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Vitamin K2

4.8
★ ★ ★ ★ ★
(357 ratings)
Vitamin K 180 mcg
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Score75
A potent and focused MK-7 capsule with clear dosing, but generic sourcing, dry delivery, and high cost weaken its practical value.
How scoring works
Capsule
Quantity:30 Capsule(s) • (30 servings)
Goals:
Heart Health
Bone Health
General Health
Cardiovascular Support
Anti-Aging

Score 75

A potent and focused MK-7 capsule with clear dosing, but generic sourcing, dry delivery, and high cost weaken its practical value.
How scoring works

Also available as

1 option
90 servings K 180 mcg • 90 Capsule(s) • 90 servings $69.99 ($0.77 per serving)
$27.99($0.93 per serving)
Vitacost
$ 34.99
iHerb
$ 30.79
Pure Formulas
$ 27.99
Vitacost
$ 34.99
Report prices

Analysis

The long-lasting MK-7 form supports vitamin K-dependent proteins involved in bone and arterial calcium management. Its substantial amount provides strong depth in that selected pathway.

The capsule does not identify a branded or all-trans source and has no lipid carrier. Those gaps are more noticeable given the high serving cost.

The product fits adults seeking a higher MK-7 amount in a simple formula. More economical options may offer similar dosing with stronger source disclosure or softgel delivery.

Who is it for
  • Adults seeking a substantial MK-7 amount
  • Users wanting a single-ingredient capsule
  • People who do not need bundled vitamin D
Best for
  • Bone-protein activation
  • Calcium placement
  • Focused K2 supplementation

Pros

  • Substantial MK-7 amount
  • Subtype is clearly disclosed
  • Simple formula

Cons

  • High serving cost
  • No branded or all-trans claim
  • Dry capsule lacks a lipid carrier

Warnings

  • MK-7 can oppose warfarin and related vitamin K antagonist medicines
  • Keep intake consistent if anticoagulation therapy permits use
  • Take with a fat-containing meal unless directed otherwise

Nutrient quality

92 Highest impact

Menaquinone-7 is a well-regarded, long-acting vitamin K2 form, and the vitamin K2 amount is substantial for a focused standalone supplement. The amount is fairly assertive but has no established toxicity concern for healthy adults, while the single-active formula is not padded with low-value ingredients.

Ingredient transparency

84 Highest impact

Specific amounts are listed for every supplied active ingredient. No proprietary blend hides active doses, while capsule, softgel, or tablet excipients are not included in the supplied details.

Customer satisfaction

70 High impact

The supplied aggregate satisfaction metric is very strong, and the feedback volume is sufficient for a reasonably stable aggregate metric. No review excerpts were provided, so recurring complaints and purpose-specific experiences cannot be checked.

Value for money

47 Lower impact

A focused formula and well-regarded vitamin K2 form support good value. Each serving provides a meaningful active amount with little burden, while the formula avoids unnecessary active extras.

Report analysis

Goals

Heart Health
Heart Health
Impact
Highest effect
A- Goal FitA+ Strength of SupportC CoverageA+ Formula Quality
Vitamin K · 180 mcg

Vitamin K2 as MK-7 directly supports calcium handling relevant to arterial flexibility. The 180 mcg amount is substantial and the subtype is fully disclosed.

The focused capsule gives excellent depth for one arterial-health pathway but does not cover lipids, vascular tone, or cardiac energy. MK-7 directly opposes warfarin and related vitamin K antagonists, so intake should remain medically managed and consistent for users of those medicines.

Study evidence
Vitamin K Mixed 62 studies
Bone Health
Bone Health
Impact
Highest effect
B Goal FitA+ Strength of SupportC- CoverageA+ Formula Quality
Vitamin K · 180 mcg

MK-7 supports activation of proteins that help incorporate calcium into bone, giving it a clear bone-remodeling role. Human evidence is relevant for vitamin-K status and bone markers, though K2 alone does not supply structural minerals.

The 180 mcg amount and menaquinone-7 subtype are fully disclosed in a focused formula. MK-7 can oppose warfarin and other vitamin-K-antagonist anticoagulants, so stable intake and prescriber guidance are essential.

Study evidence
Vitamin K Supportive 78 studies
General Health
General Health
Impact
Highest effect
A- Goal FitA- Strength of SupportC- CoverageA Formula Quality
Vitamin K · 180 mcg

Vitamin K2 in the MK-7 form provides focused support for calcium handling, bone maintenance, and cardiovascular health. The amount is well aligned with regular foundational use.

The label clearly names the active form, but it does not identify an all-trans or branded source or provide a lipid carrier. Vitamin K2 can oppose warfarin and related vitamin K antagonist drugs, so people using those medicines need clinician-guided, consistent vitamin K intake.

Study evidence
Vitamin K Supportive 34 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B- Goal FitA Strength of SupportD+ CoverageA Formula Quality
Vitamin K · 180 mcg

Vitamin K2 as MK-7 supports proteins involved in directing calcium away from soft tissues, giving it a plausible arterial-health role. Evidence for improving broad cardiovascular outcomes remains less established than evidence for core lipid or blood-pressure interventions.

