Product Image

B-Complex 100

The Vitamin Shoppe
4.7
★ ★ ★ ★ ★
(195 ratings)
Thiamin 100 mg
Riboflavin 100 mg
Vitamin B6 100 mg
Biotin 300 mcg
Vitamin B5 100 mg
Choline 19 mg
Vitamin B12 100 mcg
Product Image
Score65
Broad and economical high-potency coverage is undermined by an unnecessarily aggressive vitamin B6 amount.
How scoring works
Quantity:100 Capsule(s) • (100 servings)
Goals:
Energy
General Health

Score 65

Broad and economical high-potency coverage is undermined by an unnecessarily aggressive vitamin B6 amount.
How scoring works
$23.99($0.23 per serving)
iHerb
$ 23.99
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Analysis

High amounts of thiamine, riboflavin, niacinamide, pyridoxine, and pantothenic acid give the product substantial metabolic coverage. Methylcobalamin and d-biotin are useful form choices, while choline is present only in a small amount.

The 100 mg vitamin B6 serving reaches an aggressive level for daily use and may contribute to sensory nerve symptoms over time. Standard pyridoxine also requires conversion to its active coenzyme form.

One capsule and a large supply make the product convenient and economical. It is better suited to limited or clinician-directed use than indefinite daily supplementation at the full amount.

Who is it for
  • Adults seeking a high-potency B-complex
  • Short-term users under informed guidance
  • People who value one-capsule convenience
Best for
  • Broad B-vitamin intake
  • High-potency thiamine and riboflavin
  • Convenient once-daily use

Pros

  • Wide B-vitamin coverage
  • Uses methylcobalamin and d-biotin
  • Good value per serving

Cons

  • Contains 100 mg of vitamin B6
  • Choline amount is too small for focused use
  • Several nutrients use conventional forms

Warnings

  • Long-term daily use of 100 mg pyridoxine may cause tingling, numbness, or balance problems
  • Do not stack with other vitamin B6 products
  • The 100 mg niacinamide amount may cause nausea or stomach discomfort in sensitive users

Nutrient quality

59 Moderate impact

The formula mixes useful active forms with older conventional vitamin forms. Several vitamins are supplied at very high amounts while choline and other additions are comparatively weak.

.

Ingredient transparency

73 High impact

Core amounts are shown, though duplicate or split entries make parts of the label confusing. A complete excipient list is not available in the supplied data.

.

Customer satisfaction

71 High impact

The average rating is strong. The rating volume is adequate for a useful satisfaction signal.

.

Value for money

58 Moderate impact

The supply provides weak value per effective serving. Most additions have a plausible role, though some add limited value.

.
Report analysis

Goals

Energy
Energy
Impact
High effect
A- Goal FitB- Strength of SupportB- CoverageA Formula Quality
Vitamin B5 · 100 mgRiboflavin · 100 mgThiamin · 100 mgVitamin B12 · 100 mcg

A complete B-vitamin set directly supports carbohydrate, fat, and protein metabolism. Core B vitamins are supplied at very high amounts, and methylcobalamin improves B12 quality.

The formula does not address acute alertness, stress resilience, or major mitochondrial cofactors such as CoQ10. The very high vitamin B6 amount is not well suited to indefinite daily use.

Study evidence
Vitamin B12 Disputed 14 studies
General Health
Daily Energy Vitality
General Health
Impact
High effect
B+ Goal FitB- Strength of SupportB CoverageB+ Formula Quality
Folate · 667 mcg DFEVitamin B12 · 100 mcg

A complete B-complex supports normal energy metabolism, blood formation, and nervous-system function. Methylcobalamin improves the quality of the B12 component.

Several other vitamins use basic forms, and the 100 mg vitamin B6 amount is unnecessarily high for routine long-term use. The focused capsule remains transparent and avoids a large proprietary blend.

Study evidence
Vitamin B12 Adverse 66 studies
Heart Health
Heart Health
Impact
Moderate effect
C Goal FitC Strength of SupportC CoverageC+ Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 100 mgFolate · 667 mcg DFE

Folate, B6, and methylcobalamin support a connected homocysteine pathway relevant to vascular health. Conventional folate and 100 mg pyridoxine weaken the formulation for long-term use.

The B-complex provides coherent metabolic coverage but does not address lipid, vascular-tone, or cardiac-energy pathways. Chronic use of the high pyridoxine amount may raise peripheral neuropathy risk.

Study evidence
Folate Supportive 116 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies
Metabolism Boost
Metabolism Boost
Impact
Moderate effect
C- Goal FitC Strength of SupportD CoverageB+ Formula Quality
Biotin · 300 mcgNiacin · 100 mg NEVitamin B12 · 100 mcgRiboflavin · 100 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 100 mg

A high-dose B-complex supports the enzyme reactions needed for cellular energy production. It does not directly address thermogenesis, thyroid function, glucose control, or mitochondrial transport.

Methylcobalamin is a useful active form, but excessive B6 and otherwise conventional forms weaken balance. Daily long-term use of 100 mg vitamin B6 carries a meaningful risk of tingling, numbness, or other nerve symptoms.

Study evidence
Riboflavin Mixed 5 studies
Vitamin B6 Supportive 16 studies
Hair Health
Hair Health
Impact
Moderate effect
C- Goal FitC Strength of SupportD CoverageC- Formula Quality
Biotin · 300 mcg

Active B12, d-biotin, and folate support hair when a B-vitamin deficiency contributes to shedding or poor keratin metabolism. The formula does not provide zinc, iron, structural amino acids, or a hormonal pathway.

Methylcobalamin and d-biotin are favorable forms, but the biotin amount is oriented to routine nutrition. Vitamin B6 at 100 mg can cause nerve damage with prolonged daily use and makes the high-potency blend unsuitable for routine hair support.

Study evidence
Biotin Supportive 4 studies
Folate Mixed 15 studies
Vitamin B12 Disputed 17 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Mononitrate, Vitamin B1)
 100 mg
Riboflavin (Vitamin B2)
 100 mg
Niacin (Niacinamide)
 100 mg NE
Vitamin B6 (Pyridoxine Hydrochloride)
 100 mg
Folate
667 mcg DFE
Vitamin B12 (Methylcobalamin)
 100 mcg
Biotin (D-Biotin)
 300 mcg
Pantothenic Acid (D-Calcium Pantothenate)
 100 mg
Choline (Choline Bitartrate)
 19 mg
Inositol
100 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Thiamin (Thiamine Mononitrate, Vitamin B1) · 100 mg OverallScore88
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The formula uses thiamine mononitrate, a standard water-soluble thiamin source. The clearly stated amount reaches the high-potency range, although the conventional delivery format offers no special absorption advantage. A low serving cost and substantial dose make the active-dose value favorable for a B-complex.

View ingredientView products
Riboflavin (Vitamin B2) · 100 mg OverallScore77
D- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The 100 mg serving provides high-potency support, but standard riboflavin requires conversion to its active coenzyme form. The one vegetable capsule supports efficient release, and no unnecessary artificial additives are listed. The serving offers exceptional value for its form and potency.

View ingredientView products
Vitamin B6 (Pyridoxine Hydrochloride) · 100 mg OverallScore69
C+ Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyA+ Value

The formula uses pyridoxine hydrochloride with riboflavin to support conversion, but the 100 mg dose reaches the chronic-use safety ceiling. Long-term use at that level may raise peripheral neuropathy risk, especially when combined with other B6 sources. The serving is economical and clearly labeled.

