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K2-7 + D3

4.7
★ ★ ★ ★ ★
(131 ratings)
Vitamin K 150 mcg
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Score82
A substantial D3 and MK-7 pairing gives focused support for calcium use, but the dry capsule and narrow nutrient coverage are meaningful trade-offs.
How scoring works
Capsule
Quantity:60 Capsule(s) • (60 servings)
Goals:
Bone Health
Anti-Aging
Heart Health
General Health
Cardiovascular Support

Score 82

A substantial D3 and MK-7 pairing gives focused support for calcium use, but the dry capsule and narrow nutrient coverage are meaningful trade-offs.
How scoring works
$33.99($0.56 per serving)
iHerb
$ 33.99
Pure Formulas
$ 33.99
Report prices

Analysis

Vitamin D3 at 50 mcg supports calcium absorption, while 150 mcg of MK-7 supports vitamin-K-dependent proteins involved in calcium placement. The combination is particularly relevant to bone and vascular support.

Both active forms and amounts are easy to assess, and the formula avoids unrelated additions. The supplied information does not identify a branded MK-7 source or an oil carrier.

People seeking a focused D3 and K2 pair may find it practical. Calcium, magnesium, and structural bone nutrients still need to come from food or other products.

Who is it for
  • Adults seeking combined vitamin D3 and K2
  • People focused on bone-mineral support
  • Users who already obtain calcium and magnesium elsewhere
Best for
  • Daily calcium-handling support
  • A clearly disclosed D3 and MK-7 combination
  • Bone and vascular nutrient support

Pros

  • Provides 150 mcg of long-acting MK-7
  • Pairs K2 with 50 mcg of vitamin D3
  • Clearly states both active amounts
  • Keeps the formula focused

Cons

  • Dry-capsule delivery gives no built-in fat source for this fat-soluble nutrient
  • The supplied label does not identify a branded or verified all-trans MK-7 source
  • Does not provide calcium or magnesium
  • Covers calcium handling but not the wider range of bone or cardiovascular pathways

Warnings

  • Vitamin K can counteract warfarin and other vitamin K antagonist anticoagulants; use requires prescriber-guided consistency.
  • The 50 mcg vitamin D3 amount should be counted with food, multivitamins, and other D supplements.
  • Fat-malabsorption conditions can make vitamin K uptake unreliable, so response may need clinical monitoring.

Nutrient quality

92 Highest impact

Well-regarded forms and meaningful doses create a focused combination. The formula is balanced and avoids unrelated active ingredients.

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Ingredient transparency

82 Highest impact

The active forms and amounts are clear with no proprietary blend. Missing intake directions and capsule excipients are the main disclosure gaps.

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Customer satisfaction

65 High impact

Aggregate satisfaction is strong and based on a limited evidence base. No firsthand experience details are supplied, so recurring complaints and purpose alignment cannot be checked.

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Value for money

83 Highest impact

Useful forms and a sound serving position support good value. The package remains competitive in its category.

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Report analysis

Goals

Bone Health
Bone Health
Impact
Highest effect
A Goal FitA+ Strength of SupportB CoverageA+ Formula Quality
Vitamin K · 150 mcgVitamin D · 50 mcg

Vitamin D3 and menaquinone-7 form a strong bone-signaling combination that supports calcium absorption and placement. Their clearly stated amounts are substantial for a focused daily formula.

The product does not supply calcium, magnesium, or collagen, so it depends on adequate structural nutrient intake elsewhere. Vitamin K2 can counteract warfarin and related vitamin K antagonists, making clinician-guided consistency important for users of those medicines.

Study evidence
Vitamin K Supportive 78 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
A- Goal FitA Strength of SupportB- CoverageA+ Formula Quality
Vitamin K · 150 mcgVitamin D · 50 mcg

Vitamin K2 and D3 form a focused healthy-aging pair for skeletal strength and vascular calcium management. The 150 mcg K2-7 and 50 mcg D3 amounts are both substantial and fully disclosed.

The formula offers strong depth in calcium regulation but no mitochondrial, glycation, or inflammatory breadth. Vitamin K can oppose warfarin-type anticoagulants, so intake should remain consistent under prescriber guidance.

Study evidence
Vitamin K Supportive 27 studies
Heart Health
Heart Health
Impact
Highest effect
B+ Goal FitA+ Strength of SupportB- CoverageA+ Formula Quality
Vitamin K · 150 mcgVitamin D · 50 mcg

Vitamin D3 and K2-7 form a complementary pair for calcium handling and arterial health. The 150 mcg K2 amount is well aligned with daily MK-7 use, while D3 supports calcium regulation when vitamin D status is low.

Both amounts are clearly disclosed and the compact formula avoids unrelated additions. Vitamin K2 can oppose warfarin and other vitamin-K-antagonist anticoagulants, so users of those medicines need stable intake and prescriber guidance.

Study evidence
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
General Health
General Health
Impact
Highest effect
A- Goal FitA- Strength of SupportB- CoverageA+ Formula Quality
Vitamin D · 50 mcgVitamin K · 150 mcg

Vitamin K2 and vitamin D3 form a coherent pair for calcium handling and foundational skeletal support. Both actives use relevant forms and are disclosed at meaningful amounts.

The formula has strong depth for one nutrient pathway but does not cover the wider range expected from a broad wellness product. Its dry capsule does not provide an explicit fat-based delivery aid for these fat-soluble vitamins.

