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Vitamins D3 & K2

4.8
★ ★ ★ ★ ★
(295 ratings)
Vitamin K 150 mcg
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Score80
A clean D3 and MK-7 capsule with strong form transparency. High vitamin D makes it better suited to monitored repletion than ordinary maintenance.
How scoring works
Capsule
Quantity:90 Capsule(s) • (90 servings)
Goals:
Bone Health
Cardiovascular Support
General Health
Heart Health
Anti-Aging

Score 80

A clean D3 and MK-7 capsule with strong form transparency. High vitamin D makes it better suited to monitored repletion than ordinary maintenance.
How scoring works
$29.95($0.33 per serving)
iHerb
$ 35.95
Pure Formulas
$ 29.95
Report prices

Analysis

The capsule combines 125 mcg of cholecalciferol with 150 mcg of menaquinone-7. Both are favorable forms and the K2 amount is substantial for focused support.

A two-active formula makes dose assessment easy and avoids label clutter. The main limitation is balance: K2 is practical, while vitamin D is high for routine unsupervised use.

It best fits adults following a defined high-dose vitamin D plan who also want MK-7. People seeking simple maintenance should choose a lower-D3 combination.

Who is it for
  • Adults with a monitored high-dose vitamin D plan
  • People seeking substantial MK-7
  • Users wanting a simple two-active capsule
Best for
  • High-strength D3 with K2
  • Clinician-guided vitamin D repletion
  • Focused calcium-regulation support

Pros

  • Uses cholecalciferol
  • Provides 150 mcg of MK-7
  • Clearly states both amounts
  • Avoids unrelated ingredients

Cons

  • Vitamin D exceeds the usual adult upper intake level
  • Not ideal for casual long-term use
  • Requires total vitamin D tracking
  • No stated fat carrier in the capsule

Warnings

  • The 125 mcg vitamin D amount exceeds the usual adult daily upper intake level, so total intake and blood levels should be clinically reviewed.
  • Vitamin K2 can oppose warfarin and related vitamin K antagonists.

Nutrient quality

86 Highest impact

Cholecalciferol and menaquinone-7 are well-regarded forms. Both vitamins are supplied in meaningful amounts for bone support.

Ingredient transparency

82 Highest impact

Every active ingredient has a specific amount. Inactive ingredients are not supplied.

Customer satisfaction

67 High impact

The supplied average indicates very strong aggregate satisfaction. No detailed experience reports are available to identify repeated complaints or confirm perceived benefits.

Value for money

82 Highest impact

The high-quality forms support reasonable value for the cost. Serving value appears moderate for a focused vitamin combination.

Report analysis

Goals

Bone Health
Bone Health
Impact
Highest effect
A Goal FitA Strength of SupportB- CoverageA+ Formula Quality
Vitamin K · 150 mcgVitamin D · 125 mcg

Vitamin D3 and MK-7 form a targeted combination for calcium absorption and placement in bone. Both are supplied at substantial, clearly disclosed amounts.

The lean formula offers strong cofactor depth but does not provide calcium, magnesium, or collagen. People using warfarin or another vitamin K antagonist need clinician-guided consistency because MK-7 can change anticoagulant control.

Study evidence
Vitamin K Supportive 78 studies
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
A- Goal FitA Strength of SupportB+ CoverageA+ Formula Quality
Vitamin K · 150 mcgVitamin D · 125 mcg

MK-7 vitamin K2 supports proteins involved in directing calcium away from soft tissues, while vitamin D3 complements calcium regulation. The K2 amount is well aligned with targeted use and its form is clearly identified.

The simple combination provides focused vascular-calcium support but does not cover lipid or cardiac-energy pathways. Vitamin K2 can counteract warfarin and related vitamin K antagonists, so consistent clinician-guided use is important for people taking them.

Study evidence
Vitamin K Supportive 40 studies
General Health
General Health
Impact
Highest effect
A Goal FitB+ Strength of SupportB CoverageA+ Formula Quality
Vitamin D · 125 mcgVitamin K · 150 mcg

Vitamin D3 and MK-7 are a well-matched pair for calcium regulation, immune function, and skeletal support. The MK-7 form and both amounts are clearly disclosed, giving the formula strong functional depth.

