Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Scientific Opinion on the substantiation of a health claim related to Rhodiola rosea L. extract and reduction of mental fatigue pursuant to Article 13(5) of Regulation (EC) No 1924/2006.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
Guideline / consensusflagStress Relief forscienceRhodiola
- Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes.
Łuszczak J; Kocki J · Annals of agricultural and environmental medicine : AAEM · 2026
Systematic review19 studies pooledflagStress Relief flagCognitive Support forscienceRhodiola
- [Effects of rhodiola rosea on oxidative stress and negative emotional states in patients with obstructive sleep apnea].
Yu HL; Zhang PP; Zhang C; Zhang X; Li ZZ; Li WQ; Fu AS · Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2019
Randomized trial90 participantsflagStress Relief forscienceRhodiola
- Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial.
Lekomtseva Y; Zhukova I; Wacker A · Complementary medicine research · 2019
Single-arm trial100 participantsflagStress Relief flagEnergy flagGeneral Health forscienceRhodiola
- Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
Randomized trial34 participantsflagStress Relief forscienceTheanine
- Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study.
Furushima D; Sugiyama I; Nomura Y; Unno K; Yamada H · Journal of nutritional science and vitaminology · 2023
Randomized trial120 participantsflagStress Relief forscienceTheanine
- L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
Randomized trial46 participantsflagStress Relief forscienceTheanine
- Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
Randomized trial30 participantsflagStress Relief flagBrain Health flagCognitive Support forscienceTheanine
- The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials.
Hung SK; Perry R; Ernst E · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012
Systematic review11 studies pooledflagMental Focus forscienceRhodiola
- Dose-Response Effects of Short-Term Rhodiola rosea (Golden Root Extract) Supplementation on Anaerobic Exercise Performance and Cognitive Function in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study.
Koozehchian MS; Newton AT; Mabrey G; Bonness FM; Rafajlovska R; Naderi A · Nutrients · 2025
Randomized trial27 participantsflagMental Focus flagBrain Health forscienceRhodiola
- Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men.
Jówko E; Sadowski J; Długołęcka B; Gierczuk D; Opaszowski B; Cieśliński I · Journal of sport and health science · 2022
Randomized trial26 participantsflagMental Focus flagProductivity Boost forscienceRhodiola
- Acute Rhodiola rosea intake can improve endurance exercise performance.
De Bock K; Eijnde BO; Ramaekers M; Hespel P · International journal of sport nutrition and exercise metabolism · 2004
Randomized trial24 participantsflagMental Focus forscienceRhodiola
- Promising, but Not Completely Conclusive-The Effect of l-Theanine on Cognitive Performance Based on the Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Trials.
Mátyus RO; Szikora Z; Bodó D; Vargáné Szabó B; Csupor É; Csupor D; Tóth B · Journal of clinical medicine · 2025
Meta-analysis148 participants5 studies pooledflagMental Focus forscienceTheanine
- Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
Meta-analysis50 studies pooledflagMental Focus flagBrain Health flagCognitive Support forscienceTheanine
- L-theanine improves neurophysiological measures of attention in a dose-dependent manner: a double-blind, placebo-controlled, crossover study.
Dassanayake TL; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2022
Randomized trial27 participantsflagMental Focus forscienceTheanine
- A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood.
Dodd FL; Kennedy DO; Riby LM; Haskell-Ramsay CF · Psychopharmacology · 2016
Randomized trial24 participantsflagMental Focus forscienceTheanine
- Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial.
Mao JJ; Xie SX; Zee J; Soeller I; Li QS; Rockwell K; Amsterdam JD · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2015
Randomized trial57 participantsflagMood Support forscienceRhodiola
- Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.
Urata M; Sakurai H; Ueno F; Maruki T; Tada T; Uchida T; Matsumoto Y; Murao M; Tomita M; Baba H; Kato M; Tsuboi T; Watanabe K · Neuropsychopharmacology reports · 2025
Meta-analysis1,049 participants2 studies pooledflagMood Support forscienceRhodiola
- Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence.