The 180 mcg amount is well aligned and clearly disclosed, though the dry capsule lacks a lipid carrier. MK-7 can oppose warfarin and related vitamin K antagonists, so users of those medicines need medically managed and consistent vitamin K intake.

Study evidence
Vitamin K Supportive 40 studies
Anti-Aging
Anti-Aging
Impact
High effect
B- Goal FitA- Strength of SupportD CoverageA Formula Quality
Vitamin K · 180 mcg

MK-7 provides targeted support for calcium handling in blood vessels and bones. The clearly disclosed amount is well aligned, although the dry capsule has no stated lipid carrier.

The formula offers meaningful depth in one aging-related pathway rather than broad coverage. MK-7 can interfere with warfarin and related vitamin K antagonists, requiring consistent clinician-managed vitamin K intake for users of those medicines.

Study evidence
Vitamin K Supportive 27 studies

Ingredients

IngredientAmount per serving
Vitamin K2 (Menaquinone-7)
 180 mcg
Adults 18–50
Report overview
Vitamin K (Menaquinone-7) · 180 mcg OverallScore71
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The disclosed MK-7 form and clinically aligned amount support good vitamin K2 quality and practical use. The capsule lacks a stated lipid carrier or with-food direction, which may limit absorption confidence. Its high cost is difficult to justify because no branded or all-trans source is identified.

View ingredientView products
Loading alternative details
86 Performance

Vitamin K2 MK-7 (Menaquinone-7) 90 mcg

Carlson
Compared with 180 mcg of MK-7 vitamin K2, the alternative provides 90 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger alignment with the Vitamin K collection. Its focused formula offers solid routine value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
87 Performance

Vitamin K2 as MK-7 100 mcg

Healthy Origins
Compared with 180 mcg of MK-7 vitamin K2, the alternative provides 100 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger alignment with the Vitamin K collection. Vitamin K2 can reduce the effect of warfarin-type anticoagulants.
87 Performance

Vitamin K2 100 mcg

SR Sports Research
Compared with 180 mcg of MK-7 vitamin K2, the alternative provides 100 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger alignment with the Vitamin K collection. Vitamin K2 can reduce the effect of warfarin-type anticoagulants, so intake changes require prescriber guidance.
88 Budget

Vitamin K2 MK-7 100 mcg

Nutricost
The supplied serving cost is lower, while the formula provides 100 mcg of MK-7 vitamin K2. Vitamin K2 can interfere with warfarin-type anticoagulants.
89 Budget

Mega D-3 5000 IU & MK-7 180 mcg

NOW
The supplied serving cost is lower, while the formula provides 125 mcg of vitamin D3 with 180 mcg of MK-7 vitamin K2. High vitamin D remains the main dosing limitation, while the dry capsule lacks stated fat-intake guidance.
85 Budget

Vitamin K2 MenaQ7 100 mcg

AN Amazing Nutrition Amazing Formulas
The supplied serving cost is lower, while the formula provides vitamin k2. Its vitamin K can counteract warfarin and related vitamin K antagonists, so people using those medicines need clinician-directed intake.
87 Value

MK-7 Vitamin K-2 100 mcg

NOW
100 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Its long supply supports strong value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
87 Value

Low Dose Vitamin K2 (MK-7) 45 mcg

Life Extension
45 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Its focused formula offers good routine value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
86 Value

Vitamin K2 MK-7 (Menaquinone-7) 90 mcg

Carlson
90 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Its focused formula offers solid routine value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsHeart Health Cardiovascular Support forVitamin K
  2. Vitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials.
    Vlasschaert C; Goss CJ; Pilkey NG; McKeown S; Holden RM · Nutrients · 2021
    Systematic review9 studies pooledHeart Health forVitamin K
  3. Vitamin K Supplementation to Improve Vascular Stiffness in CKD: The K4Kidneys Randomized Controlled Trial.
    Witham MD; Lees JS; White M; Band M; Bell S; Chantler DJ; Ford I; Fulton RL; Kennedy G; Littleford RC; McCrea IV; McGlynn D; Panarelli M; Ralston MR; Rutherford E; Severn A; Thomson N; Traynor JP; Struthers AD; Wetherall K; Mark PB · Journal of the American Society of Nephrology : JASN · 2021
    Randomized trial159 participantsHeart Health forVitamin K
  4. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  5. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.
    Huang ZB; Wan SL; Lu YJ; Ning L; Liu C; Fan SW · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Meta-analysis6,759 participants19 studies pooledBone Health forVitamin K
  6. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  7. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  8. The relationship between vitamin K and peripheral arterial disease.
    Vissers LET; Dalmeijer GW; Boer JMA; Verschuren WMM; van der Schouw YT; Beulens JWJ · Atherosclerosis · 2017
    Cohort study36,629 participantsCardiovascular Support forVitamin K
  9. Interventions to Attenuate Cardiovascular Calcification Progression: A Systematic Review of Randomized Clinical Trials.
    Murali S; Smith ER; Tiong MK; Tan SJ; Toussaint ND · Journal of the American Heart Association · 2024
    Systematic review9,901 participants49 studies pooledCardiovascular Support forVitamin K
  10. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  11. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  12. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  13. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  14. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  15. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  16. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  17. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  18. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  19. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  20. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  21. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  22. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  23. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  24. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  25. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  26. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K