The dry capsule has no stated lipid carrier, which is a limitation for two fat-soluble nutrients. The vitamin D3 amount exceeds the usual adult daily upper intake level, while MK-7 can counteract warfarin and related vitamin K antagonist medicines.

Study evidence
Vitamin K Supportive 34 studies
Heart Health
Heart Health
Impact
Highest effect
B+ Goal FitA Strength of SupportB- CoverageA+ Formula Quality
Vitamin K · 150 mcgVitamin D · 125 mcg

Vitamin D3 and menaquinone-7 form a strong calcium-management pairing relevant to arterial flexibility. Both preferred forms and their substantial amounts are clearly disclosed.

The formula is focused and does not address lipids, cardiac energy, or vascular tone. Vitamin K2 can counteract warfarin and related vitamin K antagonists, making clinician-guided consistency important for users of those medicines.

Study evidence
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
B+ Goal FitA+ Strength of SupportC CoverageA+ Formula Quality
Vitamin K · 150 mcgVitamin D · 125 mcg

Vitamin D3 and vitamin K2 as MK-7 form a logical pairing for bone strength and calcium handling with age. MK-7 is substantial at 150 mcg, while the 125 mcg vitamin D3 amount is high for routine unsupervised use.

The focused capsule gives strong depth for skeletal and vascular calcium regulation but does not address other major aging pathways. MK-7 directly opposes warfarin, and prolonged high-dose vitamin D3 may raise calcium levels, so users of vitamin K antagonists or people prone to hypercalcemia need clinical oversight.

Study evidence
Vitamin K Supportive 27 studies

Ingredients

IngredientAmount per serving
Vitamin D3 (Cholecalciferol)
 125 mcg
Vitamin K2 (Menaquinone-7)
 150 mcg
Adults 18–50 Women
Report overview
Vitamin K (Menaquinone-7) · 150 mcg OverallScore87
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Generic MK-7 provides a well-aligned amount and is paired with vitamin D3. The low serving cost supports strong dose efficiency, although the dry capsule lacks a stated fat-based delivery aid. Vitamin K can counteract warfarin and related vitamin K antagonists, so users of those medicines need clinician-guided consistency.

View ingredientView products
Loading alternative details
87 Performance

Vitamin K2 100 mcg

SR Sports Research
<p>The formula provides 100 mcg of Vitamin K2 (Menaquinone-7), which may be a better fit than the original’s 150 mcg of Vitamin K2 (Menaquinone-7) and 125 mcg of Vitamin D3 (Cholecalciferol) when its specific vitamin K form and companion nutrients are preferred. Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
86 Performance

Vitamin K2 MK-7 (Menaquinone-7) 90 mcg

Carlson
<p>The formula provides 90 mcg of Vitamin K2 (Menaquinone-7), which may be a better fit than the original’s 150 mcg of Vitamin K2 (Menaquinone-7) and 125 mcg of Vitamin D3 (Cholecalciferol) when its specific vitamin K form and companion nutrients are preferred. Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
87 Performance

Vitamin K2 as MK-7 100 mcg

Healthy Origins
<p>The formula provides 100 mcg of Vitamin K2 (Menaquinone-7), which may be a better fit than the original’s 150 mcg of Vitamin K2 (Menaquinone-7) and 125 mcg of Vitamin D3 (Cholecalciferol) when its specific vitamin K form and companion nutrients are preferred. Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
88 Budget

Vitamin K2 MK-7 100 mcg

Nutricost
<p>At a lower recurring cost, the formula provides 100 mcg of Vitamin K (Menaquinone-7), making it a practical budget alternative to the original’s 150 mcg of Vitamin K2 (Menaquinone-7) and 125 mcg of Vitamin D3 (Cholecalciferol). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
87 Budget