Sarris J; Panossian A; Schweitzer I; Stough C; Scholey A · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2012
Systematic review66 studies pooledflagMood Support forscienceRhodiola
- A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
Olsson EM; von Schéele B; Panossian AG · Planta medica · 2009
Randomized trial60 participantsflagMood Support flagCognitive Support flagProductivity Boost forscienceRhodiola
- Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
Meta-analysis127,477 participants13 studies pooledflagCardiovascular Support forscienceFish Oil
- A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
Meta-analysis1,524 participants17 studies pooledflagCardiovascular Support forscienceFish Oil
- Vitamin D, Marine n-3 Fatty Acids, and Primary Prevention of Cardiovascular Disease Current Evidence.
Manson JE; Bassuk SS; Cook NR; Lee IM; Mora S; Albert CM; Buring JE; VITAL Research Group · Circulation research · 2020
Randomized trial25,871 participantsflagCardiovascular Support forscienceFish Oil
- Regular use of fish oil supplements and course of cardiovascular diseases: prospective cohort study.
Chen G; Qian ZM; Zhang J; Zhang S; Zhang Z; Vaughn MG; Aaron HE; Wang C; Lip GY; Lin H · BMJ medicine · 2024
Cohort study415,737 participantsflagCardiovascular Support forscienceFish Oil
- Marine n-3 fatty acid treatment for carotid plaques in patients with type 2 diabetes.
Zhuang P; Liu X; Jia W; Zheng W; Wan X; Chen W; Gu J; Li Y; Lan X; Li H; Tong W; Wu Y; Wu X; Ao Y; Ye H; Wu F; Zhu L; Zhang L; Li Y; Meng D; Tian Y; Wang A; Wu S; Zhu F; Zhang Y; Shi H; Yu X; Zhang F; Zhang Y; Jiao J · Cardiovascular diabetology · 2026
Randomized trial415 participantsflagCardiovascular Support forscienceFish Oil
- Antenatal magnesium sulfate and neuroprotection.
Doyle LW · Current opinion in pediatrics · 2012
Meta-analysis6,145 participants5 studies pooledflagBrain Health forscienceMagnesium
- No. 376-Magnesium Sulphate for Fetal Neuroprotection.
Magee LA; De Silva DA; Sawchuck D; Synnes A; von Dadelszen P · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2020
Guideline / consensus4,446 participantsflagBrain Health forscienceMagnesium
- Magnesium Sulfate Before Preterm Birth for Neuroprotection: An Updated Cochrane Systematic Review.
Shepherd ES; Goldsmith S; Doyle LW; Middleton P; Marret S; Rouse DJ; Pryde P; Wolf HT; Crowther CA · Obstetrics and gynecology · 2024
Systematic review5,917 participants6 studies pooledflagBrain Health forscienceMagnesium
- Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta-analysis and trial sequential analysis.
Wolf HT; Huusom LD; Henriksen TB; Hegaard HK; Brok J; Pinborg A · BJOG : an international journal of obstetrics and gynaecology · 2020
Meta-analysis5,917 participants6 studies pooledflagBrain Health forscienceMagnesium
- Magnesium sulfate and fetal neuroprotection: overview of clinical evidence.
Chollat C; Marret S · Neural regeneration research · 2020
Narrative reviewflagBrain Health forscienceMagnesium
- A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers.
Boyle NB; Billington J; Lawton C; Quadt F; Dye L · Nutritional neuroscience · 2022
Randomized trial100 participantsflagBrain Health forscienceRhodiola
- Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.
Panossian A; Wikman G; Sarris J · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2010
Narrative reviewflagBrain Health forscienceRhodiola
- Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.
Darbinyan V; Kteyan A; Panossian A; Gabrielian E; Wikman G; Wagner H · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2001
Randomized trial56 participantsflagBrain Health flagGeneral Health flagProductivity Boost forscienceRhodiola
- Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event-related potential dual task study.
