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ADK Vitamins

4.8
★ ★ ★ ★ ★
(2448 ratings)
Vitamin K 1000 mcg
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Score74
Best suited to adults using a professionally directed high-potency fat-soluble vitamin plan; the combined vitamin K exposure is extremely high and vitamin D is concentrated, making the formula poorly balanced for unsupervised general use.
How scoring works
Capsule
Quantity:180 Capsule(s) • (180 servings)
Goals:
Bone Health
Anti-Aging
General Health
Cardiovascular Support

Score 74

Best suited to adults using a professionally directed high-potency fat-soluble vitamin plan; the combined vitamin K exposure is extremely high and vitamin D is concentrated, making the formula poorly balanced for unsupervised general use.
How scoring works
$34.99($0.19 per serving)
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Analysis

Vitamins A, D3, K1, MK-4, and MK-7 provide unusually broad fat-soluble nutrient coverage with full amount disclosure. The label provides enough detail to judge the central vitamin strategy.

The combined vitamin K exposure is extremely high and vitamin D is concentrated, making the formula poorly balanced for unsupervised general use. Format, dose, and companion nutrients determine whether it is appropriate for daily use.

The best fit is adults using a professionally directed high-potency fat-soluble vitamin plan. Vitamin K and vitamin D support normal physiology, but the practical benefit depends on baseline intake and individual need.

Who is it for
  • Adults using a professionally directed high-potency fat-soluble vitamin plan
  • Adults whose current vitamin intake matches the listed potency
  • Users able to account for vitamin K medication interactions
Best for
  • Includes both K1 and two K2 forms
  • Provides preformed vitamin A and D3
  • Users who accept that extremely high total vitamin k

Pros

  • Includes both K1 and two K2 forms
  • Provides preformed vitamin A and D3
  • Clearly discloses each amount
  • Long bottle supply

Cons

  • Extremely high total vitamin K
  • Vitamin D reaches the usual adult upper limit
  • Dry capsule lacks a stated fat carrier
  • Overbuilt for routine maintenance

Warnings

  • The very high combined K1, MK-4, and MK-7 exposure can strongly counteract warfarin and related vitamin K antagonist anticoagulants.
  • The 125 mcg vitamin D3 serving reaches the usual adult daily upper limit and should not be stacked casually.
  • Preformed vitamin A from retinyl palmitate should be counted with other vitamin A sources, particularly during pregnancy.

Nutrient quality

60 Moderate impact

The label specifies D3, K1, MK-4, and MK-7, but the dry capsule has no stated lipid carrier, and the formula supplies unusually large K1, MK-4, and MK-7 amounts alongside concentrated vitamin D3. The unusually large combined vitamin K amounts are unnecessarily aggressive for general use, while vitamins A, D, and K share related roles, but the extreme amounts weaken general-use suitability.

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Ingredient transparency

84 Highest impact

Every listed active ingredient has a specific amount, and no proprietary blend hides the dose of a listed active ingredient. Serving count is supplied, but complete daily-use directions are not provided, while inactive ingredients and excipients are not included in the supplied label details.

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Customer satisfaction

75 High impact

The supplied average rating is strong, and substantial review volume gives the average rating useful credibility. Specific review themes are unavailable, so repeated negatives and real-world fit remain uncertain.

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Value for money

75 High impact

Uneven dosing and incomplete details weaken the value of the broader formula, and the low serving cost provides strong practical value. The focused active profile is not inflated by low-value additions, while the product is reasonably competitive but lacks a clear quality or value advantage.

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Report analysis

Goals

Bone Health
Impact
Highest effect
A+ Goal FitA- Strength of SupportA CoverageA+ Formula Quality
Vitamin K · 1800 mcgVitamin D · 125 mcg

The formula directly targets mineral structure, absorption, and remodeling with multiple bone-specific actives. Hydroxyapatite calcium, vitamin D, vitamin K, magnesium, and boron have strong complementary skeletal rationale.

The formula provides useful amounts across calcium, magnesium, vitamin D, K2, boron, and phosphorus. The formula covers mineral structure, absorption, remodeling, and trace-mineral support.

Study evidence
Vitamin D Supportive 202 studies
Vitamin K Supportive 78 studies
Anti-Aging
Impact
Highest effect
B+ Goal FitB Strength of SupportB CoverageA Formula Quality
Vitamin K · 1800 mcgVitamin D · 125 mcg

Vitamin D3 with K1, MK-4, and MK-7 broadly supports bone, immune, and arterial resilience. The combination addresses several age-related foundations but does not target mitochondrial energy or tissue glycation.

