Product Image

Vitamin K2 100 mcg

4.8
★ ★ ★ ★ ★
(3429 ratings)
Vitamin K 100 mcg
Product Image
Score76
Best suited to users specifically directed to take a low MK-4 amount; the 100 mcg amount is too small for a compelling MK-4 strategy, which usually requires a different dosing approach than MK-7.
How scoring works
Capsule
Quantity:240 Capsule(s) • (240 servings)
Goals:
General Health

Score 76

Best suited to users specifically directed to take a low MK-4 amount; the 100 mcg amount is too small for a compelling MK-4 strategy, which usually requires a different dosing approach than MK-7.
How scoring works
$13.46($0.05 per serving)
Vitacost
$ 14.95
iHerb
$ 14.95
Walmart
$ 13.46
iHerb
$ 14.95
Report prices

Analysis

A simple capsule clearly provides vitamin K2 as short-acting MK-4 at very low serving cost. The label provides enough detail to judge the central vitamin strategy.

The 100 mcg amount is too small for a compelling MK-4 strategy, which usually requires a different dosing approach than MK-7. Format, dose, and companion nutrients determine whether it is appropriate for daily use.

The best fit is users specifically directed to take a low MK-4 amount. Vitamin K and vitamin D support normal physiology, but the practical benefit depends on baseline intake and individual need.

Who is it for
  • Users specifically directed to take a low MK-4 amount
  • Adults whose current vitamin intake matches the listed potency
  • Users able to account for vitamin K medication interactions
Best for
  • Clearly identifies MK-4
  • Very low serving cost
  • Users who accept that mk-4 amount is very low

Pros

  • Clearly identifies MK-4
  • Very low serving cost
  • Large 240-serving bottle
  • Simple one-ingredient design

Cons

  • MK-4 amount is very low
  • Short-acting form may require different dosing
  • Dry capsule lacks a fat carrier
  • Poor substitute for a 100 mcg MK-7 product

Warnings

  • The 100 mcg MK-4 vitamin K serving can counteract warfarin and related vitamin K antagonist anticoagulants.
  • Bile-acid sequestrants and orlistat can reduce absorption of fat-soluble vitamin K, which may make this capsule less reliable.
  • People with fat-malabsorption conditions may not absorb the listed vitamin K consistently and should use an individualized plan.

Nutrient quality

62 Moderate impact

Menatetrenone is MK-4, a shorter-acting K2 form that is less practical at this amount than MK-7, and the 100 mcg MK-4 amount is small compared with the quantities generally used for this shorter-acting form. The listed MK-4 amount is not excessive, although it may be too small for its intended role, while mK-4 fits vitamin K2 use, but the short-acting form is weakly matched to a low once-daily amount.

.

Ingredient transparency

84 Highest impact

Every listed active ingredient has a specific amount, and no proprietary blend hides the dose of a listed active ingredient. Serving count is supplied, but complete daily-use directions are not provided, while inactive ingredients and excipients are not included in the supplied label details.

.

Customer satisfaction

75 High impact

The supplied average rating is strong, and substantial review volume gives the average rating useful credibility. Specific review themes are unavailable, so repeated negatives and real-world fit remain uncertain.

.

Value for money

82 Highest impact

Dose or form limitations make the formula difficult to justify on quality alone, and the very low serving cost provides excellent practical value. The focused active profile is not inflated by low-value additions, while the product is reasonably competitive but lacks a clear quality or value advantage.

.
Report analysis

Goals

General Health
Impact
High effect
B+ Goal FitD+ Strength of SupportD- CoverageA- Formula Quality
Vitamin K · 100 mcg

Vitamin K2 is relevant to calcium metabolism, but the MK-4 form is supplied at a modest amount. Clear subtype and amount disclosure make the label easy to assess.

The dry capsule lacks a stated lipid carrier, and the amount is less compelling than doses commonly used for short-acting MK-4. Vitamin K can interfere with warfarin and other vitamin K antagonist medicines, so users of those drugs need clinician-guided consistency.

Study evidence
Vitamin K Supportive 34 studies
Anti-Aging
Impact
Moderate effect
C Goal FitF Strength of SupportF CoverageA- Formula Quality
Vitamin K · 100 mcg

Vitamin K2 as MK-4 is relevant to calcium handling and bone maintenance. Its healthy-aging value is mainly foundational for skeletal and vascular function rather than a direct cellular-longevity effect.

The 100 mcg MK-4 amount is far below amounts commonly used for this shorter-acting form. Vitamin K can counteract warfarin and other vitamin K antagonist anticoagulants, so medicine dosing requires clinician-guided consistency.

Study evidence
Vitamin K Supportive 27 studies
Heart Health
Impact
Moderate effect
C Goal FitD- Strength of SupportF CoverageB+ Formula Quality
Vitamin K · 100 mcg

Vitamin K2 is relevant to calcium regulation, but the product uses short-acting menaquinone-4 rather than the preferred MK-7 form. The 100 mcg amount is far below the milligram-level amounts commonly used for focused MK-4 supplementation.

A single clearly identified active keeps the label simple, yet it offers limited cardiovascular depth at this dose. Vitamin K2 can oppose warfarin and related vitamin K antagonist medicines, requiring clinician-guided consistency for users of those drugs.

Study evidence
Vitamin K Mixed 62 studies
Bone Health
Impact
Moderate effect
B- Goal FitF Strength of SupportF CoverageB- Formula Quality
Vitamin K · 100 mcg

Vitamin K2 can activate proteins involved in binding calcium within bone. The label identifies menatetrenone, also called MK-4, as the sole active form.

The supplied amount is far below the milligram-scale MK-4 doses commonly used in direct skeletal research. Without vitamin D, calcium, magnesium, or matrix support, the product offers a narrow and underdosed bone pathway.

Study evidence
Vitamin K Supportive 78 studies
Cardiovascular Support
Impact
Moderate effect
D Goal FitD- Strength of SupportF CoverageA- Formula Quality
Vitamin K · 100 mcg

MK-4 supports vitamin K biology but is less aligned with sustained arterial calcium management than MK-7. Cardiovascular evidence for this low MK-4 amount is limited compared with longer-lasting MK-7.

The menatetrenone amount is far below amounts typically used for MK-4-specific effects. Menatetrenone is clearly identified, but the format offers no absorption-focused lipid details.

Study evidence
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per serving
Vitamin K2 (Menatetrenone)
100 mcg
Gluten Free Adults 18–50
Report overview
F Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyF Value

The formula supplies vitamin K2 as menatetrenone, the shorter-acting MK-4 form, rather than the preferred MK-7 form. Its low serving cost is attractive, but it does not provide an effective MK-7 serving and gives no fat-focused intake guidance. Vitamin K can counteract warfarin and other vitamin K antagonist anticoagulants, so users of these medicines need clinician-guided consistency.

Loading alternative details
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  2. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  3. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  4. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  5. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  6. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  7. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  8. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  9. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  10. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  11. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  12. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  13. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  14. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  15. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  16. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  17. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  18. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  19. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  20. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K