MK-7 Vitamin K-2 100 mcg

NOW
<p>At a lower recurring cost, the formula provides 100 mcg of Vitamin K2 (Menaquinone-7), making it a practical budget alternative to the original’s 150 mcg of Vitamin K2 (Menaquinone-7) and 125 mcg of Vitamin D3 (Cholecalciferol). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
85 Budget

Vitamin K2 MenaQ7 100 mcg

AN Amazing Nutrition Amazing Formulas
<p>At a lower recurring cost, the formula provides 100 mcg of Vitamin K2 (Natto), making it a practical budget alternative to the original’s 150 mcg of Vitamin K2 (Menaquinone-7) and 125 mcg of Vitamin D3 (Cholecalciferol). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
86 Value

Vitamins D3 2500 IU (62.5 mcg) & K2 120 mcg

NaturesPlus
<p>The formula combines 120 mcg of Vitamin K2 (Menaquinone-7) and 62.50 mcg of Vitamin D3 (Cholecalciferol) with favorable serving value, which may offer a better quality-to-cost balance than the original’s 150 mcg of Vitamin K2 (Menaquinone-7) and 125 mcg of Vitamin D3 (Cholecalciferol). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
87 Value

MK-7 Vitamin K-2 100 mcg

NOW
<p>The formula combines 100 mcg of Vitamin K-2 (Menaquinone-7) with favorable serving value, which may offer a better quality-to-cost balance than the original’s 150 mcg of Vitamin K2 (Menaquinone-7) and 125 mcg of Vitamin D3 (Cholecalciferol). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
86 Value

Vitamin K2 100 mcg + Vitamin D3 125 mcg

Nutricost
<p>The formula combines 100 mcg of Vitamin K (Menaquinone-7) and 125 mcg of Vitamin D (Cholecalciferol) with favorable serving value, which may offer a better quality-to-cost balance than the original’s 150 mcg of Vitamin K2 (Menaquinone-7) and 125 mcg of Vitamin D3 (Cholecalciferol). The high vitamin D amount warrants attention to total intake, and vitamin K may interfere with warfarin-type anticoagulants.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  2. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.
    Huang ZB; Wan SL; Lu YJ; Ning L; Liu C; Fan SW · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Meta-analysis6,759 participants19 studies pooledBone Health forVitamin K
  3. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  4. Comparison of concurrent treatment with vitamin K2 and risedronate compared with treatment with risedronate alone in patients with osteoporosis: Japanese Osteoporosis Intervention Trial-03.
    Tanaka S; Miyazaki T; Uemura Y; Miyakawa N; Gorai I; Nakamura T; Fukunaga M; Ohashi Y; Ohta H; Mori S; Hagino H; Hosoi T; Sugimoto T; Itoi E; Orimo H; Shiraki M · Journal of bone and mineral metabolism · 2018
    Randomized trial1,874 participantsBone Health forVitamin K
  5. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  6. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  7. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  8. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  9. Interventions to Attenuate Cardiovascular Calcification Progression: A Systematic Review of Randomized Clinical Trials.
    Murali S; Smith ER; Tiong MK; Tan SJ; Toussaint ND · Journal of the American Heart Association · 2024
    Systematic review9,901 participants49 studies pooledCardiovascular Support forVitamin K
  10. Intake of dietary phylloquinone and menaquinones and risk of stroke.
    Vissers LE; Dalmeijer GW; Boer JM; Monique Verschuren WM; van der Schouw YT; Beulens JW · Journal of the American Heart Association · 2014
    Cohort study35,476 participantsCardiovascular Support forVitamin K
  11. Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease.
    van den Heuvel EG; van Schoor NM; Lips P; Magdeleyns EJ; Deeg DJ; Vermeer C; den Heijer M · Maturitas · 2014
    Cohort study577 participantsCardiovascular Support forVitamin K
  12. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  13. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  14. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  15. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  16. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  17. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  18. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  19. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  20. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  21. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  22. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  23. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  24. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  25. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  26. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  27. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsHeart Health forVitamin D
  28. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  29. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  30. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisHeart Health forVitamin D
  31. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K