Product Image

Ortho Sleep

AOR Advanced Orthomolecular Research Advanced
4.3
★ ★ ★ ★ ★
(468 ratings)
Theanine 200 mg
5-HTP 100 mg
GABA 100 mg
Valerian 150 mg
Melatonin 3 mg
Product Image
Score95

A high-end sleep and relaxation supplement that uses amino acids and melatonin to support deep rest.

How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Sleep Support
Stress Relief
Brain Health
Mood Support
Cognitive Support
Productivity Boost
Weight Loss

Score 95

A high-end sleep and relaxation supplement that uses amino acids and melatonin to support deep rest.

How scoring works
$34.89($1.16 per serving)
Amazon
$ 34.89
Pure Formulas
$ 35.17
iHerb
$ 24.61
Report prices

Analysis

This product targets multiple pathways in the brain to help induce calm and support a steady sleep-wake cycle. It includes 200mg of L-theanine, which is a meaningful dose for helping the mind wind down after a busy day.

With 100mg of 5-HTP, it also supports the body's natural production of serotonin, which may help with nighttime mood and relaxation. It is a premium choice for someone who values highly specific, orthomolecular dosing for their recovery.

Pros

  • Clinical 200mg dose of L-Theanine
  • Includes 5-HTP for serotonin support
  • High transparency in ingredient labeling
  • Targets both mind and body relaxation

Cons

  • Price per serving is significantly higher than average
  • 5-HTP may cause vivid dreams for some
  • Capsule count only lasts 30 days

Warnings

  • Do not take if you are on SSRIs or MAOIs
  • May cause significant daytime drowsiness if taken late
  • Talk to a doctor if you have a history of asthma

Nutrient quality

99 Highest impact

Utilization of high-quality botanical extracts and clinical-strength doses of theanine provides robust support for sleep. Selection of multiple neurotransmitter precursors ensures comprehensive coverage of relaxation pathways.

Ingredient transparency

100 Highest impact

Milligram amounts for every active component are clearly disclosed, ensuring high label accuracy for the user. Full transparency regarding the concentrations of botanical extracts allows for precise evaluation of the formula's depth.

Customer satisfaction

91 Highest impact

Average ratings are strong and supported by a reliable volume of verified reviews from users with complex sleep needs. Feedback suggests that the multi-pathway approach is highly effective for improving sleep quality.

Value for money

87 Highest impact

The premium price point is justified by the exceptional quality and concentration of clinical-strength ingredients. It remains a high-value choice for individuals seeking intensive support rather than entry-level sleep aids.

Report analysis

Goals

Sleep Support
Impact
Highest effect
A+ Goal FitA+ Strength of SupportA+ CoverageA+ Formula Quality

Melatonin, 5-HTP, and GABA provide a multi-faceted approach to regulating the sleep-wake cycle and promoting relaxation.

L-Theanine and botanical extracts further support reducing sleep latency and improving the overall quality of rest.

View goal →
Stress Relief
Impact
Highest effect
A+ Goal FitA Strength of SupportA+ CoverageA+ Formula Quality

This sophisticated evening formula combines several clinically studied ingredients, including L-Theanine, GABA, and 5-HTP, to provide a multi-layered approach to relaxation. These actives work synergistically to calm the nervous system and promote emotional balance before sleep.

Including Lemon Balm and Valerian extracts further enhances the formula's ability to reduce occasional anxiousness and support a state of rest. This comprehensive stack appears well aligned for users seeking intensive, multi-pathway support for evening stress management and restorative sleep.

View goal →
Brain Health
Impact
Highest effect
A- Goal FitA+ Strength of SupportA- CoverageA+ Formula Quality

L-Theanine, GABA, and 5-HTP are combined with melatonin to support the brain's transition into restorative sleep. These ingredients may contribute to healthy neurotransmitter balance for mental calm and focus.

