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Stress-Defy

Irwin Naturals
4.5
★ ★ ★ ★ ★
(667 ratings)
Theanine 100 mg
Thiamin 26 mg
Vitamin B6 50 mg
Rhodiola
Riboflavin 26 mg
Ginkgo
Product Image
Score76
A coherent stress softgel with useful theanine and adaptogens, limited by high B6 and incomplete ginkgo and rhodiola standardization.
How scoring works
Quantity:84 Softgel(s) • (42 servings)
Goals:
Stress Relief
Mood Support
Brain Health
Cognitive Support
Productivity Boost
Mental Focus

Score 76

A coherent stress softgel with useful theanine and adaptogens, limited by high B6 and incomplete ginkgo and rhodiola standardization.
How scoring works
$30.94($0.73 per serving)
iHerb
$ 30.99
Pure Formulas
$ 30.99
Amazon
$ 30.94
Vitacost
$ 30.99
Walmart
$ 30.94
Report prices

Analysis

L-theanine, rhodiola, holy basil, skullcap, and GABA create a balanced calming and resilience-oriented blend. B vitamins support energy metabolism, while flaxseed oil and the softgel format provide a lipid matrix.

Rhodiola marker names are supplied without percentages or a species, and ginkgo lacks marker detail. Several actives are reasonable as supporting amounts, but the formula does not establish strong stand-alone potency for most botanicals.

Vitamin B6 is supplied at a high amount for daily long-term use, and ginkgo adds a specific medication interaction. The blend fits occasional or deliberately monitored stress support better than a simple indefinite routine.

Who is it for
  • Adults seeking broad stress-resilience support
  • Users who prefer softgels
  • People not taking anticoagulant or antiplatelet medicines
Best for
  • Combined theanine and adaptogen use
  • Stress support with B vitamins
  • Shorter-term monitored routines

Pros

  • Meaningful L-theanine amount
  • Coherent botanical combination
  • Softgel includes a lipid matrix

Cons

  • High vitamin B6 for long-term routine use
  • Ginkgo standardization is missing
  • Rhodiola species and marker percentages are absent

Warnings

  • Ginkgo may increase bleeding risk with anticoagulant or antiplatelet medicines.
  • The 50 mg vitamin B6 amount makes prolonged daily use a point to review rather than assume is suitable.

Nutrient quality

74 High impact

The actives fit stress resilience, relaxation, and calm attention well. The vitamin B6 amount is aggressive for prolonged daily use.

Ingredient transparency

86 Highest impact

All active amounts are listed. The full softgel excipient list is not supplied.

Customer satisfaction

67 High impact

Feedback volume is substantial enough to stabilize the aggregate signal. No complaint text is supplied, so repeated negative themes cannot be assessed.

Value for money

72 High impact

A coherent botanical and theanine core supports fair formula value. Most extras are relevant, though magnesium and some nutrients are token amounts.

Report analysis

Goals

Stress Relief
Stress Relief
Impact
Highest effect
A- Goal FitB Strength of SupportA- CoverageB+ Formula Quality
Magnesium · 13 mgGABA · 60 mgVitamin B6 · 50 mgTheanine · 100 mg

L-theanine, rhodiola, holy basil, GABA, skullcap, and B vitamins combine relaxed-alertness, adaptogenic, and metabolic stress pathways. Theanine reaches a useful amount, while rhodiola names both major marker families.

Rhodiola species and marker percentages are missing, and GABA and magnesium are modest. Ginkgo may increase bleeding risk with anticoagulants, while prolonged use of the high vitamin B6 amount deserves caution because excessive exposure can affect nerves.

Study evidence
GABA Supportive 6 studies
Magnesium Supportive 13 studies
Rhodiola Supportive 16 studies
Theanine Supportive 16 studies
Vitamin B6 Supportive 10 studies
Mood Support
Mood Support
Impact
Highest effect
B+ Goal FitB- Strength of SupportB+ CoverageB+ Formula Quality
Vitamin B6 · 50 mgMagnesium · 13 mg

L-theanine, Rhodiola, holy basil, skullcap, GABA, and vitamin B6 create a directly relevant stress-and-calming formula. It covers both adaptive stress response and inhibitory signaling.

Theanine is well aligned, while Rhodiola and GABA are modest and several botanical marker percentages are unclear. Ginkgo may increase bleeding risk with anticoagulants, and prolonged intake of 50 mg vitamin B6 deserves caution because excessive exposure can affect nerves.

