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StressMaster

Advanced Nutrition by Zahler
4.6
★ ★ ★ ★ ★
(2893 ratings)
Theanine 100 mg
GABA 250 mg
Valerian 450 mg
Eleuthero 300 mg
Folate 1333.33 mcg
Product Image
Score61
A deep relaxation blend with useful valerian, GABA, and theanine, but broad sedation, unclear botanical potency, and licorice-related concerns demand careful use.
How scoring works
Quantity:120 Capsule(s) • (30 servings)
Goals:
Sleep Support
Stress Relief
Mood Support
Productivity Boost

Score 61

A deep relaxation blend with useful valerian, GABA, and theanine, but broad sedation, unclear botanical potency, and licorice-related concerns demand careful use.
How scoring works
$36.38($1.21 per serving)
iHerb
$ 42.81
Amazon
$ 36.38
Pure Formulas
$ 45.47
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Analysis

Valerian is supplied at a meaningful raw-root amount, while GABA and L-theanine strengthen the calming side of the blend. Rhodiola and eleuthero add a more activating stress-adaptation angle, giving the formula broader coverage but also a less uniform effect.

Many botanicals are powders or extracts without active-marker standardization, and eleuthero is low for plain root powder. The folate amount is high and its form is not identified, while no vitamin B12 is listed to balance prolonged high folate intake.

Valerian, passionflower, skullcap, hops, GABA, and theanine may produce substantial drowsiness together. Licorice adds a separate concern for blood pressure and potassium, so this is not a casual daytime formula despite its stress-focused positioning.

Who is it for
  • Adults seeking a strong multi-herb evening relaxation blend
  • People comfortable with a four-capsule serving
Best for
  • Evening stress relief
  • Pre-sleep relaxation
  • Broad calming botanical coverage

Pros

  • Meaningful valerian root amount
  • Useful GABA and L-theanine amounts
  • Multiple complementary calming botanicals
  • Most ingredient amounts are disclosed

Cons

  • Many botanicals lack standardization
  • Eleuthero is low for root powder
  • High folate without listed vitamin B12
  • High cost per serving

Warnings

  • The combined valerian, passionflower, skullcap, hops, GABA, and theanine may cause marked drowsiness; avoid driving and alcohol.
  • Licorice root may raise blood pressure or lower potassium, especially with prolonged use or in susceptible people.
  • High folate without vitamin B12 may mask signs of vitamin B12 deficiency.

Nutrient quality

61 Moderate impact

Several central actives reach useful amounts, especially valerian, rhodiola, GABA, and theanine. Unspecified folate, raw botanical powders, a crowded herb list, and potentially aggressive nutrient amounts weaken quality.

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Ingredient transparency

72 High impact

Active amounts are broadly clear and no proprietary blend hides the listed doses. Missing inactive ingredients and incomplete usage or source details prevent full label transparency.

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Customer satisfaction

70 High impact

The average rating is strong and supported by a very large review base. No specific feedback themes are supplied, so repetitive drowsiness complaints and real-world purpose fit remain uncertain.

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Value for money

39 Lower impact

Meaningful doses of several core stress actives provide substance, but missing standardization lowers quality confidence. A high serving cost and many loosely characterized herbs make the formula poor value for routine use.

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Goals

Sleep Support
Sleep Support
Impact
Highest effect
A- Goal FitA- Strength of SupportA- CoverageA- Formula Quality
Theanine · 100 mg

Substantial valerian, GABA, and theanine create a well-aligned relaxation formula for sleep onset. Each main calming ingredient is individually disclosed at a useful amount.

Raw valerian root lacks extract standardization, and the formula does not address circadian timing with melatonin. Valerian and hops can cause drowsiness, while licorice may raise blood pressure or lower potassium in susceptible users.

Study evidence
GABA Supportive 4 studies
Theanine Supportive 8 studies
Valerian Supportive 31 studies
Stress Relief
Stress Relief
Impact
Highest effect
A- Goal FitB+ Strength of SupportA CoverageB- Formula Quality
Folate · 1333.33 mcgGABA · 250 mgVitamin C · 750 mcgEleuthero · 300 mgTheanine · 100 mg

Rhodiola, valerian, GABA, passionflower, theanine, and eleuthero combine adaptogenic and calming neurotransmitter pathways. Rhodiola, valerian, and GABA reach meaningful amounts, while theanine supports relaxed alertness.

Most botanicals are powders or incompletely standardized extracts, which limits potency certainty. Licorice may raise blood pressure or lower potassium in susceptible users, while valerian, hops, and other calming herbs may cause drowsiness.

Study evidence
Eleuthero No effect 1 study
GABA Supportive 6 studies
Theanine Supportive 16 studies
Valerian Supportive 18 studies
Mood Support
Mood Support
Impact
Highest effect
A- Goal FitB Strength of SupportA CoverageB Formula Quality
Folate · 1333.33 mcg

Rhodiola, valerian, GABA, passionflower, and L-theanine provide broad stress and relaxation support at mostly useful amounts. Eleuthero adds an adaptogenic pathway, although botanical standardization is limited.

Activating adaptogens sit beside several sedating herbs, which may not suit every time of day. Valerian, hops, passionflower, and GABA can add drowsiness, while licorice may raise blood pressure or lower potassium in susceptible users.

Study evidence
GABA Supportive 12 studies
Theanine Supportive 12 studies
Valerian Supportive 17 studies
Productivity Boost
Productivity Boost
Impact
High effect
B Goal FitB- Strength of SupportB- CoverageB Formula Quality
Eleuthero · 300 mgEleuthero · 300 mgTheanine · 100 mg

Rhodiola, L-theanine, and eleuthero form a clear adaptogenic and calm-focus strategy for stress-related fatigue. The formula supports steady attention rather than stimulant-driven alertness.

Rhodiola and L-theanine reach useful disclosed amounts, while raw eleuthero powder is underpowered and extract standardization is limited. The compact combination remains coherent, but evidence depends heavily on the quality of the rhodiola extract.

Study evidence
Eleuthero No effect 1 study
Eleuthero Not classified

No linked studies yet.

Theanine Supportive 5 studies
Cognitive Support
Cognitive Support
Impact
Moderate effect
C+ Goal FitC+ Strength of SupportB- CoverageD Formula Quality
Folate · 1333.33 mcgTheanine · 100 mg

Rhodiola and L-theanine provide meaningful stress-resilience and calm-focus support. The many valerian, passionflower, hops, skullcap, and GABA ingredients shift the formula toward sedation rather than broad cognitive performance.

Rhodiola reaches a substantial amount, but missing standardization and the crowded calming blend reduce predictability. The high folate amount lacks a stated form and accompanying vitamin B12, which may mask anemia while neurological effects of B12 deficiency progress.

Study evidence
Folate Supportive 68 studies
Theanine Supportive 25 studies
Energy
Energy
Impact
Moderate effect
C+ Goal FitC Strength of SupportC CoverageF Formula Quality

Rhodiola is supplied at a meaningful amount and may support resilience during fatigue. L-theanine can promote calm focus, but the rest of the blend leans heavily toward relaxation and sleep.

Valerian, GABA, passionflower, hops, and skullcap may cause drowsiness, which conflicts with an energy goal. Eleuthero is underdosed as raw root powder, and most botanicals lack standardization details.

Study evidence
Eleuthero Disputed 3 studies
Theanine Not classified

No linked studies yet.

Ingredients

IngredientAmount per serving
Vitamin A (Beta-Carotene)
 1500 mcg
Vitamin C (Ascorbic Acid)
 750 mcg
Vitamin E (D-Alpha-Tocopheryl Succinate)
 134 mg
Folate
1333.33 mcg
Valerian root powder
450 mg
Rhodiola root extract
400 mg
Eleuthero root powder
300 mg
Gamma Amino Butyric Acid
250 mg
Passionflower, Powder
200 mg
Chinese Skullcap, Powder
200 mg
Hops flower powder
150 mg
Sarsaparilla root powder
100 mg
Licorice root powder
100 mg
Dandelion root powder
100 mg
Wood Betony, Powder
100 mg
L-Theanine
100 mg
Adults 18–50 Kosher Dairy Free Vegetarian
Report overview
Theanine · 100 mg OverallScore76
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The active L-isomer and optimal dose are clearly stated, but no branded purity standard is given. Exact ingredient disclosure supports confident dose verification. High cost per standard theanine amount is the main weakness.

View ingredientView products
GABA · 250 mg OverallScore75
B- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyD- Value

The clearly disclosed 250 mg GABA dose reaches the preferred standalone range, but its source is an unbranded standard form. Capsule delivery is conventional, and the high serving cost makes the GABA-specific value weak. Licorice root may raise blood pressure or lower potassium in susceptible users, while valerian and hops may add drowsiness.

View ingredientView products
Valerian · 450 mg OverallScore65
C- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The 450 mg root dose falls within the stated target range and is disclosed separately. Raw root powder lacks the concentration and standardization of a characterized extract, while capsules keep its odor contained. The serving is expensive relative to the collection and offers no special valerian standardization to justify the premium.

View ingredientView products
Loading alternative details
76 Performance

Best-Rest Formula

Pure Encapsulations
<p>Branded L-theanine, active vitamin B6, substantial GABA, valerian, melatonin, and calming herbs provide a more technically focused sleep formula. Botanical marker percentages remain undisclosed, and the sedating combination should not be used before driving.</p>
83 Performance

ZenMind

NutriCology
<p>Branded L-theanine and a substantial GABA amount create a simpler, fully disclosed relaxation formula without high folate, licorice, or a long herb stack. Swallowed GABA has uncertain brain availability, and combined calming ingredients may cause drowsiness.</p>
72 Performance

Insomnitol

Designs for Health
<p>Multiple clearly dosed calming ingredients create strong sleep, stress, and mood alignment. The broad sedating combination may cause next-day drowsiness, while 5-HTP can interact with serotonin-raising medicines.</p>
77 Budget

Sleep Support

The Vitamin Shoppe
<p>A lower serving cost provides useful L-theanine, GABA, melatonin, valerian, and 5-HTP for sleep and stress support. Raw valerian is less concentrated and 5-HTP can interact with serotonin-raising medicines.</p>
78 Budget

Sleep

NOW
<p>A much lower serving cost combines substantial valerian, hops, passionflower, and GABA with all active amounts visible. Botanical marker strengths are unclear and the sedating combination may cause additive drowsiness.</p>
75 Budget

Sleep & Stress Support

Solgar
<p>A lower serving cost keeps valerian and a full theanine amount in a coherent evening formula. Incomplete botanical standardization and additive drowsiness with alcohol or sedative medicines remain important limitations.</p>
74 Value

Chewable GABA

NOW
<p>A much lower serving cost provides substantial GABA with smaller amounts of taurine, inositol, and L-theanine in a convenient chewable. Oral GABA has uncertain brain availability, and the carbohydrate base plus possible drowsiness limit formula focus.</p>
69 Value

Goodbye Stress Berry Verbena

OLLY
<p>GABA, L-theanine, and lemon balm provide gentle stress support at a lower serving cost and with fewer safety concerns than high folate plus licorice. All three amounts are modest, and the calming combination may still add to alcohol or sedative effects.</p>
71 Value

PM Formula

Nature's Way
<p>Valerian, hops, theanine, and black cohosh create a lower-cost nighttime formula with fewer ingredients to assess. Valerian marker strength is incomplete, theanine is lightly dosed, and the combined herbs may impair alertness.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
    Ziegler G; Ploch M; Miettinen-Baumann A; Collet W · European journal of medical research · 2003
    Randomized trial202 participantsSleep Support forValerian
  2. A systematic review of insomnia and complementary medicine.
    Sarris J; Byrne GJ · Sleep medicine reviews · 2011
    Systematic review20 studies pooledSleep Support forValerian
  3. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  4. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  5. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsSleep Support Brain Health Cognitive Support forTheanine
  6. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsSleep Support forTheanine
  7. Medicinal Plants for Insomnia Related to Anxiety: An Updated Review.
    Borrás S; Martínez-Solís I; Ríos JL · Planta medica · 2021
    Systematic reviewStress Relief forValerian
  8. Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
    Zhang W; Yan Y; Wu Y; Yang H; Zhu P; Yan F; Zhao R; Tian P; Wang T; Fan Q; Su Z · Pharmacological research · 2022
    Meta-analysis29 participants29 studies pooledStress Relief forValerian
  9. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief Mood Support forGABA
  10. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsStress Relief Mood Support forTheanine
  11. Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study.
    Furushima D; Sugiyama I; Nomura Y; Unno K; Yamada H · Journal of nutritional science and vitaminology · 2023
    Randomized trial120 participantsStress Relief forTheanine
  12. B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis.
    Wang Z; Zhu W; Xing Y; Jia J; Tang Y · Nutrition reviews · 2022
    Meta-analysis46,175 participants95 studies pooledBrain Health Cognitive Support forFolate
  13. Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial.
    Catena A; Muñoz-Machicao JA; Torres-Espínola FJ; Martínez-Zaldívar C; Diaz-Piedra C; Gil A; Haile G; Györei E; Molloy AM; Decsi T; Koletzko B; Campoy C · The American journal of clinical nutrition · 2016
    Randomized trial136 participantsBrain Health Mental Focus forFolate
  14. Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.
    Liu Y; Yu Z; Cai Z; Zhao L; Wang Y; Guo Y; Su X; Miao Y; Yi B; Wang Y; Zhang X · The journal of prevention of Alzheimer's disease · 2025
    Randomized trial220 participantsBrain Health forFolate
  15. Circulating folate concentrations and the risk of mild cognitive impairment: A prospective study on the older Chinese population without folic acid fortification.
    Fu J; Liu Q; Zhu Y; Sun C; Duan H; Huang L; Zhou D; Wang Z; Zhao J; Li Z; Ma F; Li W; Liu H; Zhang X; Chen Y; Wang G; Du Y; Huang G · European journal of neurology · 2022
    Cohort study3,974 participantsBrain Health forFolate
  16. Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment.
    Jang S; Han JW; Shin J; Kim TH; Kwak KP; Kim K; Kim BJ; Kim SG; Kim JL; Kim TH; Moon SW; Park JY; Park JH; Byun S; Suh SW; Seo J; So Y; Ryu SH; Youn JC; Lee KH; Lee DY; Lee DW; Lee SB; Lee JJ; Lee JR; Jeong H; Jeong HG; Jhoo JH; Han K; Hong JW; Kim KW · Psychiatry investigation · 2020
    Cohort study3,910 participantsBrain Health forFolate
  17. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  18. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support Mental Focus forTheanine
  19. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  20. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus Productivity Boost forTheanine
  21. Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China.
    Ma F; Wu T; Zhao J; Han F; Marseglia A; Liu H; Huang G · The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Randomized trial180 participantsCognitive Support forFolate
  22. Serum folate and B12 levels in association with cognitive impairment among seniors: results from the VELESTINO study in Greece and meta-analysis.
    Michelakos T; Kousoulis AA; Katsiardanis K; Dessypris N; Anastasiou A; Katsiardani KP; Kanavidis P; Stefanadis C; Papadopoulos FC; Petridou ET · Journal of aging and health · 2013
    Meta-analysis8,122 participants9 studies pooledCognitive Support forFolate
  23. Homocysteine and folate as risk factors for dementia and Alzheimer disease.
    Ravaglia G; Forti P; Maioli F; Martelli M; Servadei L; Brunetti N; Porcellini E; Licastro F · The American journal of clinical nutrition · 2005
    Cohort study816 participantsCognitive Support forFolate
  24. Folate mediates cognitive impairment of aged people with periodontitis.
    Liu F; Liu Y; Feng Y; Zhao J; Wang M; Ye M; Zhang Y; Gan X; Pan Q; Shen J · Nutritional neuroscience · 2025
    Cross-sectional study1,966 participantsCognitive Support forFolate
  25. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  26. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support Mental Focus forTheanine
  27. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.
    Panossian A; Wikman G · Current clinical pharmacology · 2009
    Narrative reviewEnergy Mental Focus forEleuthero
  28. Randomized controlled trial of Siberian ginseng for chronic fatigue.
    Hartz AJ; Bentler S; Noyes R; Hoehns J; Logemann C; Sinift S; Butani Y; Wang W; Brake K; Ernst M; Kautzman H · Psychological medicine · 2004
    Randomized trial96 participantsEnergy forEleuthero
  29. The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human
    J Kuo, K W Chen, I S Cheng, P H Tsai, Y J Lu, N Y Lee · Chinese Journal of Physiology · 2010
    Randomized trial9 participantsEnergy forEleuthero
  30. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  31. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  32. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  33. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  34. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  35. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration.
    Panossian A; Wagner H · Phytotherapy research : PTR · 2005
    Narrative reviewMental Focus forEleuthero
  36. No benefit adding eleutherococcus senticosus to stress management training in stress-related fatigue/weakness, impaired work or concentration, a randomized controlled study.
    Schaffler K; Wolf OT; Burkart M · Pharmacopsychiatry · 2014
    Randomized trial144 participantsMental Focus Productivity Boost Stress Relief forEleuthero
  37. Cerebral folate receptor autoantibodies in autism spectrum disorder.
    Frye RE; Sequeira JM; Quadros EV; James SJ; Rossignol DA · Molecular psychiatry · 2014
    Non-randomized trial93 participantsMental Focus forFolate
  38. Folate, vitamin B-12, and cognitive function in the Boston Puerto Rican Health Study.
    Boumenna T; Scott TM; Lee JS; Palacios N; Tucker KL · The American journal of clinical nutrition · 2026
    Cross-sectional study1,408 participantsMental Focus forFolate
  39. Vitamins B9 and B12 in children with attention deficit hyperactivity disorder (ADHD).
    Razavinia F; Ebrahimiyan A; Faal Siahkal S; Ghazinezhad N; Abedi P · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2024
    Meta-analysis982 participants6 studies pooledMental Focus forFolate
  40. Does L-Methylfolate Supplement Methylphenidate Pharmacotherapy in Attention-Deficit/Hyperactivity Disorder?: Evidence of Lack of Benefit From a Double-Blind, Placebo-Controlled, Randomized Clinical Trial.
    Surman C; Ceranoglu A; Vaudreuil C; Albright B; Uchida M; Yule A; Spencer A; Boland H; Grossman R; Rhodewalt L; Fitzgerald M; Biederman J · Journal of clinical psychopharmacology · 2019
    Randomized trial44 participantsMental Focus forFolate
  41. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsMental Focus Productivity Boost Stress Relief forTheanine
  42. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  43. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  44. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  45. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  46. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  47. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  48. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  49. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsMood Support Stress Relief forTheanine Stress Relief forGABA
  50. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  51. Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
    Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
    Randomized trial80 participantsMood Support Sleep Support Stress Relief forValerian
  52. Chemotypic diversity and neuroactive potential of Valeriana jatamansi Jones: a systematic review on phytochemistry, pharmacology and standardisation challenges.
    Nisar S; Jan N; Hassan I; Andleeb L; Shabir PA · Natural product research · 2026
    Meta-analysis12 studies pooledMood Support forValerian
  53. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
    Shinjyo N; Waddell G; Green J · Journal of evidence-based integrative medicine · 2021
    Meta-analysis6,894 participants60 studies pooledMood Support forValerian
  54. Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study.
    Farah GJ; Ferreira GZ; Danieletto-Zanna CF; Luppi CR; Jacomacci WP · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2020
    Randomized trial20 participantsMood Support forValerian
  55. Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.
    Araújo JO; Bergamaschi CC; Lopes LC; Guimarães CC; de Andrade NK; Ramacciato JC; Motta RHL · BMJ open · 2021
    Systematic review327 participants12 studies pooledMood Support Stress Relief forValerian
  56. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledProductivity Boost forTheanine
  57. Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
  58. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsProductivity Boost forTheanine
  59. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  60. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsSleep Support Stress Relief forGABA
  61. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  62. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  63. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine
  64. Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.
    Hajizadeh I; Jamshidi M; Kazemi M; Kargar H; Sadeghi T · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2023
    Randomized trial40 participantsSleep Support forValerian
  65. Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.
    Schicktanz N; Gerhards C; Schlitt T; Aerni A; Müggler E; de Quervain D; Papassotiropoulos A; Boonen G; Drewe J; Butterweck V · Brain and behavior · 2025
    Randomized trial40 participantsSleep Support forValerian
  66. Valerian for sleep: a systematic review and meta-analysis.
    Bent S; Padula A; Moore D; Patterson M; Mehling W · The American journal of medicine · 2006
    Meta-analysis1,093 participants16 studies pooledSleep Support forValerian
  67. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  68. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  69. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  70. Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.
    Velasquez ACA; Tsuji M; Dos Santos Cordeiro L; Petinati MFP; Rebellato NLB; Sebastiani AM; da Costa DJ; Scariot R · Oral and maxillofacial surgery · 2024
    Randomized trial54 participantsStress Relief forValerian
  71. Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions.
    Cropley M; Cave Z; Ellis J; Middleton RW · Phytotherapy research : PTR · 2002
    Non-randomized trial54 participantsStress Relief forValerian
  72. Stress-induced insomnia treated with kava and valerian: singly and in combination.
    Wheatley D · Human psychopharmacology · 2019
    Single-arm trial24 participantsStress Relief forValerian