A diverse blend of botanicals like Lemon Balm and Valerian provides additional support for the nervous system. The inclusion of 200mg of theanine supports the induction of alpha brain waves for a focused sense of calm.

View goal →
Mood Support
Impact
Highest effect
A Goal FitA- Strength of SupportA CoverageA+ Formula Quality

Ortho Sleep combines 5-HTP, GABA, and L-theanine with several calming botanicals to address emotional and sleep-related stress. This multi-pathway approach targets serotonin production, inhibitory signaling, and HPA-axis relaxation.

Ingredients such as lemon balm, valerian, and passionflower provide broad botanical support for a calm mental state. The 100 mg of 5-HTP is meaningfully dosed for supporting serotonin levels in a comprehensive evening stack.

View goal →
Cognitive Support
Impact
Highest effect
B+ Goal FitA Strength of SupportA- CoverageA+ Formula Quality

Sleep-driven cognitive support is provided through a complex stack of calming amino acids and herbs.

L-Theanine, GABA, and 5-HTP are combined with Melatonin to support deep, restorative sleep.

View goal →
Productivity Boost
Impact
Highest effect
C+ Goal FitA Strength of SupportA- CoverageA Formula Quality

L-Theanine, 5-HTP, GABA, and Melatonin are combined in this comprehensive formula to support foundational recovery through improved sleep quality. While these ingredients promote relaxation, they are less aligned with acute, daytime productivity goals.

The inclusion of multiple neurotransmitter modulators provides a broad strategy for mitigating the stress that can hinder mental clarity. This product is best suited for evening use to ensure the restorative rest necessary for high productivity the following day.

View goal →

Ingredients

IngredientAmount per serving
Lemon Balm (Melissa officinalis L.) aerial parts extract
300 mg
L-Theanine
200 mg
Valerian (Valeriana officinalis L.) root extract
150 mg
GABA
100 mg
L-5-Hydroxytryptophan (Griffonia)
 100 mg
Passionflower (Passiflora incarnata L.) aerial parts extract
32 mg
Melatonin
3 mg
Gluten Free Adults 18–50 Vegan Dairy Free Women Vegetarian
Report overview
Theanine · 200 mg OverallScore88
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value
Ortho Sleep is a sophisticated nighttime formula combining 200mg of L-Theanine with 5-HTP, GABA, and melatonin. It addresses sleep from several metabolic pathways, making it an excellent choice for complex sleep challenges.
View ingredientView products
GABA · 100 mg OverallScore70
B- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD- Value
This sophisticated sleep aid uses a lower dose of GABA as part of a complex matrix that includes melatonin and 5-HTP. It is a high-end formulation for those with complex sleep challenges.
View ingredientView products
5-HTP (Griffonia) · 100 mg OverallScore70
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
This complex sleep formula includes 5-HTP alongside other calming botanicals to promote restful nights. While the ingredient quality is high, the high price point makes it a premium option rather than a value-driven one.
View ingredientView products
94 Value

Lights Out Sleep

ALLMAX
4.4
★★★★★
(545 ratings)
This formula provides a nearly identical mix of 5-HTP, GABA, theanine, and melatonin at a more competitive price per serving. It also includes standardized valerian and lavender extract to provide broad-spectrum nighttime support.
Other sellers (1)
94 Value

Tranquil Sleep

Natural Factors Stress-Relax
4.4
★★★★★
(2035 ratings)
Utilizing branded Suntheanine with 5-HTP and melatonin offers a high-quality approach to reducing sleep latency. This well-studied combination provides reliable results for mental relaxation and circadian rhythm support.
Other sellers (2)
90 Value

Sleep & Stress Support

Solgar
4.4
★★★★★
(675 ratings)
High-dose L-theanine and valerian root extract are paired with passionflower to support a calm state before bed. This formula provides a robust herbal and amino acid profile for those seeking stress relief and improved sleep.
Other sellers (3)
94 Performance

