; Hulter HN; Krapf R · The Journal of clinical endocrinology and metabolism · 2013
    Randomized trial201 participantsBone Health forPotassium
  71. Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women.
    Frassetto L; Morris RC; Sebastian A · The Journal of clinical endocrinology and metabolism · 2005
    Randomized trial170 participantsBone Health forPotassium
  72. Partial neutralization of the acidogenic Western diet with potassium citrate increases bone mass in postmenopausal women with osteopenia.
    Jehle S; Zanetti A; Muser J; Hulter HN; Krapf R · Journal of the American Society of Nephrology : JASN · 2007
    Randomized trial161 participantsBone Health forPotassium
  73. Potassium citrate supplementation results in sustained improvement in calcium balance in older men and women.
    Moseley KF; Weaver CM; Appel L; Sebastian A; Sellmeyer DE · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013
    Randomized trial52 participantsBone Health forPotassium
  74. Effects of potassium chloride and potassium bicarbonate on endothelial function, cardiovascular risk factors, and bone turnover in mild hypertensives.
    He FJ; Marciniak M; Carney C; Markandu ND; Anand V; Fraser WD; Dalton RN; Kaski JC; MacGregor GA · Hypertension (Dallas, Tex. : 1979) · 2010
    Randomized trial42 participantsBone Health forPotassium
  75. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  76. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  77. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  78. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  79. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium Cardiovascular Support forVitamin D
  80. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  81. Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis.
    Rozemeijer S; Hemilä H; van Baaren M; de Man AME · BMC cardiovascular disorders · 2023
    Meta-analysis872 participants7 studies pooledCardiovascular Support forVitamin C
  82. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension.
    Taddei S; Virdis A; Ghiadoni L; Magagna A; Salvetti A · Circulation · 1998
    Clinical trial49 participantsCardiovascular Support forVitamin C
  83. Vitamin C supplementation improves blood pressure and oxidative stress after acute exercise in patients with poorly controlled type 2 diabetes mellitus: A randomized, placebo-controlled, cross-over study.
    Boonthongkaew C; Tong-Un T; Kanpetta Y; Chaungchot N; Leelayuwat C; Leelayuwat N · The Chinese journal of physiology · 2021
    Randomized trial24 participantsCardiovascular Support forVitamin C
  84. Vascular benefits of vitamin C supplementation against fine particulate air pollution in healthy adults: A double-blind randomised crossover trial.
    Ren J; Liang J; Wang J; Yin B; Zhang F; Li X; Zhu S; Tian H; Cui Q; Song J; Liu G; Ling W; Ma Y · Ecotoxicology and environmental safety · 2022
    Randomized trial58 participantsCardiovascular Support forVitamin C
  85. Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes.
    Mullan BA; Young IS; Fee H; McCance DR · Hypertension (Dallas, Tex. : 1979) · 2003
    Randomized trial30 participantsCardiovascular Support forVitamin C
  86. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
    Kumar V; Yadav AK; Lal A; Kumar V; Singhal M; Billot L; Gupta KL; Banerjee D; Jha V · Journal of the American Society of Nephrology : JASN · 2017
    Randomized trial120 participantsCardiovascular Support forVitamin D
  87. Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
    Porto C; Petribu K; Barbosa N; Magalhães R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; Magalhães J; Sougey E; Silva T; Junio A; Bandeira F; Leão R · American heart journal plus : cardiology research and practice · 2025
    Randomized trial224 participantsCardiovascular Support forVitamin D
  88. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
    Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y · PloS one · 2017
    Randomized trial70 participantsCardiovascular Support forVitamin D
  89. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsCardiovascular Support forVitamin D
  90. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  91. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  92. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  93. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  94. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  95. Oral zinc supplementation for the treatment of acute diarrhea in children: a systematic review and meta-analysis.
    Lamberti LM; Walker CL; Chan KY; Jian WY; Black RE · Nutrients · 2014
    Meta-analysis18,822 participants104 studies pooledDigestive Health forZinc
  96. Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial.
    Bhatnagar S; Bahl R; Sharma PK; Kumar GT; Saxena SK; Bhan MK · Journal of pediatric gastroenterology and nutrition · 2004
    Randomized trial287 participantsDigestive Health forZinc
  97. Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial.
    Dhingra U; Kisenge R; Sudfeld CR; Dhingra P; Somji S; Dutta A; Bakari M; Deb S; Devi P; Liu E; Chauhan A; Kumar J; Semwal OP; Aboud S; Bahl R; Ashorn P; Simon J; Duggan CP; Sazawal S; Manji K · The New England journal of medicine · 2020
    Randomized trial4,500 participantsDigestive Health forZinc
  98. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsDigestive Health forZinc
  99. Short-course prophylactic zinc supplementation for diarrhea morbidity in infants of 6 to 11 months.
    Malik A; Taneja DK; Devasenapathy N; Rajeshwari K · Pediatrics · 2013
    Randomized trial272 participantsDigestive Health forZinc
  100. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  101. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  102. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  103. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  104. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  105. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  106. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  107. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  108. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D
  109. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  110. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  111. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  112. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  113. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  114. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  115. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  116. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  117. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  118. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  119. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  120. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledGeneral Health forVitamin K
  121. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  122. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  123. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  124. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  125. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  126. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  127. Essentiality of boron for healthy bones and joints.
    Newnham RE · Environmental health perspectives · 1995
    Randomized trial20 participantsJoint Health forBoron
  128. Short-term efficacy of calcium fructoborate on subjects with knee discomfort: a comparative, double-blind, placebo-controlled clinical study
    Zbigniew Pietrzkowski, Michael J Phelan, Robert Keller, Cynthia Shu, Ruby Argumedo, Tania Reyes-Izquierdo · Clinical Interventions in Aging · 2014
    Randomized trial60 participantsJoint Health forBoron
  129. A double-blind, placebo-controlled pilot study to evaluate the effect of calcium fructoborate on systemic inflammation and dyslipidemia markers for middle-aged people with primary osteoarthritis
    Romulus Scorei, Paul Mitrut, Iulian Petrisor, Iulia Scorei · Biological Trace Element Research · 2011
    Randomized trial60 participantsJoint Health forBoron
  130. Analgesic effect and safety of single-dose intra-articular magnesium after arthroscopic surgery: a systematic review and meta-analysis.
    Zeng C; Li YS; Wei J; Xie DX; Xie X; Li LJ; Gao SG; Luo W; Xiong YL; Xiao WF; Lei GH · Scientific reports · 2018
    Meta-analysis16 studies pooledJoint Health forMagnesium
  131. Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis.
    Zeng C; Wei J; Terkeltaub R; Yang T; Choi HK; Wang YL; Xie DX; Hunter DJ; Zhang Y; Li H; Cui Y; Li LJ; Lei GH · Arthritis research & therapy · 2018
    Cross-sectional study13,947 participantsJoint Health forMagnesium
  132. Low magnesium intake is associated with increased knee pain in subjects with radiographic knee osteoarthritis: data from the Osteoarthritis Initiative.
    Shmagel A; Onizuka N; Langsetmo L; Vo T; Foley R; Ensrud K; Valen P · Osteoarthritis and cartilage · 2019
    Cohort study2,548 participantsJoint Health forMagnesium
  133. Associations of magnesium depletion score with the incidence and mortality of osteoarthritis: a nationwide study.
    Ma R; Zhang C; Liu J; Ren J; Huang H; Wang G; Ding Y; Li X · Frontiers in immunology · 2025
    Observational study19,394 participantsJoint Health forMagnesium
  134. Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in People with Symptomatic Knee Osteoarthritis.
    Zhang Y; Chen T; Luo P; Li S; Zhu J; Xue S; Cao P; Zhu Z; Li J; Wang X; Wluka AE; Cicuttini F; Ruan G; Ding C · Nutrients · 2022
    Cohort study392 participantsJoint Health forMagnesium
  135. Silicon Interpositional Arthroplasty for Temporo-mandibular Joint Ankylosis.
    Agarwal P; Singh MP; Tiwari S; Sharma D · Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Single-arm trial20 participantsJoint Health forSilicon
  136. A 12-week randomized, double-blind, placebo-controlled multicenter study of choline-stabilized orthosilicic acid in patients with symptomatic knee osteoarthritis.
    Geusens P; Pavelka K; Rovensky J; Vanhoof J; Demeester N; Calomme M; Vanden Berghe D · BMC musculoskeletal disorders · 2017
    Randomized trial211 participantsJoint Health forSilicon
  137. Comparison of tendon suspension-interposition and silicon spacers in the treatment of degenerative osteoarthritis of the base of the thumb.
    Lehmann O; Herren DB; Simmen BR · Annales de chirurgie de la main et du membre superieur : organe officiel des societes de chirurgie de la main = Annals of hand and upper limb surgery · 2000
    Observational study102 participantsJoint Health forSilicon
  138. Ultrasonographic assessment of the quadriceps muscle and femoral cartilage in transtibial amputees using different prostheses.
    Şahin Onat Ş; Malas FÜ; Öztürk GT; Akkaya N; Kara M; Özçakar L · Prosthetics and orthotics international · 2017
    Cross-sectional study38 participantsJoint Health forSilicon
  139. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsJoint Health forVitamin C
  140. Effects of Multiple Intravenous Doses of Perioperative Vitamin C on Pain Management Following Total Hip Arthroplasty.
    Han G; Ye Y; Kang P · Drug design, development and therapy · 2025
    Randomized trial100 participantsJoint Health forVitamin C
  141. Osteoarthritis prevalence and modifiable factors: a population study.
    Plotnikoff R; Karunamuni N; Lytvyak E; Penfold C; Schopflocher D; Imayama I; Johnson ST; Raine K · BMC public health · 2016
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  142. Anti-Inflammatory Effect of Vitamin C during the Postoperative Period in Patients Subjected to Total Knee Arthroplasty: A Randomized Controlled Trial.
    Ramón R; Holguín E; Chiriboga JD; Rubio N; Ballesteros C; Ezechieli M · Journal of personalized medicine · 2023
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  143. Musculoskeletal manifestations of scurvy.
    Fain O · Joint bone spine · 2005
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  144. Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis.
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  145. Vitamin D Deficiency Leads to Poorer Health Outcomes and Greater Length of Stay After Total Knee Arthroplasty and Supplementation Improves Outcomes: A Systematic Review and Meta-Analysis.
    Vivek K; Kamal R; Perera E; Gupte CM · JBJS reviews · 2024
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  147. Baseline 25-hydroxyvitamin D levels predict the effects of vitamin D supplementation on joint symptoms and cartilage loss in patients with knee osteoarthritis.
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  150. Associations Between Dietary Intake of Vitamin K and Changes in Symptomatic and Structural Changes in Patients With Knee Osteoarthritis.
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  151. Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: dietary survey in a population-based cohort of the ROAD study.
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  152. The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence.
    Chin KY · Nutrients · 2021
    Narrative reviewJoint Health forVitamin K
  153. Vitamin K deficiency is associated with incident knee osteoarthritis.
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    Cohort study1,180 participantsJoint Health forVitamin K
  154. Predictive Model of Nail Consistency Using Scanning Electron Microscopy with Energy-Dispersive X-Ray.
    Mingorance Álvarez E; Martínez Quintana R; Pérez Pico AM; Mayordomo R · Biology · 2021
    Cross-sectional study57 participantsNail Health forCalcium
  155. Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin.
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  156. Nail Supplements: When, How, and Why?
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    Narrative reviewNail Health forSilicon
  157. Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient.
    Dunleavy KA; Ungaro RC; Manning L; Gold S; Novak J; Colombel JF · Crohn's & colitis 360 · 2023
    Other20 participantsNail Health forVitamin C
  158. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forZinc
  159. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  160. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  161. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  162. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  163. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  164. Biochemical and physiologic consequences of boron deprivation in humans.
    Nielsen FH · Environmental health perspectives · 1995
    Single-arm trial12 participantsTestosterone Support forBoron
  165. Plasma boron and the effects of boron supplementation in males.
    Green NR; Ferrando AA · Environmental health perspectives · 1995
    Randomized trial19 participantsTestosterone Support forBoron
  166. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines
    Mohammad Reza Naghii, Mahmoud Mofid, Ali Reza Asgari, Mehdi Hedayati, Maryam-Saddat Daneshpour · Journal of Trace Elements in Medicine and Biology · 2011
    Non-randomized trial8 participantsTestosterone Support forBoron
  167. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  168. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  169. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  170. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  171. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium
  172. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
    Jamilian M; Foroozanfard F; Rahmani E; Talebi M; Bahmani F; Asemi Z · Nutrients · 2018
    Randomized trial90 participantsTestosterone Support forVitamin D
  173. Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial.
    Al-Bayyari N; Al-Domi H; Zayed F; Hailat R; Eaton A · Clinical nutrition (Edinburgh, Scotland) · 2021
    Randomized trial60 participantsTestosterone Support forVitamin D
  174. Association between plasma 25-OH vitamin D and testosterone levels in men.
    Nimptsch K; Platz EA; Willett WC; Giovannucci E · Clinical endocrinology · 2012
    Case-control study1,362 participantsTestosterone Support forVitamin D
  175. Causal Link Between Vitamin D and Total Testosterone in Men: A Mendelian Randomization Analysis.
    Chen C; Zhai H; Cheng J; Weng P; Chen Y; Li Q; Wang C; Xia F; Wang N; Lu Y · The Journal of clinical endocrinology and metabolism · 2020
    Other4,254 participantsTestosterone Support forVitamin D
  176. Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men.
    Rafiq R; van Schoor NM; Sohl E; Zillikens MC; Oosterwerff MM; Schaap L; Lips P; de Jongh RT · The Journal of steroid biochemistry and molecular biology · 2017
    Cohort study643 participantsTestosterone Support forVitamin D
  177. Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.
    Meeker JD; Rossano MG; Protas B; Padmanahban V; Diamond MP; Puscheck E; Daly D; Paneth N; Wirth JJ · Fertility and sterility · 2010
    Cross-sectional study219 participantsTestosterone Support forZinc
  178. Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review.
    Santos HO; Cadegiani FA; Forbes SC · Clinical therapeutics · 2022
    Scoping reviewTestosterone Support forZinc
  179. Zinc is an Essential Element for Male Fertility: A Review of Zn Roles in Men's Health, Germination, Sperm Quality, and Fertilization.
    Fallah A; Mohammad-Hasani A; Colagar AH · Journal of reproduction & infertility · 2020
    Narrative reviewTestosterone Support forZinc
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    Prasad AS · Clinics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc
  181. Clinical, endocrinologic, and biochemical effects of zinc deficiency.
    Prasad AS · Special topics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc