Product Image

Immunity Sleep + Elderberry Midnight Berry

OLLY
4.2
★ ★ ★ ★ ★
(261 ratings)
Theanine 100 mg
Melatonin 3 mg
European Elder 65 mg
Product Image
Score73
Melatonin and theanine make the gummy useful for sleep, with vitamin C and zinc adding basic immune nutrition. Lightly dosed botanicals and limited value weaken the immunity side.
How scoring works
Quantity:36 Gummy(ies) • (18 servings)
Goals:
Sleep Support
Immunity
General Health
Stress Relief
Mood Support

Score 73

Melatonin and theanine make the gummy useful for sleep, with vitamin C and zinc adding basic immune nutrition. Lightly dosed botanicals and limited value weaken the immunity side.
How scoring works

Also available as

1 option
30 servings • Berry Brave European Elder 65 mg • 45 Gummy(ies) • 15 servings $13.99 ($0.93 per serving)
$12.99($0.72 per serving)
Walmart
$ 13.99
Vitacost
$ 12.99
Report prices

Analysis

Melatonin at 3 mg and L-theanine at 100 mg provide the clearest sleep-onset and relaxation support. Lemon balm is limited to 20 mg, so it is unlikely to contribute much compared with the two lead nighttime ingredients.

Vitamin C, zinc citrate, and selenium add useful immune-related nutrients. Black elderberry at 65 mg and echinacea at 20 mg lack extract ratios or active-marker standards, making their botanical strength uncertain.

The gummy format may be easy to take, but it adds carbohydrates and provides only a short supply. It fits users wanting a convenient sleep gummy with basic immune nutrients more than those seeking a focused elderberry product.

Who is it for
  • Adults seeking nighttime sleep support
  • People who want several calming pathways in one formula
  • Adults who prefer a gummy format
Best for
  • Bedtime relaxation
  • Sleep-onset support
  • Sleep support with basic immune nutrients

Pros

  • Provides 3 mg melatonin
  • Includes 100 mg L-theanine
  • Adds vitamin C, zinc, and selenium
  • Uses a convenient gummy format

Cons

  • Elderberry and echinacea are modestly dosed
  • Botanical potency is not standardized
  • Gummies add carbohydrates
  • The container provides a short supply

Warnings

  • Melatonin may cause next-day drowsiness, especially when sleep time is short.
  • Do not combine the gummies casually with alcohol, sedatives, or other melatonin products.
  • Do not drive or perform alertness-dependent tasks after taking the sleep gummy.

Nutrient quality

77 High impact

Citrate zinc and L-theanine are useful forms, but the botanical extracts lack detailed standardization; melatonin and theanine are meaningful, while lemon balm and echinacea are light additions. The doses are generally conservative, with drowsiness as the main melatonin-related concern; the formula reasonably combines sleep and basic immune support; carbohydrates and small botanical additions reduce formula efficiency.

.

Ingredient transparency

77 High impact

Every listed active has a specific amount; no proprietary blend hides key doses. Most names are clear, although elderberry species, plant part, and extract strength are not supplied; serving directions and inactive ingredients are not included in the supplied details.

.

Customer satisfaction

67 High impact

The supplied aggregate average is only moderate, and no individual feedback is available; the large rating sample improves confidence in the aggregate average, but no individual feedback is supplied. Detailed feedback is absent, so repeated complaints cannot be assessed; real-world fit with the intended purpose remains uncertain.

.

Value for money

67 High impact

The dual-purpose formula partly supports its cost, but the gummy base limits quality; active value is moderate because several supporting ingredients are lightly dosed. The gummy format and small extras add cost without much active value; the product is less economical than simple melatonin and theanine options.

.
Report analysis

Goals

Sleep Support
Sleep Support
Impact
Highest effect
A Goal FitB+ Strength of SupportB CoverageC+ Formula Quality
Melatonin · 3 mgTheanine · 100 mg

Melatonin and L-theanine provide direct circadian and relaxation support at useful amounts. Lemon balm adds modest calming support, while the remaining ingredients focus more on immunity than sleep.

The immediate-release gummy format may help sleep onset but does not provide sustained overnight delivery. Melatonin can cause next-day drowsiness in sensitive users, so driving or operating machinery should be avoided if that occurs.

Study evidence
Melatonin Supportive 181 studies
Theanine Supportive 8 studies
Immunity
Immunity
Impact
High effect
C+ Goal FitB Strength of SupportB- CoverageC+ Formula Quality
Vitamin C · 90 mgZinc · 5 mgSelenium · 15 mcgEuropean Elder · 65 mg

The gummy combines melatonin and L-theanine for sleep support with modest vitamin C, zinc, selenium, and botanical additions. Better sleep can support daily resilience, but the formula is more targeted to nighttime use than broad foundational nutrition.

Several immune-oriented extracts are present at small amounts, so depth is uneven across the long ingredient list. Melatonin can cause next-day drowsiness and may intensify the effects of sedatives or alcohol.

Study evidence
Melatonin Supportive 10 studies
Selenium Mixed 37 studies
Vitamin C Supportive 53 studies
Zinc Supportive 73 studies
General Health
General Health
Impact
High effect
C+ Goal FitB- Strength of SupportB CoverageB- Formula Quality
Selenium · 15 mcgZinc · 5 mgVitamin C · 90 mg

Vitamin C, zinc, and selenium provide basic immune and antioxidant support, while melatonin and L-theanine target sleep. The combination links nighttime rest with general resilience, though its two themes are not equally strong.

Melatonin and L-theanine are supplied at meaningful amounts, but the elderberry, echinacea, and lemon balm extracts are modest and lack standardization details. The 3 mg melatonin can cause drowsiness, so the gummies are not appropriate before driving or other alertness-dependent tasks.

Study evidence
European Elder Supportive 2 studies
Melatonin Supportive 69 studies
Selenium Supportive 70 studies
Vitamin C Supportive 56 studies
Zinc Supportive 60 studies
Stress Relief
Stress Relief
Impact
High effect
B- Goal FitB Strength of SupportC CoverageC- Formula Quality
Vitamin C · 90 mgTheanine · 100 mg

The 100 mg L-theanine amount provides the formula’s clearest stress-relief support, while melatonin mainly targets sleep timing rather than daytime stress. Immune nutrients and elderberry dilute the stress focus, and lemon balm is present only as a small companion.

All active amounts are visible, but the gummy format and generic ingredient sources offer limited form assurance. Melatonin may cause next-day drowsiness, so avoid driving or other alertness-dependent tasks if affected.

Study evidence
Melatonin Supportive 21 studies
Theanine Supportive 16 studies
Mood Support
Mood Support
Impact
High effect
C+ Goal FitB- Strength of SupportC+ CoverageC- Formula Quality

L-theanine, melatonin, and lemon balm may improve calm indirectly by supporting sleep. The immune-focused vitamins and botanicals add little direct mood value.

Theanine and melatonin are supplied at practical amounts, while lemon balm is light. Melatonin can cause next-day drowsiness and should not be combined with alcohol or other sedatives before activities requiring alertness.

Study evidence
Theanine Supportive 12 studies
Zinc Supportive 43 studies
Brain Health
Brain Health
Impact
Moderate effect
C- Goal FitB- Strength of SupportC- CoverageD+ Formula Quality

Melatonin and L-theanine may indirectly support cognition by improving sleep onset and evening calm. The formula does not directly target memory, neuroprotection, or daytime mental performance.

Immune nutrients and botanicals dominate much of the blend and add little brain-specific value. The 3 mg melatonin amount may cause next-day drowsiness in sensitive users, so driving should be avoided if alertness is affected.

Study evidence
Melatonin Supportive 29 studies
Theanine Supportive 17 studies
Cognitive Support
Cognitive Support
Impact
Moderate effect
D+ Goal FitC+ Strength of SupportD- CoverageD Formula Quality
Theanine · 100 mg

L-theanine may ease tension, while melatonin supports sleep that can indirectly affect next-day cognition. The formula is built for bedtime and immune support rather than active memory or daytime focus.

Theanine is modest, and most ingredients do not address brain membranes, learning, or sustained mental energy. Melatonin can cause next-day drowsiness and should not be combined with driving or other tasks requiring alertness after use.

Study evidence
Theanine Supportive 25 studies
Zinc Supportive 48 studies

Ingredients

IngredientAmount per serving
Calories
20 Calorie(s)
Total Carbohydrates
4 Gram(s)
Vitamin C (Ascorbic Acid)
 90 mg
Zinc (Zinc Citrate)
 5 mg
Selenium (Sodium Selenite)
 15 mcg
L-Theanine
100 mg
Melatonin
3 mg
Lemon Balm extract
20 mg
Black Elderberry extract
65 mg
Echinacea extract
20 mg
Gluten Free Adults 18–50
Report overview
Theanine · 100 mg OverallScore76
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The clearly disclosed L-theanine dose sits in an effective range for a calming sleep blend. Generic sourcing leaves purity and branded-form evidence unspecified, while the normalized L-theanine cost is high. Added melatonin may cause next-day drowsiness in sensitive users, so avoid driving if affected.

View ingredientView products
Melatonin · 3 mg OverallScore54
F Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD Value

The 3 mg melatonin dose is well aligned with sleep initiation, and L-theanine plus lemon balm broaden the nighttime formula. The immediate-release gummy serving does not provide sustained overnight delivery, and no independent purity certification is supplied. Its high per-serving cost is partly offset by the complex blend of sleep and immune-support ingredients.

View ingredientView products
European Elder · 65 mg OverallScore45
D- Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyF Value

The label discloses an elderberry extract amount, but it does not identify the species, berry part, or concentration. The dose sits in the lower functional range and is secondary to a broader sleep-focused formula. Melatonin may cause drowsiness, so the gummies fit bedtime use and should not be taken before driving.

View ingredientView products
Loading alternative details
87 Performance

Sleep Regimen 3-in-1

NOW
A fully disclosed blend of 200 mg theanine, 3 mg melatonin, and 50 mg 5-HTP is simpler and much more economical than the original. It omits valerian and GABA, while 5-HTP can interact with serotonin-raising medicines.
82 Performance

Tranquil Sleep

Natural Factors Stress-Relax
Branded Suntheanine, 3 mg melatonin, and a modest 5-HTP amount provide a more focused and clearly characterized bedtime blend than the original. Valerian and GABA are absent, and 5-HTP can interact with serotonin-raising medicines.
85 Performance

3 a.m. Melatonin Fast Dissolve Lavender Vanilla

Natrol
Fast-dissolve melatonin with a modest theanine amount provides a simple, economical sleep-onset option compared with the original. It lacks valerian, GABA, and deeper calming support, while melatonin can still cause next-day drowsiness.
73 Budget

Restful Sleep Blackberry Zen

OLLY
A substantial theanine amount and melatonin preserve the original product’s core bedtime support at a lower serving cost. The lightly dosed herbs add little depth, and the gummy format does not provide all-night maintenance.
64 Budget

Sleep + Calm Strawberry

Natrol
Theanine and melatonin provide direct sleep-onset support at a lower serving cost than the original. The melatonin amount is less conservative, and the opaque botanical blend prevents ingredient-specific safety review.
62 Budget

Triple Action Sleep

Solgar
Theanine and staged melatonin delivery provide a lower-cost sleep option than the original. The very high melatonin amount raises morning-grogginess risk, and an undisclosed herbal blend prevents full safety assessment.
82 Value

Melatonin Elderberry DropIns Natural Cherry Flavor

KAL
Low-dose melatonin and elderberry preserve both of the original product’s defining themes at a much lower serving cost. The flexible liquid format is practical, although elderberry standardization and sustained-release details are absent.
79 Value

Sleep+ Immune Health Berry

Natrol Kids
Low-dose melatonin, elderberry, vitamin C, vitamin D, and zinc maintain both sleep and immune coverage with better value than the original. Conflicting serving information and unstandardized elderberry create avoidable dosing and quality uncertainty.
80 Value

Tranquil Sleep

Natural Factors Stress-Relax
Branded Suntheanine, melatonin, and modest 5-HTP provide a concise sleep blend with a long supply and favorable value relative to the original. It lacks valerian and GABA, while 5-HTP remains unsuitable with some serotonin-raising medicines.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  2. Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
    Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Meta-analysis516 participants8 studies pooledSleep Support forMelatonin
  3. Unintended consequences: college students' melatonin usage, sleep disturbance, and depressive symptoms.
    Peltz JS; Rogge R · Sleep and biological rhythms · 2025
    Cohort study331 participantsSleep Support forMelatonin
  4. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  5. Melatonin for pre- and postoperative anxiety in adults.
    Hansen MV; Halladin NL; Rosenberg J; Gögenur I; Møller AM · The Cochrane database of systematic reviews · 2015
    Meta-analysis774 participants12 studies pooledStress Relief forMelatonin
  6. The Biological Clock Influenced by Burnout, Hormonal Dysregulation and Circadian Misalignment: A Systematic Review.
    Ungurianu A; Marina V · Clocks & sleep · 2025
    Systematic review195 participants37 studies pooledStress Relief forMelatonin
  7. No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial.
    Kücükakin B; Wilhelmsen M; Lykkesfeldt J; Reiter RJ; Rosenberg J; Gögenur I · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2010
    Randomized trial50 participantsStress Relief forMelatonin
  8. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  9. Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study.
    Furushima D; Sugiyama I; Nomura Y; Unno K; Yamada H · Journal of nutritional science and vitaminology · 2023
    Randomized trial120 participantsStress Relief forTheanine
  10. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsSleep Support Stress Relief forTheanine
  11. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  12. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  13. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  14. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  15. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  16. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  17. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  18. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support forTheanine
  19. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  20. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health forTheanine
  21. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  22. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support forTheanine
  23. Efficacy of Zinc Supplement in Minimal hepatic Encephalopathy: A prospective, Randomized Controlled Study (Zinc-MHE Trial).
    Janyajirawong R; Vilaichone RK; Sethasine S · Asian Pacific journal of cancer prevention : APJCP · 2021
    Randomized trial69 participantsCognitive Support forZinc
  24. Effects of zinc supplementation on parent and teacher behaviour rating scores in low socioeconomic level Turkish primary school children.
    Uçkardeş Y; Ozmert EN; Unal F; Yurdakök K · Acta paediatrica (Oslo, Norway : 1992) · 2009
    Randomized trial226 participantsCognitive Support forZinc
  25. L-shaped association between dietary zinc intake and cognitive decline in Chinese older people.
    Meng Q; Liu M; Zu C; Su X; Wei Y; Gan X; Zhang Y; He P; Zhou C; Ye Z; Liu C; Qin X · Age and ageing · 2024
    Cohort study3,106 participantsCognitive Support forZinc
  26. The efficacy of zinc augmentation in children with attention deficit hyperactivity disorder under treatment with methylphenidate: A randomized controlled trial.
    Noorazar SG; Malek A; Aghaei SM; Yasamineh N; Kalejahi P · Asian journal of psychiatry · 2021
    Randomized trial60 participantsCognitive Support forZinc
  27. A preliminary report: effects of zinc and micronutrient repletion on growth and neuropsychological function of urban Chinese children.
    Penland JG; Sandstead HH; Alcock NW; Dayal HH; Chen XC; Li JS; Zhao F; Yang JJ · Journal of the American College of Nutrition · 1997
    Randomized trial372 participantsCognitive Support forZinc
  28. Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial.
    Tiralongo E; Wee SS; Lea RA · Nutrients · 2016
    Randomized trial312 participantsGeneral Health forEuropean Elder
  29. COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?
    Silveira D; Prieto-Garcia JM; Boylan F; Estrada O; Fonseca-Bazzo YM; Jamal CM; Magalhães PO; Pereira EO; Tomczyk M; Heinrich M · Frontiers in pharmacology · 2023
    Narrative reviewGeneral Health forEuropean Elder
  30. Melatonin for preventing and treating jet lag.
    Herxheimer A; Petrie KJ · The Cochrane database of systematic reviews · 2001
    Systematic review10 studies pooledGeneral Health forMelatonin
  31. Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life.
    Schroder CM; Malow BA; Maras A; Melmed RD; Findling RL; Breddy J; Nir T; Shahmoon S; Zisapel N; Gringras P · Journal of autism and developmental disorders · 2019
    Randomized trial125 participantsGeneral Health forMelatonin
  32. Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.
    Fatemeh G; Sajjad M; Niloufar R; Neda S; Leila S; Khadijeh M · Journal of neurology · 2022
    Meta-analysis23 studies pooledGeneral Health forMelatonin
  33. Efficacy of melatonin for chronic insomnia: Systematic reviews and meta-analyses.
    Choi K; Lee YJ; Park S; Je NK; Suh HS · Sleep medicine reviews · 2022
    Meta-analysis24 studies pooledGeneral Health forMelatonin
  34. Effectiveness of melatonin for the treatment of nocturia: a randomized controlled trial.
    Leerasiri P; Pariyaeksut P; Hengrasmee P; Asumpinwong C · International urogynecology journal · 2023
    Randomized trial60 participantsGeneral Health forMelatonin
  35. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledGeneral Health forSelenium
  36. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  37. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health forSelenium
  38. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsGeneral Health forSelenium
  39. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledGeneral Health forSelenium
  40. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  41. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  42. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  43. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  44. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  45. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  46. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  47. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  48. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  49. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  50. Exogenous melatonin boosts vaccine-induced immunity in individuals with high pre-existing influenza immunity.
    Oda K; Danko J; Villasante E; Bergmann-Leitner E; Lee R; Wijayalath W · Frontiers in immunology · 2025
    Randomized trialImmunity forMelatonin
  51. Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis.
    Chojnacki C; Wisniewska-Jarosinska M; Walecka-Kapica E; Klupinska G; Jaworek J; Chojnacki J · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2012
    Randomized trial60 participantsImmunity forMelatonin
  52. Pineal-opioid system interactions in the control of immunoinflammatory responses.
    Lissoni P; Barni S; Tancini G; Fossati V; Frigerio F · Annals of the New York Academy of Sciences · 1995
    Clinical trial130 participantsImmunity forMelatonin
  53. Influenza vaccine response is predicted by chronotype and differentially associated with pre- and post-vaccination sleep.
    Harrison EM; Lee RU; Porter CK; Isidean SD; Easterling AP; White L; Boulifard DA; DeTizio K; Liang Z; Sedegah M; Danko J; Glickman GL · Brain, behavior, & immunity - health · 2026
    Randomized trialImmunity forMelatonin
  54. Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality.
    Tan DX; Reiter RJ · Life sciences · 2022
    Narrative review19 participantsImmunity forMelatonin
  55. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  56. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  57. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  58. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  59. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  60. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  61. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  62. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  63. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  64. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  65. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  66. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  67. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  68. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  69. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  70. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  71. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsMood Support Stress Relief forTheanine
  72. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  73. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsMood Support Stress Relief forTheanine
  74. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  75. Zinc in depression: From development to treatment: A comparative/ dose response meta-analysis of observational studies and randomized controlled trials.
    Yosaee S; Clark CCT; Keshtkaran Z; Ashourpour M; Keshani P; Soltani S · General hospital psychiatry · 2022
    Meta-analysisMood Support forZinc
  76. Dietary zinc and iron intake and risk of depression: A meta-analysis.
    Li Z; Li B; Song X; Zhang D · Psychiatry research · 2017
    Meta-analysis9 studies pooledMood Support forZinc
  77. Zinc sulphate: A reasonable choice for depression management in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial.
    Salari S; Khomand P; Arasteh M; Yousefzamani B; Hassanzadeh K · Pharmacological reports : PR · 2016
    Randomized trial43 participantsMood Support forZinc
  78. Comparative efficacy and tolerability of nutraceuticals for depressive disorder: A systematic review and network meta-analysis.
    Cheng YC; Huang WL; Chen WY; Huang YC; Kuo PH; Tu YK · Psychological medicine · 2025
    Meta-analysis17,437 participants192 studies pooledMood Support forZinc
  79. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce.
    Sarris J; Ravindran A; Yatham LN; Marx W; Rucklidge JJ; McIntyre RS; Akhondzadeh S; Benedetti F; Caneo C; Cramer H; Cribb L; de Manincor M; Dean O; Deslandes AC; Freeman MP; Gangadhar B; Harvey BH; Kasper S; Lake J; Lopresti A; Lu L; Metri NJ; Mischoulon D; Ng CH; Nishi D; Rahimi R; Seedat S; Sinclair J; Su KP; Zhang ZJ; Berk M · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2022
    Guideline / consensusMood Support forZinc
  80. Melatonin treatment for age-related insomnia.
    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
    Randomized trial30 participantsSleep Support forMelatonin
  81. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
    Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
    Meta-analysis409 participants8 studies pooledSleep Support forMelatonin
  82. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
    Randomized trial791 participantsSleep Support forMelatonin
  83. Effects of exogenous melatonin on sleep: a meta-analysis.
    Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
    Meta-analysis284 participants8 studies pooledSleep Support forMelatonin
  84. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  85. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine
  86. The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.
    Rahafard S; Akbari Jokar Z; Hosseini SA; Alaee E · Annals of medicine and surgery (2012) · 2024
    Randomized trial202 participantsStress Relief forMelatonin
  87. Comparison of Effects of Melatonin and Gabapentin on Post Operative Anxiety and Pain in Lumbar Spine Surgery: A Randomized Clinical Trial.
    Javaherforooshzadeh F; Amirpour I; Janatmakan F; Soltanzadeh M · Anesthesiology and pain medicine · 2022
    Randomized trial90 participantsStress Relief forMelatonin
  88. Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.
    Demirhan Kayacik A; İlcioglu K · Archives of women's mental health · 2024
    Meta-analysis441 participants5 studies pooledStress Relief forMelatonin
  89. Premedication effect of melatonin on propofol induction dose for anesthesia, anxiety, orientation and sedation after abdominal surgery: a double-blinded randomized trial.
    Norouzi A; Fateh S; Modir H; Kamali A; Akrami L · Medical gas research · 2020
    Randomized trial88 participantsStress Relief forMelatonin
  90. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsStress Relief forTheanine