Product Image

Prenatal Essentials Chewable

Seeking Health
4.9
★ ★ ★ ★ ★
(2239 ratings)
Vitamin B6 15 mg
Iodine 220 mcg
Manganese 2 mg
Vitamin K 100 mcg
Molybdenum 50 mcg
Riboflavin 10 mg
Copper 0.75 mg
Product Image
Score77
A well-designed prenatal with methylfolate, active B vitamins, D3, MK-7, and chelated minerals. Calcium and magnesium are incomplete, while vitamin A and B6 totals need monitoring.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
General Health
Energy
Heart Health
Detoxification
Hair Health
Bone Health
Anti-Aging
Metabolism Boost

Score 77

A well-designed prenatal with methylfolate, active B vitamins, D3, MK-7, and chelated minerals. Calcium and magnesium are incomplete, while vitamin A and B6 totals need monitoring.
How scoring works
$38.00($1.26 per serving)
iHerb
$ 38.00
Vitacost
$ 38.00
Walmart
$ 38.00
Pure Formulas
$ 38.00
Report prices

Analysis

Methylfolate, active B vitamins, vitamin D3, MK-7, and chelated minerals provide strong form quality. Betaine and carotenoids add useful breadth without replacing the core prenatal nutrients.

Calcium and magnesium provide only partial coverage, so diet or separate supplementation may still matter. Preformed vitamin A and elevated vitamin B6 should be counted across all prenatal and nausea-support products.

The formula suits pregnant users who want a compact, form-conscious prenatal and can address missing minerals through the broader care plan. Medication and total-intake review remain important during pregnancy.

Who is it for
  • Pregnant users seeking active nutrient forms
  • People who prefer a compact prenatal
  • Users able to cover remaining calcium and magnesium needs
Best for
  • Methylfolate and active B-vitamin intake
  • Vitamin D3 and MK-7 coverage
  • Chelated prenatal minerals

Pros

  • Uses methylfolate and active B vitamins
  • Includes vitamin D3 and MK-7
  • Provides chelated minerals and carotenoids

Cons

  • Calcium and magnesium are only partial
  • Preformed vitamin A needs total-intake review
  • Vitamin B6 is elevated

Warnings

  • Preformed vitamin A intake should be reviewed during pregnancy and not casually stacked with retinol products.
  • Prolonged elevated vitamin B6 intake may increase nerve-symptom risk, especially when combined with nausea products containing B6.
  • Vitamin K can oppose warfarin and requires prescriber guidance.

Nutrient quality

89 Highest impact

The ingredient form and serving amount provide solid nutritional support. The formula remains reasonably focused without obvious excessive dosing.

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Ingredient transparency

89 Highest impact

Active amounts and ingredient names are mostly easy to assess. A complete inactive-ingredient list and full use directions are not included in the supplied facts.

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Customer satisfaction

71 High impact

The aggregate rating is very strong supported by substantial review volume. No specific feedback is supplied to confirm recurring complaints or purpose-related experiences.

.

Value for money

54 Moderate impact

The format and short supply weaken value relative to simpler category products. Most of the cost appears directed toward the core active formula.

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Report analysis

Goals

General Health
General Health
Impact
Highest effect
A Goal FitA- Strength of SupportA CoverageA Formula Quality
Folate · 1360 mcg DFEVitamin B12 · 100 mcgVitamin D · 25 mcgMagnesium · 100 mgVitamin K · 100 mcgBoron · 1 mgZinc · 13 mgVitamin C · 100 mg

A broad vitamin and mineral base addresses many nutritional needs relevant to pregnancy and general health. Several active or chelated forms strengthen absorption and disclosure quality.

The formula omits iron and choline, so it may not cover all common prenatal needs on its own. Its preformed vitamin A and high folate content also make it important to avoid unplanned stacking with other prenatal supplements.