Study evidence
GABA Supportive 12 studies
Rhodiola Supportive 15 studies
Theanine Supportive 12 studies
Vitamin B6 Supportive 19 studies
Brain Health
Brain Health
Impact
High effect
B+ Goal FitB Strength of SupportB+ CoverageB Formula Quality
Vitamin B6 · 50 mgThiamin · 26 mgMagnesium · 13 mg

Rhodiola, theanine, ginkgo, holy basil, and skullcap directly support stress resilience, calm focus, and circulation. Standardized botanical markers and useful theanine and ginkgo amounts improve the targeted design.

The rhodiola amount is moderate and the formula does not address neuronal membranes or long-term structural support. Prolonged daily use of 50 mg vitamin B6 may increase the risk of tingling, numbness, or other nerve symptoms.

Study evidence
Ginkgo Supportive 90 studies
Rhodiola Supportive 8 studies
Theanine Supportive 17 studies
Vitamin B6 Supportive 29 studies
Cognitive Support
Cognitive Support
Impact
High effect
B Goal FitC+ Strength of SupportB+ CoverageB+ Formula Quality
Thiamin · 26 mgVitamin B6 · 50 mgMagnesium · 13 mgTheanine · 100 mg

L-theanine, rhodiola, and ginkgo create a useful combination for calm attention, stress resilience, and circulation. Theanine is well dosed, while rhodiola and ginkgo are supporting amounts with incomplete standardization.

B vitamins broaden the energy and neurotransmitter foundation without overwhelming the main adaptogenic design. Ginkgo may increase bleeding risk with anticoagulant or antiplatelet medicines, and the high B6 amount may raise neuropathy risk with prolonged use.

Study evidence
Ginkgo Supportive 87 studies
Rhodiola Supportive 7 studies
Theanine Supportive 25 studies
Productivity Boost
Productivity Boost
Impact
High effect
B Goal FitC Strength of SupportB CoverageB+ Formula Quality
Vitamin B6 · 50 mgMagnesium · 13 mgTheanine · 100 mg

L-theanine, rhodiola, holy basil, ginkgo, and B vitamins target stress-related fatigue and mental performance. Theanine and standardized adaptogens have relevant evidence, while the rhodiola amount is light and ginkgo standardization is incomplete.

The 100 mg theanine amount is useful, but rhodiola at 100 mg and magnesium at 13 mg provide limited depth. Theanine is clearly identified and rhodiola markers are named, though their percentages and the ginkgo markers are missing. Ginkgo may increase bleeding risk when combined with anticoagulant or antiplatelet medicines.

Study evidence
Ginkgo Supportive 20 studies
Ginkgo Supportive 12 studies
Magnesium Supportive 10 studies
Rhodiola Supportive 7 studies
Theanine Supportive 5 studies
Mental Focus
Mental Focus
Impact
High effect
B- Goal FitC Strength of SupportB- CoverageB- Formula Quality
Vitamin B6 · 50 mgMagnesium · 13 mgTheanine · 100 mg

L-theanine at 100 mg supports calm attention, while rhodiola, ginkgo, holy basil, and B vitamins add stress-resilience and cognitive pathways. Rhodiola marker percentages and ginkgo standardization are incomplete, so the botanical potency is less certain than the label breadth suggests.

The blend is more suited to maintaining focus under stress than producing strong stimulation. Skullcap and GABA may feel calming enough to reduce alertness in some users, while ginkgo may interact with anticoagulant or antiplatelet medicines.

Study evidence
Ginkgo Supportive 28 studies
Rhodiola Supportive 15 studies
Theanine Supportive 19 studies

Ingredients

IngredientAmount per serving
Calories
20 Calorie(s)
Total Fat
1 Gram(s)
Total Carbohydrates
1 Gram(s)
Protein
1 Gram(s)
Thiamine (Thiamine Mononitrate)
 26 mg
Riboflavin
26 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 50 mg
Calcium (Calcium Citrate)
 19 mg
Magnesium (Magnesium Citrate)
 13 mg
Flaxseed Oil
1400 mg
Skullcap extract (Baicalein)
 200 mg
Holy Basil extract (Ursolic Acid)
 150 mg
GABA
60 mg
Gingko extract
100 mg
L-Theanine
100 mg
Rhodiola extract (Rosavins, Salidrosides)
 100 mg
BioPerine Complex
3 mg
Adults 18–50 Women
Report overview
Theanine · 100 mg OverallScore76
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
+1

The active L-isomer and an optimal dose are clearly disclosed. Generic sourcing leaves purity less certain than a branded form. Cost per standard theanine amount is high.