Superior Sleep

Doctor's Best
4.3
★★★★★
(457 ratings)
Standardized Sensoril ashwagandha and high-dose 5-HTP (200mg) provide intensive support for cortisol balance and serotonin pathways. This formula is excellently aligned for individuals seeking deep rest through multifaceted stress and hormonal support.
Other sellers (3)
94 Performance

ZenMind

NutriCology
4.6
★★★★★
(285 ratings)
High-purity Suntheanine and PharmaGABA provide focused support for inducing a calm mental state without causing drowsiness. This combination is ideal for those seeking a high-quality, targeted approach to neurological relaxation.
Other sellers (3)
95 Performance

Genius Sleep Aid

The Genius Brand
5.0
★★★★★
(2422 ratings)
The inclusion of rutaecarpine may help clear residual caffeine to further support the transition into deep sleep. Combining this with high-dose glycine and a physiological melatonin dose supports metabolic and neurological recovery.
Other sellers (1)
97 Budget

Sleep Regimen 3-in-1

NOW
4.5
★★★★★
(1145 ratings)
Providing a core combination of 5-HTP, L-theanine, and melatonin offers significant support for relaxation at a much lower cost. This streamlined formula focuses on key neurotransmitter precursors to assist with sleep initiation.
Other sellers (5)
96 Budget

3 a.m. Melatonin Fast Dissolve Lavender Vanilla

Natrol
4.7
★★★★★
(259 ratings)
Fast-dissolving tablets containing 3mg of melatonin and L-theanine provide a rapid-acting solution for nighttime rest. This format allows for quick absorption and is an excellent value for those seeking simple yet effective support.
Other sellers (1)
90 Budget

5-HTP 100 mg

Solgar
4.7
★★★★★
(1884 ratings)
Combining 100mg of 5-HTP with valerian and magnesium glycinate provides foundational support for serotonin and relaxation. The inclusion of active B6 ensures efficient cofactor support for mood and sleep regulation.
Other sellers (4)
94 Value

Lights Out Sleep

ALLMAX
4.4
★★★★★
(545 ratings)
This formula provides a nearly identical mix of 5-HTP, GABA, theanine, and melatonin at a more competitive price per serving. It also includes standardized valerian and lavender extract to provide broad-spectrum nighttime support.
Other sellers (1)
94 Value

Tranquil Sleep

Natural Factors Stress-Relax
4.4
★★★★★
(2035 ratings)
Utilizing branded Suntheanine with 5-HTP and melatonin offers a high-quality approach to reducing sleep latency. This well-studied combination provides reliable results for mental relaxation and circadian rhythm support.
Other sellers (2)
90 Value

Sleep & Stress Support

Solgar
4.4
★★★★★
(675 ratings)
High-dose L-theanine and valerian root extract are paired with passionflower to support a calm state before bed. This formula provides a robust herbal and amino acid profile for those seeking stress relief and improved sleep.
Other sellers (3)
94 Performance

Superior Sleep

Doctor's Best
4.3
★★★★★
(457 ratings)
Standardized Sensoril ashwagandha and high-dose 5-HTP (200mg) provide intensive support for cortisol balance and serotonin pathways. This formula is excellently aligned for individuals seeking deep rest through multifaceted stress and hormonal support.
Other sellers (3)
94 Performance

ZenMind

NutriCology
4.6
★★★★★
(285 ratings)
High-purity Suntheanine and PharmaGABA provide focused support for inducing a calm mental state without causing drowsiness. This combination is ideal for those seeking a high-quality, targeted approach to neurological relaxation.
Other sellers (3)
95 Performance

Genius Sleep Aid

The Genius Brand
5.0
★★★★★
(2422 ratings)
The inclusion of rutaecarpine may help clear residual caffeine to further support the transition into deep sleep. Combining this with high-dose glycine and a physiological melatonin dose supports metabolic and neurological recovery.
Other sellers (1)
Report alternatives