Study evidence
Folate Supportive 80 studies
Energy
Energy
Impact
High effect
B Goal FitB+ Strength of SupportC+ CoverageB+ Formula Quality
Iodine · 220 mcgVitamin D · 25 mcgVitamin B5 · 20 mgMagnesium · 100 mgRiboflavin · 10 mgThiamin · 5 mgVitamin B12 · 100 mcg

B vitamins, iodine, magnesium, and chromium provide broad support for metabolic energy and thyroid-related nutrient needs. Active forms and meaningful amounts improve confidence in most of the core nutrients.

The prenatal design covers many nutritional needs but does not include an alertness or adaptogen pathway. Magnesium remains below the stated energy target, and vitamin B12 is substantial but below the stated ideal amount.

Study evidence
Iodine Adverse 3 studies
Magnesium Supportive 4 studies
Heart Health
Heart Health
Impact
High effect
B Goal FitB+ Strength of SupportB CoverageC Formula Quality
Vitamin K · 100 mcgMagnesium · 100 mgVitamin B12 · 100 mcgVitamin B6 · 15 mgFolate · 1360 mcg DFEVitamin D · 25 mcg

Vitamin K2, vitamin D3, active B vitamins, magnesium, and antioxidants cover several cardiovascular foundations. The formula is designed for prenatal nutrition rather than focused heart support, so many ingredients are not central to this goal.

MK-7, Quatrefolic, active vitamin B6, and well-identified mineral forms strengthen quality. Vitamin K2 can oppose warfarin and other vitamin K antagonist anticoagulants, making the interaction specific and important.

Study evidence
Magnesium Supportive 158 studies
Vitamin B6 Supportive 44 studies
Vitamin K Mixed 62 studies
Detoxification
Detoxification
Impact
High effect
C+ Goal FitB+ Strength of SupportB- CoverageC+ Formula Quality
Folate · 1360 mcg DFEVitamin B12 · 100 mcgVitamin B6 · 15 mgMolybdenum · 50 mcgMagnesium · 100 mgVitamin E · 50 mgZinc · 13 mgVitamin C · 100 mgRiboflavin · 10 mg

Molybdenum, selenium, methylation nutrients, and antioxidants provide several useful detoxification cofactors. The cofactor amounts are meaningful for nutritional support, though no primary liver active reaches a dedicated therapeutic dose.

The formula remains a prenatal multivitamin rather than a targeted liver product, so its support is broad but indirect. The active vitamins and trace minerals form a coherent cofactor network.

Study evidence
Folate Supportive 16 studies
Molybdenum Adverse 1 study
Hair Health
Hair Health
Impact
High effect
B- Goal FitB- Strength of SupportC CoverageB- Formula Quality
Biotin · 150 mcgVitamin D · 25 mcgZinc · 13 mgVitamin C · 100 mg

Several well-formed nutrients can support hair when pregnancy-related intake needs are high. No iron or structural protein keeps the coverage incomplete for shedding concerns.

Chelated minerals and active vitamins are strong formulation choices. The prenatal design is broad but remains transparent and logically constructed.

Study evidence
Biotin Supportive 4 studies
Copper Adverse 4 studies
Vitamin C Mixed 5 studies
Vitamin D Disputed 34 studies
Zinc Supportive 22 studies
Bone Health
Bone Health
Impact
High effect
B Goal FitB- Strength of SupportB- CoverageC- Formula Quality
Vitamin K · 100 mcgMagnesium · 100 mgCalcium · 100 mgVitamin D · 25 mcgCopper · 0.75 mgManganese · 2 mgBoron · 1 mgZinc · 13 mgVitamin C · 100 mg

Calcium, magnesium, vitamin D3, MK-7, boron, and trace minerals cover several skeletal needs. Favorable chelated and malate forms improve quality, but most structural-mineral amounts remain modest.

The comprehensive prenatal design includes many nutrients unrelated to dedicated bone support and no collagen or other matrix ingredient. MK-7 can interfere with warfarin and related vitamin K antagonists, requiring consistent clinician-managed vitamin K intake for users of those medicines.