View ingredientView products
Thiamin (Thiamine Mononitrate) · 26 mg OverallScore65
B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value

Thiamine mononitrate supplies a moderate B1 dose within a broader stress-support blend. The active amount is stated clearly, but the softgel adds no documented absorption advantage for thiamine. Cost efficiency is low for the amount of B1 delivered.

View ingredientView products
Vitamin B6 (Pyridoxine Hydrochloride) · 50 mg OverallScore61
D Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Pyridoxine hydrochloride can supply B6, and included riboflavin may support conversion, but the form is less direct than P-5-P. The 50 mg serving falls within the preferred range. The supplied data omit the other-ingredients list, so additive purity cannot be checked. Its high serving cost is hard to justify for the B6 form supplied.

View ingredientView products
Loading alternative details
79 Performance

Cortisol Calm

Pure Encapsulations
<p>Standardized ashwagandha, rhodiola, magnolia, and theanine create a more focused stress formula without the original high vitamin B6 burden. Doses are mostly clear, although duplicate vitamin entries and missing inactive ingredients reduce label polish.</p>
72 Performance

Focus-R

LifeSeasons
<p>Theanine, methylcobalamin, caffeine, ginkgo, and several botanicals provide broad calm-focus support that closely matches the original goals. Kava can add sedation and liver concerns, ginkgo may increase bleeding risk, and caffeine may worsen anxiety or sleep.</p>
83 Performance

Pure Energy

Swanson
<p>Fully stated caffeine, rhodiola, and theanine amounts create a concise formula for energy and focused productivity. The stimulant emphasis can worsen anxiety or sleep, so it is less suitable when calm stress support is the main need.</p>
74 Budget

Totally Zen

Carlson
<p>Theanine, GABA, and broad B vitamins preserve a practical calm-focus direction at a much lower serving cost. Mixed magnesium forms and elevated vitamin B6 remain concerns, while rhodiola and ginkgo from the original are omitted.</p>
70 Budget

Kyolic GABA Vitamin B1 B6 & B12

Kyolic
<p>GABA, aged garlic, and B vitamins provide a cheaper calming and nutrient option. Vitamin forms are unspecified, pyridoxine is elevated, and aged garlic may add to bleeding risk with anticoagulant or antiplatelet medicines.</p>
77 Budget

B-Complex with C

Mason Natural
<p>Meaningful B vitamins and vitamin C provide inexpensive energy-metabolism support with clear amounts. The formula lacks the original theanine, rhodiola, holy basil, skullcap, and ginkgo, so its stress coverage is much narrower.</p>
74 Value

Totally Zen

Carlson
<p>Theanine, GABA, and B vitamins provide close calm-focus coverage with strong serving value. Vitamin B6 remains relatively high, magnesium uses mixed forms, and the original rhodiola and ginkgo are absent.</p>
64 Value

Menopause Comfort Support

Zoi Research
<p>Theanine, red clover, soy isoflavones, and black cohosh offer lower-cost calming support for a menopause-specific use case. Hidden blends, unstandardized botanicals, and elevated vitamin B6 make it less transparent and less broadly applicable than the original.</p>
77 Value

Nu-Thera Multivitamin with P5P

Kirkman
<p>Active riboflavin and B6, folinate, bisglycinate magnesium, and citrate minerals provide strong nutrient forms at favorable value. The formula lacks the original calming botanicals, while 50 mg of vitamin B6 remains too high for routine long-term use.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledMental Focus Brain Health Cognitive Support forTheanine
  2. Ginkgo biloba for cognitive impairment and dementia.
    Birks J; Grimley Evans J · The Cochrane database of systematic reviews · 2009
    Meta-analysis2,016 participants36 studies pooledMental Focus forGinkgo
  3. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce.
    Sarris J; Ravindran A; Yatham LN; Marx W; Rucklidge JJ; McIntyre RS; Akhondzadeh S; Benedetti F; Caneo C; Cramer H; Cribb L; de Manincor M; Dean O; Deslandes AC; Freeman MP; Gangadhar B; Harvey BH; Kasper S; Lake J; Lopresti A; Lu L; Metri NJ; Mischoulon D; Ng CH; Nishi D; Rahimi R; Seedat S; Sinclair J; Su KP; Zhang ZJ; Berk M · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2022
    Guideline / consensusStress Relief forRhodiola
  4. Comparative effects of Bacopa monnieri and Ginkgo biloba on cognitive functions: A systematic review and network meta-analysis.
    Tiemtad P; Ingkaninan K; Temkitthawon P; Thimkorn P; Rattanachaisit N; Teaktong T; Dhippayom T · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026
    Meta-analysis2,107 participants29 studies pooledMental Focus forGinkgo
  5. Dose-Response Effects of Short-Term Rhodiola rosea (Golden Root Extract) Supplementation on Anaerobic Exercise Performance and Cognitive Function in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study.
    Koozehchian MS; Newton AT; Mabrey G; Bonness FM; Rafajlovska R; Naderi A · Nutrients · 2025
    Randomized trial27 participantsMental Focus Brain Health forRhodiola
  6. Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes.
    Łuszczak J; Kocki J · Annals of agricultural and environmental medicine : AAEM · 2026
    Systematic review19 studies pooledStress Relief Cognitive Support forRhodiola
  7. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.
    Panossian A; Wikman G · Current clinical pharmacology · 2009
    Narrative reviewMental Focus Cognitive Support forRhodiola
  8. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsStress Relief Brain Health Cognitive Support Sleep Support forTheanine
  9. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  10. Promising, but Not Completely Conclusive-The Effect of l-Theanine on Cognitive Performance Based on the Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Trials.
    Mátyus RO; Szikora Z; Bodó D; Vargáné Szabó B; Csupor É; Csupor D; Tóth B · Journal of clinical medicine · 2025
    Meta-analysis148 participants5 studies pooledMental Focus forTheanine
  11. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsStress Relief Mood Support forTheanine Stress Relief forGABA
  12. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsStress Relief Sleep Support forTheanine
  13. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsMental Focus Productivity Boost forTheanine
  14. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses.
    Yoto A; Motoki M; Murao S; Yokogoshi H · Journal of physiological anthropology · 2013
    Randomized trial14 participantsStress Relief forTheanine
  15. Is Ginkgo biloba a cognitive enhancer in healthy individuals? A meta-analysis.
    Laws KR; Sweetnam H; Kondel TK · Human psychopharmacology · 2014
    Meta-analysis1,132 participants13 studies pooledMental Focus forGinkgo
  16. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.
    Spasov AA; Wikman GK; Mandrikov VB; Mironova IA; Neumoin VV · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2000
    Randomized trialMental Focus Productivity Boost forRhodiola
  17. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialStress Relief Brain Health forTheanine
  18. Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study.
    Furushima D; Sugiyama I; Nomura Y; Unno K; Yamada H · Journal of nutritional science and vitaminology · 2023
    Randomized trial120 participantsStress Relief forTheanine
  19. Ginkgo biloba Extract EGb 761 in the Treatment of Patients with Mild Neurocognitive Impairment: A Systematic Review.
    Hort J; Duning T; Hoerr R · Neuropsychiatric disease and treatment · 2023
    Systematic review946 participants9 studies pooledMental Focus forGinkgo
  20. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD).
    Bystritsky A; Kerwin L; Feusner JD · Journal of alternative and complementary medicine (New York, N.Y.) · 2008
    Single-arm trial10 participantsStress Relief forRhodiola
  21. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.
    Sarris J; McIntyre E; Camfield DA · CNS drugs · 2013
    Narrative reviewStress Relief forRhodiola
  22. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  23. L-theanine improves neurophysiological measures of attention in a dose-dependent manner: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2022