View ingredientView products
Loading alternative details
85 Performance

BioCoenzymated Active B Complex

Natural Factors
<p>Active forms of thiamine, riboflavin, vitamin B6, folate, and vitamin B12 make this a well-designed B-complex. Its ingredient forms and goal coverage compare favorably because the original has a less focused B-vitamin profile, although folic acid is less active than methylfolate.</p>
81 Performance

CellularActive Coenzyme B-Complex

Bluebonnet
<p>Several coenzyme B-vitamin forms create broad, well-priced nutritional coverage. Its ingredient forms and goal coverage compare favorably because the original has a less focused B-vitamin profile, although folic acid is less active than methylfolate.</p>
75 Performance

B-Complex

Paradise Earth's Blend
<p>Active forms of thiamin, riboflavin, vitamin B6, folate, and vitamin B12 make this a well-designed metabolic B-complex. Its ingredient forms and goal coverage compare favorably because the original has a less focused B-vitamin profile, although its concentrated doses are more appropriate for deliberate use than casual stacking.</p>
80 Budget

B-Complex '100'

Solgar
<p>A broad high-potency B-vitamin profile supports normal energy metabolism, but most forms are conventional and several amounts greatly exceed routine needs. Its lower serving cost improves value compared with the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
63 Budget

Ultra B-100 Complex

Mason Natural
<p>The high-potency B-complex delivers large amounts of several vitamins but relies mostly on conventional forms. Its lower serving cost improves value compared with the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
80 Budget

B-100 Complex with B2 Coenzyme

Nature's Way
<p>Active riboflavin and partial P-5-P improve this otherwise conventional high-potency B-complex. Its lower serving cost improves value compared with the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
81 Value

Activated B-Complex High Bioavailability

Swanson
<p>Active B-vitamin forms, benfotiamine, and pantethine create a high-quality, focused formula at a reasonable cost. The balance of ingredient quality, goal fit, and serving cost is favorable versus the original, although its concentrated doses are more appropriate for deliberate use than casual stacking.</p>
83 Value

High Potency Vitamin B Complex

Lake Avenue Nutrition
<p>Active riboflavin, P-5-P, methylfolate, and methylcobalamin create a high-quality, long-supply B-complex. The balance of ingredient quality, goal fit, and serving cost is favorable versus the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
85 Value