Study evidence
Boron Supportive 5 studies
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Vitamin K Supportive 78 studies

Ingredients

IngredientAmount per serving
Vitamin A (Beta-Carotene, Retinyl Palmitate)
 1500 mcg RAE
Vitamin C (Ascorbic Acid)
 100 mg
Vitamin D3 (Cholecalciferol)
 25 mcg
Vitamin E (D-Alpha-Tocopheryl Succinate)
 50 mg
Thiamine (Thiamine Hydrochloride)
 5 mg
Riboflavin (Riboflavin 5-Phosphate Sodium)
 10 mg
Niacin
25 mg
Vitamin B6 (Pyridoxal 5-Phosphate)
 15 mg
Folate (Quatrefolic)
 1360 mcg DFE
MecobalActive (Vitamin B12)
 100 mcg
Biotin
150 mcg
Pantothenic Acid (D-Calcium Pantothenate)
 20 mg
Calcium (Dicalcium Malate)
 100 mg
Iodine (Potassium Iodide)
 220 mcg
Magnesium (Dimagnesium Malate)
 100 mg
Zinc (Zinc Bisglycinate Chelate)
 13 mg
SelenoExcell (Selenium)
 50 mcg
Copper (Copper Bisglycinate Chelate)
 0.75 mg
Manganese (Manganese Bisglycinate Chelate)
 2 mg
Chromium (Chromium Nicotinate Glycinate Chelate)
 100 mcg
Molybdenum (Molybdenum Glycinate Chelate)
 50 mcg
Betaine
150 mg
Zeaxanthin (Tagetes erecta)
 1 mg
Boron (Bororganic Glycine)
 1 mg
Lutein (Marigold Flower Extract)
 1 mg
Vitamin K2 (Menaquinone-7)
 100 mcg
Gluten Free Dairy Free Pregnant Women 18–50
Report overview
Vitamin B6 (Pyridoxal 5-Phosphate) · 15 mg OverallScore90
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

Active pyridoxal 5-phosphate provides a metabolically ready form of B6. The 15 mg amount sits in the preferred range without reaching the chronic safety ceiling. The serving cost limits value despite otherwise useful formulation features.

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Iodine (Potassium Iodide) · 220 mcg OverallScore87
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The potassium iodide source provides stable, readily absorbed iodine at a suitable daily amount. The label clearly states the iodine yield, and capsule delivery is convenient. Selenium adds a useful cofactor, although the high serving cost limits iodine-focused value.

View ingredientView products
Manganese (Manganese Bisglycinate Chelate) · 2 mg OverallScore78
A+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value

The prenatal capsule uses a premium manganese chelate at a conservative maintenance amount. The elemental amount is suitable for daily maintenance but modest for targeted bone or joint support. The high serving cost weakens value for someone focused on manganese alone.

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Loading alternative details
91 Performance

Prenatal Essentials Methyl-Free

Seeking Health
<p>Folinic acid with adenosylcobalamin and hydroxocobalamin offers a methyl-free route for people who do not tolerate methylated B vitamins. The remaining prenatal foundation closely matches the original, including P5P, vitamin K2, iodine, and chelated minerals.</p>
70 Performance

Minimal and Essential

Vital Nutrients
<p>Methylfolate, methylcobalamin, selenomethionine, and citrate or glycinate minerals create a compact formula with strong forms. It lacks prenatal-specific breadth and the original's iodine level, so it is not a direct replacement despite its cleaner maintenance profile.</p>
66 Performance

Multi For Him

Nature Made
<p>A straightforward once-daily formula uses moderate B-vitamin amounts and avoids proprietary blends. Conventional mineral forms and a men's rather than prenatal design limit suitability, but the simpler dose balance may suit general maintenance outside pregnancy.</p>
77 Budget