    Randomized trial27 participantsMental Focus forTheanine
  24. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsMental Focus Cognitive Support forTheanine
  25. Acute Rhodiola rosea intake can improve endurance exercise performance.
    De Bock K; Eijnde BO; Ramaekers M; Hespel P · International journal of sport nutrition and exercise metabolism · 2004
    Randomized trial24 participantsMental Focus forRhodiola
  26. Effects of Rhodiola rosea on Physical and Decision-Making Performance in Football Players: A Randomised Controlled Trial.
    Dou Y; Wang Y; Zhang W; Jiang Y; Zhang J; Yang T; Han Z; Li Y; Liu C; Ren D · Nutrients · 2026
    Randomized trial24 participantsMental Focus Energy forRhodiola
  27. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials.
    Hung SK; Perry R; Ernst E · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012
    Systematic review11 studies pooledMental Focus forRhodiola
  28. Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men.
    Jówko E; Sadowski J; Długołęcka B; Gierczuk D; Opaszowski B; Cieśliński I · Journal of sport and health science · 2022
    Randomized trial26 participantsMental Focus Productivity Boost forRhodiola
  29. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialMental Focus Brain Health Productivity Boost forTheanine
  30. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledStress Relief Mood Support forTheanine
  31. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.
    Panossian A; Wikman G; Sarris J · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2010
    Narrative reviewMental Focus Brain Health forRhodiola
  32. The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence.
    Ivanova Stojcheva E; Quintela JC · Molecules (Basel, Switzerland) · 2022
    Narrative reviewStress Relief Mental Focus Productivity Boost forRhodiola
  33. Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial.
    Lekomtseva Y; Zhukova I; Wacker A · Complementary medicine research · 2019
    Single-arm trial100 participantsStress Relief Energy forRhodiola
  34. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsStress Relief Mental Focus Productivity Boost forTheanine
  35. Stress management and the role of Rhodiola rosea: a review.
    Anghelescu IG; Edwards D; Seifritz E; Kasper S · International journal of psychiatry in clinical practice · 2019
    Narrative reviewStress Relief forRhodiola
  36. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsStress Relief Mood Support forTheanine
  37. The influence of adaptogens on ultraweak biophoton emission: a pilot-experiment.
    Schutgens FW; Neogi P; van Wijk EP; van Wijk R; Wikman G; Wiegant FA · Phytotherapy research : PTR · 2009
    Randomized trial30 participantsStress Relief forRhodiola
  38. [Effects of rhodiola rosea on oxidative stress and negative emotional states in patients with obstructive sleep apnea].
    Yu HL; Zhang PP; Zhang C; Zhang X; Li ZZ; Li WQ; Fu AS · Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2019
    Randomized trial90 participantsStress Relief forRhodiola
  39. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsMental Focus Cognitive Support forTheanine
  40. The effects of an acute dose of Rhodiola rosea on endurance exercise performance.
    Noreen EE; Buckley JG; Lewis SL; Brandauer J; Stuempfle KJ · Journal of strength and conditioning research · 2013
    Randomized trial18 participantsMental Focus forRhodiola
  41. Scientific Opinion on the substantiation of a health claim related to Rhodiola rosea L. extract and reduction of mental fatigue pursuant to Article 13(5) of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusStress Relief forRhodiola
  42. Modulation of cognitive performance following single doses of 120 mg Ginkgo biloba extract administered to healthy young volunteers.
    Kennedy DO; Jackson PA; Haskell CF; Scholey AB · Human psychopharmacology · 2008
    Randomized trial78 participantsMental Focus Productivity Boost forGinkgo
  43. Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng, and a ginkgo/ginseng combination to healthy young adults.
    Kennedy DO; Scholey AB; Wesnes KA · Physiology & behavior · 2002
    Randomized trial20 participantsMental Focus forGinkgo
  44. A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood.
    Dodd FL; Kennedy DO; Riby LM; Haskell-Ramsay CF · Psychopharmacology · 2016
    Randomized trial24 participantsMental Focus forTheanine
  45. Ginkgo biloba: no robust effect on cognitive abilities or mood in healthy young or older adults.
    Burns NR; Bryan J; Nettelbeck T · Human psychopharmacology · 2006
    Randomized trial197 participantsMental Focus forGinkgo
  46. Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia.
    Kanowski S; Herrmann WM; Stephan K; Wierich W; Hörr R · Pharmacopsychiatry · 1996
    Randomized trial216 participantsMental Focus forGinkgo
  47. Complementary medicines (herbal and nutritional products) in the treatment of Attention Deficit Hyperactivity Disorder (ADHD): a systematic review of the evidence.
