Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.
Taskozhina G; Batyrova G; Umarova G; Issanguzhina Z; Kereyeva N · Journal of clinical medicine · 2024
Narrative reviewflagBone Health forscienceManganese
- Associations of multiple metals with bone mineral density: A population-based study in US adults.
Wei MH; Cui Y; Zhou HL; Song WJ; Di DS; Zhang RY; Huang Q; Liu JA; Wang Q · Chemosphere · 2021
Cross-sectional studyflagBone Health forscienceManganese
- Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
Wang C; Zhu Y; Long H; Ou M; Zhao S · PloS one · 2022
Cross-sectional study9,732 participantsflagBone Health forscienceManganese
- Correlation between bone mineral density and serum trace element contents of elderly males in Beijing urban area.
Wang L; Yu H; Yang G; Zhang Y; Wang W; Su T; Ma W; Yang F; Chen L; He L; Ma Y; Zhang Y · International journal of clinical and experimental medicine · 2016
Cross-sectional study91 participantsflagBone Health forscienceManganese
- The Role of Sex Steroid Hormones in the Association Between Manganese Exposure and Bone Mineral Density: National Health and Nutrition Examination Survey 2013-2018.
Zhao X; Li J; Yu J; Shi Y; Tang M · Toxics · 2025
Cross-sectional study8,617 participantsflagBone Health forscienceManganese
- Association of radioactive iodine treatment with survivorship symptoms and primary care utilisation in women of reproductive age with thyroid cancer: a retrospective cohort study.
Devanarayan P; Hartman M; Partin M · Family medicine and community health · 2026
Cohort study10,882 participantsflagEnergy forscienceIodine
- Energy level and fatigue after surgery for thyroid cancer: A population-based study of patient-reported outcomes.
Hughes DT; Reyes-Gastelum D; Kovatch KJ; Hamilton AS; Ward KC; Haymart MR · Surgery · 2020
Cohort study2,584 participantsflagEnergy forscienceIodine
- Health-Related Quality of Life in Differentiated Thyroid Cancer Survivors: A Cross-Sectional Study From Turkey.
Gültekin A; Kahraman MY; Şengöz T; Şimşek FS · Head & neck · 2026
Cross-sectional study202 participantsflagEnergy forscienceIodine
- Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial.
Van Wyck DB; Mangione A; Morrison J; Hadley PE; Jehle JA; Goodnough LT · Transfusion · 2010
Randomized trial477 participantsflagEnergy forscienceIron
- The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.
Macher S; Herster C; Holter M; Moritz M; Matzhold EM; Stojakovic T; Pieber TR; Schlenke P; Drexler C; Amrein K · Nutrients · 2021
Randomized trial176 participantsflagEnergy forscienceIron
- Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP).
Breymann C; Milman N; Mezzacasa A; Bernard R; Dudenhausen J; FER-ASAP investigators · Journal of perinatal medicine · 2018
Randomized trial252 participantsflagEnergy forscienceIron
- Effect of iron therapy on fatigue symptoms in non-anaemic iron deficient women of reproductive age- A Randomized Controlled Trial.
Sultana N; Bajwa FA; Sikandar MZ; Haider MM; Majeed T · JPMA. The Journal of the Pakistan Medical Association · 2026
Randomized trial164 participantsflagEnergy forscienceIron
- Intravenous iron isomaltoside treatment of women suffering from severe fatigue after postpartum hemorrhage.