Koop T; Dienel A; Heldmann M; Münte TF · Phytotherapy research : PTR · 2021
Single-arm trial50 participantsflagBrain Health flagCognitive Support forscienceRhodiola
- A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
Randomized trialflagBrain Health flagStress Relief forscienceTheanine
- Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
Randomized trial27 participantsflagBrain Health flagCognitive Support forscienceTheanine
- Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
Randomized trialflagBrain Health flagMental Focus flagProductivity Boost forscienceTheanine
- Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
Randomized trial309 participantsflagCardiovascular Support forscienceFish Oil
- Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
Randomized trial422 participantsflagCardiovascular Support forscienceFish Oil
- Effect of High-Dose Marine Omega-3 Fatty Acids on Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Sekikawa A; Cui C; Sugiyama D; Fabio A; Harris WS; Zhang X · Nutrients · 2020
Meta-analysis6 studies pooledflagCardiovascular Support forscienceFish Oil
- Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
Meta-analysis313,041 participants16 studies pooledflagCardiovascular Support forscienceMagnesium
- Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
Meta-analysis532,979 participants19 studies pooledflagCardiovascular Support forscienceMagnesium
- Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
Meta-analysis544,581 participants18 studies pooledflagCardiovascular Support forscienceMagnesium
- Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
Meta-analysisflagCardiovascular Support forscienceMagnesium flagCardiovascular Support forscienceVitamin D
- Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
Meta-analysis200,934 participants20 studies pooledflagCardiovascular Support forscienceMagnesium
- A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
Kumar V; Yadav AK; Lal A; Kumar V; Singhal M; Billot L; Gupta KL; Banerjee D; Jha V · Journal of the American Society of Nephrology : JASN · 2017
Randomized trial120 participantsflagCardiovascular Support forscienceVitamin D
- Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
Porto C; Petribu K; Barbosa N; Magalhães R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; Magalhães J; Sougey E; Silva T; Junio A; Bandeira F; Leão R · American heart journal plus : cardiology research and practice · 2025
Randomized trial224 participantsflagCardiovascular Support forscienceVitamin D
- Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y · PloS one · 2017
Randomized trial70 participantsflagCardiovascular Support forscienceVitamin D
- Paricalcitol and endothelial function in chronic kidney disease trial.
Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
Randomized trial88 participantsflagCardiovascular Support forscienceVitamin D
- Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.
Doyle LW; Crowther CA; Middleton P; Marret S; Rouse D · The Cochrane database of systematic reviews · 2009
Meta-analysis6,145 participants5 studies pooledflagCognitive Support forscienceMagnesium
- Effects of magnesium valproate adjuvant therapy on patients with dementia: A systematic review and meta-analysis.
Zhang C; Sun L; Sun H · Medicine · 2022
Meta-analysis1,899 participants22 studies pooledflagCognitive Support forscienceMagnesium
- Effects of magnesium supplementation on serum brain-derived neurotrophic factor levels and cognitive function in patients undergoing fluoxetine therapy for depression.
Noor NJ; Syamsuddin S; Liaury K; Tawali S; Idris I; Azis I; Lisal ST · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
Randomized trial40 participantsflagCognitive Support forscienceMagnesium
- Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
Randomized trial80 participantsflagCognitive Support flagEnergy forscienceMagnesium
- Could intraoperative magnesium sulphate protect against postoperative cognitive dysfunction?
Hassan WF; Tawfik MH; Nabil TM; Abd Elkareem RM · Minerva anestesiologica · 2021
Randomized trial80 participantsflagCognitive Support forscienceMagnesium
- Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.
Panossian A; Wikman G · Current clinical pharmacology · 2009
Narrative reviewflagCognitive Support flagMental Focus forscienceRhodiola
- Central additive effect of Ginkgo biloba and Rhodiola rosea on psychomotor vigilance task and short-term working memory accuracy.
Al-Kuraishy HM · Journal of intercultural ethnopharmacology · 2016
Clinical trial112 participantsflagCognitive Support forscienceRhodiola
- Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
Randomized trial32 participantsflagCognitive Support forscienceTheanine
- Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
Clinical trial20 participantsflagCognitive Support flagMental Focus forscienceTheanine
- Total magnesium intake and risk of frailty in older women.
Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
Cohort study81,524 participantsflagEnergy forscienceMagnesium
- Red blood cell magnesium and chronic fatigue syndrome.
Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
Randomized trial32 participantsflagEnergy forscienceMagnesium
- Exercise, magnesium and immune function.
Laires MJ; Monteiro C · Magnesium research · 2008
Narrative reviewflagEnergy forscienceMagnesium
- The Effect of Short-Term Rhodiola rosea Supplementation on Simulated Game Time, Perceived Fatigue, and Performance in Basketball Players.
Wang J; Zhao H; Yu L; Zhao K; Jiang W; Liu S; Dai J; Xu L; Sun P; Yun H; Liu C · Nutrients · 2025
Randomized trial48 participantsflagEnergy forscienceRhodiola
- Effects of Rhodiola rosea on Physical and Decision-Making Performance in Football Players: A Randomised Controlled Trial.
Dou Y; Wang Y; Zhang W; Jiang Y; Zhang J; Yang T; Han Z; Li Y; Liu C; Ren D · Nutrients · 2026
Randomized trial24 participantsflagEnergy flagMental Focus forscienceRhodiola
- Combined Effects of Rhodiola Rosea and Caffeine Supplementation on Straight Punch Explosive Power in Untrained and Trained Boxing Volunteers: A Synergistic Approach.
Tao B; Sun H; Li H; Xu Z; Xu Y; Chen L; Ma C; Zhang X; Yu L; Bao S; Liu C · Metabolites · 2025
Randomized trial96 participantsflagEnergy forscienceRhodiola
- Combined Rhodiola rosea and eccentric training boost endurance performance and lower-limb reactive strength in recreationally active women.
Wang IL; Su Y; Zhang L; Tang M; Chen YM · Frontiers in physiology · 2025
Randomized trial30 participantsflagEnergy forscienceRhodiola
- Parenteral Nutrition Containing Fish Oil for Hospitalized Non-Intensive Care Unit (ICU) Patients: A Systematic Review, Meta-Analysis, and Cost-Effectiveness Analysis.
Pradelli L; Heller AR; Klek S; Mayer K; Rosenthal MD; Muscaritoli M · Nutrients · 2025
Meta-analysis29 studies pooledflagGeneral Health forscienceFish Oil
- Effects of fish oil during hemodialysis on nutritional status and quality of life: a randomized double-blinded trial.
Zhang C; Ge C; Wang J; Sun D · Food & nutrition research · 2022
Randomized trial103 participantsflagGeneral Health forscienceFish Oil
- The effects of fish oil plus vitamin D3 intervention on non-alcoholic fatty liver disease: a randomized controlled trial.
Guo XF; Wang C; Yang T; Ma WJ; Zhai J; Zhao T; Xu TC; Li J; Liu H; Sinclair AJ; Li D · European journal of nutrition · 2022
Randomized trial111 participantsflagGeneral Health forscienceFish Oil
- Circulating Docosahexaenoic Acid and Risk of All-Cause and Cause-Specific Mortality.
O'Keefe EL; O'Keefe JH; Tintle NL; Westra J; Albuisson L; Harris WS · Mayo Clinic proceedings · 2024
Meta-analysis117,702 participants17 studies pooledflagGeneral Health forscienceFish Oil
- Omega-3 dietary supplements and the risk of cardiovascular events: a systematic review.
Marik PE; Varon J · Clinical cardiology · 2010
Meta-analysis39,044 participants11 studies pooledflagGeneral Health forscienceFish Oil
- Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
Meta-analysis1,257 participants20 studies pooledflagGeneral Health forscienceMagnesium
- Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
Woods KL; Fletcher S · Lancet (London, England) · 1994
Randomized trial2,316 participantsflagGeneral Health forscienceMagnesium
- Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
Cohort study10,999 participantsflagGeneral Health forscienceMagnesium
- Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
Cohort study9,359 participantsflagGeneral Health forscienceMagnesium
- The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
Randomized trial64 participantsflagGeneral Health forscienceMagnesium
- Actaea racemosa L. Is More Effective in Combination with Rhodiola rosea L. for Relief of Menopausal Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study.
