Product Image

Women's 55+ Multivitamin

Innate Response Formulas
4.7
★ ★ ★ ★ ★
(202 ratings)
Choline 200 mg
Biotin 300 mcg
Molybdenum 60 mcg
Chromium 120 mcg
Green Tea 250 mg
Product Image
Score74
Active B vitamins, D3, choline, and green tea are useful, but the listed copper amount is implausibly low beside zinc. Clarifying that mineral balance is important before long-term use.
How scoring works
Quantity:120 Tablet(s) • (60 servings)
Goals:
Detoxification
Cognitive Support
Anti-Aging

Score 74

Active B vitamins, D3, choline, and green tea are useful, but the listed copper amount is implausibly low beside zinc. Clarifying that mineral balance is important before long-term use.
How scoring works
$44.99($0.74 per serving)
Pure Formulas
$ 74.99
Vitacost
$ 74.99
iHerb
$ 44.99
Report prices

Analysis

The two-tablet formula uses L-5-MTHF, methylcobalamin, P-5-P, active riboflavin, vitamin D3, and natural vitamin E. Two hundred milligrams of choline and 250 mg green-tea extract add meaningful non-vitamin support.

The listed copper amount is only 0.20 mcg beside 15 mg zinc, an extreme imbalance if accurate. Calcium and magnesium are not meaningfully included, and several mineral sources are described broadly through yeast.

The product may suit older women seeking an iron-free, active-form multi, but the copper listing needs clarification before long-term use. Its premium position is harder to justify while that basic mineral question remains unresolved.

Who is it for
  • Women over fifty seeking active vitamin forms
  • Adults who do not need supplemental iron
  • Users willing to clarify the copper label
Best for
  • Active folate and B12 coverage
  • Iron-free daily nutrition
  • Choline and green-tea supplementation

Pros

  • Uses active folate, B12, B6, and riboflavin
  • Provides vitamin D3 and natural vitamin E
  • Includes 200 mg choline
  • Adds 250 mg green-tea extract

Cons

  • Listed copper is extremely low beside zinc
  • Does not cover calcium or magnesium
  • Requires two tablets
  • Premium value is weakened by label uncertainty

Warnings

  • Do not use long term until the listed copper amount is clarified, because 15 mg zinc with virtually no copper could impair mineral balance.
  • Green-tea extract may not suit caffeine-sensitive users if residual caffeine is present but undisclosed.
  • Chromium may add to the effect of glucose-lowering medicines and requires monitored use in treated diabetes.

Nutrient quality

84 Highest impact

Active vitamin forms, chelated minerals, and meaningful choline create a strong foundation. Duplicate form entries and selective mineral coverage modestly limit balance.

.

Ingredient transparency

69 High impact

Most ingredients have clear names, forms, and amounts without hidden blends. Repeated form entries and missing usage and excipient details leave some ambiguity.

.

Customer satisfaction

67 High impact

Aggregate satisfaction is strong and supported by a substantial evidence base. No firsthand experience details are supplied, so recurring complaints and purpose alignment cannot be checked.

.

Value for money

74 High impact

Useful core ingredients provide fair value despite some trade-offs. The package remains reasonably competitive.

.
Report analysis

Goals

Detoxification
Detoxification
Impact
High effect
C+ Goal FitC+ Strength of SupportB CoverageB Formula Quality
Folate · 340 mcg DFEVitamin B12 · 20 mcgVitamin B6 · 6 mgMolybdenum · 60 mcgSelenium · 50 mcgVitamin E · 15 mgZinc · 15 mgVitamin C · 100 mgCholine · 200 mgRiboflavin · 2.6 mg

The broad nutrient formula supports several processes tied to natural clearance, including methylation, antioxidant enzymes, liver fat transport, and sulfite metabolism. Its primary design remains general multivitamin support rather than focused detoxification.

Active forms of folate, vitamin B6, and vitamin B12 strengthen the formula, while choline and several antioxidant nutrients are clearly dosed. Green tea lacks catechin and caffeine disclosure, and the molybdenum form and amount are less convincing for targeted use.

Study evidence
Choline Supportive 6 studies
Folate Supportive 16 studies
Green Tea Disputed 16 studies
Molybdenum Adverse 1 study
Vitamin C Supportive 9 studies
Zinc Supportive 30 studies
Cognitive Support
Cognitive Support
Impact
High effect
B- Goal FitB- Strength of SupportC+ CoverageC- Formula Quality
Choline · 200 mgThiamin · 2 mgVitamin B6 · 6 mgFolate · 340 mcg DFEVitamin B12 · 20 mcgVitamin D · 25 mcgGreen Tea · 250 mg

Choline, green tea, active-form B vitamins, and antioxidant nutrients provide several routes to foundational cognition and calm alertness. The 200 mg choline amount is useful, while green tea marker and caffeine details are missing.