B-Complex Plus

Pure Encapsulations
<p>Methylfolate, methylcobalamin, P-5-P, and activated riboflavin create a focused, well-balanced B-complex. The balance of ingredient quality, goal fit, and serving cost is favorable versus the original, although the high pyridoxine amount is less suitable for long-term daily use.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders.
    Olivieri G; Bordugo A; Burnyte B; Costetti A; Couce ML; Diogo L; Feillet F; Froese DS; Greco B; Gueant JL; Hannibal L; Hörster F; Kožich V; La Marca G; Manoli I; Mochel F; Orazi L; Pérez B; Schiff M; Schwahn BC; Schwartz I; Stepien KM; Sykut-Cegielska J; Tangeraas T; Zetterström RH; Dionisi-Vici C; Huemer M · Journal of inherited metabolic disease · 2026
    Guideline / consensusMetabolism Boost forVitamin B12
  2. Cross-Sectional Study of the Prevalence of Cobalamin Deficiency and Vitamin B12 Supplementation Habits among Vegetarian and Vegan Children in the Czech Republic.
    Světnička M; Sigal A; Selinger E; Heniková M; El-Lababidi E; Gojda J · Nutrients · 2022
    Cross-sectional study200 participantsMetabolism Boost forVitamin B12
  3. Vitamin B12 and Folate Concentrations in Recent-onset Type 2 Diabetes and the Effect of Metformin Treatment.
    Kanti G; Anadol-Schmitz E; Bobrov P; Strassburger K; Kahl S; Zaharia OP; Sarabhai T; Karusheva Y; Burkart V; Markgraf DF; Trenkamp S; Ziegler D; Szendroedi J; Roden M; GDS Group · The Journal of clinical endocrinology and metabolism · 2021
    Cross-sectional study249 participantsMetabolism Boost forVitamin B12
  4. Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
    Carmel R; Melnyk S; James SJ · Blood · 2003
    Observational study39 participantsMetabolism Boost forVitamin B12
  5. Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults.
    Dhir S; Tarasenko M; Napoli E; Giulivi C · Frontiers in psychiatry · 2026
    Narrative reviewMetabolism Boost forThiamin
  6. Insights Into Thiamine Supplementation in Patients With Septic Shock.
    Costa NA; Pereira AG; Sugizaki CSA; Vieira NM; Garcia LR; de Paiva SAR; Zornoff LAM; Azevedo PS; Polegato BF; Minicucci MF · Frontiers in medicine · 2022
    Narrative reviewMetabolism Boost forThiamin
  7. Thiamine-dependent processes and treatment strategies in neurodegeneration.
    Gibson GE; Blass JP · Antioxidants & redox signaling · 2007
    Narrative reviewMetabolism Boost forThiamin
  8. High-resolution plasma metabolomics and thiamine status in critically Ill adult patients.
    Gundogan K; Nellis MM; Ozer NT; Ergul SS; Sahin GG; Temel S; Yuksel RC; Teeny S; Alvarez JA; Sungur M; Jones DP; Ziegler TR · Metabolomics : Official journal of the Metabolomic Society · 2024
    Cross-sectional study76 participantsMetabolism Boost forThiamin
  9. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  10. Pyridoxine challenge reflects pediatric hypophosphatasia severity and thereby examines tissue-nonspecific alkaline phosphatase's role in vitamin B6 metabolism.
    Whyte MP; Zhang F; Mack KE; Wenkert D; Gottesman GS; Ericson KL; Cole JT; Coburn SP · Bone · 2024
    Non-randomized trial149 participantsMetabolism Boost forVitamin B6
  11. Vitamin B6 requirements of women using oral contraceptives.
    Leklem JE; Brown RR; Rose DP; Linkswiler HM · The American journal of clinical nutrition · 1975
    Non-randomized trial24 participantsMetabolism Boost forVitamin B6
  12. Double-blind trial of pyridoxine (vitamin B6) in the treatment of steroid-dependent asthma.
    Sur S; Camara M; Buchmeier A; Morgan S; Nelson HS · Annals of allergy · 1993
    Randomized trial31 participantsMetabolism Boost forVitamin B6
  13. Biotin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusMetabolism Boost forBiotin
  14. Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
    Perry CA; West AA; Gayle A; Lucas LK; Yan J; Jiang X; Malysheva O; Caudill MA · The Journal of nutrition · 2015
    Clinical trial75 participantsMetabolism Boost forBiotin
  15. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  16. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  17. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  18. Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline.
    González-Domínguez R; Castellano-Escuder P; Lefèvre-Arbogast S; Low DY; Du Preez A; Ruigrok SR; Lee H; Helmer C; Pallàs M; Urpi-Sarda M; Sánchez-Pla A; Korosi A; Lucassen PJ; Aigner L; Manach C; Thuret S; Samieri C; Andres-Lacueva C · Alzheimer's research & therapy · 2022
    Observational studyMetabolism Boost forVitamin B5
  19. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  20. Pantothenate synthetase is essential but not limiting for pantothenate biosynthesis in Arabidopsis.
    Jonczyk R; Ronconi S; Rychlik M; Genschel U · Plant molecular biology · 2008
    OtherMetabolism Boost forVitamin B5
  21. Exploring auxotrophy and engineering vitamin B6 prototrophy in the acetogen Clostridium sp. AWRP.
    Kwon SJ; Lee J; Lee HS · Applied and environmental microbiology · 2024
    Clinical trialMetabolism Boost forVitamin B5
  22. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  23. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  24. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  25. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  26. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  27. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  28. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  29. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  30. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  31. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  32. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
  33. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  34. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  35. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  36. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  37. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  38. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  39. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  40. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  41. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  42. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  43. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  44. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  45. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  46. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  47. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate Heart Health forVitamin B6
  48. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  49. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  50. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  51. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsHeart Health forVitamin B12
  52. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  53. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  54. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  55. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsHeart Health forVitamin B6
  56. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  57. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  58. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6
  59. Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects.
    Chuang CZ; Boyles A; Legardeur B; Su J; Japa S; Lopez-S A · The American journal of the medical sciences · 2006
    Non-randomized trial34 participantsMetabolism Boost forRiboflavin
  60. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledMetabolism Boost forRiboflavin
  61. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  62. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  63. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  64. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6