Pkhaladze L; Davidova N; Khomasuridze A; Shengelia R; Panossian AG · Pharmaceuticals (Basel, Switzerland) · 2024
Randomized trial220 participantsflagGeneral Health forscienceRhodiola
- A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.
Spasov AA; Wikman GK; Mandrikov VB; Mironova IA; Neumoin VV · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2000
Randomized trialflagGeneral Health flagProductivity Boost forscienceRhodiola
- [The effect of the preparation rodakson on the psychophysiological and physical adaptation of students to an academic load].
Spasov AA; Mandrikov VB; Mironova IA · Eksperimental'naia i klinicheskaia farmakologiia · 2000
Clinical trialflagGeneral Health forscienceRhodiola
- Vitamin D supplementation for prevention of mortality in adults.
Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
Meta-analysis95,286 participants159 studies pooledflagGeneral Health forscienceVitamin D
- Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
Randomized trial90 participantsflagGeneral Health forscienceVitamin D
- The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
Meta-analysis2,495 participants19 studies pooledflagGeneral Health forscienceVitamin D
- Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
Systematic review84 studies pooledflagGeneral Health forscienceVitamin D
- Meta-analysis of long-term vitamin D supplementation on overall mortality.
Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
Meta-analysis42 studies pooledflagGeneral Health forscienceVitamin D
- Relationship between Whole-Blood Magnesium and Cognitive Performance among Chinese Adults.
Lu Z; He R; Zhang Y; Li B; Li F; Fu Y; Rong S · Nutrients · 2023
Cross-sectional study1,006 participantsflagMental Focus forscienceMagnesium
- Serum Magnesium and Cognitive Function Among Qatari Adults.
Al-Ghazali K; Eltayeb S; Musleh A; Al-Abdi T; Ganji V; Shi Z · Frontiers in aging neuroscience · 2020
Cross-sectional study1,000 participantsflagMental Focus forscienceMagnesium
- Magnesium status and attention deficit hyperactivity disorder (ADHD): A meta-analysis.
Effatpanah M; Rezaei M; Effatpanah H; Effatpanah Z; Varkaneh HK; Mousavi SM; Fatahi S; Rinaldi G; Hashemi R · Psychiatry research · 2019
Meta-analysisflagMental Focus forscienceMagnesium
- The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial.
Hemamy M; Pahlavani N; Amanollahi A; Islam SMS; McVicar J; Askari G; Malekahmadi M · BMC pediatrics · 2021
Randomized trial33 participantsflagMental Focus forscienceMagnesium
- The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
Lopresti AL; Smith SJ · Frontiers in nutrition · 2026
Randomized trial100 participantsflagMental Focus forscienceMagnesium
- Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
Randomized trial30 participantsflagMental Focus flagProductivity Boost flagStress Relief forscienceTheanine
- Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
Randomized trial24 participantsflagMental Focus forscienceTheanine
- Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes.
Anderson RA; Cheng N; Bryden NA; Polansky MM; Cheng N; Chi J; Feng J · Diabetes · 1997
Randomized trial180 participantsflagMetabolism Boost forscienceChromium
- Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Jamilian M; Asemi Z · Annals of nutrition & metabolism · 2016
Randomized trial64 participantsflagMetabolism Boost forscienceChromium
- A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review.
Kooshki F; Tutunchi H; Vajdi M; Karimi A; Niazkar HR; Shoorei H; Pourghassem Gargari B · Clinical and experimental pharmacology & physiology · 2024
Systematic review33 studies pooledflagMetabolism Boost forscienceChromium
- Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis.
Hu X; Wang W; Su X; Peng H; Tan Z; Li Y; Huang Y · PeerJ · 2023
Meta-analysis2,362 participants41 studies pooledflagMetabolism Boost forscienceChromium
- [Chromium supplementation in patients with type 2 diabetes and high risk of type 2 diabetes: a meta-analysis of randomized controlled trials].
San Mauro-Martin I; Ruiz-León AM; Camina-Martín MA; Garicano-Vilar E; Collado-Yurrita L; Mateo-Silleras Bd; Redondo Del Río Mde P · Nutricion hospitalaria · 2017
Meta-analysis13 studies pooledflagMetabolism Boost forscienceChromium
- Association of magnesium consumption with type 2 diabetes and glucose metabolism: A systematic review and pooled study with trial sequential analysis.