    Sarris J; Kean J; Schweitzer I; Lake J · Complementary therapies in medicine · 2012
    Systematic review16 studies pooledMental Focus forGinkgo
  48. Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia.
    Kanowski S; Herrmann WM; Stephan K; Wierich W; Hörr R · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012
    Randomized trial216 participantsMental Focus forGinkgo
  49. Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis.
    Tan MS; Yu JT; Tan CC; Wang HF; Meng XF; Wang C; Jiang T; Zhu XC; Tan L · Journal of Alzheimer's disease : JAD · 2015
    Meta-analysis2,561 participants9 studies pooledBrain Health forGinkgo
  50. Efficacy of Ginkgo biloba extract EGb 761® in dementia with behavioural and psychological symptoms: A systematic review.
    von Gunten A; Schlaefke S; Überla K · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2017
    Meta-analysis1,628 participants4 studies pooledBrain Health Cognitive Support forGinkgo
  51. Ginkgo biloba extract EGb 761 is safe and effective in the treatment of mild dementia - a meta-analysis of patient subgroups in randomised controlled trials.
    Riepe M; Hoerr R; Schlaefke S · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2025
    Meta-analysis782 participants4 studies pooledBrain Health Productivity Boost forGinkgo
  52. Ginkgo biloba extract EGb 761® improves cognition and overall condition after ischemic stroke: Results from a pilot randomized trial.
    Cui M; You T; Zhao Y; Liu R; Guan Y; Liu J; Liu X; Wang X; Dong Q · Frontiers in pharmacology · 2023
    Randomized trial201 participantsBrain Health Productivity Boost forGinkgo
  53. Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg.
    Herrschaft H; Nacu A; Likhachev S; Sholomov I; Hoerr R; Schlaefke S · Journal of psychiatric research · 2012
    Randomized trial410 participantsBrain Health forGinkgo
  54. A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers.
    Boyle NB; Billington J; Lawton C; Quadt F; Dye L · Nutritional neuroscience · 2022
    Randomized trial100 participantsBrain Health forRhodiola
  55. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.
    Darbinyan V; Kteyan A; Panossian A; Gabrielian E; Wikman G; Wagner H · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2001
    Randomized trial56 participantsBrain Health Productivity Boost forRhodiola
  56. Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event-related potential dual task study.
    Koop T; Dienel A; Heldmann M; Münte TF · Phytotherapy research : PTR · 2021
    Single-arm trial50 participantsBrain Health Cognitive Support forRhodiola
  57. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  58. Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.
    Zhang C; Luo J; Yuan C; Ding D · Journal of Alzheimer's disease : JAD · 2021
    Meta-analysis21 studies pooledBrain Health forVitamin B6
  59. Relationship between serum pyridoxal 5'-phosphate concentration and cognitive function in older Japanese.
    Itoh K; Kuwabara A; Otsuka R; Sugimoto T; Sakurai T; Niida S; Ao M; Tanaka K; Takenaka S; Kanouchi H · Journal of clinical biochemistry and nutrition · 2025
    Cross-sectional study266 participantsBrain Health forVitamin B6
  60. A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women.
    Dhivya K; Sarumathy S; Manigandan G · Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Randomized trial180 participantsBrain Health forVitamin B6
  61. Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
    Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
    Cohort study949 participantsBrain Health forVitamin B6
  62. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review.
    Iolascon G; Gimigliano R; Bianco M; De Sire A; Moretti A; Giusti A; Malavolta N; Migliaccio S; Migliore A; Napoli N; Piscitelli P; Resmini G; Tarantino U; Gimigliano F · The journal of nutrition, health & aging · 2017
    Scoping review12 studies pooledBrain Health forVitamin B6
  63. Efficacy of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke: a predefined exploratory analysis of a multicenter, double-blind, randomized controlled trial.
    Tian X; Xu Q; Xia X; Zhang Y; Meng X; Wang A · Journal of neurology · 2024
    Randomized trial3,163 participantsCognitive Support forGinkgo
  64. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group.
    Le Bars PL; Katz MM; Berman N; Itil TM; Freedman AM; Schatzberg AF · JAMA · 1997
    Randomized trial309 participantsCognitive Support Productivity Boost forGinkgo
  65. Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761. Findings from a randomized controlled trial.
    Bachinskaya N; Hoerr R; Ihl R · Neuropsychiatric disease and treatment · 2011
    Randomized trial410 participantsCognitive Support forGinkgo
  66. Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: a randomized controlled trial.
    Ihl R; Bachinskaya N; Korczyn AD; Vakhapova V; Tribanek M; Hoerr R; Napryeyenko O; GOTADAY Study Group · International journal of geriatric psychiatry · 2013
    Randomized trial410 participantsCognitive Support forGinkgo
  67. Central additive effect of Ginkgo biloba and Rhodiola rosea on psychomotor vigilance task and short-term working memory accuracy.
    Al-Kuraishy HM · Journal of intercultural ethnopharmacology · 2016
    Clinical trial112 participantsCognitive Support forRhodiola
  68. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
    Olsson EM; von Schéele B; Panossian AG · Planta medica · 2009
    Randomized trial60 participantsCognitive Support Productivity Boost forRhodiola
  69. The Effect of Short-Term Rhodiola rosea Supplementation on Simulated Game Time, Perceived Fatigue, and Performance in Basketball Players.
    Wang J; Zhao H; Yu L; Zhao K; Jiang W; Liu S; Dai J; Xu L; Sun P; Yun H; Liu C · Nutrients · 2025
    Randomized trial48 participantsEnergy forRhodiola
  70. Combined Effects of Rhodiola Rosea and Caffeine Supplementation on Straight Punch Explosive Power in Untrained and Trained Boxing Volunteers: A Synergistic Approach.
    Tao B; Sun H; Li H; Xu Z; Xu Y; Chen L; Ma C; Zhang X; Yu L; Bao S; Liu C · Metabolites · 2025
    Randomized trial96 participantsEnergy forRhodiola
  71. Combined Rhodiola rosea and eccentric training boost endurance performance and lower-limb reactive strength in recreationally active women.
    Wang IL; Su Y; Zhang L; Tang M; Chen YM · Frontiers in physiology · 2025
    Randomized trial30 participantsEnergy forRhodiola
  72. Ginkgo biloba extract improved cognitive and neurological functions of acute ischaemic stroke: a randomised controlled trial.
    Li S; Zhang X; Fang Q; Zhou J; Zhang M; Wang H; Chen Y; Xu B; Wu Y; Qian L; Xu Y · Stroke and vascular neurology · 2021
    Randomized trial348 participantsMental Focus forGinkgo
  73. Ginkgo biloba in the Aging Process: A Narrative Review.
    Barbalho SM; Direito R; Laurindo LF; Marton LT; Guiguer EL; Goulart RA; Tofano RJ; Carvalho ACA; Flato UAP; Capelluppi Tofano VA; Detregiachi CRP; Bueno PCS; Girio RSJ; Araújo AC · Antioxidants (Basel, Switzerland) · 2024
    Narrative review14 studies pooledMental Focus forGinkgo
  74. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsMood Support Stress Relief forGABA
  75. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  76. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  77. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  78. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  79. Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.
    Urata M; Sakurai H; Ueno F; Maruki T; Tada T; Uchida T; Matsumoto Y; Murao M; Tomita M; Baba H; Kato M; Tsuboi T; Watanabe K · Neuropsychopharmacology reports · 2025
    Meta-analysis1,049 participants2 studies pooledMood Support forRhodiola
  80. The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate, Substrate Utilisation, Mood State, and Perceptions of Exertion, Arousal, and Pleasure/Displeasure in Active Men.
    Duncan MJ; Clarke ND · Journal of sports medicine (Hindawi Publishing Corporation) · 2015
    Clinical trial10 participantsMood Support forRhodiola
  81. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence.
    Sarris J; Panossian A; Schweitzer I; Stough C; Scholey A · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2012
    Systematic review66 studies pooledMood Support forRhodiola
  82. Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials.
    Moragrega I; Ríos JL · Planta medica · 2022
    Systematic reviewMood Support forRhodiola
  83. Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms.
    Kasper S; Dienel A · Neuropsychiatric disease and treatment · 2020
    Single-arm trial118 participantsMood Support forRhodiola
  84. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  85. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  86. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  87. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support Stress Relief forVitamin B6
  88. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  89. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  90. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  91. [Ginkgo biloba extract EGb 761 in the treatment of dementia: evidence of efficacy and tolerability].
    Kasper S; Schubert H · Fortschritte der Neurologie-Psychiatrie · 2009
    Meta-analysis10 studies pooledProductivity Boost forGinkgo
  92. Dietary Flavonoids and Human Cognition: A Meta-Analysis.
    Cheng N; Bell L; Lamport DJ; Williams CM · Molecular nutrition & food research · 2022
    Meta-analysis5,519 participants80 studies pooledProductivity Boost forGinkgo
  93. Limited cognitive benefits in Stage +2 postmenopausal women after 6 weeks of treatment with Ginkgo biloba.
    Elsabagh S; Hartley DE; File SE · Journal of psychopharmacology (Oxford, England) · 2005
    Randomized trial87 participantsProductivity Boost forGinkgo
  94. Efficacy and safety of Ginkgo biloba extract EGb 761 in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo-controlled, double-blind, multi-center trial.
    Gavrilova SI; Preuss UW; Wong JW; Hoerr R; Kaschel R; Bachinskaya N; GIMCIPlus Study Group · International journal of geriatric psychiatry · 2015
    Randomized trial160 participantsProductivity Boost forGinkgo
  95. Cross-sectional and longitudinal associations of magnesium intake and cognition in the Healthy Aging Longitudinal Study in Taiwan.
    Tao MH; Chuang SC; Wu IC; Chan HT; Cheng CW; Chen HL; Lee MM; Chang HY; Hsiung CA; Hsu CC · European journal of nutrition · 2024
    Cohort study5,663 participantsProductivity Boost forMagnesium
  96. Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients.
    Tu X; Qiu H; Lin S; He W; Huang G; Zhang X; Wu Y; He J · Neuropsychiatric disease and treatment · 2022
    Cohort study327 participantsProductivity Boost forMagnesium
  97. The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
    Lopresti AL; Smith SJ · Frontiers in nutrition · 2026
    Randomized trial100 participantsProductivity Boost forMagnesium
  98. Hypomagnesemia and Acute Cognitive Decline in Older Adults: An Evaluation of Clinical Practice and Cognitive Outcomes at a National Health Service (NHS) Trust in England.
    Lai XN; Sadhwani V; Ng WM; Gani A · Cureus · 2025
    Cohort study667 participantsProductivity Boost forMagnesium
  99. Magnesium Depletion Score as a Novel Predictor of Cognitive Impairment: A Population-Based Cross-Sectional Study From NHANES.
    Chen M; Xue R; Zhang M; Zhang J; Zheng J; Ye D; Sun J · Journal of the American Medical Directors Association · 2025
    Cross-sectional study2,768 participantsProductivity Boost forMagnesium
  100. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledProductivity Boost forTheanine
  101. Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
  102. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  103. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  104. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  105. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsSleep Support Stress Relief forGABA
  106. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  107. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  108. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  109. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  110. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  111. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  112. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  113. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine
  114. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  115. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  116. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  117. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  118. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  119. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  120. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  121. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  122. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  123. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  124. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  125. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium Stress Relief forVitamin B6
  126. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  127. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  128. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6
  129. Magnesium intake is inversely associated with risk of obesity in a 30-year prospective follow-up study among American young adults.
    Lu L; Chen C; Yang K; Zhu J; Xun P; Shikany JM; He K · European journal of nutrition · 2021
    Cohort study5,115 participantsWeight Loss forMagnesium
  130. Clinical and Metabolic Responses to Magnesium Supplementation in Women with Polycystic Ovary Syndrome.
    Farsinejad-Marj M; Azadbakht L; Mardanian F; Saneei P; Esmaillzadeh A · Biological trace element research · 2021
    Randomized trial60 participantsWeight Loss forMagnesium
  131. An inverse association between magnesium in 24-h urine and cardiovascular risk factors in middle-aged subjects in 50 CARDIAC Study populations.
    Yamori Y; Sagara M; Mizushima S; Liu L; Ikeda K; Nara Y; CARDIAC Study Group · Hypertension research : official journal of the Japanese Society of Hypertension · 2015
    Cross-sectional study4,211 participantsWeight Loss forMagnesium
  132. The effect of magnesium supplementation on anthropometric indices: a systematic review and dose-response meta-analysis of clinical trials.
    Rafiee M; Ghavami A; Rashidian A; Hadi A; Askari G · The British journal of nutrition · 2021
    Meta-analysis2,013 participants28 studies pooledWeight Loss forMagnesium
  133. The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials.
    Askari M; Mozaffari H; Jafari A; Ghanbari M; Darooghegi Mofrad M · Critical reviews in food science and nutrition · 2021
    Meta-analysis32 studies pooledWeight Loss forMagnesium