Product Image

Spark

Eu Natural
4.2
★ ★ ★ ★ ★
(2056 ratings)
Folate 400 mcg
Iodine 150 mcg
Selenium 140 mcg
Zinc 22.5 mg
Thiamin 15 mg
Copper 0.5 mg
Vitamin D 4000 IU
Product Image
Score59
A strong thyroid-nutrient base with an opaque central blend. High iodine and vitamin D make clinician review especially important.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Immunity
General Health
Testosterone Support
Metabolism Boost
Hair Health
Detoxification
Energy
Cardiovascular Support

Score 59

A strong thyroid-nutrient base with an opaque central blend. High iodine and vitamin D make clinician review especially important.
How scoring works
$24.99($0.83 per serving)
iHerb
$ 31.99
Vitacost
$ 34.07
Pure Formulas
$ 29.99
Amazon
$ 24.99
Report prices

Analysis

The named nutrient core includes active folate and B12, magnesium malate, zinc, selenium, iodine, and chromium. Several forms are well chosen, but the amounts should be considered alongside thyroid status and medicines.

A 604 mg thyroid complex is not disclosed in the supplied data. Hidden botanical or glandular ingredients would materially change both suitability and safety.

Vitamin D reaches 4,000 IU and iodine totals 300 mcg from two sources. The formula requires full-label review and is not a general multivitamin for casual use.

Who is it for
  • Adults using thyroid support under professional guidance
  • Users able to review the full thyroid-complex label
  • People not stacking vitamin D or iodine
Best for
  • Targeted thyroid-nutrient planning
  • Active folate and B12 support
  • Use after medication review

Pros

  • Uses methylfolate and methylcobalamin
  • Provides selenium and zinc
  • Includes magnesium malate
  • Chelated trace minerals

Cons

  • Thyroid complex hides ingredients and doses
  • Iodine amount is substantial
  • Vitamin D reaches the adult upper limit
  • Not suited to casual stacking

Warnings

  • Iodine and undisclosed thyroid actives may complicate thyroid disease or thyroid hormone treatment
  • Do not stack the 4,000 IU vitamin D amount without reviewing total intake
  • Separate mineral-containing supplements from levothyroxine as directed
  • Chromium may influence glucose control with diabetes medicines

Nutrient quality

67 High impact

The disclosed nutrients are meaningful, but the thyroid complex cannot be assessed by component. Vitamin D at 4,000 IU reaches the adult upper intake level, while two iodine entries may produce a high total.

Ingredient transparency

49 Lower impact

Named nutrients have amounts, but the thyroid complex is disclosed only as a total. The proprietary thyroid complex hides its component ingredients and doses.

Customer satisfaction

66 High impact

The favorable rating is supported by a very large review base. No review text is available to assess recurring complaints or firsthand results.

Value for money

59 Moderate impact

Good nutrient forms partly justify the cost, but the hidden thyroid complex lowers assessable quality. Serving value is fair because a major part of each serving cannot be judged.

Report analysis

Goals

Immunity
Impact
Highest effect
A- Goal FitA- Strength of SupportB CoverageB- Formula Quality
Magnesium · 80 mgZinc · 22.5 mgVitamin D · 4000 IUSelenium · 140 mcg

Vitamin D3, zinc, selenium, copper, and several vitamins provide strong direct support for immune signaling, cell function, and antioxidant control. Zinc aspartate, L-selenomethionine, and chelated copper improve mineral quality.

The thyroid blend is hidden, so its added immune relevance cannot be assessed. The vitamin D amount reaches the usual adult daily upper intake level and should be considered alongside other supplemental sources.

Study evidence
Selenium Mixed 37 studies
Vitamin D Supportive 85 studies
Zinc Supportive 73 studies
General Health
Impact
Highest effect
B+ Goal FitA- Strength of SupportB+ CoverageB Formula Quality
Folate · 400 mcgVitamin B12 · 120 mcgVitamin D · 4000 IUMagnesium · 80 mgSelenium · 140 mcgZinc · 22.5 mg

Vitamin D3, L-methylfolate, methylcobalamin, magnesium malate, zinc, selenium, iodine, and copper provide broad support for metabolic and thyroid-related functions. Most important nutrients use favorable forms and meaningful amounts.

The thyroid-focused blend is not broken into individual doses, so its added contribution cannot be judged. The zinc-to-copper balance and total iodine exposure deserve attention when combining this with other supplements.

Study evidence
Folate Supportive 80 studies
Magnesium Supportive 114 studies
Selenium Supportive 70 studies
Vitamin B12 Adverse 66 studies
Vitamin D Supportive 115 studies
Zinc Supportive 60 studies
Testosterone Support
Impact
High effect
B- Goal FitA- Strength of SupportB CoverageB- Formula Quality
Magnesium · 80 mgZinc · 22.5 mgVitamin D · 4000 IU

Vitamin D3, zinc aspartate, magnesium malate, vitamin B6, and selenium provide a strong foundational endocrine profile. The formula covers steroidogenesis nutrients well but does not include boron, ashwagandha, fenugreek, or nettle.