Holm C; Thomsen LL; Langhoff-Roos J · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019
Randomized trial85 participantsflagEnergy forscienceIron
- Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
Meta-analysis345 participants5 studies pooledflagEnergy forscienceVitamin D
- Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
Randomized trial40 participantsflagEnergy forscienceVitamin D
- Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
Randomized trial91 participantsflagEnergy forscienceVitamin D
- The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
Elfituri S · Reumatologia · 2024
Randomized trial68 participantsflagEnergy forscienceVitamin D
- The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
Randomized trial40 participantsflagEnergy forscienceVitamin D
- Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
Cohort study7,857 participantsflagGeneral Health forscienceVitamin K
- Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
Meta-analysis3,891 participants3 studies pooledflagGeneral Health forscienceVitamin K
- The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
Randomized trial49 participantsflagGeneral Health forscienceVitamin K
- Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
Meta-analysis7 studies pooledflagGeneral Health forscienceVitamin K
- Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
Cohort study1,436 participantsflagGeneral Health forscienceVitamin K
- Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
Randomized trial144 participantsflagGeneral Health forscienceZinc
- Zinc supplementation in young children with acute diarrhea in India.
Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
Randomized trial937 participantsflagGeneral Health forscienceZinc
- Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
Randomized trial4,753 participantsflagGeneral Health forscienceZinc
- Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
Randomized trial84 participantsflagGeneral Health forscienceZinc
- Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
Randomized trial142 participantsflagGeneral Health forscienceZinc
- Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
Randomized trial20,702 participantsflagHeart Health forscienceFolate
- Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
Case-control study985 participantsflagHeart Health forscienceFolate
- Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
Meta-analysis369,746 participants11 studies pooledflagHeart Health forscienceFolate
- Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
Meta-analysis423,304 participants25 studies pooledflagHeart Health forscienceFolate
- The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
Wondemagegn AT; Afework M · SAGE open medicine · 2022
Meta-analysis37 studies pooledflagHeart Health forscienceFolate
- Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
Cohort study53,372 participantsflagHeart Health forscienceVitamin K
- Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
Randomized trial244 participantsflagHeart Health forscienceVitamin K
- The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
Randomized trial149 participantsflagHeart Health forscienceVitamin K
- Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
Cohort study55,545 participantsflagHeart Health forscienceVitamin K
- Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
Cohort study56,048 participantsflagHeart Health forscienceVitamin K
- The immune response in iron-deficient children: Impaired cellular defense mechanisms with altered humoral components.
Macdougall LG; Anderson R; McNab GM; Katz J · The Journal of pediatrics · 1975
Single-arm trial27 participantsflagImmunity forscienceIron
- The role of iron homeostasis in remodeling immune function and regulating inflammatory disease.
Mu Q; Chen L; Gao X; Shen S; Sheng W; Min J; Wang F · Science bulletin · 2023
Narrative reviewflagImmunity forscienceIron
- Hepcidin--a peptide hormone at the interface of innate immunity and iron metabolism.
Ganz T · Current topics in microbiology and immunology · 2006
Narrative reviewflagImmunity forscienceIron
- Adaptive immunity and vaccination - iron in the spotlight.
Preston AE; Drakesmith H; Frost JN · Immunotherapy advances · 2025
Narrative reviewflagImmunity forscienceIron
- Buried Treasure: Evolutionary Perspectives on Microbial Iron Piracy.
Barber MF; Elde NC · Trends in genetics : TIG · 2016
Narrative reviewflagImmunity forscienceIron
- Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
Randomized trial119 participantsflagImmunity forscienceSelenium
- Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
Randomized trial62 participantsflagImmunity forscienceSelenium
- Chemoprevention trial of human hepatitis with selenium supplementation in China.
Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
Non-randomized trial20,847 participantsflagImmunity forscienceSelenium
- Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
Randomized trial70 participantsflagImmunity forscienceSelenium
- Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
Randomized trial70 participantsflagImmunity forscienceSelenium
- Depressed immune response to tetanus in children with vitamin A deficiency.
Semba RD; Muhilal; Scott AL; Natadisastra G; Wirasasmita S; Mele L; Ridwan E; West KP; Sommer A · The Journal of nutrition · 1992
Randomized trial236 participantsflagImmunity forscienceVitamin A
- Impact of a single megadose of vitamin A at delivery on breastmilk of mothers and morbidity of their infants.
Roy SK; Islam A; Molla A; Akramuzzaman SM; Jahan F; Fuchs G · European journal of clinical nutrition · 1997
Randomized trial50 participantsflagImmunity forscienceVitamin A
- Vitamin A supplementation reduces measles morbidity in young African children: a randomized, placebo-controlled, double-blind trial.
Coutsoudis A; Broughton M; Coovadia HM · The American journal of clinical nutrition · 1991
Randomized trial60 participantsflagImmunity forscienceVitamin A
- Vitamin A supplementation enhances specific IgG antibody levels and total lymphocyte numbers while improving morbidity in measles.
Coutsoudis A; Kiepiela P; Coovadia HM; Broughton M · The Pediatric infectious disease journal · 1992
Randomized trial60 participantsflagImmunity forscienceVitamin A
- Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children.
Long KZ; Santos JI; Estrada Garcia T; Haas M; Firestone M; Bhagwat J; Dupont HL; Hertzmark E; Rosado JL; Nanthakumar NN · The Journal of nutrition · 2006
Randomized trial127 participantsflagImmunity forscienceVitamin A
- Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
Guideline / consensusflagImmunity forscienceVitamin C
- Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
Meta-analysis2,334 participants14 studies pooledflagImmunity forscienceVitamin C
- Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
Meta-analysisflagImmunity forscienceVitamin C
- New evidence for antioxidant properties of vitamin C.
Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
Randomized trial20 participantsflagImmunity forscienceVitamin C
- Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
Calder PC; Kreider RB; McKay DL · Nutrients · 2025
Systematic review13 studies pooledflagImmunity forscienceVitamin C
- Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
Martineau AR; Jolliffe DA; Greenberg L; Aloia JF; Bergman P; Dubnov-Raz G; Esposito S; Ganmaa D; Ginde AA; Goodall EC; Grant CC; Janssens W; Jensen ME; Kerley CP; Laaksi I; Manaseki-Holland S; Mauger D; Murdoch DR; Neale R; Rees JR; Simpson S; Stelmach I; Trilok Kumar G; Urashima M; Camargo CA; Griffiths CJ; Hooper RL · Health technology assessment (Winchester, England) · 2020
Meta-analysis11,321 participants25 studies pooledflagImmunity forscienceVitamin D
- Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
Zhu Z; Zhu X; Gu L; Zhan Y; Chen L; Li X · Frontiers in nutrition · 2022
Meta-analysis4,859 participants10 studies pooledflagImmunity forscienceVitamin D
- Vitamin D3 and deconvoluting a rash.
Ernst MK; Evans ST; Techner JM; Rothbaum RM; Christensen LF; Onay UV; Biyashev D; Demczuk MM; Nguyen CV; Honda KS; McCormick TS; Tsoi LC; Gudjonsson JE; Cooper KD; Lu KQ · JCI insight · 2023
Randomized trial28 participantsflagImmunity forscienceVitamin D
- Effect of vitamin D3 supplementation on cellular immunity and inflammatory markers in COVID-19 patients admitted to the ICU.
Bychinin MV; Klypa TV; Mandel IA; Yusubalieva GM; Baklaushev VP; Kolyshkina NA; Troitsky AV · Scientific reports · 2022
Randomized trial110 participantsflagImmunity forscienceVitamin D
- Current opinion on the role of vitamin D supplementation in respiratory infections and asthma/COPD exacerbations: A need to establish publication guidelines for overcoming the unpublished data.
Anitua E; Tierno R; Alkhraisat MH · Clinical nutrition (Edinburgh, Scotland) · 2022
Meta-analysis50,554 participants65 studies pooledflagImmunity forscienceVitamin D
- Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
Meta-analysis199,055 participants115 studies pooledflagImmunity forscienceZinc
- Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
Randomized trial609 participantsflagImmunity forscienceZinc
- A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
Randomized trial64 participantsflagImmunity forscienceZinc
- The effect of zinc and vitamin A supplementation on immune response in an older population.
Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
Randomized trial136 participantsflagImmunity forscienceZinc
- The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
Systematic review13 studies pooledflagImmunity forscienceZinc