Prenatal

Carlson
<p>The lower serving cost adds iron bisglycinate and fish oil to broad prenatal vitamin and mineral coverage. DHA and EPA amounts are undisclosed and preformed vitamin A and several vitamins are high, so the formula needs closer label review than the original.</p>
65 Budget

Daily Vits

NOW
<p>A far lower serving cost provides methylcobalamin, folate, vitamin K, zinc bisglycinate, iodine, and broad basic vitamins. Calcium and magnesium are token amounts and it is not a prenatal formula, so the saving comes with major coverage gaps.</p>
62 Budget

Alive! Women's Ultra Potency Complete Multivitamin

Nature's Way
<p>The serving cost is far lower and the formula supplies iron, iodine, vitamin D3, methylcobalamin, and broad vitamins. It is a general women's multi rather than a prenatal, with folic acid, basic minerals, and low choline, so it should not be treated as a complete pregnancy substitute.</p>
72 Value

The Big One without Iron

Metabolic Maintenance
<p>A lower serving cost brings active B vitamins, methylcobalamin, vitamin K, selenomethionine, and several useful trace-mineral forms. High preformed vitamin A and the lack of prenatal-specific design make clinician review important before considering it during pregnancy.</p>
68 Value

Adult's Chewable Delicious Apple Cinnamon Flavor

Natures Plus Source of Life
<p>A chewable format and lower serving cost make this easier to use while vitamin K, B vitamins, iodine, copper, manganese, and molybdenum retain partial overlap. It is not prenatal-specific and does not match the original's active folate and chelated-mineral quality, so the value advantage comes with important limitations.</p>
63 Value