Useful doses and organic mineral forms make the nutrient contribution easy to assess. The thyroid-focused additions broaden metabolic support without creating a direct cortisol or free-hormone pathway.

Study evidence
Magnesium Disputed 5 studies
Selenium No effect 16 studies
Vitamin D Supportive 56 studies
Zinc Disputed 7 studies
Metabolism Boost
Impact
High effect
C+ Goal FitB- Strength of SupportB- CoverageC+ Formula Quality
Niacin · 10 mgVitamin B12 · 120 mcgRiboflavin · 17 mgThiamin · 15 mgVitamin B5 · 10 mgVitamin B6 · 10 mgVitamin D · 4000 IUZinc · 22.5 mgMagnesium · 80 mg

Iodine, selenium, zinc, chromium, magnesium, and B vitamins form a credible thyroid-centered metabolic foundation. The formula does not include a direct thermogenic, and the thyroid complex is not individually disclosed.

Iodine, selenium, and zinc are useful, while chromium and magnesium remain modest. The high vitamin D amount leaves little room for additional vitamin D from other supplements.

Study evidence
Chromium Supportive 47 studies
Iodine Mixed 17 studies
Magnesium Supportive 61 studies
Selenium Mixed 28 studies
Vitamin D Supportive 65 studies
Zinc Supportive 12 studies
Hair Health
Impact
High effect
C+ Goal FitB- Strength of SupportC+ CoverageC Formula Quality
Vitamin D · 4000 IUZinc · 22.5 mg

Zinc, iodine, selenium, vitamin D3, methylfolate, and B12 provide broad support for follicle nutrition and thyroid function. The mineral amounts are generally substantial and may help when deficiency contributes to shedding.

A thyroid complex with undisclosed individual amounts makes the formula difficult to assess fully. The duplicate iodine forms and high selenium exposure also make label verification important for users taking other thyroid or selenium products.

Study evidence
Copper Adverse 4 studies
Folate Mixed 15 studies
Iodine No effect 1 study
Selenium Disputed 7 studies
Vitamin B12 Disputed 17 studies
Vitamin D Disputed 34 studies
Zinc Supportive 22 studies
Impact
High effect
B- Goal FitB Strength of SupportC CoverageC- Formula Quality
Folate · 400 mcgVitamin B12 · 120 mcgVitamin B6 · 10 mgSelenium · 140 mcgMagnesium · 80 mgZinc · 22.5 mgRiboflavin · 17 mg

L-selenomethionine, methylfolate, methylcobalamin, zinc, and riboflavin support antioxidant recycling and methylation. Selenium is the strongest detoxification-relevant component, while the thyroid-focused blend does not provide direct liver support.

The selenium amount is meaningful and the main nutrient forms are well identified. A proprietary thyroid blend and duplicate iodine sources add complexity without showing broader metabolic-clearance depth.

Study evidence
Folate Supportive 16 studies
Selenium Supportive 10 studies
Vitamin B12 Supportive 8 studies
Zinc Supportive 30 studies

Ingredients

IngredientAmount per serving
Vitamin D (Cholecalciferol)
4000 IU
Thiamine (Thiamine Hydrochloride)
15 mg
Riboflavin (Vitamin B2)
17 mg
Niacin (Niacinamide)
10 mg
Vitamin B6 (Pyridoxine Hydrochloride)
10 mg
Folate (L-Methylfolate)
400 mcg
Vitamin B12 (Methylcobalamin)
120 mcg
Pantothenic Acid (Calcium Pantothenate)
10 mg
Iodine (Kelp, Potassium Iodide)
150 mcg
Magnesium (Magnesium Malate)
80 mg
Zinc (Zinc Aspartate)
22.5 mg
Selenium (L-Selenomethionine)
140 mcg
Manganese (Manganese Bisglycinate)
1 mg
Copper (Copper Bisglycinate)
0.5 mg
Chromium (Chromium Polynicotinate)
120 mcg
Spark Thyroid Complex
604 mg
Gluten Free Adults 18–50
Report overview
A Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyD- Value

L-methylfolate is a body-ready active folate form that bypasses the MTHFR conversion step. The effective amount of 400 mcg DFE falls within the preferred general-support range. Vitamin B12 is included at 120 mcg, which provides appropriate masking-risk protection, while the serving cost is high for the folate quality and amount supplied.

B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC+ Value

Potassium iodide supports reliable absorption, but the accompanying generic kelp lacks a purity or origin claim. The 150 mcg amount is suitable for daily maintenance and is clearly disclosed in a convenient capsule. Value is moderate after accounting for the substantial selenium cofactor.

A+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value
+1

L-selenomethionine provides high form quality and precise disclosure. The 140 mcg amount fits effective maintenance use while retaining a comfortable safety margin. The wider thyroid-support formula may add utility, but selenium-specific value is limited.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Selenium and the course of mild Graves' orbitopathy.
    Marcocci C; Kahaly GJ; Krassas GE; Bartalena L; Prummel M; Stahl M; Altea MA; Nardi M; Pitz S; Boboridis K; Sivelli P; von Arx G; Mourits MP; Baldeschi L; Bencivelli W; Wiersinga W; European Group on Graves' Orbitopathy · The New England journal of medicine · 2011
    Randomized trial159 participantsAnti-Inflammatory Support forSelenium
  2. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial.
    Asemi Z; Jamilian M; Mesdaghinia E; Esmaillzadeh A · Nutrition (Burbank, Los Angeles County, Calif.) · 2016
    Randomized trial70 participantsAnti-Inflammatory Support Metabolism Boost forSelenium
  3. Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease.
    Farrokhian A; Bahmani F; Taghizadeh M; Mirhashemi SM; Aarabi MH; Raygan F; Aghadavod E; Asemi Z · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2017
    Randomized trial60 participantsAnti-Inflammatory Support forSelenium
  4. The effects of selenium supplementation on cardiovascular risk factors in patients with metabolic diseases ‒ A systematic review and meta-analysis of randomized controlled trials.
    Qiu W; Huang N; Zhang K; Qiu H; Guo Z; Han F; Sun X; Hou N; Kan C · Nutricion hospitalaria · 2026
    Meta-analysis656 participants11 studies pooledAnti-Inflammatory Support forSelenium
  5. Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Kamali A; Amirani E; Asemi Z · Biological trace element research · 2020
    Randomized trial33 participantsAnti-Inflammatory Support forSelenium
  6. Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study.
    Zhou A; Hyppönen E · International journal of epidemiology · 2023
    Observational study294,970 participantsAnti-Inflammatory Support forVitamin D
  7. Vitamin D in Children With Inflammatory Bowel Disease: A Randomized Controlled Clinical Trial.
    El Amrousy D; El Ashry H; Hodeib H; Hassan S · Journal of clinical gastroenterology · 2021
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  8. Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers.
    Gao YQ; Gao YH; Xing JH · World journal of diabetes · 2025
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  9. Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES.
    Yang F; Sun M; Sun C; Li J; Yang X; Bi C; Wang M; Pu L; Wang J; Wang C; Xie M; Yao Y; Jin L · Scientific reports · 2020
    Cross-sectional study9,809 participantsAnti-Inflammatory Support forVitamin D
  10. Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.
    Zhang C; Cui J; Li S; Shen J; Luo X; Yao Y; Shi H · BMC geriatrics · 2024
    Cohort study3,072 participantsAnti-Inflammatory Support forVitamin D
  11. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent.
    Bao B; Prasad AS; Beck FW; Fitzgerald JT; Snell D; Bao GW; Singh T; Cardozo LJ · The American journal of clinical nutrition · 2010
    Randomized trial40 participantsAnti-Inflammatory Support forZinc
  12. Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
    Nazari M; Nikbaf-Shandiz M; Pashayee-Khamene F; Bagheri R; Goudarzi K; Hosseinnia NV; Dolatshahi S; Omran HS; Amirani N; Ashtary-Larky D; Asbaghi O; Ghanavati M · Biological trace element research · 2024
    Meta-analysis23 studies pooledAnti-Inflammatory Support forZinc
  13. The Effects of Zinc Supplementation on C-Reactive Protein and Inflammatory Cytokines: A Meta-Analysis and Systematical Review.
    Ceylan MN; Akdas S; Yazihan N · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Meta-analysis73 studies pooledAnti-Inflammatory Support forZinc
  14. The Effects of Zinc Sulfate Supplementation on Serum Copeptin, C-Reactive Protein and Metabolic Markers in Zinc-Deficient Diabetic Patients on Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Hosseini R; Montazerifar F; Shahraki E; Karajibani M; Mokhtari AM; Dashipour AR; Ferns GA; Jalali M · Biological trace element research · 2021
    Randomized trial46 participantsAnti-Inflammatory Support forZinc
  15. Zinc supplementation and cardiovascular disease risk factors: A GRADE-assessed systematic review and dose-response meta-analysis.
    Nazari M; Ashtary-Larky D; Nikbaf-Shandiz M; Goudarzi K; Bagheri R; Dolatshahi S; Omran HS; Amirani N; Ghanavati M; Asbaghi O · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023
    Meta-analysis75 studies pooledAnti-Inflammatory Support forZinc
  16. The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.
    Ju Y; Xiong W; Pang Y; Chen Z; Hou J; Zheng S; Li Z; Liu T; Xia H; Xia M; Zhong Y; Li J; Jiang X · Biological trace element research · 2026
    Scoping review18 studies pooledBone Health forCopper
  17. Association between dietary copper, iron, zinc, selenium intake and osteopenia or osteoporosis in elderly hypertensive patients: a retrospective cohort study.
    Chen M; Jia L; Gao R · Frontiers in nutrition · 2024
    Cohort study5,286 participantsBone Health forCopper
  18. Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.
    Hu M; Wang Z; Li C; Zheng Y; Hu J · Medicine · 2025
    Cross-sectional studyBone Health forCopper
  19. The association between dietary mineral intake and bone mineral density: a cross-sectional study.
    Wei M; Wei J; Huang S · Journal of health, population, and nutrition · 2025
    Cross-sectional study11,520 participantsBone Health forCopper
  20. Association between dietary copper intake and bone mineral density in children and adolescents aged 8-19 years: A cross-sectional study.
    Cui A; Yan J; Li H; Fan Z; Wei X; Wang H; Zhuang Y · PloS one · 2024
    Cross-sectional study6,965 participantsBone Health forCopper
  21. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  22. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  23. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  24. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  25. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  26. Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES.
    Ling R; Ai Y; Chen C; Zhang J; Zou Z; Cheng S; Li C; Li X; Wang B · Metabolites · 2023
    Cross-sectional study2,640 participantsBone Health forManganese
  27. The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.
    Taskozhina G; Batyrova G; Umarova G; Issanguzhina Z; Kereyeva N · Journal of clinical medicine · 2024
    Narrative reviewBone Health forManganese
  28. Associations of multiple metals with bone mineral density: A population-based study in US adults.
    Wei MH; Cui Y; Zhou HL; Song WJ; Di DS; Zhang RY; Huang Q; Liu JA; Wang Q · Chemosphere · 2021
    Cross-sectional studyBone Health forManganese
  29. Sex-specific associations of urinary mixed-metal concentrations with femoral bone mineral density among older people: an NHANES (2017-2020) analysis.
    Li H; Li G; Yi M; Zhou J; Deng Y; Huang Y; He S; Meng X; Liu L · Frontiers in public health · 2024
    Cross-sectional study31 participantsBone Health forManganese
  30. Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
    Wang C; Zhu Y; Long H; Ou M; Zhao S · PloS one · 2022
    Cross-sectional study9,732 participantsBone Health forManganese
  31. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  32. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  33. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  34. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  35. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  36. Increased incidence of fractures in middle-aged and elderly men with low intakes of phosphorus and zinc.
    Elmståhl S; Gullberg B; Janzon L; Johnell O; Elmståhl B · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1999
    Cohort study6,576 participantsBone Health forZinc
  37. Zinc Supplementation Increases Procollagen Type 1 Amino-Terminal Propeptide in Premenarcheal Girls: A Randomized Controlled Trial.
    Berger PK; Pollock NK; Laing EM; Chertin V; Bernard PJ; Grider A; Shapses SA; Ding KH; Isales CM; Lewis RD · The Journal of nutrition · 2016
    Randomized trial147 participantsBone Health forZinc
  38. Randomized controlled trial of prenatal zinc supplementation and fetal bone growth.
    Merialdi M; Caulfield LE; Zavaleta N; Figueroa A; Costigan KA; Dominici F; Dipietro JA · The American journal of clinical nutrition · 2004
    Randomized trial242 participantsBone Health forZinc
  39. The effects of zinc supplementation on serum zinc, alkaline phosphatase activity and fracture healing of bones.
    Sadighi A; Roshan MM; Moradi A; Ostadrahimi A · Saudi medical journal · 2009
    Randomized trial60 participantsBone Health forZinc
  40. Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects.
    Ceylan MN; Akdas S; Yazihan N · Biological trace element research · 2021
    Meta-analysis40 studies pooledBone Health forZinc
  41. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  42. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  43. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  44. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  45. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  46. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  47. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  48. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  49. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium Cardiovascular Support Heart Health forVitamin D
  50. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  51. Effect of supplementation with high-selenium yeast on plasma lipids: a randomized trial.
    Rayman MP; Stranges S; Griffin BA; Pastor-Barriuso R; Guallar E · Annals of internal medicine · 2011
    Randomized trial501 participantsCardiovascular Support Heart Health forSelenium
  52. Association of selenium and cadmium with heart failure and mortality based on the National Health and Nutrition Examination Survey.
    Xing X; Xu M; Yang L; Shao C; Wang Y; Qi M; Niu X; Gao D · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2023
    Cohort study15,689 participantsCardiovascular Support forSelenium
  53. Higher serum selenium concentration is associated with lower risk of all-cause and cardiovascular mortality among individuals with chronic kidney disease: A population-based cohort study of NHANES.
    Zhu D; Zhong Q; Lin T; Song T · Frontiers in nutrition · 2023
    Cohort study3,063 participantsCardiovascular Support Heart Health forSelenium
  54. Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis.
    Kuria A; Tian H; Li M; Wang Y; Aaseth JO; Zang J; Cao Y · Critical reviews in food science and nutrition · 2021
    Meta-analysis13 studies pooledCardiovascular Support forSelenium
  55. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledCardiovascular Support General Health forSelenium
  56. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  57. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  58. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  59. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  60. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  61. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
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  62. Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
    Porto C; Petribu K; Barbosa N; Magalhães R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; Magalhães J; Sougey E; Silva T; Junio A; Bandeira F; Leão R · American heart journal plus : cardiology research and practice · 2025
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    Asgarshirazi M; Shariat M; Sheikh M · Hepatobiliary & pancreatic diseases international : HBPD INT · 2018
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  70. Supplementation with selenium can influence nausea, fatigue, physical, renal, and liver function of children and adolescents with cancer.
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  72. Comprehensive Insights into the Health Effects of Selenium Exposure and Supplementation Among the Chinese Community Middle-Aged and Elderly: a Combined Retrospective Cohort Study and Intervention Study.
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  73. Heavy metals and metalloids exposure and liver function in Chinese adults - A nationally representative cross-sectional study.
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  74. Selenium-Biofortified Strawberries Improve Glucose Homeostasis and Hepatic Function: A 30-Day Randomized Controlled Trial in Healthy Adults.
    Vasto S; Di Rosa L; Ferrantelli V; Fiore AS; Giordano CP; Cannizzaro A; Sabatino L; Macaluso A; Caldarella R; Caldara GF; Baldassano S · Nutrients · 2026
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  75. Antidotes for acute cyanide poisoning.
    Borron SW; Baud FJ · Current pharmaceutical biotechnology · 2013
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  76. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation.
    Borron SW; Baud FJ; Barriot P; Imbert M; Bismuth C · Annals of emergency medicine · 2007
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    Kadjo AF; Dasgupta PK; Boss GR · Analytical methods : advancing methods and applications · 2023
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  79. Investigating vitamin B12 levels in children with obesity: the role of metformin.
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  82. Effect of zinc on liver cirrhosis with hyperammonemia: a preliminary randomized, placebo-controlled double-blind trial.
    Katayama K; Saito M; Kawaguchi T; Endo R; Sawara K; Nishiguchi S; Kato A; Kohgo H; Suzuki K; Sakaida I; Ueno Y; Habu D; Ito T; Moriwaki H; Suzuki K · Nutrition (Burbank, Los Angeles County, Calif.) · 2015
    Randomized trial18 participantsDetoxification forZinc
  83. Effects of low dose zinc supplementation on biochemical markers in non-alcoholic cirrhosis: a randomized clinical trial.
    Somi MH; Rezaeifar P; Ostad Rahimi A; Moshrefi B · Archives of Iranian medicine · 2012
    Randomized trial60 participantsDetoxification forZinc
  84. Correlation of Serum Zinc Levels with Hepatic Encephalopathy Severity in Patients with Decompensated Liver Cirrhosis: A Prospective Observational Study from Egypt.
    Semeya AA; Elgamal R; Othman AAA · Biological trace element research · 2025
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  85. Association of radioactive iodine treatment with survivorship symptoms and primary care utilisation in women of reproductive age with thyroid cancer: a retrospective cohort study.
    Devanarayan P; Hartman M; Partin M · Family medicine and community health · 2026
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  89. Total magnesium intake and risk of frailty in older women.
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  91. Exercise, magnesium and immune function.
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    Narrative reviewEnergy forMagnesium
  92. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
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  93. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
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  94. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
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    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
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    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
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  99. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
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  100. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
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    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  102. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
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    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  104. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  105. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  106. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  107. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  108. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health forSelenium
  109. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
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  110. Updates on clinical studies of selenium supplementation in radiotherapy.
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    Systematic review16 studies pooledGeneral Health forSelenium
  111. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  112. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  113. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
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    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  115. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
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  117. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
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    Systematic review84 studies pooledGeneral Health forVitamin D
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    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
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    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
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    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
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    Randomized trial142 participantsGeneral Health forZinc
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    Yoganathan S; Sudhakar SV; Arunachal G; Thomas M; Subramanian A; George R; Danda S · Annals of Indian Academy of Neurology · 2022
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    In vitro / ex vivo studyHair Health forCopper
  129. Preserving fibre health: reducing oxidative stress throughout the life of the hair fibre.
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    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
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  131. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
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  132. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
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  134. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
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  135. [Evaluation of the role of dietary intake in the occurrence of alopecia].
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  136. Beyond Efficacy: 0.6% Selenium Disulfide Shampoo Matches 2% Ketoconazole for Seborrheic Dermatitis with Superior Cosmesis.
    Farris PK; Barbosa V; Houshman EB; Kovylkina N · Journal of drugs in dermatology : JDD · 2026
    Randomized trial87 participantsHair Health forSelenium
  137. Selenium Disulfide-based shampoo applied for 4 weeks significantly improves dandruff and seborrheic dermatitis.
    Turcu G; Artenie C; Nowicka D; Arenbergerová M; Lazaridou E; Khobzei K; Ataseven A; Part M; Leclerc-Mercier S · European journal of dermatology : EJD · 2023
    Observational study1,407 participantsHair Health forSelenium
  138. A Comparative Randomized Clinical Study Assessing the Efficacy of a 1% Selenium Disulfide-Based Shampoo versus 2% Ketoconazole Shampoo in Subjects with Moderate to Severe Scalp Seborrheic Dermatitis.
    Barbosa V; Melo DF; Vañó-Galván S; Lutchmanen-Kolanthan V; Sant'Anna B; Leclerc-Mercier S; Reygagne P · Skin appendage disorders · 2025
    Randomized trial64 participantsHair Health forSelenium
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    Jin W; Zheng H; Shan B; Wu Y · The Journal of dermatology · 2018
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    Systematic reviewHair Health forSelenium
  141. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  142. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  143. Hair Loss After Laparoscopic Sleeve Gastrectomy.
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  144. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  145. Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis.
    Lee S; Kim BJ; Lee CH; Lee WS · Journal of the European Academy of Dermatology and Venereology : JEADV · 2018
    Meta-analysis2,039 participants14 studies pooledHair Health forVitamin D
  146. Intralesional vitamin D3 in treatment of alopecia areata: A randomized controlled clinical trial.
    Rashad AF; Elgamal E; Fouda I · Journal of cosmetic dermatology · 2022
    Randomized trial60 participantsHair Health forVitamin D
  147. Vitamin D and its Analogs in Treatment of Mild to Moderate Alopecia Areata: Systematic Review and Meta-Analysis.
    Alsaati AA; Kaliyadan F; Alsaadoun D; Alzakry LM; Alzabadin RA; Hakami TH; Rubaian NFB · Indian dermatology online journal · 2025
    Meta-analysisHair Health forVitamin D
  148. Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial.
    El Taieb MA; Hegazy EM; Ibrahim HM; Osman AB; Abualhamd M · Archives of dermatological research · 2020
    Randomized trial60 participantsHair Health forVitamin D
  149. Serum 25 hydroxyvitamin D in non-scarring alopecia: A systematic review and meta-analysis.
    Chen Y; Dong X; Wang Y; Li Y; Xiong L; Li L · Journal of cosmetic dermatology · 2024
    Meta-analysis10,670 participants23 studies pooledHair Health forVitamin D
  150. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  151. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  152. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
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    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  154. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  155. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
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  156. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
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    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
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  158. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
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    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
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    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
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    Kou L; Meng F; Fu G; Zhang R · Cardiovascular toxicology · 2025
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    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  169. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
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    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
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    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
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    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
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    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  176. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
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  177. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
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    Martineau AR; Jolliffe DA; Greenberg L; Aloia JF; Bergman P; Dubnov-Raz G; Esposito S; Ganmaa D; Ginde AA; Goodall EC; Grant CC; Janssens W; Jensen ME; Kerley CP; Laaksi I; Manaseki-Holland S; Mauger D; Murdoch DR; Neale R; Rees JR; Simpson S; Stelmach I; Trilok Kumar G; Urashima M; Camargo CA; Griffiths CJ; Hooper RL · Health technology assessment (Winchester, England) · 2020
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  180. Vitamin D3 and deconvoluting a rash.
    Ernst MK; Evans ST; Techner JM; Rothbaum RM; Christensen LF; Onay UV; Biyashev D; Demczuk MM; Nguyen CV; Honda KS; McCormick TS; Tsoi LC; Gudjonsson JE; Cooper KD; Lu KQ · JCI insight · 2023
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    Bychinin MV; Klypa TV; Mandel IA; Yusubalieva GM; Baklaushev VP; Kolyshkina NA; Troitsky AV · Scientific reports · 2022
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    Anitua E; Tierno R; Alkhraisat MH · Clinical nutrition (Edinburgh, Scotland) · 2022
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    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
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    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
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    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
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    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
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  188. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes.
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    Randomized trial180 participantsMetabolism Boost forChromium
  189. Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Jamilian M; Asemi Z · Annals of nutrition & metabolism · 2016
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  190. A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review.
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    Hu X; Wang W; Su X; Peng H; Tan Z; Li Y; Huang Y · PeerJ · 2023
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    San Mauro-Martin I; Ruiz-León AM; Camina-Martín MA; Garicano-Vilar E; Collado-Yurrita L; Mateo-Silleras Bd; Redondo Del Río Mde P · Nutricion hospitalaria · 2017
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  194. Effect of oral iodized oil on thyroid size and thyroid hormone metabolism in children with concurrent selenium and iodine deficiency.
    Zimmermann MB; Adou P; Torresani T; Zeder C; Hurrell RF · European journal of clinical nutrition · 2000
    Single-arm trial51 participantsMetabolism Boost forIodine
  195. Serum Iodine Concentration as a Biomarker for Individual Iodine Nutrition and Thyroid Function in Pregnant Women: A Cross-Sectional Study in Hubei Province.
    Xu M; Dai X; Wang Z; Guo C; Zhang B; Guo H · Public health nutrition · 2026
    Cross-sectional study1,197 participantsMetabolism Boost forIodine
  196. Iron status influences the efficacy of iodine prophylaxis in goitrous children in Côte d'Ivoire.
    Zimmermann MB · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2002
    OtherMetabolism Boost forIodine
  197. Persistence of goiter despite oral iodine supplementation in goitrous children with iron deficiency anemia in Côte d'Ivoire.
    Zimmermann M; Adou P; Torresani T; Zeder C; Hurrell R · The American journal of clinical nutrition · 2000
    Non-randomized trial109 participantsMetabolism Boost forIodine
  198. Association of magnesium consumption with type 2 diabetes and glucose metabolism: A systematic review and pooled study with trial sequential analysis.
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    Tan X; Huang Y · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2022
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  200. Impact of oral magnesium supplementation on glycemic and cardiometabolic outcomes in prediabetic adults: a systematic review and meta-analysis.
    Basit A; Kumar S; Ahmed H; Babar R; Saeed SS; Siddiqui TA; Khan S; Saeed A; Khan M; Hanif H; Fasih A; Shabbir S; Kumar H; Kumar L; Raja A; Kumar S; Chander S · Journal of diabetes and metabolic disorders · 2026
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  201. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial.
    Rodríguez-Morán M; Guerrero-Romero F · Diabetes care · 2003
    Randomized trial63 participantsMetabolism Boost forMagnesium
  202. Magnesium Supplementation and the Effects on Wound Healing and Metabolic Status in Patients with Diabetic Foot Ulcer: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Razzaghi R; Pidar F; Momen-Heravi M; Bahmani F; Akbari H; Asemi Z · Biological trace element research · 2018
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  203. Metabolic response to selenium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.
    Jamilian M; Razavi M; Fakhrie Kashan Z; Ghandi Y; Bagherian T; Asemi Z · Clinical endocrinology · 2016
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  204. The Effects of Selenium Supplementation on Gene Expression Related to Insulin and Lipid Metabolism, and Pregnancy Outcomes in Patients with Gestational Diabetes Mellitus: a Randomized, Double-Blind, Placebo-Controlled Trial.
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  205. Glycemic and lipid responses to selenium-enriched vs. zeaxanthin-enriched eggs in patients with type 2 diabetes: a 12-week randomized controlled trial.
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    Duan Y; Zhang S; Ma X; Li L; Jia K · African journal of reproductive health · 2026
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    Mitri J; Dawson-Hughes B; Hu FB; Pittas AG · The American journal of clinical nutrition · 2011
    Randomized trial92 participantsMetabolism Boost forVitamin D
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    Suka M; Tsuruta H; Takao T; Yanagisawa H · Diabetology international · 2026
    Cross-sectional study533 participantsMetabolism Boost forZinc
  213. Zinc and the Innovative Zinc-α2-Glycoprotein Adipokine Play an Important Role in Lipid Metabolism: A Critical Review.
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    Narrative reviewMetabolism Boost forZinc
  214. Capsaicin and Zinc Signalling Pathways as Promising Targets for Managing Insulin Resistance and Type 2 Diabetes.
    Ferdowsi PV; Ahuja KDK; Beckett JM; Myers S · Molecules (Basel, Switzerland) · 2023
    Narrative reviewMetabolism Boost forZinc
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    Ahmad R; Shaju R; Atfi A; Razzaque MS · Cells · 2024
    Narrative reviewMetabolism Boost forZinc
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    Borges-Vieira JG; Cardoso CKS · Nutritional neuroscience · 2023
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    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
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    Edney LC; Burns NR; Danthiir V · The British journal of nutrition · 2016
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    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
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    Bahmani F; Karamali M; Shakeri H; Asemi Z · Clinical endocrinology · 2015
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    Taylor MJ; Carney SM; Goodwin GM; Geddes JR · Journal of psychopharmacology (Oxford, England) · 2004
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  233. Depressive symptoms and associated factors among women preparing for pregnancy: a population-based study from the Seoul metropolitan preconception health management program.
    Lee HJ; Shin W; Han JY; Choi HZ; Kang J; Woo SY · BMC women's health · 2026
    Cross-sectional study14,004 participantsStress Relief forFolate
  234. Folate administration decreases oxidative status and blood pressure in postmenopausal women.
    Cagnacci A; Cannoletta M; Xholli A; Piacenti I; Palma F; Palmieri B · European journal of nutrition · 2016
    Randomized trial30 participantsStress Relief forFolate
  235. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
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  236. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  237. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
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    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
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    Siddiqua TJ; Akhtar E; Haq MA; Shahab-Ferdows S; Hampel D; Islam S; Ahmed T; Allen LH; Raqib R · BMC nutrition · 2024
    Randomized trial68 participantsStress Relief forVitamin B12
  240. Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study.
    Bjelland I; Tell GS; Vollset SE; Refsum H; Ueland PM · Archives of general psychiatry · 2003
    Cross-sectional study5,948 participantsStress Relief forVitamin B12
  241. Vitamin B12 deficiency and neuropsychiatric symptoms in Lebanon: A cross-sectional study of vegans, vegetarians, and omnivores.
    Al Jassem O; Kheir K; Ismail A; Abou-Abbas L; Masri A; Haddad C; Nasrallah K; El Masry J · PloS one · 2024
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  242. A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and 'At-Risk' Individuals
    Lauren M. Young, Andrew Pipingas, David J. White, Sarah Gauci, Andrew Scholey · Nutrients · 2019
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    Stephen J. Long, David Benton · Psychosomatic Medicine · 2013
    Meta-analysis8 studies pooledStress Relief forVitamin B12
  244. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  245. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  246. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  247. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  248. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium
  249. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study.
    Safarinejad MR; Safarinejad S · The Journal of urology · 2009
    Randomized trial468 participantsTestosterone Support forSelenium
  250. The association between metal exposure and semen quality in Chinese males: The mediating effect of androgens.
    Liu P; Yuan G; Zhou Q; Liu Y; He X; Zhang H; Guo Y; Wen Y; Huang S; Ke Y; Chen J · Environmental pollution (Barking, Essex : 1987) · 2020
    Cross-sectional study1,136 participantsTestosterone Support forSelenium
  251. In utero and peripubertal metals exposure in relation to reproductive hormones and sexual maturation and progression among girls in Mexico City.
    Ashrap P; Sánchez BN; Téllez-Rojo MM; Basu N; Tamayo-Ortiz M; Peterson KE; Meeker JD; Watkins DJ · Environmental research · 2019
    Observational study132 participantsTestosterone Support forSelenium
  252. Relationship between serum levels of testosterone, zinc and selenium in infertile males attending fertility clinic in Nnewi, south east Nigeria.
    Oluboyo AO; Adijeh RU; Onyenekwe CC; Oluboyo BO; Mbaeri TC; Odiegwu CN; Chukwuma GO; Onwuasoanya UF · African journal of medicine and medical sciences · 2013
    Observational studyTestosterone Support forSelenium
  253. EVALUATION OF MALE SEX HORMONES AND TRACE ELEMENTS IN MALE TYPE 2 DIABETIC PATIENTS ATTENDING NNAMDI AZIKIWE UNIVERSITY TEACHING HOSPITAL DIABETIC CLINICS.
    Ubajaka CF; Meludu SC; Dioka CE; Onah CE; Osuji CU; Modebe IA; Ifeadike GC; Okwara JE; Amah UK; Nnebue CC · Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria · 2015
    Cross-sectional studyTestosterone Support forSelenium
  254. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
    Jamilian M; Foroozanfard F; Rahmani E; Talebi M; Bahmani F; Asemi Z · Nutrients · 2018
    Randomized trial90 participantsTestosterone Support forVitamin D
  255. Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial.
    Al-Bayyari N; Al-Domi H; Zayed F; Hailat R; Eaton A · Clinical nutrition (Edinburgh, Scotland) · 2021
    Randomized trial60 participantsTestosterone Support forVitamin D
  256. Association between plasma 25-OH vitamin D and testosterone levels in men.
    Nimptsch K; Platz EA; Willett WC; Giovannucci E · Clinical endocrinology · 2012
    Case-control study1,362 participantsTestosterone Support forVitamin D
  257. Causal Link Between Vitamin D and Total Testosterone in Men: A Mendelian Randomization Analysis.
    Chen C; Zhai H; Cheng J; Weng P; Chen Y; Li Q; Wang C; Xia F; Wang N; Lu Y · The Journal of clinical endocrinology and metabolism · 2020
    Other4,254 participantsTestosterone Support forVitamin D
  258. Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men.
    Rafiq R; van Schoor NM; Sohl E; Zillikens MC; Oosterwerff MM; Schaap L; Lips P; de Jongh RT · The Journal of steroid biochemistry and molecular biology · 2017
    Cohort study643 participantsTestosterone Support forVitamin D
  259. Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.
    Meeker JD; Rossano MG; Protas B; Padmanahban V; Diamond MP; Puscheck E; Daly D; Paneth N; Wirth JJ · Fertility and sterility · 2010
    Cross-sectional study219 participantsTestosterone Support forZinc
  260. Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review.
    Santos HO; Cadegiani FA; Forbes SC · Clinical therapeutics · 2022
    Scoping reviewTestosterone Support forZinc
  261. Zinc is an Essential Element for Male Fertility: A Review of Zn Roles in Men's Health, Germination, Sperm Quality, and Fertilization.
    Fallah A; Mohammad-Hasani A; Colagar AH · Journal of reproduction & infertility · 2020
    Narrative reviewTestosterone Support forZinc
  262. Clinical, endocrinological and biochemical effects of zinc deficiency.
    Prasad AS · Clinics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc
  263. Clinical, endocrinologic, and biochemical effects of zinc deficiency.
    Prasad AS · Special topics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc