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MK-7 Vitamin K-2 Extra Strength - 300 mcg

NOW
4.8
★ ★ ★ ★ ★
(7786 ratings)
Vitamin K 300 mcg
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Score84
A concentrated 300 mcg MK-7 capsule provides strong single-nutrient depth, but its dose is more aggressive than routine maintenance requires.
How scoring works
Quantity:60 Capsule(s) • (60 servings)
Goals:
Bone Health
Heart Health
Anti-Aging
Cardiovascular Support
General Health

Score 84

A concentrated 300 mcg MK-7 capsule provides strong single-nutrient depth, but its dose is more aggressive than routine maintenance requires.
How scoring works

Also available as

2 options
100 mcg • 60 Capsule(s) servings K 100 mcg • 60 Capsule(s) • 60 servings $7.00 ($0.11 per serving) 100 mcg • 120 Capsule(s) servings K 100 mcg • 120 Capsule(s) • 120 servings $19.93 ($0.16 per serving)
$20.30($0.33 per serving)
Vitacost
$ 21.97
Pure Formulas
$ 21.16
Daily Vita
$ 20.30
iHerb
$ 21.42
iHerb
$ 21.42
Report prices

Analysis

A 300 mcg serving delivers a high amount of long-acting menaquinone-7. It offers strong depth for calcium-handling pathways but is not necessary for many people seeking ordinary maintenance.

The formula is simple and the active amount is easy to assess. A dry capsule and lack of branded or all-trans source verification are the main formulation weaknesses.

It best suits someone deliberately looking for high-strength MK-7 rather than a first-time K2 user. A lower-dose product offers more flexibility for modest daily intake.

Who is it for
  • Adults specifically seeking high-strength MK-7
  • Experienced K2 users with an established dosing plan
  • People who cover complementary nutrients separately
Best for
  • Concentrated vitamin K2 intake
  • High-dose MK-7 plans
  • Focused calcium-handling support

Pros

  • Provides 300 mcg of MK-7
  • Clearly identifies the active form
  • Simple single-ingredient design
  • Good value for the supplied amount

Cons

  • Dose is high for ordinary maintenance
  • Dry-capsule delivery gives no built-in fat source for this fat-soluble nutrient
  • The supplied label does not identify a branded or verified all-trans MK-7 source
  • No vitamin D3 or structural minerals

Warnings

  • Vitamin K can counteract warfarin and other vitamin K antagonist anticoagulants; use requires prescriber-guided consistency.
  • The 300 mcg amount is a high-strength serving, so increasing intake further is unlikely to be appropriate without a clear reason.
  • Fat-malabsorption conditions can make vitamin K uptake unreliable, so response may need clinical monitoring.

Nutrient quality

88 Highest impact

A well-regarded form and clearly sufficient amount provide a focused formula. The unusually high dose is unnecessary for many routine users.

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Ingredient transparency

84 Highest impact

The active form and amount are exceptionally clear with no hidden blend. Missing intake directions and capsule excipients are the only notable gaps.

.

Customer satisfaction

73 High impact

Aggregate satisfaction is very strong and supported by an extensive evidence base. No firsthand experience details are supplied, so recurring complaints and purpose alignment cannot be checked.

.

Value for money

89 Highest impact

Useful forms and a sound serving position support good value. The package remains competitive in its category.

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Report analysis

Goals

Bone Health
Bone Health
Impact
Highest effect
A- Goal FitA+ Strength of SupportC+ CoverageA+ Formula Quality
Vitamin K · 300 mcg

MK-7 directly supports osteocalcin activation and calcium incorporation into bone. The 300 mcg amount is clearly disclosed and substantial for targeted K2 use.

The focused design does not provide calcium, magnesium, vitamin D, or a protein-matrix ingredient. Vitamin K2 can oppose warfarin and other vitamin K antagonists, so people using those medicines should not add it without prescriber guidance.

Study evidence
Vitamin K Supportive 78 studies
Heart Health
Heart Health
Impact
Highest effect
A Goal FitA+ Strength of SupportC- CoverageA Formula Quality
Vitamin K · 300 mcg

MK-7 directly supports activation of proteins involved in keeping calcium in bone and away from arteries. The substantial amount and clearly identified form create a focused vascular-health formula.

The product does not address lipids, blood pressure, or cardiac energy, but its chosen pathway has strong depth. Vitamin K2 can counteract warfarin and other vitamin K antagonists, so those medicines require prescriber-guided intake.