Iron-Free Formula VM-75

Solgar
<p>The serving cost is much lower and broad B vitamins, iodine, copper, and molybdenum provide basic daily coverage. The formula is not prenatal-specific and lacks the original's vitamin K, chromium, manganese, and active prenatal design, so it is only a partial alternative.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES.
    Ling R; Ai Y; Chen C; Zhang J; Zou Z; Cheng S; Li C; Li X; Wang B · Metabolites · 2023
    Cross-sectional study2,640 participantsBone Health forManganese
  2. Association of Urinary Cadmium and Antimony with Osteoporosis Risk in Postmenopausal Brazilian Women: Insights from a 20 Metal(loid) Biomonitoring Study.
    Kunioka CT; de Oliveira Souza VC; Rocha BA; Júnior FB; Belo L; Manso MC; Carvalho M · Toxics · 2025
    Cohort study380 participantsBone Health forManganese
  3. Correlation between bone mineral density and serum trace element contents of elderly males in Beijing urban area.
    Wang L; Yu H; Yang G; Zhang Y; Wang W; Su T; Ma W; Yang F; Chen L; He L; Ma Y; Zhang Y · International journal of clinical and experimental medicine · 2016
    Cross-sectional study91 participantsBone Health forManganese
  4. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  5. Double-blind trial of pyridoxine (vitamin B6) in the treatment of steroid-dependent asthma.
    Sur S; Camara M; Buchmeier A; Morgan S; Nelson HS · Annals of allergy · 1993
    Randomized trial31 participantsMetabolism Boost forVitamin B6
  6. Pyridoxine challenge reflects pediatric hypophosphatasia severity and thereby examines tissue-nonspecific alkaline phosphatase's role in vitamin B6 metabolism.
    Whyte MP; Zhang F; Mack KE; Wenkert D; Gottesman GS; Ericson KL; Cole JT; Coburn SP · Bone · 2024
    Non-randomized trial149 participantsMetabolism Boost forVitamin B6
  7. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis.
    Hu X; Wang W; Su X; Peng H; Tan Z; Li Y; Huang Y · PeerJ · 2023
    Meta-analysis2,362 participants41 studies pooledMetabolism Boost forChromium
  8. Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity.
    Masharani U; Gjerde C; McCoy S; Maddux BA; Hessler D; Goldfine ID; Youngren JF · BMC endocrine disorders · 2013
    Randomized trial31 participantsMetabolism Boost forChromium
  9. Improved meta-analytic methods show no effect of chromium supplements on fasting glucose.
    Bailey CH · Biological trace element research · 2014
    Meta-analysis809 participants16 studies pooledMetabolism Boost forChromium
  10. The Effects of Supplementation with Chromium on Insulin Resistance Indices in Women with Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
    Heshmati J; Omani-Samani R; Vesali S; Maroufizadeh S; Rezaeinejad M; Razavi M; Sepidarkish M · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2018
    Meta-analysis268 participants5 studies pooledMetabolism Boost forChromium
  11. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging forVitamin K
  12. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  13. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  14. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  15. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  16. [Comparative study of the urinary excretion of boron, calcium, magnesium and phosphorus in postmenopausal women with and without osteoporosis].
    José Ramón V; Mora Mora M; Marino Alarcón O; Hernández G; Josefina Linares L; Urdaneta Romero H; Arévalo González E · Investigacion clinica · 2013
    Case-control study45 participantsBone Health forBoron
  17. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.
    Nielsen FH; Hunt CD; Mullen LM; Hunt JR · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 1987
    Single-arm trial12 participantsBone Health forBoron
  18. The relationship between boron and magnesium status and bone mineral density in the human: a review.
    Volpe SL; Taper LJ; Meacham S · Magnesium research · 1994
    Narrative reviewBone Health forBoron
  19. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes.
    Meacham SL; Taper LJ; Volpe SL · Environmental health perspectives · 1995
    Randomized trial28 participantsBone Health forBoron
  20. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations
    C D Hunt, J L Herbel, F H Nielsen · The American Journal of Clinical Nutrition · 1997
    Non-randomized trial11 participantsBone Health forBoron
  21. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  22. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  23. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  24. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  25. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  26. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  27. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  28. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  29. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  30. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  31. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  32. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  33. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  34. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  35. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  36. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  37. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  38. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  39. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  40. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  41. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  42. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  43. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  44. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  45. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  46. Comparison of efficacy of folic acid and silymarin in the management of antiepileptic drug induced liver injury: a randomized clinical trial.