Study evidence
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
B- Goal FitA+ Strength of SupportC- CoverageA+ Formula Quality
Vitamin K · 150 mcgVitamin D · 50 mcg

Vitamin K2 as MK-7 and vitamin D3 form a targeted pair for directing calcium toward bone rather than soft tissue. That mechanism is relevant to vascular health, although evidence for direct cardiovascular outcome improvement is less established than for lipid or blood-pressure interventions.

Both forms and amounts are clearly disclosed, and the K2 dose is substantial. Vitamin K2 can interfere with warfarin and related vitamin K antagonist therapy, so the combination requires clinician-guided consistency in that setting.

Study evidence
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per serving
Vitamin D3 (Cholecalciferol)
 50 mcg
Vitamin K2-7
150 mcg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
Vitamin K · 150 mcg OverallScore83
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

The disclosed K2-7 amount is well aligned with common daily use and is paired with vitamin D3. Label clarity is good, and the cost stays close to the collection midpoint. The dry capsule lacks a stated lipid carrier or with-food direction, while the MK-7 source is not branded.

View ingredientView products
Loading alternative details
86 Performance

Vitamins D3 1000 IU (25 mcg) & K2 100 mcg

NaturesPlus
Compared with vitamin d3 with vitamin k2-7, the alternative provides 25 mcg of vitamin D3 with 100 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger alignment with the Vitamin K collection. Its dry capsule lacks a lipid carrier, and MK-7 requires consistent intake for people using warfarin.
88 Performance

D3 + K2 Green Apple

EZ Melts
Compared with vitamin d3 with vitamin k2-7, the alternative provides 125 mcg of vitamin D3 with 120 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger alignment with the Vitamin K collection. High vitamin D and absent fat-based delivery guidance are the main limitations, while value is favorable.
86 Performance

K2 MK-7 180 mcg & D3 5000 IU

Protocol For Life Balance
Compared with vitamin d3 with vitamin k2-7, the alternative provides 125 mcg of vitamin D3 with 180 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger alignment with the Vitamin K collection. Its vitamin D amount is high, and serving value is only moderate beside lower-cost peers.
88 Budget

Vitamin K2 MK-7 100 mcg

Nutricost
The supplied serving cost is lower, while the formula provides 100 mcg of MK-7 vitamin K2. Vitamin K2 can interfere with warfarin-type anticoagulants.
89 Budget

Mega D-3 5000 IU & MK-7 180 mcg

NOW
The supplied serving cost is lower, while the formula provides 125 mcg of vitamin D3 with 180 mcg of MK-7 vitamin K2. High vitamin D remains the main dosing limitation, while the dry capsule lacks stated fat-intake guidance.
85 Budget

Vitamin K2 MenaQ7 100 mcg

AN Amazing Nutrition Amazing Formulas
The supplied serving cost is lower, while the formula provides vitamin k2. Its vitamin K can counteract warfarin and related vitamin K antagonists, so people using those medicines need clinician-directed intake.
86 Value

Vitamins D3 2500 IU (62.5 mcg) & K2 120 mcg

NaturesPlus
62.5 mcg of vitamin D3 with 120 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Its dry tablet lacks a lipid carrier, and MK-7 requires consistent intake for people using warfarin.
87 Value

Vitamin D3 25 mcg (1000 IU) & K2 120 mcg

Natural Factors
25 mcg of vitamin D3 with 120 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Duplicate K2 source entries create minor label ambiguity, though the softgel and strong value are practical strengths.
86 Value

Vitamin K2 100 mcg + Vitamin D3 125 mcg

Nutricost
125 mcg of vitamin D3 with 100 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Vitamin K2 can interfere with warfarin-type anticoagulants.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  2. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.
    Huang ZB; Wan SL; Lu YJ; Ning L; Liu C; Fan SW · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Meta-analysis6,759 participants19 studies pooledBone Health forVitamin K
  3. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  4. Comparison of concurrent treatment with vitamin K2 and risedronate compared with treatment with risedronate alone in patients with osteoporosis: Japanese Osteoporosis Intervention Trial-03.
    Tanaka S; Miyazaki T; Uemura Y; Miyakawa N; Gorai I; Nakamura T; Fukunaga M; Ohashi Y; Ohta H; Mori S; Hagino H; Hosoi T; Sugimoto T; Itoi E; Orimo H; Shiraki M · Journal of bone and mineral metabolism · 2018
    Randomized trial1,874 participantsBone Health forVitamin K
  5. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  6. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  7. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  8. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  9. Interventions to Attenuate Cardiovascular Calcification Progression: A Systematic Review of Randomized Clinical Trials.
    Murali S; Smith ER; Tiong MK; Tan SJ; Toussaint ND · Journal of the American Heart Association · 2024
    Systematic review9,901 participants49 studies pooledCardiovascular Support forVitamin K
  10. Intake of dietary phylloquinone and menaquinones and risk of stroke.
    Vissers LE; Dalmeijer GW; Boer JM; Monique Verschuren WM; van der Schouw YT; Beulens JW · Journal of the American Heart Association · 2014
    Cohort study35,476 participantsCardiovascular Support forVitamin K
  11. Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease.
    van den Heuvel EG; van Schoor NM; Lips P; Magdeleyns EJ; Deeg DJ; Vermeer C; den Heijer M · Maturitas · 2014
    Cohort study577 participantsCardiovascular Support forVitamin K
  12. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  13. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  14. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  15. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  16. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  17. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  18. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  19. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  20. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  21. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  22. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  23. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  24. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  25. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  26. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  27. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  28. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  29. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  30. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  31. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  32. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsHeart Health forVitamin D
  33. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  34. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  35. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisHeart Health forVitamin D
  36. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K