All vitamin forms are disclosed, although the vitamin K amounts are unusually high and provide more exposure than typical daily formulas. The high vitamin K content can strongly oppose warfarin and other vitamin K antagonist anticoagulants, while the high vitamin D3 amount can raise calcium levels.

Study evidence
Vitamin K Supportive 27 studies
General Health
Impact
High effect
A Goal FitC Strength of SupportC+ CoverageA- Formula Quality
Vitamin D · 125 mcgVitamin K · 1800 mcg

Vitamins A, D3, K1, MK-4, and MK-7 form a complementary fat-soluble vitamin combination for bone, immune, and calcium metabolism support. Every vitamin subtype and amount is clearly stated.

The MK-7 amount is far above common general-use ranges, and the vitamin D3 amount is also concentrated. The unusually high vitamin K content can strongly oppose warfarin and similar vitamin K antagonist medicines, so users need prescriber oversight.

Study evidence
Vitamin K Supportive 34 studies
Cardiovascular Support
Impact
High effect
B Goal FitC+ Strength of SupportC- CoverageB- Formula Quality
Vitamin K · 1800 mcgVitamin D · 125 mcg

Vitamin K2 and vitamin D support calcium handling that may influence arterial health. The unusually high vitamin amounts are not a substitute for established cardiovascular risk management.

The K1, MK-4, MK-7, vitamin D3, and vitamin A forms are listed, but duplicate K2 entries make total interpretation less clear. Vitamin K can reduce warfarin’s effect, while the high vitamin D amount warrants attention to total intake and calcium status.

Study evidence
Vitamin D Mixed 170 studies
Vitamin K Supportive 40 studies
Heart Health
Impact
Moderate effect
B- Goal FitC+ Strength of SupportD CoverageC+ Formula Quality
Vitamin K · 1800 mcgVitamin D · 125 mcg

Vitamin D3 and vitamin K2 provide a coherent calcium-management pathway with possible arterial relevance. Vitamin A and high vitamin K1 add little direct cardiovascular advantage beyond the core D3 and K2 pairing.

Both MK-4 and MK-7 are named, but the unusually high repeated K2 amounts make the label difficult to interpret and the vitamin D3 amount reaches the usual adult upper intake limit. Vitamin K can counteract warfarin, while excessive vitamin D over time may raise calcium and cause kidney or heart-rhythm problems.

Study evidence
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies

Ingredients

IngredientAmount per serving
Vitamin A (Retinyl Palmitate)
900 mcg
Vitamin D3 (Cholecalciferol)
125 mcg
Vitamin K1 (Phylloquinone)
1000 mcg
Vitamin K2 (Menaquinone-4, Menaquinone-7)
1800 mcg
Adults 18–50
Report overview
C+ Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyA+ Value

The formula supplies MK-7 in a far higher amount than the preferred general-use range, alongside substantial MK-4 and vitamin K1. Clear subtype disclosure and a low serving cost are useful, but the dry capsule lacks stated fat-containing meal guidance and the MK-7 source is not branded. The unusually high combined vitamin K content can strongly oppose warfarin and similar vitamin K antagonist anticoagulants, so users of those medicines need prescriber oversight.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  2. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  3. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  4. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  5. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  6. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  7. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  8. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  9. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  10. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  11. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  12. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  13. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  14. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  15. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  16. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forVitamin D
  17. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
    Kumar V; Yadav AK; Lal A; Kumar V; Singhal M; Billot L; Gupta KL; Banerjee D; Jha V · Journal of the American Society of Nephrology : JASN · 2017
    Randomized trial120 participantsCardiovascular Support forVitamin D
  18. Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
    Porto C; Petribu K; Barbosa N; Magalhães R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; Magalhães J; Sougey E; Silva T; Junio A; Bandeira F; Leão R · American heart journal plus : cardiology research and practice · 2025
    Randomized trial224 participantsCardiovascular Support forVitamin D
  19. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
    Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y · PloS one · 2017
    Randomized trial70 participantsCardiovascular Support forVitamin D
  20. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsCardiovascular Support Heart Health forVitamin D
  21. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  22. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  23. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  24. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  25. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  26. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  27. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  28. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  29. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  30. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  31. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  32. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  33. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K