    Asgarshirazi M; Shariat M; Sheikh M · Hepatobiliary & pancreatic diseases international : HBPD INT · 2018
    Randomized trial55 participantsDetoxification forFolate
  47. Homocysteine, folate, and nonalcoholic fatty liver disease: a systematic review with meta-analysis and Mendelian randomization investigation.
    Yuan S; Chen J; Dan L; Xie Y; Sun Y; Li X; Larsson SC · The American journal of clinical nutrition · 2022
    Meta-analysis30,368 participants22 studies pooledDetoxification forFolate
  48. Serum folate levels and urinary arsenic methylation profiles in the US population: NHANES, 2003-2012.
    Zhang X; Xu X; Zhong Y; Power MC; Taylor BD; Carrillo G · Journal of exposure science & environmental epidemiology · 2020
    Cross-sectional study11,016 participantsDetoxification forFolate
  49. Association between serum folate levels and blood concentrations of cadmium and lead in US adults.
    Wu Z; Hu H; Wang C; Wu J; Xiong Y; Fu Y; Cheng X; Su H; Li P · Environmental science and pollution research international · 2022
    Cross-sectional study15,501 participantsDetoxification forFolate
  50. Effects of Folic Acid Supplementation on Liver Enzymes, Lipid Profile, and Insulin Resistance in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial.
    Molaqanbari MR; Zarringol S; Talari HR; Taghizadeh M; Bahmani F; Mohtashamian A; Ebrahimzadeh A; Sharifi N · Advanced biomedical research · 2023
    Randomized trial66 participantsDetoxification forFolate
  51. Human molybdenum exposure risk in industrial regions of China: New critical effect indicators and reference dose.
    Kuang HX; Li MY; Zeng XW; Chen D; Zhou Y; Zheng T; Xiang MD; Wu QZ; Chen XC; Dong GH; Yu YJ · Ecotoxicology and environmental safety · 2024
    Cross-sectional study2,267 participantsDetoxification forMolybdenum
  52. Association of radioactive iodine treatment with survivorship symptoms and primary care utilisation in women of reproductive age with thyroid cancer: a retrospective cohort study.
    Devanarayan P; Hartman M; Partin M · Family medicine and community health · 2026
    Cohort study10,882 participantsEnergy forIodine
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    Hughes DT; Reyes-Gastelum D; Kovatch KJ; Hamilton AS; Ward KC; Haymart MR · Surgery · 2020
    Cohort study2,584 participantsEnergy forIodine
  54. Health-Related Quality of Life in Differentiated Thyroid Cancer Survivors: A Cross-Sectional Study From Turkey.
    Gültekin A; Kahraman MY; Şengöz T; Şimşek FS · Head & neck · 2026
    Cross-sectional study202 participantsEnergy forIodine
  55. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  56. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
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    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  58. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
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    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
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    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  61. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
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    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
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    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  64. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
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    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  66. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  67. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  68. Menkes disease and response to copper histidine: An Indian case series.
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    Bhat YJ; Manzoor S; Khan AR; Qayoom S · Indian journal of dermatology, venereology and leprology · 2009
    Case-control study100 participantsHair Health forCopper
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    Millington KR; Marsh JM · International journal of cosmetic science · 2021
    In vitro / ex vivo studyHair Health forCopper
  71. Preserving fibre health: reducing oxidative stress throughout the life of the hair fibre.
    Marsh JM; Davis MG; Lucas RL; Reilman R; Styczynski PB; Li C; Mamak M; McComb DW; Williams RE; Godfrey S; Navqi KR; Chechik V · International journal of cosmetic science · 2016
    In vitro / ex vivo studyHair Health forCopper
  72. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  73. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  74. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  75. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  76. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
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    Lee S; Kim BJ; Lee CH; Lee WS · Journal of the European Academy of Dermatology and Venereology : JEADV · 2018
    Meta-analysis2,039 participants14 studies pooledHair Health forVitamin D
  78. Intralesional vitamin D3 in treatment of alopecia areata: A randomized controlled clinical trial.
    Rashad AF; Elgamal E; Fouda I · Journal of cosmetic dermatology · 2022
    Randomized trial60 participantsHair Health forVitamin D
  79. Vitamin D and its Analogs in Treatment of Mild to Moderate Alopecia Areata: Systematic Review and Meta-Analysis.
    Alsaati AA; Kaliyadan F; Alsaadoun D; Alzakry LM; Alzabadin RA; Hakami TH; Rubaian NFB · Indian dermatology online journal · 2025
    Meta-analysisHair Health forVitamin D
  80. Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial.
    El Taieb MA; Hegazy EM; Ibrahim HM; Osman AB; Abualhamd M · Archives of dermatological research · 2020
    Randomized trial60 participantsHair Health forVitamin D
  81. Serum 25 hydroxyvitamin D in non-scarring alopecia: A systematic review and meta-analysis.
    Chen Y; Dong X; Wang Y; Li Y; Xiong L; Li L · Journal of cosmetic dermatology · 2024
    Meta-analysis10,670 participants23 studies pooledHair Health forVitamin D
  82. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  83. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
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    Randomized trialHair Health forZinc
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  85. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
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    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  87. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledHeart Health forMagnesium
  88. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  89. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  90. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  91. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisHeart Health forMagnesium
  92. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forVitamin B6
  93. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  94. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  95. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6
  96. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K
  97. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes.
    Anderson RA; Cheng N; Bryden NA; Polansky MM; Cheng N; Chi J; Feng J · Diabetes · 1997
    Randomized trial180 participantsMetabolism Boost forChromium
  98. Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Jamilian M; Asemi Z · Annals of nutrition & metabolism · 2016
    Randomized trial64 participantsMetabolism Boost forChromium
  99. A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review.
    Kooshki F; Tutunchi H; Vajdi M; Karimi A; Niazkar HR; Shoorei H; Pourghassem Gargari B · Clinical and experimental pharmacology & physiology · 2024
    Systematic review33 studies pooledMetabolism Boost forChromium
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    San Mauro-Martin I; Ruiz-León AM; Camina-Martín MA; Garicano-Vilar E; Collado-Yurrita L; Mateo-Silleras Bd; Redondo Del Río Mde P · Nutricion hospitalaria · 2017
    Meta-analysis13 studies pooledMetabolism Boost forChromium
  101. Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial.
    Herter-Aeberli I; Cherkaoui M; El Ansari N; Rohner R; Stinca S; Chabaa L; von Eckardstein A; Aboussad A; Zimmermann MB · The Journal of nutrition · 2015
    Randomized trial163 participantsMetabolism Boost forIodine
  102. Effect of oral iodized oil on thyroid size and thyroid hormone metabolism in children with concurrent selenium and iodine deficiency.
    Zimmermann MB; Adou P; Torresani T; Zeder C; Hurrell RF · European journal of clinical nutrition · 2000
    Single-arm trial51 participantsMetabolism Boost forIodine
  103. Serum Iodine Concentration as a Biomarker for Individual Iodine Nutrition and Thyroid Function in Pregnant Women: A Cross-Sectional Study in Hubei Province.
    Xu M; Dai X; Wang Z; Guo C; Zhang B; Guo H · Public health nutrition · 2026
    Cross-sectional study1,197 participantsMetabolism Boost forIodine
  104. Iron status influences the efficacy of iodine prophylaxis in goitrous children in Côte d'Ivoire.
    Zimmermann MB · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2002
    OtherMetabolism Boost forIodine
  105. Persistence of goiter despite oral iodine supplementation in goitrous children with iron deficiency anemia in Côte d'Ivoire.
    Zimmermann M; Adou P; Torresani T; Zeder C; Hurrell R · The American journal of clinical nutrition · 2000
    Non-randomized trial109 participantsMetabolism Boost forIodine
  106. Association of magnesium consumption with type 2 diabetes and glucose metabolism: A systematic review and pooled study with trial sequential analysis.
    Zhao B; Deng H; Li B; Chen L; Zou F; Hu L; Wei Y; Zhang W · Diabetes/metabolism research and reviews · 2021
    Meta-analysis1,168 participants26 studies pooledMetabolism Boost forMagnesium
  107. Magnesium supplementation for glycemic status in women with gestational diabetes: a systematic review and meta-analysis.
    Tan X; Huang Y · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2022
    Meta-analysis4 studies pooledMetabolism Boost forMagnesium
  108. Impact of oral magnesium supplementation on glycemic and cardiometabolic outcomes in prediabetic adults: a systematic review and meta-analysis.
    Basit A; Kumar S; Ahmed H; Babar R; Saeed SS; Siddiqui TA; Khan S; Saeed A; Khan M; Hanif H; Fasih A; Shabbir S; Kumar H; Kumar L; Raja A; Kumar S; Chander S · Journal of diabetes and metabolic disorders · 2026
    Meta-analysis384 participants5 studies pooledMetabolism Boost forMagnesium
  109. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial.
    Rodríguez-Morán M; Guerrero-Romero F · Diabetes care · 2003
    Randomized trial63 participantsMetabolism Boost forMagnesium
  110. Magnesium Supplementation and the Effects on Wound Healing and Metabolic Status in Patients with Diabetic Foot Ulcer: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Razzaghi R; Pidar F; Momen-Heravi M; Bahmani F; Akbari H; Asemi Z · Biological trace element research · 2018
    Randomized trial70 participantsMetabolism Boost forMagnesium