Study evidence
Vitamin K Mixed 62 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
B+ Goal FitA+ Strength of SupportC+ CoverageA+ Formula Quality
Vitamin K · 300 mcg

A high amount of MK-7 supports calcium regulation relevant to vascular and skeletal aging. The active forms and amounts are clearly stated.

The formula addresses a specific healthy-aging pathway rather than broad biological aging. Vitamin K can oppose warfarin and other vitamin K antagonists, so people using those medicines should not add it without prescriber guidance.

Study evidence
Vitamin K Supportive 27 studies
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
B- Goal FitA+ Strength of SupportC- CoverageA+ Formula Quality
Vitamin K · 300 mcg

MK-7 vitamin K2 supports activation of proteins involved in directing calcium away from arteries and toward bone. Evidence for improving clinical cardiovascular outcomes remains less established than its mechanism.

The form is clearly identified and the amount is substantial for MK-7. Vitamin K2 can oppose warfarin and related vitamin K antagonist anticoagulants, so the dose should not be changed without coordinated monitoring.

Study evidence
Vitamin K Supportive 40 studies
General Health
General Health
Impact
Highest effect
B+ Goal FitA- Strength of SupportC- CoverageA+ Formula Quality
Vitamin K · 300 mcg

Menaquinone-7 provides a bioactive vitamin K2 form that supports calcium handling and bone-related proteins. The clearly stated amount gives strong depth for this single nutrient.

The narrow formula does not cover broad daily wellness pathways. Vitamin K2 can interfere with warfarin-type anticoagulants, so users of those medicines need consistent intake and prescriber guidance.

Study evidence
Vitamin K Supportive 34 studies

Ingredients

IngredientAmount per serving
Vitamin K2 (Menaquinone-7)
 300 mcg
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
Vitamin K (Menaquinone-7) · 300 mcg OverallScore78
C+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyA+ Value

A 300 mcg MK-7 serving provides a high amount in a focused formula. The subtype is clear, but generic sourcing and dry-capsule delivery reduce quality. People using warfarin or another vitamin-K-antagonist anticoagulant need clinician guidance because this dose can oppose treatment.

View ingredientView products
Loading alternative details
86 Performance

Vitamin K2 MK-7 (Menaquinone-7) 90 mcg

Carlson
Compared with 300 mcg of MK-7 vitamin K2, the alternative provides 90 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger alignment with the Vitamin K collection. Its focused formula offers solid routine value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
87 Performance

Vitamin K2 as MK-7 100 mcg

Healthy Origins
Compared with 300 mcg of MK-7 vitamin K2, the alternative provides 100 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger alignment with the Vitamin K collection. Vitamin K2 can reduce the effect of warfarin-type anticoagulants.
87 Performance

Vitamin K2 100 mcg

SR Sports Research
Compared with 300 mcg of MK-7 vitamin K2, the alternative provides 100 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger alignment with the Vitamin K collection. Vitamin K2 can reduce the effect of warfarin-type anticoagulants, so intake changes require prescriber guidance.
88 Budget

Vitamin K2 MK-7 100 mcg

Nutricost
The supplied serving cost is lower, while the formula provides 100 mcg of MK-7 vitamin K2. Vitamin K2 can interfere with warfarin-type anticoagulants.
89 Budget

Mega D-3 5000 IU & MK-7 180 mcg

NOW
The supplied serving cost is lower, while the formula provides 125 mcg of vitamin D3 with 180 mcg of MK-7 vitamin K2. High vitamin D remains the main dosing limitation, while the dry capsule lacks stated fat-intake guidance.
85 Budget

Vitamin K2 MenaQ7 100 mcg

AN Amazing Nutrition Amazing Formulas
The supplied serving cost is lower, while the formula provides vitamin k2. Its vitamin K can counteract warfarin and related vitamin K antagonists, so people using those medicines need clinician-directed intake.
87 Value

MK-7 Vitamin K-2 100 mcg

NOW
100 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Its long supply supports strong value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
87 Value

Low Dose Vitamin K2 (MK-7) 45 mcg

Life Extension
45 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Its focused formula offers good routine value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
86 Value

Vitamin K2 MK-7 (Menaquinone-7) 90 mcg

Carlson
90 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Its focused formula offers solid routine value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  2. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  3. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  4. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  5. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  6. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  7. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  8. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  9. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  10. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  11. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  12. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  13. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  14. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  15. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  16. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  17. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  18. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  19. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  20. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  21. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K