The broad multivitamin may help most when correcting nutritional gaps rather than acting as a targeted nootropic. Missing amounts for L-theanine, caffeine, and EGCG make the green tea contribution difficult to predict.

Study evidence
Choline Supportive 76 studies
Folate Supportive 68 studies
Green Tea Supportive 32 studies
Anti-Aging
Anti-Aging
Impact
High effect
B- Goal FitC Strength of SupportB- CoverageC- Formula Quality
Folate · 340 mcg DFEVitamin B12 · 20 mcgVitamin D · 25 mcgGreen Tea · 250 mg

The age-targeted multivitamin covers bone, methylation, antioxidant, and basic cognitive nutrition. Its green tea extract adds a plausible longevity pathway, but EGCG and caffeine amounts are not disclosed.

Several active vitamin forms are useful, while the large ingredient list makes the formula broad rather than potent in specialized anti-aging compounds. Undisclosed caffeine from green tea may affect sleep or alertness in sensitive users.

Study evidence
Green Tea Supportive 9 studies
Skin Health
Skin Health
Impact
Moderate effect
C- Goal FitB- Strength of SupportC+ CoverageD+ Formula Quality
Zinc · 15 mgVitamin C · 100 mgCopper · 0.2 mcgSelenium · 50 mcgGreen Tea · 250 mgVitamin E · 15 mg

Vitamin C, vitamin E, zinc, biotin, and beta-carotene provide foundational skin nutrients, while green tea may add antioxidant support. The formula is a broad age-targeted multivitamin rather than a dedicated product for skin hydration, structure, or photo-protection.

Several preferred nutrient forms are disclosed, but green tea lacks EGCG, polyphenol, and caffeine details. Broad vitamin coverage is useful for dietary gaps but creates substantial non-skin padding.

Study evidence
Biotin Supportive 10 studies
Green Tea Supportive 37 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 38 studies
Zinc Supportive 66 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Moderate effect
C- Goal FitF Strength of SupportC CoverageC- Formula Quality
Vitamin D · 25 mcgVitamin E · 15 mgVitamin C · 100 mgGreen Tea · 250 mg

Green tea, vitamin C, vitamin E, zinc, and selenium offer broad antioxidant and metabolic support relevant to inflammatory balance. Active B-vitamin forms improve the general nutrient quality.

The green tea extract has no EGCG standardization or caffeine disclosure, so its main anti-inflammatory active cannot be quantified. The extensive multivitamin design creates breadth but little targeted depth for inflammation support.

Study evidence
Green Tea Mixed 16 studies
Selenium Supportive 34 studies
Vitamin C Supportive 50 studies
Vitamin E Supportive 20 studies
Zinc Supportive 64 studies

Ingredients

IngredientAmount per serving
Vitamin A (Beta Carotene)
 360 mcg RAE
Vitamin C (organic Orange)
 100 mg
Vitamin D3 (S. cerevisiae)
 25 mcg
Vitamin E (D-Alpha-Tocopherol)
 15 mg
Thiamin (Thiamine HCl)
 2 mg
Riboflavin (Riboflavin 5'-Phosphate Sodium)
 2.6 mg
Niacin (Niacinamide, S. cerevisiae)
 20 mg NE
Vitamin B6 (Pyridoxal 5-Phosphate)
 6 mg
Folate (L-5-MTHF)
 340 mcg DFE
Vitamin B12 (Methylcobalamin)
 20 mcg
Biotin (Brown Rice)
 300 mcg
Pantothenic Acid (Calcium D-Pantothenate)
 8 mg
Choline (Choline Bitartrate)
 200 mg
Iodine (S. cerevisiae)
 50 mcg
Zinc (Rice Amino Acid Chelate)
 15 mg
Selenium (S. cerevisiae)
 50 mcg
Copper (S. cerevisiae)
 0.2 mcg
Manganese (S. cerevisiae)
 1 mg
Chromium (S. cerevisiae)
 120 mcg
Molybdenum (S. cerevisiae)
 60 mcg
Green Tea leaf extract
250 mg
Gluten Free Kosher Dairy Free Women 50+ Vegetarian
Report overview
Choline (Choline Bitartrate) · 200 mg OverallScore65
B Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

Choline bitartrate provides a practical systemic form, but it is less targeted to cognitive support than Alpha-GPC or CDP-choline. The label gives a moderate elemental choline dose in a two-tablet serving and clearly identifies its source. Cost efficiency is weak for the amount delivered, especially without a premium choline form.

View ingredientView products
Biotin (Brown Rice) · 300 mcg OverallScore56
B- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyC Value

A women’s multivitamin supplies Biotin from brown rice alongside age-focused nutrients. The clearly disclosed 300 mcg amount is nutritional rather than a high-potency hair or nail dose. The source is named, but the biologically active isomer is not confirmed.

View ingredientView products
Molybdenum (S. cerevisiae) · 60 mcg OverallScore34
F Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyD- Value

The yeast-based label does not name a recognized molybdenum compound or verified branded source, leaving absorption quality uncertain. The amount falls below the collection's target range, though it remains comfortably within the adult upper limit. The broad multivitamin formula adds useful cofactors, but its relatively high cost and weak molybdenum disclosure limit its fit for focused supplementation.

View ingredientView products
Loading alternative details
75 Performance

Multi for Women 55+

MegaFood
<p>A women-focused profile keeps active B vitamins, methylfolate, methylcobalamin, choline, zinc, chromium, molybdenum, and green tea while using clearly named chelates for several minerals. Duplicate form entries still create ambiguity, and calcium plus magnesium remain absent.</p>
76 Performance

Men's 40+ Multivitamin

INNATE Response Formulas
<p>Active B vitamins, methylfolate, methylcobalamin, vitamin D3, vitamin K2, choline, and broad trace nutrients improve form specificity and add vitamin K coverage. The men-oriented formula omits green tea, calcium, and magnesium, so it is suitable only when sex-specific positioning is not important.</p>
62 Performance

Sugar Armor

NaturesPlus
<p>Green tea and chromium preserve two specialty collections while chicory, sea vegetables, and rhodiola add a metabolic-support direction. The formula is not a multivitamin, and missing iodine, caffeine, and active-marker disclosure limits assessment.</p>
61 Budget

Women Over 40 One Daily

MegaFood
<p>A lower serving cost keeps a women-oriented base with vitamin D3, iodine, zinc, selenium, chromium, molybdenum, and B vitamins. Choline and green tea are absent, while conventional forms, duplicate entries, and an opaque food blend reduce precision.</p>
59 Budget

Men Over 40 One Daily Iron Free

INNATE Response Formulas
<p>Lower serving cost retains a broad iron-free vitamin-and-mineral base with iodine, zinc, chromium, and molybdenum. The men-oriented profile omits choline and green tea, and its conventional forms plus opaque blend make it a poor fit unless sex-specific positioning is unimportant.</p>
71 Budget

Kid Vits Berry Blast

NOW
<p>Very low serving cost provides biotin, chromium, molybdenum, vitamins, and several minerals. The child-oriented profile is not a direct substitute for an older woman’s multi, and low choline plus conventional forms require careful age-specific review.</p>
76 Value

Multi for Women 55+

MegaFood
<p>A closely aligned women’s formula retains methylfolate, methylcobalamin, active vitamin B6, choline, chelated minerals, and green tea with better serving value. Repeated nutrient-form entries still create ambiguity, and calcium plus magnesium are absent.</p>
78 Value

Cinnamon Chromium & Biotin

Natrol
<p>Biotin and chromium deliver inexpensive, clearly disclosed coverage of two shared collections, with cinnamon extract adding a focused metabolic active. The narrow formula does not replace broad daily nutrition, and concentrated biotin can interfere with some laboratory tests.</p>
64 Value

Everyday Multivitamin without A & D

Kirkman
<p>A long supply adds citrate or bisglycinate calcium and magnesium alongside active vitamin B6 and riboflavin phosphate at favorable serving value. Vitamins A and D, chromium, molybdenum, and green tea are absent, while choline is only lightly dosed.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Green tea and coffee intake and risk of cognitive decline in older adults: the National Institute for Longevity Sciences, Longitudinal Study of Aging.
    Shirai Y; Kuriki K; Otsuka R; Kato Y; Nishita Y; Tange C; Tomida M; Imai T; Ando F; Shimokata H · Public health nutrition · 2021
    Cohort study1,305 participantsAnti-Aging forGreen Tea
  2. Associations of green tea, coffee, and soft drink consumption with longitudinal changes in leukocyte telomere length.
    Sohn I; Shin C; Baik I · Scientific reports · 2023
    Cohort study1,952 participantsAnti-Aging forGreen Tea
  3. Can teatime increase one's lifetime?
    Nakachi K; Eguchi H; Imai K · Ageing research reviews · 2003
    Cohort studyAnti-Aging forGreen Tea
  4. Influences of tea consumption on self-rated health and life satisfaction among older adults: Evidence from the CLHLS.
    Zou M; Sun C; Yang M; Li C; Wang S; Zheng D; Wang J; Yu L; Sun L; Wang Y; Chen H; Zeng Y · PsyCh journal · 2025
    Cohort study78,345 participantsAnti-Aging forGreen Tea
  5. Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin.
    Chiu AE; Chan JL; Kern DG; Kohler S; Rehmus WE; Kimball AB · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
    Randomized trial40 participantsAnti-Aging forGreen Tea
  6. The effects of green tea on acne vulgaris: A systematic review and meta-analysis of randomized clinical trials.
    Kim S; Park TH; Kim WI; Park S; Kim JH; Cho MK · Phytotherapy research : PTR · 2021
    Meta-analysis247 participants5 studies pooledAnti-Inflammatory Support forGreen Tea
  7. Green Tea Catechin Association with Ultraviolet Radiation-Induced Erythema: A Systematic Review and Meta-Analysis.
    Kapoor MP; Sugita M; Fukuzawa Y; Timm D; Ozeki M; Okubo T · Molecules (Basel, Switzerland) · 2021
    Meta-analysis100 participants6 studies pooledAnti-Inflammatory Support Skin Health forGreen Tea
  8. Efficacy of (-)-epigallocatechin gallate delivered by a new-type scaler tip during scaling and root planing on chronic periodontitis: a split-mouth, randomized clinical trial.
    Wang Y; Zeng J; Yuan Q; Luan Q · BMC oral health · 2021
    Randomized trial20 participantsAnti-Inflammatory Support forGreen Tea
  9. Camellia Sinensis Mouthwashes in Oral Care: a Systematic Review.
    Tafazoli A; Tafazoli Moghadam E · Journal of dentistry (Shiraz, Iran) · 2020
    Systematic review69 studies pooledAnti-Inflammatory Support forGreen Tea
  10. Skin photoprotection by green tea: antioxidant and immunomodulatory effects.
    Katiyar SK · Current drug targets. Immune, endocrine and metabolic disorders · 2004
    Narrative reviewAnti-Inflammatory Support forGreen Tea
  11. Selenium and the course of mild Graves' orbitopathy.
    Marcocci C; Kahaly GJ; Krassas GE; Bartalena L; Prummel M; Stahl M; Altea MA; Nardi M; Pitz S; Boboridis K; Sivelli P; von Arx G; Mourits MP; Baldeschi L; Bencivelli W; Wiersinga W; European Group on Graves' Orbitopathy · The New England journal of medicine · 2011
    Randomized trial159 participantsAnti-Inflammatory Support forSelenium
  12. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial.
    Asemi Z; Jamilian M; Mesdaghinia E; Esmaillzadeh A · Nutrition (Burbank, Los Angeles County, Calif.) · 2016
    Randomized trial70 participantsAnti-Inflammatory Support forSelenium
  13. Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease.
    Farrokhian A; Bahmani F; Taghizadeh M; Mirhashemi SM; Aarabi MH; Raygan F; Aghadavod E; Asemi Z · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2017
    Randomized trial60 participantsAnti-Inflammatory Support forSelenium
  14. The effects of selenium supplementation on cardiovascular risk factors in patients with metabolic diseases ‒ A systematic review and meta-analysis of randomized controlled trials.
    Qiu W; Huang N; Zhang K; Qiu H; Guo Z; Han F; Sun X; Hou N; Kan C · Nutricion hospitalaria · 2026
    Meta-analysis656 participants11 studies pooledAnti-Inflammatory Support forSelenium
  15. Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Kamali A; Amirani E; Asemi Z · Biological trace element research · 2020
    Randomized trial33 participantsAnti-Inflammatory Support forSelenium
  16. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  17. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  18. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  19. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  20. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  21. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
    Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  22. Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
    Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
    Meta-analysis495 participants12 studies pooledAnti-Inflammatory Support forVitamin E
  23. Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
    Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
    Meta-analysis46 studies pooledAnti-Inflammatory Support forVitamin E
  24. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
    Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
    Meta-analysis8 studies pooledAnti-Inflammatory Support forVitamin E
  25. Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
    Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
    Randomized trial71 participantsAnti-Inflammatory Support forVitamin E
  26. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent.
    Bao B; Prasad AS; Beck FW; Fitzgerald JT; Snell D; Bao GW; Singh T; Cardozo LJ · The American journal of clinical nutrition · 2010
    Randomized trial40 participantsAnti-Inflammatory Support forZinc
  27. Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
    Nazari M; Nikbaf-Shandiz M; Pashayee-Khamene F; Bagheri R; Goudarzi K; Hosseinnia NV; Dolatshahi S; Omran HS; Amirani N; Ashtary-Larky D; Asbaghi O; Ghanavati M · Biological trace element research · 2024
    Meta-analysis23 studies pooledAnti-Inflammatory Support forZinc
  28. The Effects of Zinc Supplementation on C-Reactive Protein and Inflammatory Cytokines: A Meta-Analysis and Systematical Review.
    Ceylan MN; Akdas S; Yazihan N · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Meta-analysis73 studies pooledAnti-Inflammatory Support forZinc
  29. The Effects of Zinc Sulfate Supplementation on Serum Copeptin, C-Reactive Protein and Metabolic Markers in Zinc-Deficient Diabetic Patients on Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Hosseini R; Montazerifar F; Shahraki E; Karajibani M; Mokhtari AM; Dashipour AR; Ferns GA; Jalali M · Biological trace element research · 2021
    Randomized trial46 participantsAnti-Inflammatory Support forZinc
  30. Zinc supplementation and cardiovascular disease risk factors: A GRADE-assessed systematic review and dose-response meta-analysis.
    Nazari M; Ashtary-Larky D; Nikbaf-Shandiz M; Goudarzi K; Bagheri R; Dolatshahi S; Omran HS; Amirani N; Ghanavati M; Asbaghi O · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023
    Meta-analysis75 studies pooledAnti-Inflammatory Support forZinc
  31. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
    De Jesus Moreno Moreno M · Clinical therapeutics · 2003
    Randomized trial261 participantsCognitive Support forCholine
  32. Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study.
    Niu YY; Yan HY; Zhong JF; Diao ZQ; Li J; Li CP; Chen LH; Huang WQ; Xu M; Xu ZT; Liang XF; Li ZH; Liu D · The American journal of clinical nutrition · 2025
    Cohort study125,594 participantsCognitive Support forCholine
  33. Choline intake during pregnancy and child cognition at age 7 years.
    Boeke CE; Gillman MW; Hughes MD; Rifas-Shiman SL; Villamor E; Oken E · American journal of epidemiology · 2013
    Cohort study895 participantsCognitive Support forCholine
  34. Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
    Sohn M; Park YH; Lim S · Diabetes, obesity & metabolism · 2025
    Randomized trial36 participantsCognitive Support forCholine
  35. Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
    Warton FL; Molteno CD; Warton CMR; Wintermark P; Lindinger NM; Dodge NC; Zöllei L; van der Kouwe AJW; Carter RC; Jacobson JL; Jacobson SW; Meintjes EM · Alcoholism, clinical and experimental research · 2022
    Randomized trial52 participantsCognitive Support forCholine
  36. Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China.
    Ma F; Wu T; Zhao J; Han F; Marseglia A; Liu H; Huang G · The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Randomized trial180 participantsCognitive Support forFolate
  37. Serum folate and B12 levels in association with cognitive impairment among seniors: results from the VELESTINO study in Greece and meta-analysis.
    Michelakos T; Kousoulis AA; Katsiardanis K; Dessypris N; Anastasiou A; Katsiardani KP; Kanavidis P; Stefanadis C; Papadopoulos FC; Petridou ET · Journal of aging and health · 2013
    Meta-analysis8,122 participants9 studies pooledCognitive Support forFolate
  38. B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis.
    Wang Z; Zhu W; Xing Y; Jia J; Tang Y · Nutrition reviews · 2022
    Meta-analysis46,175 participants95 studies pooledCognitive Support forFolate
  39. Homocysteine and folate as risk factors for dementia and Alzheimer disease.
    Ravaglia G; Forti P; Maioli F; Martelli M; Servadei L; Brunetti N; Porcellini E; Licastro F · The American journal of clinical nutrition · 2005
    Cohort study816 participantsCognitive Support forFolate
  40. Folate mediates cognitive impairment of aged people with periodontitis.
    Liu F; Liu Y; Feng Y; Zhao J; Wang M; Ye M; Zhang Y; Gan X; Pan Q; Shen J · Nutritional neuroscience · 2025
    Cross-sectional study1,966 participantsCognitive Support forFolate
  41. Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial.
    de la Torre R; de Sola S; Hernandez G; Farré M; Pujol J; Rodriguez J; Espadaler JM; Langohr K; Cuenca-Royo A; Principe A; Xicota L; Janel N; Catuara-Solarz S; Sanchez-Benavides G; Bléhaut H; Dueñas-Espín I; Del Hoyo L; Benejam B; Blanco-Hinojo L; Videla S; Fitó M; Delabar JM; Dierssen M; TESDAD study group · The Lancet. Neurology · 2017
    Randomized trial87 participantsCognitive Support forGreen Tea
  42. Association between tea consumption and risk of cognitive disorders: A dose-response meta-analysis of observational studies.
    Liu X; Du X; Han G; Gao W · Oncotarget · 2018
    Meta-analysis48,435 participants17 studies pooledCognitive Support forGreen Tea
  43. Investigating the Impact of Tea Consumption on Cognitive Function and Exploring Tea-Genetic Interactions in Older Adults Aged 65-105 Years: Findings from the 2002-2018 CLHLS Data.
    Yu L; Yang M; Ye KX; Li C; Zou M; Wang J; Yuan X; Zheng D; Sun C; Zhang Y; Feng Q; Maier AB; Sun L; Feng L; Wang Y; Chen H; Zeng Y · The journal of prevention of Alzheimer's disease · 2024
    Cohort study76,270 participantsCognitive Support forGreen Tea
  44. Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline.
    Noguchi-Shinohara M; Yuki S; Dohmoto C; Ikeda Y; Samuraki M; Iwasa K; Yokogawa M; Asai K; Komai K; Nakamura H; Yamada M · PloS one · 2014
    Cohort study490 participantsCognitive Support forGreen Tea
  45. Green Tea Consumption and the Risk of Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study.
    Tomata Y; Sugiyama K; Kaiho Y; Honkura K; Watanabe T; Zhang S; Sugawara Y; Tsuji I · The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018
    Cohort study13,645 participantsCognitive Support forGreen Tea
  46. Choline and contribution to normal liver function of the foetus and exclusively breastfed infants: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Nutrition, Novel Foods and Food allergens (NDA); Turck D; Bohn T; Castenmiller J; De Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Naska A; Pentieva K; Thies F; Tsabouri S; Vinceti M; Bresson JL; Fiolet T; Siani A · EFSA journal. European Food Safety Authority · 2024
    Guideline / consensusDetoxification forCholine
  47. Adiposity May Moderate the Link Between Choline Intake and Non-alcoholic Fatty Liver Disease.
    Mazidi M; Katsiki N; Mikhailidis DP; Banach M · Journal of the American College of Nutrition · 2020
    Cross-sectional study20,643 participantsDetoxification forCholine
  48. Choline and Choline-Related Metabolites in Pediatric Short Bowel Syndrome.
    Hilberath J; Shunova A; Heister L; Poets CF; Bernhard W · Nutrients · 2026
    Observational study80 participantsDetoxification forCholine
  49. Choline Supplementation in Cystic Fibrosis-The Metabolic and Clinical Impact.
    Bernhard W; Lange R; Graepler-Mainka U; Engel C; Machann J; Hund V; Shunova A; Hector A; Riethmüller J · Nutrients · 2019
    Single-arm trial10 participantsDetoxification forCholine
  50. 1H MR Spectroscopy at 3T for Hepatic Choline Quantification in Healthy Young Women: A Translational Imaging Study with Dietary Correlation.
    Hawesa H; Alghamdi R; Allam H; Alfaifi B; Alrabiah N; Alghumaiz M; Shanawani M; Alshegri H; Hassan MG · Current medical imaging · 2026
    Cohort study88 participantsDetoxification forCholine
  51. Comparison of efficacy of folic acid and silymarin in the management of antiepileptic drug induced liver injury: a randomized clinical trial.
    Asgarshirazi M; Shariat M; Sheikh M · Hepatobiliary & pancreatic diseases international : HBPD INT · 2018
    Randomized trial55 participantsDetoxification forFolate
  52. Homocysteine, folate, and nonalcoholic fatty liver disease: a systematic review with meta-analysis and Mendelian randomization investigation.
    Yuan S; Chen J; Dan L; Xie Y; Sun Y; Li X; Larsson SC · The American journal of clinical nutrition · 2022
    Meta-analysis30,368 participants22 studies pooledDetoxification forFolate
  53. Serum folate levels and urinary arsenic methylation profiles in the US population: NHANES, 2003-2012.
    Zhang X; Xu X; Zhong Y; Power MC; Taylor BD; Carrillo G · Journal of exposure science & environmental epidemiology · 2020
    Cross-sectional study11,016 participantsDetoxification forFolate
  54. Association between serum folate levels and blood concentrations of cadmium and lead in US adults.
    Wu Z; Hu H; Wang C; Wu J; Xiong Y; Fu Y; Cheng X; Su H; Li P · Environmental science and pollution research international · 2022
    Cross-sectional study15,501 participantsDetoxification forFolate
  55. Effects of Folic Acid Supplementation on Liver Enzymes, Lipid Profile, and Insulin Resistance in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial.
    Molaqanbari MR; Zarringol S; Talari HR; Taghizadeh M; Bahmani F; Mohtashamian A; Ebrahimzadeh A; Sharifi N · Advanced biomedical research · 2023
    Randomized trial66 participantsDetoxification forFolate
  56. Therapeutic benefits of green tea extract on various parameters in non-alcoholic fatty liver disease patients.
    Hussain M; Habib-Ur-Rehman; Akhtar L · Pakistan journal of medical sciences · 2024
    Randomized trial80 participantsDetoxification forGreen Tea
  57. The Effect of Green Tea Extract Supplementation on Liver Enzymes in Patients with Nonalcoholic Fatty Liver Disease.
    Pezeshki A; Safi S; Feizi A; Askari G; Karami F · International journal of preventive medicine · 2016
    Randomized trial80 participantsDetoxification forGreen Tea
  58. Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: a double-blind placebo-controlled study.
    Sakata R; Nakamura T; Torimura T; Ueno T; Sata M · International journal of molecular medicine · 2014
    Randomized trial17 participantsDetoxification forGreen Tea
  59. Green tea consumption is associated with decreased DNA damage among GSTM1-positive smokers regardless of their hOGG1 genotype.
    Hakim IA; Chow HH; Harris RB · The Journal of nutrition · 2008
    Randomized trialDetoxification forGreen Tea
  60. Modulation of human glutathione s-transferases by polyphenon e intervention.
    Chow HH; Hakim IA; Vining DR; Crowell JA; Tome ME; Ranger-Moore J; Cordova CA; Mikhael DM; Briehl MM; Alberts DS · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2007
    Single-arm trial42 participantsDetoxification forGreen Tea
  61. Human molybdenum exposure risk in industrial regions of China: New critical effect indicators and reference dose.
    Kuang HX; Li MY; Zeng XW; Chen D; Zhou Y; Zheng T; Xiang MD; Wu QZ; Chen XC; Dong GH; Yu YJ · Ecotoxicology and environmental safety · 2024
    Cross-sectional study2,267 participantsDetoxification forMolybdenum
  62. Vitamin C supplementation ameliorates liver function profile and antiviral treatment response in Hepatitis C patients.
    Nayila I; Javed MS; Khan MA; Hussain G; Raza Naqvi SA; Ali S; Jabeen Z; Shahnawaz S; Akram R; Iman T; Hassan Dogar MZ; Malik SA · Pakistan journal of pharmaceutical sciences · 2022
    Non-randomized trial200 participantsDetoxification forVitamin C
  63. Effect of ascorbic acid-rich diet on in vivo-induced oxidative stress.
    Alleva R; Di Donato F; Strafella E; Staffolani S; Nocchi L; Borghi B; Pignotti E; Santarelli L; Tomasetti M · The British journal of nutrition · 2012
    Non-randomized trial46 participantsDetoxification forVitamin C
  64. Dietary Vitamin C Intake Is Associated With Improved Liver Function and Glucose Metabolism in Chinese Adults.
    Luo X; Zhang W; He Z; Yang H; Gao J; Wu P; Ma ZF · Frontiers in nutrition · 2022
    Observational study8,307 participantsDetoxification forVitamin C
  65. Plasma ascorbate deficiency is associated with impaired reduction of sulfamethoxazole-nitroso in HIV infection.
    Trepanier LA; Yoder AR; Bajad S; Beckwith MD; Bellehumeur JL; Graziano FM · Journal of acquired immune deficiency syndromes (1999) · 2005
    Observational studyDetoxification forVitamin C
  66. Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso.
    Lavergne SN; Kurian JR; Bajad SU; Maki JE; Yoder AR; Guzinski MV; Graziano FM; Trepanier LA · Toxicology · 2006
    Clinical trial53 participantsDetoxification forVitamin C
  67. [Therapy of Wilson disease].
    Smolarek C; Stremmel W · Zeitschrift fur Gastroenterologie · 1999
    Narrative reviewDetoxification forZinc
  68. Efficacy of Zinc Supplement in Minimal hepatic Encephalopathy: A prospective, Randomized Controlled Study (Zinc-MHE Trial).
    Janyajirawong R; Vilaichone RK; Sethasine S · Asian Pacific journal of cancer prevention : APJCP · 2021
    Randomized trial69 participantsDetoxification forZinc
  69. Effect of zinc on liver cirrhosis with hyperammonemia: a preliminary randomized, placebo-controlled double-blind trial.
    Katayama K; Saito M; Kawaguchi T; Endo R; Sawara K; Nishiguchi S; Kato A; Kohgo H; Suzuki K; Sakaida I; Ueno Y; Habu D; Ito T; Moriwaki H; Suzuki K · Nutrition (Burbank, Los Angeles County, Calif.) · 2015
    Randomized trial18 participantsDetoxification forZinc
  70. Effects of low dose zinc supplementation on biochemical markers in non-alcoholic cirrhosis: a randomized clinical trial.
    Somi MH; Rezaeifar P; Ostad Rahimi A; Moshrefi B · Archives of Iranian medicine · 2012
    Randomized trial60 participantsDetoxification forZinc
  71. Correlation of Serum Zinc Levels with Hepatic Encephalopathy Severity in Patients with Decompensated Liver Cirrhosis: A Prospective Observational Study from Egypt.
    Semeya AA; Elgamal R; Othman AAA · Biological trace element research · 2025
    Observational study200 participantsDetoxification forZinc
  72. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsSkin Health forBiotin
  73. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters.
    Aksac SE; Bilgili SG; Yavuz GO; Yavuz IH; Aksac M; Karadag AS · International journal of dermatology · 2021
    Non-randomized trial60 participantsSkin Health forBiotin
  74. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsSkin Health forBiotin
  75. Generalized seborrhoeic dermatitis. Clinical and therapeutic data of 25 patients.
    Messaritakis J; Kattamis C; Karabula C; Matsaniotis N · Archives of disease in childhood · 1976
    Non-randomized trial25 participantsSkin Health forBiotin
  76. Holocarboxylase synthetase deficiency: novel clinical and molecular findings.
    Tammachote R; Janklat S; Tongkobpetch S; Suphapeetiporn K; Shotelersuk V · Clinical genetics · 2010
    Case series4 participantsSkin Health forBiotin
  77. Topical Polyphenon E in the treatment of external genital and perianal warts: a randomized controlled trial.
    Stockfleth E; Beti H; Orasan R; Grigorian F; Mescheder A; Tawfik H; Thielert C · The British journal of dermatology · 2008
    Randomized trial503 participantsSkin Health forGreen Tea
  78. Efficacy, safety and tolerability of green tea catechins in the treatment of external anogenital warts: a systematic review and meta-analysis.
    Tzellos TG; Sardeli C; Lallas A; Papazisis G; Chourdakis M; Kouvelas D · Journal of the European Academy of Dermatology and Venereology : JEADV · 2011
    Meta-analysis1,247 participants3 studies pooledSkin Health forGreen Tea
  79. Green tea polyphenols provide photoprotection, increase microcirculation, and modulate skin properties of women.
    Heinrich U; Moore CE; De Spirt S; Tronnier H; Stahl W · The Journal of nutrition · 2011
    Randomized trial60 participantsSkin Health forGreen Tea
  80. Efficacy of Epigallocatechin-3-Gallate in Preventing Dermatitis in Patients With Breast Cancer Receiving Postoperative Radiotherapy: A Double-Blind, Placebo-Controlled, Phase 2 Randomized Clinical Trial.
    Zhao H; Zhu W; Zhao X; Li X; Zhou Z; Zheng M; Meng X; Kong L; Zhang S; He D; Xing L; Yu J · JAMA dermatology · 2022
    Randomized trial180 participantsSkin Health forGreen Tea
  81. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  82. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  83. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  84. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  85. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  86. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
    Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
    Randomized trial45 participantsSkin Health forVitamin E
  87. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
    Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
    Meta-analysis20 studies pooledSkin Health forVitamin E
  88. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forVitamin E Skin Health forZinc
  89. Effects of tocotrienol on aging skin: A systematic review.
    Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
    Systematic reviewSkin Health forVitamin E
  90. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
    Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
    Randomized trialSkin Health forVitamin E
  91. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  92. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  93. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  94. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc