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B-Complex #6

Thorne
4.7
★ ★ ★ ★ ★
(4822 ratings)
Niacin 80 mg
Thiamin 40 mg
Vitamin B5 45 mg
Riboflavin 30 mg
Choline 14 mg
Vitamin B6 100 mg
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Score69
Complete coverage and methylcobalamin cannot offset the 100 mg B6 amount. The product is too aggressive for ordinary long-term B-complex use.
How scoring works
Quantity:60 Capsule(s) • (60 servings)
Goals:
Energy
Metabolism Boost

Score 69

Complete coverage and methylcobalamin cannot offset the 100 mg B6 amount. The product is too aggressive for ordinary long-term B-complex use.
How scoring works
$26.00($0.43 per serving)
iHerb
$ 26.00
Amazon
$ 26.00
Vitacost
$ 26.00
Pure Formulas
$ 26.00
Vitacost
$ 26.00
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Analysis

Thiamine, riboflavin, niacinamide, B6, folate, methylcobalamin, biotin, pantothenic acid, and choline form a complete B complex. Methylcobalamin is the clearest form-quality advantage.

The B6 form and folate form are not stated, while choline citrate contributes only 14 mg. Most of the practical value therefore comes from the core vitamins rather than the small choline addition.

Vitamin B6 reaches 100 mg in one capsule, an amount that can cause nerve injury when used repeatedly. A lower-B6 formula is far more suitable for daily energy or metabolism support.

Who is it for
  • Adults with a professionally defined need for high-dose B6
  • Short-term users who require a complete B complex
  • People able to avoid all other B6 sources
Best for
  • Supervised high-potency supplementation
  • Short-duration B-vitamin repletion
  • Methylcobalamin within a complete complex

Pros

  • Uses methylcobalamin
  • Provides all core B vitamins
  • Uses niacinamide
  • Requires one capsule per serving

Cons

  • Contains 100 mg of vitamin B6
  • Does not disclose the B6 form
  • Does not disclose the folate form
  • Choline is only 14 mg

Warnings

  • The 100 mg vitamin B6 amount may cause tingling, numbness, balance problems, or other nerve symptoms with repeated use.
  • Do not combine it with other B6 supplements unless total intake is clinically managed.
  • The 80 mg niacinamide amount may cause nausea or stomach upset in sensitive users.

Nutrient quality

62 Moderate impact

Methylcobalamin and choline citrate are useful, while several vitamin forms are not identified. The very high vitamin B6 amount creates a substantial neuropathy concern with long-term use.

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Ingredient transparency

84 Highest impact

Specific amounts are supplied for every listed active ingredient. No proprietary blend hides the listed doses.

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Customer satisfaction

71 High impact

The supplied aggregate rating is very strong. No complaint themes or purpose-specific experience details are supplied.

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Value for money

53 Moderate impact

Quality or dose limitations weaken the premium position. The compact formula contains few obvious low-value additions.

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Goals

Energy
Impact
Highest effect
B+ Goal FitB+ Strength of SupportC CoverageA+ Formula Quality
Vitamin B5 · 45 mgRiboflavin · 30 mgThiamin · 40 mgVitamin B12 · 100 mcg

A focused active B-complex supports metabolic energy but not acute alertness. Methylcobalamin is useful yet remains below the focused B12 target.

Active folate and coenzyme B-vitamin forms strengthen quality and disclosure. The single-capsule formula is streamlined, though it covers only one energy pathway.

Study evidence
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Metabolism Boost
Impact
Moderate effect
D+ Goal FitC- Strength of SupportD+ CoverageB Formula Quality
Biotin · 80 mcgNiacin · 80 mgVitamin B12 · 100 mcgRiboflavin · 30 mgThiamin · 40 mgVitamin B5 · 45 mgVitamin B6 · 100 mg

High-dose B vitamins support the reactions that convert food into cellular energy, but they do not directly increase energy expenditure in well-nourished users. The formula lacks chromium, magnesium, thyroid cofactors, carnitine, caffeine, and other focused metabolic actives.

Methylcobalamin is favorable, while several other B-vitamin forms are basic or incompletely specified. The 100 mg vitamin B6 amount may raise nerve-symptom risk with prolonged daily use.

Study evidence
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Hydrochloride)
40 mg
Riboflavin
30 mg
Niacin (Niacinamide)
80 mg
Vitamin B6
100 mg
Folate
334 mcg DFE
Vitamin B12 (Methylcobalamin)
100 mcg
Biotin
80 mcg
Pantothenic Acid (Calcium Pantothenate)
45 mg
Choline (Choline Citrate)
14 mg
Gluten Free Adults 18–50
Report overview
Niacin (Niacinamide) · 80 mg OverallScore70
B+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value

Niacinamide is clearly identified and fits a general B-complex, though the 80 mg amount sits just below the preferred range for stand-alone niacinamide use. The capsule uses no special release technology, but the disclosed non-flushing form lowers concern about a typical niacin flush. Its serving cost is high for a standard niacin ingredient.

B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value

Thiamine hydrochloride is a standard, clearly disclosed form at a moderate 40 mg dose. The capsule format has no stated liposomal or other enhanced delivery system. Cost per active amount is high for the thiamin delivered.

A- Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyF Value

Calcium pantothenate provides a stable, well-absorbed B5 form with clear source disclosure. The 45 mg serving supports basic intake but falls just below the collection median and lacks stronger therapeutic potency. Cost efficiency is poor when calculated against the amount of active B5 delivered.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  2. Double-blind trial of pyridoxine (vitamin B6) in the treatment of steroid-dependent asthma.
    Sur S; Camara M; Buchmeier A; Morgan S; Nelson HS · Annals of allergy · 1993
    Randomized trial31 participantsMetabolism Boost forVitamin B6
  3. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  4. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  5. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  6. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  7. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  8. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  9. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  10. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  11. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  12. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  13. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  14. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  15. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  16. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  17. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  18. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6