Product Image

Totally Zen

Carlson
4.7
★ ★ ★ ★ ★
(460 ratings)
Theanine 100 mg
Vitamin B6 25 mg
GABA 200 mg
Niacin 25 mg
Thiamin 10 mg
Riboflavin 10 mg
Product Image
Score74
A useful theanine-GABA pairing is backed by broad nutrient coverage and good practical value. Conventional forms and a high daily B6 amount keep it from a higher tier.
How scoring works
Quantity:120 Capsule(s) • (120 servings)
Goals:
Stress Relief
Energy
Cognitive Support
Brain Health
Mental Focus
Productivity Boost

Score 74

A useful theanine-GABA pairing is backed by broad nutrient coverage and good practical value. Conventional forms and a high daily B6 amount keep it from a higher tier.
How scoring works

Also available as

1 option
30 servings 1 Capsule(s) • 30 Capsule(s) • 30 servings $8.42 ($0.28 per serving)
$29.67($0.24 per serving)
iHerb
$ 29.67
Pure Formulas
$ 29.67
Report prices

Analysis

L-theanine and GABA provide a sensible combination for calm focus and evening relaxation. Their exact 100 mg and 200 mg amounts are easy to assess, though neither is especially substantial.

Vitamin C, B vitamins, and magnesium broaden the formula beyond simple stress support. Part of the magnesium comes from oxide, and cyanocobalamin plus pyridoxine are conventional forms rather than more active alternatives.

The long container life makes the formula practical for regular use, but the 25 mg vitamin B6 amount argues against casual indefinite dosing. It suits users who value broad nutritional coverage more than a tightly focused calming formula.

Who is it for
  • Adults seeking mild calm-focus support
  • Users who want calming ingredients with B vitamins
  • People looking for a long-supply capsule
Best for
  • Daytime stress support
  • Occasional evening relaxation
  • Broad nutrient coverage

Pros

  • Discloses every active amount
  • Pairs theanine with GABA
  • Includes both citrate and oxide magnesium
  • Long supply per container

Cons

  • Theanine amount is modest
  • Magnesium oxide has weaker absorption
  • Uses standard cyanocobalamin and pyridoxine
  • Broad formula is less focused for sleep

Warnings

  • Daily 25 mg vitamin B6 may increase the risk of tingling or numbness with prolonged use, especially alongside other B6 products.
  • Magnesium oxide can cause loose stools or abdominal discomfort in sensitive users.
  • Theanine and GABA may cause drowsiness in some users; assess response before driving or using sedating products.

Nutrient quality

66 High impact

Theanine, GABA, and magnesium align well with relaxation, although their amounts are moderate. Mixed magnesium quality and relatively high vitamin B6 reduce the formula balance.

Ingredient transparency

79 High impact

All listed actives have amounts and no proprietary blend obscures them. Daily directions and inactive ingredients are not available in the supplied details.

Customer satisfaction

70 High impact

The strong rating is supported by a substantial review base. Absent review text prevents assessment of repeated complaints or calming experiences.

Value for money

83 Highest impact

A low serving cost and a useful calming core support good value. Ordinary vitamin forms and modest magnesium keep the formula from standing out on quality.

Report analysis

Goals

Stress Relief
Stress Relief
Impact
High effect
B+ Goal FitB- Strength of SupportB CoverageB Formula Quality
Magnesium · 50 mgFolate · 333 mcg DFEVitamin B12 · 50 mcgGABA · 200 mgVitamin B6 · 25 mgVitamin C · 90 mgTheanine · 100 mg

L-theanine and GABA provide direct calming support, with magnesium and B vitamins adding foundational cofactors. The one-capsule formula covers more than one stress pathway without a stimulant.

Theanine is well dosed, while GABA is moderate and magnesium is low with mixed citrate and oxide forms. Daily vitamin B6 at 25 mg may be unsuitable for prolonged use because high supplemental intake can affect nerves.

Study evidence
GABA Supportive 6 studies
Magnesium Supportive 13 studies
Theanine Supportive 16 studies
Vitamin B6 Supportive 10 studies
Energy
Essential Energy Nutrients
Energy
Impact
High effect
B- Goal FitC+ Strength of SupportC CoverageA Formula Quality
Vitamin B5 · 10 mgMagnesium · 50 mgRiboflavin · 10 mgThiamin · 10 mgVitamin B12 · 50 mcg

B vitamins provide modest metabolic support, while L-theanine and GABA target calm rather than direct energy production. The formula may suit stress-related mental tension but is unlikely to increase stamina or acute alertness on its own.

The theanine amount is useful and all actives are individually disclosed. Cyanocobalamin, standard B-vitamin forms, and magnesium partly from oxide reduce form quality, while the substantial GABA amount may feel calming rather than energizing.

Study evidence
Magnesium Supportive 4 studies
Theanine Not classified

No linked studies yet.

Cognitive Support
Cognitive Support
Impact
High effect
B- Goal FitB- Strength of SupportB- CoverageB Formula Quality
Thiamin · 10 mgVitamin B6 · 25 mgFolate · 333 mcg DFEVitamin B12 · 50 mcgMagnesium · 50 mgTheanine · 100 mg

L-theanine, GABA, magnesium, and B vitamins support calm attention and neurotransmitter production. The formula is better suited to stress-related distraction than to memory, processing speed, or acute alertness.

The active amounts are disclosed, but theanine is generic and magnesium mixes citrate with poorly absorbed oxide. B vitamins broaden the formula, although many actives provide modest rather than high-potency cognitive support.

Study evidence
Magnesium Supportive 24 studies
Theanine Supportive 25 studies
Brain Health
Brain Health
Impact
High effect
C+ Goal FitB- Strength of SupportB- CoverageB- Formula Quality
Folate · 333 mcg DFEVitamin B12 · 50 mcgVitamin B6 · 25 mgThiamin · 10 mgMagnesium · 50 mg

L-theanine and GABA support calm attention, while B vitamins contribute to neurotransmitter and energy metabolism. Their brain-health role is supportive rather than a direct memory or neuroprotection strategy.

Theanine and GABA are meaningfully dosed, but magnesium is low and partly supplied as oxide. A long vitamin list broadens nutritional coverage while adding limited cognitive value beyond correcting insufficiency.

Study evidence
Magnesium Supportive 86 studies
Theanine Supportive 17 studies
Mental Focus
Mental Focus
Impact
High effect
C+ Goal FitC+ Strength of SupportC+ CoverageC Formula Quality
Folate · 333 mcg DFEVitamin B6 · 25 mgVitamin B12 · 50 mcgMagnesium · 50 mgTheanine · 100 mg

L-theanine, vitamin B6, magnesium, and GABA aim to support calm concentration and neurotransmitter function. The large B-vitamin panel is more general nutritional support than a targeted acute-focus strategy.

Theanine reaches the preferred starting amount, while magnesium is modest and partly supplied as oxide. Pyridoxine rather than P5P and numerous generic vitamins reduce form quality and focus.

Study evidence
Magnesium Supportive 6 studies
Theanine Supportive 19 studies
Vitamin B6 Disputed 6 studies
Productivity Boost
Productivity Boost
Impact
High effect
C+ Goal FitC+ Strength of SupportC+ CoverageC Formula Quality
Vitamin B12 · 50 mcgVitamin B12 · 50 mcgVitamin B6 · 25 mgMagnesium · 50 mgTheanine · 100 mg

L-theanine, vitamin B6, magnesium, and GABA aim to support calm concentration and neurotransmitter function. The large B-vitamin panel offers foundational energy support but lacks a direct alertness driver.

Theanine reaches the preferred starting amount, while magnesium is modest and partly supplied as oxide. Pyridoxine rather than P5P and numerous generic vitamins reduce form quality and focus.

Study evidence
Magnesium Supportive 10 studies
Theanine Supportive 5 studies
Vitamin B6 Disputed 6 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 90 mg
Thiamine (Thiamine Hydrochloride, Vitamin B1)
 10 mg
Riboflavin (Vitamin B2)
 10 mg
Niacin (Niacinamide)
 25 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 25 mg
Folate
333 mcg DFE
Vitamin B12 (Cyanocobalamin)
 50 mcg
Pantothenic Acid (D-Calcium Pantothenate)
 10 mg
Magnesium (Magnesium Citrate, Magnesium Oxide)
 50 mg
L-Theanine
100 mg
GABA
200 mg
Gluten Free Adults 18–50 Women
Report overview
Theanine · 100 mg OverallScore88
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

A clearly disclosed L-theanine dose sits at the start of the preferred range, though the source is generic rather than branded. One capsule combines it with GABA, magnesium, and B vitamins without hiding the active amount. Cost efficiency is competitive for the amount of theanine delivered.

View ingredientView products
Vitamin B6 (Pyridoxine Hydrochloride) · 25 mg OverallScore86
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Pyridoxine hydrochloride provides a well-placed B6 dose, with riboflavin available to support conversion. A single capsule keeps the serving simple, and the supplied data show no targeted additive concerns. The complex formula is economically efficient despite relying on a non-active B6 form.

View ingredientView products
GABA · 200 mg OverallScore79
B- Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyB- Value

The capsule provides a clearly disclosed maintenance-level amount of generic GABA with L-theanine and supporting nutrients. Standard capsule delivery and the absence of a premium fermented source keep ingredient quality conventional. The moderate serving cost is reasonable for the blend, although the GABA amount sits below the preferred standalone range.

View ingredientView products
Loading alternative details
76 Performance

Stress-Defy

Irwin Naturals
<p>L-theanine, GABA, holy basil, skullcap, and rhodiola give this option a broader stress and calm-focus profile than the original. Its high vitamin B6 amount and ginkgo-related bleeding concern make long-term use less straightforward.</p>
78 Performance

Vitamins Only

Solgar
<p>Broader vitamin coverage and antioxidant nutrients make this a more complete general-health formula than the original’s narrow calming blend. It lacks GABA and L-theanine, while the vitamin B6 amount remains high for routine long-term use.</p>
77 Performance

Vitamin B Complex

California Gold Nutrition
<p>Active riboflavin and vitamin B6 forms plus methylated folate improve B-vitamin form quality compared with the original. Duplicate label entries make total exposure unclear, and the formula does not provide the original’s GABA or L-theanine.</p>
80 Budget

Super Vitamin B-Complex

Spring Valley
<p>Broad B-vitamin coverage comes at much better value and uses a far lower vitamin B6 amount than the original. It does not replace the original’s GABA or L-theanine, and unspecified vitamin forms limit quality assessment.</p>
81 Budget

Super B-Complex

Nature Made
<p>A simple B-complex with vitamin C offers broad everyday nutrient coverage and a much longer supply for the cost. Its modest vitamin B6 amount is easier to justify than the original’s, but it lacks direct calming ingredients.</p>
80 Budget

B-Complex plus Vitamin C

21st Century
<p>Vitamin C and core B vitamins provide inexpensive energy-metabolism support with much less vitamin B6 than the original. Missing folate, vitamin B12, biotin, GABA, and L-theanine make it less complete for calming goals.</p>
78 Value

B-50 Complex

21st Century
<p>A broad, clearly dosed B-complex offers far more servings for the cost while covering the original’s main B-vitamin collections. Conventional forms and a high vitamin B6 amount limit its fit for unsupervised long-term use, and it omits calming amino acids.</p>
77 Value

B-50 Complex

Nature's Way
<p>Active riboflavin and broad B-vitamin coverage provide strong nutrient value compared with the original. The high pyridoxine amount is a long-term drawback, and there is no GABA or L-theanine.</p>
74 Value

B 50 Complex

Spring Valley
<p>Core B vitamins are supplied at very low serving cost, making this a practical value alternative for energy-metabolism support. Missing chemical forms and high vitamin B6 reduce confidence, and the formula gives up the original’s calming ingredients.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  5. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  6. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  7. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  8. Current Evidence on Common Dietary Supplements for Sleep Quality.
    Esquivel MK; Ghosn B · American journal of lifestyle medicine · 2025
    Narrative reviewSleep Support forTheanine
  9. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  10. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsStress Relief Sleep Support forGABA
  11. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief Mood Support forGABA
  12. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsStress Relief forGABA Mood Support Stress Relief forTheanine
  13. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsStress Relief Mood Support forTheanine
  14. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsStress Relief Sleep Support forTheanine
  15. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  16. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  17. A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood.
    Dodd FL; Kennedy DO; Riby LM; Haskell-Ramsay CF · Psychopharmacology · 2016
    Randomized trial24 participantsMental Focus forTheanine
  18. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsMental Focus Productivity Boost forTheanine
  19. Antenatal magnesium sulfate and neuroprotection.
    Doyle LW · Current opinion in pediatrics · 2012
    Meta-analysis6,145 participants5 studies pooledBrain Health forMagnesium
  20. No. 376-Magnesium Sulphate for Fetal Neuroprotection.
    Magee LA; De Silva DA; Sawchuck D; Synnes A; von Dadelszen P · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2020
    Guideline / consensus4,446 participantsBrain Health forMagnesium
  21. Magnesium Sulfate Before Preterm Birth for Neuroprotection: An Updated Cochrane Systematic Review.
    Shepherd ES; Goldsmith S; Doyle LW; Middleton P; Marret S; Rouse DJ; Pryde P; Wolf HT; Crowther CA · Obstetrics and gynecology · 2024
    Systematic review5,917 participants6 studies pooledBrain Health forMagnesium
  22. Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta-analysis and trial sequential analysis.
    Wolf HT; Huusom LD; Henriksen TB; Hegaard HK; Brok J; Pinborg A · BJOG : an international journal of obstetrics and gynaecology · 2020
    Meta-analysis5,917 participants6 studies pooledBrain Health forMagnesium
  23. Magnesium sulfate and fetal neuroprotection: overview of clinical evidence.
    Chollat C; Marret S · Neural regeneration research · 2020
    Narrative reviewBrain Health forMagnesium
  24. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  25. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  26. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support Mental Focus forTheanine
  27. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  28. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus Productivity Boost forTheanine
  29. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.
    Doyle LW; Crowther CA; Middleton P; Marret S; Rouse D · The Cochrane database of systematic reviews · 2009
    Meta-analysis6,145 participants5 studies pooledCognitive Support forMagnesium
  30. Effects of magnesium valproate adjuvant therapy on patients with dementia: A systematic review and meta-analysis.
    Zhang C; Sun L; Sun H · Medicine · 2022
    Meta-analysis1,899 participants22 studies pooledCognitive Support forMagnesium
  31. Effects of magnesium supplementation on serum brain-derived neurotrophic factor levels and cognitive function in patients undergoing fluoxetine therapy for depression.
    Noor NJ; Syamsuddin S; Liaury K; Tawali S; Idris I; Azis I; Lisal ST · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsCognitive Support forMagnesium
  32. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsCognitive Support Energy forMagnesium
  33. Could intraoperative magnesium sulphate protect against postoperative cognitive dysfunction?
    Hassan WF; Tawfik MH; Nabil TM; Abd Elkareem RM · Minerva anestesiologica · 2021
    Randomized trial80 participantsCognitive Support forMagnesium
  34. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  35. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support Mental Focus forTheanine
  36. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  37. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  38. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  39. Relationship between Whole-Blood Magnesium and Cognitive Performance among Chinese Adults.
    Lu Z; He R; Zhang Y; Li B; Li F; Fu Y; Rong S · Nutrients · 2023
    Cross-sectional study1,006 participantsMental Focus forMagnesium
  40. Serum Magnesium and Cognitive Function Among Qatari Adults.
    Al-Ghazali K; Eltayeb S; Musleh A; Al-Abdi T; Ganji V; Shi Z · Frontiers in aging neuroscience · 2020
    Cross-sectional study1,000 participantsMental Focus forMagnesium
  41. Magnesium status and attention deficit hyperactivity disorder (ADHD): A meta-analysis.
    Effatpanah M; Rezaei M; Effatpanah H; Effatpanah Z; Varkaneh HK; Mousavi SM; Fatahi S; Rinaldi G; Hashemi R · Psychiatry research · 2019
    Meta-analysisMental Focus forMagnesium
  42. The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial.
    Hemamy M; Pahlavani N; Amanollahi A; Islam SMS; McVicar J; Askari G; Malekahmadi M · BMC pediatrics · 2021
    Randomized trial33 participantsMental Focus forMagnesium
  43. The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
    Lopresti AL; Smith SJ · Frontiers in nutrition · 2026
    Randomized trial100 participantsMental Focus Productivity Boost forMagnesium
  44. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsMental Focus Productivity Boost Stress Relief forTheanine
  45. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort.
    Deijen JB; van der Beek EJ; Orlebeke JF; van den Berg H · Psychopharmacology · 1995
    Randomized trial76 participantsMental Focus forVitamin B6
  46. The effect of vitamin B6 on cognition.
    Malouf R; Grimley Evans J · The Cochrane database of systematic reviews · 2004
    Systematic review109 participants2 studies pooledMental Focus forVitamin B6
  47. Antiemetic use during pregnancy and child neurodevelopment: population-based birth cohort study.
    Cho Y; Choi EY; Han JY; Kim H; Choe YJ; Shin JY · BMC medicine · 2025
    Cohort study630,904 participantsMental Focus forVitamin B6
  48. A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial.
    Anlacan VM; Jamora RDG; Krattinger LF; De Longis E; Hartweg M; Steinmann M; Trovò L · Frontiers in nutrition · 2026
    Randomized trial44 participantsMental Focus Productivity Boost forVitamin B6
  49. B-Vitamin Therapy for Kidney Transplant Recipients Lowers Homocysteine and Improves Selective Cognitive Outcomes in the Randomized FAVORIT Ancillary Cognitive Trial
    Tammy M Scott, Graham Rogers, Daniel E Weiner, Kathryn Livingston, Jacob Selhub, Paul F Jacques, Irwin H Rosenberg, Aron M Troen · The Journal of Prevention of Alzheimer's Disease · 2017
    Randomized trial584 participantsMental Focus forVitamin B6
  50. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  51. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  52. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  53. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  54. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  55. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support Stress Relief forMagnesium
  56. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  57. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  58. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  59. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  60. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  61. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  62. Cross-sectional and longitudinal associations of magnesium intake and cognition in the Healthy Aging Longitudinal Study in Taiwan.
    Tao MH; Chuang SC; Wu IC; Chan HT; Cheng CW; Chen HL; Lee MM; Chang HY; Hsiung CA; Hsu CC · European journal of nutrition · 2024
    Cohort study5,663 participantsProductivity Boost forMagnesium
  63. Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients.
    Tu X; Qiu H; Lin S; He W; Huang G; Zhang X; Wu Y; He J · Neuropsychiatric disease and treatment · 2022
    Cohort study327 participantsProductivity Boost forMagnesium
  64. Hypomagnesemia and Acute Cognitive Decline in Older Adults: An Evaluation of Clinical Practice and Cognitive Outcomes at a National Health Service (NHS) Trust in England.
    Lai XN; Sadhwani V; Ng WM; Gani A · Cureus · 2025
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  65. Magnesium Depletion Score as a Novel Predictor of Cognitive Impairment: A Population-Based Cross-Sectional Study From NHANES.
    Chen M; Xue R; Zhang M; Zhang J; Zheng J; Ye D; Sun J · Journal of the American Medical Directors Association · 2025
    Cross-sectional study2,768 participantsProductivity Boost forMagnesium
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    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledProductivity Boost forTheanine
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    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
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    Xu H; Wang S; Gao F; Li C · Neuropsychiatric disease and treatment · 2022
    Cross-sectional study2,421 participantsProductivity Boost forVitamin B6
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    Coburn SP; Schaltenbrand WE; Mahuren JD; Clausman RJ; Townsend D · The American journal of clinical nutrition · 1983
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  70. Identifying Key Predictors of Cognitive Dysfunction in Older People Using Supervised Machine Learning Techniques: Observational Study.
    Rankin D; Black M; Flanagan B; Hughes CF; Moore A; Hoey L; Wallace J; Gill C; Carlin P; Molloy AM; Cunningham C; McNulty H · JMIR medical informatics · 2024
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  71. Inappropriate nutrients intake is associated with lower functional status and inferior quality of life in older adults with depression.
    Guligowska A; Pigłowska M; Fife E; Kostka J; Sołtysik BK; Kroc Ł; Kostka T · Clinical interventions in aging · 2017
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  72. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  73. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  74. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  75. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  76. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  77. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
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  78. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  79. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  80. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  81. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  82. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  83. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  84. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  85. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  86. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  87. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  88. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium Stress Relief forVitamin B6
  89. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsStress Relief forVitamin B6
  90. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  91. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  92. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6