Zhao B; Deng H; Li B; Chen L; Zou F; Hu L; Wei Y; Zhang W · Diabetes/metabolism research and reviews · 2021
Meta-analysis1,168 participants26 studies pooledflagMetabolism Boost forscienceMagnesium
- Magnesium supplementation for glycemic status in women with gestational diabetes: a systematic review and meta-analysis.
Tan X; Huang Y · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2022
Meta-analysis4 studies pooledflagMetabolism Boost forscienceMagnesium
- Impact of oral magnesium supplementation on glycemic and cardiometabolic outcomes in prediabetic adults: a systematic review and meta-analysis.
Basit A; Kumar S; Ahmed H; Babar R; Saeed SS; Siddiqui TA; Khan S; Saeed A; Khan M; Hanif H; Fasih A; Shabbir S; Kumar H; Kumar L; Raja A; Kumar S; Chander S · Journal of diabetes and metabolic disorders · 2026
Meta-analysis384 participants5 studies pooledflagMetabolism Boost forscienceMagnesium
- Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial.
Rodríguez-Morán M; Guerrero-Romero F · Diabetes care · 2003
Randomized trial63 participantsflagMetabolism Boost forscienceMagnesium
- Magnesium Supplementation and the Effects on Wound Healing and Metabolic Status in Patients with Diabetic Foot Ulcer: a Randomized, Double-Blind, Placebo-Controlled Trial.
Razzaghi R; Pidar F; Momen-Heravi M; Bahmani F; Akbari H; Asemi Z · Biological trace element research · 2018
Randomized trial70 participantsflagMetabolism Boost forscienceMagnesium
- Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
Meta-analysis4,049 participants52 studies pooledflagMood Support forscienceMagnesium
- Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
Randomized trial126 participantsflagMood Support forscienceMagnesium
- Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
Randomized trial40 participantsflagMood Support forscienceMagnesium
- The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
Randomized trial46 participantsflagMood Support forscienceMagnesium
- Dietary magnesium intake and risk of depression.
Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
Cross-sectional study17,730 participantsflagMood Support forscienceMagnesium
- The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate, Substrate Utilisation, Mood State, and Perceptions of Exertion, Arousal, and Pleasure/Displeasure in Active Men.
Duncan MJ; Clarke ND · Journal of sports medicine (Hindawi Publishing Corporation) · 2015
Clinical trial10 participantsflagMood Support forscienceRhodiola
- Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials.
Moragrega I; Ríos JL · Planta medica · 2022
Systematic reviewflagMood Support forscienceRhodiola
- Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms.
Kasper S; Dienel A · Neuropsychiatric disease and treatment · 2020
Single-arm trial118 participantsflagMood Support forscienceRhodiola
- l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
Randomized trial60 participantsflagMood Support forscienceTheanine
- L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
Randomized trial60 participantsflagMood Support flagStress Relief forscienceTheanine
- The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
Systematic review9 studies pooledflagMood Support forscienceTheanine
- Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
Randomized trial168 participantsflagMood Support flagStress Relief forscienceTheanine
- Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
Randomized trial20 participantsflagMood Support forscienceTheanine
- The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence.
Ivanova Stojcheva E; Quintela JC · Molecules (Basel, Switzerland) · 2022
Narrative reviewflagProductivity Boost flagStress Relief forscienceRhodiola
- Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
Meta-analysis1,168 participants31 studies pooledflagProductivity Boost forscienceTheanine
- Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
Narrative reviewflagProductivity Boost forscienceTheanine
- Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
Randomized trial48 participantsflagProductivity Boost forscienceTheanine
- Stress management and the role of Rhodiola rosea: a review.
Anghelescu IG; Edwards D; Seifritz E; Kasper S · International journal of psychiatry in clinical practice · 2019
Narrative reviewflagStress Relief forscienceRhodiola
- Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.
Sarris J; McIntyre E; Camfield DA · CNS drugs · 2013
Narrative reviewflagStress Relief forscienceRhodiola