Product Image

New MOOD

Onnit
4.3
★ ★ ★ ★ ★
(777 ratings)
Vitamin B6 20 mg
Niacin 30 mg
Tryptophan 400 mg
5-HTP 150 mg
Product Image
Score57
Direct mood and sleep ingredients are present, but hidden blend details, weak value, and a combined serotonergic load make this a difficult formula to recommend broadly.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Stress Relief
Mood Support

Score 57

Direct mood and sleep ingredients are present, but hidden blend details, weak value, and a combined serotonergic load make this a difficult formula to recommend broadly.
How scoring works

Also available as

1 option
30 servings B6 20 mg, 5-HTP 150 mg +1 more • 30 Capsule(s) • 15 servings $23.99 ($1.59 per serving)
$56.93($1.89 per serving)
Vitacost
$ 56.93
iHerb
$ 59.90
iHerb
$ 59.90
Report prices

Analysis

5-HTP and tryptophan address the same serotonin pathway from different precursor stages, giving the formula a clear mood and sleep focus. Vitamin D3 and magnesium bisglycinate are useful forms, but the magnesium amount is small.

The 450 mg Tranquility Blend does not disclose individual ingredient amounts, which prevents a full assessment. Using both 150 mg 5-HTP and 400 mg tryptophan may also add risk without clearly proving a practical advantage over a simpler single-precursor formula.

Two capsules per serving are manageable, but the serving value is weak. The combined serotonergic load makes medication screening essential and narrows the group of people who can use the product safely.

Who is it for
  • Adults specifically seeking combined 5-HTP and tryptophan
  • Experienced users who have screened for serotonergic interactions
Best for
  • Targeted serotonin-precursor supplementation
  • Combined mood and nighttime support

Pros

  • Provides disclosed 5-HTP and tryptophan amounts
  • Uses vitamin D3 and magnesium bisglycinate
  • Has a clear mood and sleep focus

Cons

  • Tranquility Blend hides individual amounts
  • Magnesium amount is modest
  • Serving value is weak

Warnings

  • Do not combine 5-HTP and tryptophan with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonin-raising agents because dangerous serotonin excess may occur
  • The combined 5-HTP and tryptophan may cause nausea, headache, or digestive discomfort
  • Serotonergic and calming ingredients may cause drowsiness, so avoid driving until effects are known

Nutrient quality

73 High impact

Magnesium bisglycinate and vitamin D3 are useful forms, while several other forms are conventional. Tryptophan and 5-HTP are present in meaningful amounts, though the hidden blend cannot be assessed.

Ingredient transparency

54 Moderate impact

Named actives have amounts, but the ingredients within the tranquility blend do not. Inactive capsule ingredients are not disclosed.

Customer satisfaction

64 Moderate impact

The supplied average and volume indicate mixed aggregate satisfaction. No detailed experience reports are available to identify repeated complaints or confirm perceived benefits.

Value for money

37 Lower impact

Meaningful core doses are undermined by a high cost and limited transparency. The serving cost is high for a partly undisclosed formula.

Report analysis

Goals

Stress Relief
Stress Relief
Impact
High effect
B+ Goal FitB- Strength of SupportB CoverageB- Formula Quality
Vitamin D · 25 mcgMagnesium · 40 mgVitamin B6 · 20 mgTryptophan · 400 mg

The formula targets mood-related stress through serotonin precursors and calming support. It provides 400 mg of L-tryptophan, 150 mg of 5-HTP, magnesium bisglycinate, and a tranquility blend for the stated purpose.

Magnesium is present at a small amount, while the proprietary tranquility blend prevents full dose review. Combining 5-HTP and L-tryptophan with SSRIs, MAO inhibitors, or other serotonergic medicines can dangerously raise serotonin activity.

Study evidence
5-HTP Supportive 18 studies
Magnesium Supportive 13 studies
Mood Support
Mood Support
Impact
High effect
B Goal FitC+ Strength of SupportB- CoverageD+ Formula Quality
Vitamin B6 · 20 mgMagnesium · 40 mgVitamin D · 25 mcg5-HTP · 150 mg

Tryptophan and 5-HTP both feed serotonin synthesis, while magnesium, vitamin D, and B6 add supportive cofactors. Using both precursors together creates a strong serotonergic load without clear evidence that the redundancy improves mood.

The precursor amounts are disclosed, but the 450 mg Tranquility Blend hides its ingredients and doses. Combining this product with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonergic drugs can increase serotonin-toxicity risk.

Study evidence
5-HTP Supportive 9 studies
Magnesium Supportive 60 studies
Tryptophan Mixed 1 study
Vitamin B6 Supportive 19 studies
Vitamin D Supportive 163 studies
Sleep Support
Sleep Support
Impact
Moderate effect
C+ Goal FitC- Strength of SupportC CoverageC- Formula Quality
Magnesium · 40 mg

5-HTP and tryptophan support the serotonin-to-melatonin pathway, while a tranquility blend may add relaxation. The design is relevant to sleep but remains more focused on mood, and several supporting amounts or ingredients are either low or hidden.

The 5-HTP amount is substantial, while tryptophan and magnesium fall below stronger targeted ranges. Combining 5-HTP and tryptophan with SSRIs, MAO inhibitors, or triptan medicines may raise serotonin excessively and increase the risk of serotonin toxicity.

Study evidence
5-HTP Supportive 1 study
Magnesium Supportive 23 studies
Tryptophan Mixed 1 study
Weight Loss
Weight Loss
Impact
Moderate effect
D+ Goal FitC+ Strength of SupportD+ CoverageC Formula Quality
Vitamin D · 25 mcgMagnesium · 40 mg

5-HTP and tryptophan may support appetite and emotional-eating control through serotonin production, while calming nutrients may help stress-related adherence. These effects are situational and do not directly increase thermogenesis or preserve muscle.

The paired serotonin precursors create a stronger but partly redundant serotonergic design, and disclosure around the tranquility blend is limited. Combining 5-HTP and tryptophan with SSRIs, MAO inhibitors, tramadol, or other serotonin-raising agents can raise the risk of serotonin toxicity.

Study evidence
5-HTP Supportive 5 studies
Brain Health
Brain Health
Impact
Moderate effect
C- Goal FitD+ Strength of SupportD+ CoverageC- Formula Quality
Vitamin B6 · 20 mgVitamin D · 25 mcgMagnesium · 40 mg

L-tryptophan, 5-HTP, magnesium, and vitamin B6 support serotonin-related mood and relaxation pathways. The formula may help indirect aspects of brain health, but it is not designed for memory or broad cognitive performance.

Tryptophan is below the preferred targeted range, and the botanical blend hides individual amounts. Combining L-tryptophan with 5-HTP may raise serotonin-related risk for people using SSRIs, MAO inhibitors, or triptan medicines.

Study evidence
Magnesium Supportive 86 studies
Vitamin B6 Supportive 29 studies

Ingredients

IngredientAmount per serving
Vitamin D (Vitamin D3)
 25 mcg
Niacin (Inositol Hexanicotinate)
 30 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 20 mg
Magnesium (Magnesium Bisglycinate Chelate)
 40 mg
Onnit Tranquility Blend
450 mg
L-Tryptophan
400 mg
5-Hydroxytryptophan
150 mg
Gluten Free Adults 18–50
Report overview
Vitamin B6 (Pyridoxine Hydrochloride) · 20 mg OverallScore62
D+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The 20 mg dose is well targeted and comes in a practical two-capsule serving. Pyridoxine hydrochloride needs conversion, and no riboflavin is listed to support that step. Very high serving cost results in poor B6 value.

View ingredientView products
Niacin (Inositol Hexanicotinate) · 30 mg OverallScore54
C Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyF Value

Inositol hexanicotinate is clearly named but plays only a minor role in this mood formula. Tryptophan and 5-HTP drive the intended effect, while the niacin amount is modest and lacks specialized delivery. Value for niacin is poor, and combining 5-HTP or tryptophan with serotonergic medicines can raise serotonin-related risk.

View ingredientView products
Tryptophan · 400 mg OverallScore48
D+ Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value

The exact L-tryptophan amount is disclosed, but the generic source lacks purity or fermentation details. Its 400 mg dose falls below the preferred targeted range, while the broader calming blend does not contain competing branched-chain amino acids. Combining L-tryptophan with 5-HTP may raise serotonin-related risks for people using SSRIs, MAO inhibitors, or triptan medicines.

View ingredientView products
Loading alternative details
82 Performance

Sleep Nighttime Powder

youtheory
<p>Glycine, L-theanine, magnesium citrate, tryptophan, 5-HTP, and low-dose melatonin create a well-dosed nighttime formula. The ingredient focus improves on the original’s combined serotonin precursors and an undisclosed tranquility blend, although tryptophan and 5-HTP can interact with serotonergic medicines, while melatonin may increase drowsiness.</p>
83 Performance

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best
<p>A clearly disclosed 5-HTP amount with vitamin C and B6 creates a simple sleep and mood formula. The ingredient focus improves on the original’s combined serotonin precursors and an undisclosed tranquility blend, although 5-HTP may be unsuitable with serotonergic medicines unless a clinician approves the combination.</p>
83 Performance

5-HTP with Vitamin B6 & Vitamin C

Lake Avenue Nutrition
<p>A useful 5-HTP amount with vitamin C and B6 creates a simple low-cost sleep and mood formula. The ingredient focus improves on the original’s combined serotonin precursors and an undisclosed tranquility blend, although the conventional vitamin forms add limited refinement, and serotonergic medicines create an interaction concern.</p>
78 Budget

5-HTP 200 mg

NutraBio
<p>A higher serving cost means this is not a true cheaper option, although a substantial and clearly disclosed 5-HTP amount provides direct sleep and mood alignment. Vitamin B6 is unnecessarily high for regular use, and serotonergic medicines create a specific interaction concern.</p>
78 Budget

B-50 Complex

21st Century
<p>A higher serving cost means this is not a true cheaper option, although a budget B-complex provides substantial niacin and vitamin B6 with clear active disclosure. The formula is aimed at energy rather than sleep or mood, and conventional forms plus high B6 limit long-term use.</p>
62 Budget

New Mood

Onnit
<p>A higher serving cost means this is not a true cheaper option, although tryptophan, 5-HTP, magnesium bisglycinate, and vitamin D preserve the original formula’s sleep and mood focus. A hidden tranquility blend, relatively high B6, and combined serotonin precursors limit transparency and medication compatibility.</p>
81 Value

Double Strength 5-HTP 200 mg

NOW
<p>A substantial 5-HTP amount with modest supporting nutrients provides direct sleep and mood alignment at a higher serving cost. The quality-to-cost balance may improve on the original’s combined serotonin precursors and an undisclosed tranquility blend, although serotonergic medicines are a specific concern because 5-HTP can further increase serotonin activity.</p>
65 Value

Optimized Tryptophan Plus

Life Extension
<p>A meaningful tryptophan amount and disclosed lysine provide a credible sleep and mood foundation at a higher serving cost. The quality-to-cost balance may improve on the original’s combined serotonin precursors and an undisclosed tranquility blend, although an unnamed proprietary blend blocks full assessment, while niacin may cause flushing or digestive discomfort.</p>
70 Value

Serotonin Brain Food

NS Natural Stacks
<p>A substantial tryptophan amount, standardized rhodiola, and glycinate minerals create a coherent mood-support formula at a higher serving cost. The quality-to-cost balance may improve on the original’s combined serotonin precursors and an undisclosed tranquility blend, although duplicate niacin and rhodiola entries weaken clarity, and tryptophan can interact with serotonergic medicines.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  2. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  5. Symptomatic treatment of interferon-α-induced depression in hepatitis C: a systematic review.
    Baraldi S; Hepgul N; Mondelli V; Pariante CM · Journal of clinical psychopharmacology · 2012
    Systematic review64 studies pooledMood Support for5-HTP
  6. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  7. Serotonin precursors in the treatment of depression.
    van Praag HM · Advances in biochemical psychopharmacology · 1982
    Narrative reviewMood Support for5-HTP
  8. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  9. Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
    Takahashi S; Takahashi R; Masumura I; Miike A · Folia psychiatrica et neurologica japonica · 1977
    Single-arm trial14 participantsMood Support for5-HTP
  10. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  11. Antenatal magnesium sulfate and neuroprotection.
    Doyle LW · Current opinion in pediatrics · 2012
    Meta-analysis6,145 participants5 studies pooledBrain Health forMagnesium
  12. No. 376-Magnesium Sulphate for Fetal Neuroprotection.
    Magee LA; De Silva DA; Sawchuck D; Synnes A; von Dadelszen P · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2020
    Guideline / consensus4,446 participantsBrain Health forMagnesium
  13. Magnesium Sulfate Before Preterm Birth for Neuroprotection: An Updated Cochrane Systematic Review.
    Shepherd ES; Goldsmith S; Doyle LW; Middleton P; Marret S; Rouse DJ; Pryde P; Wolf HT; Crowther CA · Obstetrics and gynecology · 2024
    Systematic review5,917 participants6 studies pooledBrain Health forMagnesium
  14. Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta-analysis and trial sequential analysis.
    Wolf HT; Huusom LD; Henriksen TB; Hegaard HK; Brok J; Pinborg A · BJOG : an international journal of obstetrics and gynaecology · 2020
    Meta-analysis5,917 participants6 studies pooledBrain Health forMagnesium
  15. Magnesium sulfate and fetal neuroprotection: overview of clinical evidence.
    Chollat C; Marret S · Neural regeneration research · 2020
    Narrative reviewBrain Health forMagnesium
  16. Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.
    Zhang C; Luo J; Yuan C; Ding D · Journal of Alzheimer's disease : JAD · 2021
    Meta-analysis21 studies pooledBrain Health forVitamin B6
  17. Relationship between serum pyridoxal 5'-phosphate concentration and cognitive function in older Japanese.
    Itoh K; Kuwabara A; Otsuka R; Sugimoto T; Sakurai T; Niida S; Ao M; Tanaka K; Takenaka S; Kanouchi H · Journal of clinical biochemistry and nutrition · 2025
    Cross-sectional study266 participantsBrain Health forVitamin B6
  18. A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women.
    Dhivya K; Sarumathy S; Manigandan G · Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Randomized trial180 participantsBrain Health forVitamin B6
  19. Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
    Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
    Cohort study949 participantsBrain Health forVitamin B6
  20. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review.
    Iolascon G; Gimigliano R; Bianco M; De Sire A; Moretti A; Giusti A; Malavolta N; Migliaccio S; Migliore A; Napoli N; Piscitelli P; Resmini G; Tarantino U; Gimigliano F · The journal of nutrition, health & aging · 2017
    Scoping review12 studies pooledBrain Health forVitamin B6
  21. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  22. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support Stress Relief forMagnesium
  23. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  24. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  25. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  26. A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning
    Kikuchi AM, Tanabe A, Iwahori Y · Journal of Dietary Supplements · 2021
    Systematic review11 studies pooledMood Support forTryptophan
  27. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  28. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support forVitamin B6
  29. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  30. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  31. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  32. Meta-analysis of the effect of vitamin D on depression.
    Wang L; Su S; Liu Y · Frontiers in psychiatry · 2025
    Meta-analysis20 studies pooledMood Support forVitamin D
  33. A randomized controlled trial of vitamin D supplementation on perinatal depression: in Iranian pregnant mothers.
    Vaziri F; Nasiri S; Tavana Z; Dabbaghmanesh MH; Sharif F; Jafari P · BMC pregnancy and childbirth · 2017
    Randomized trial169 participantsMood Support forVitamin D
  34. Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort.
    Ronaldson A; Arias de la Torre J; Gaughran F; Bakolis I; Hatch SL; Hotopf M; Dregan A · Psychological medicine · 2022
    Cohort study139,128 participantsMood Support forVitamin D
  35. Association Between Low Vitamin D Levels and Depression: A Systematic Review and Meta-Analysis.
    Karim S; Natche J; Babli SA; Avinash; Matakhov D; Ferdous S; Jeyakkodi H; Alamu OS; Rizwanullah U; Hameed SA · Cureus · 2026
    Meta-analysis49,931 participants15 studies pooledMood Support forVitamin D
  36. Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study.
    Zaromytidou E; Koufakis T; Dimakopoulos G; Drivakou D; Konstantinidou S; Rakitzi P; Grammatiki M; Manthou E; Notopoulos A; Iakovou I; Gotzamani-Psarrakou A; Kotsa K · Metabolites · 2023
    Randomized trial90 participantsMood Support forVitamin D
  37. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  38. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  39. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  40. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  41. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  42. The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression
    Clarinda N Sutanto, Wen Wei Loh, Jung Eun Kim · Nutrition Reviews · 2022
    Meta-analysis4 studies pooledSleep Support forTryptophan
  43. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  44. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  45. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  46. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  47. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  48. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  49. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  50. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  51. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  52. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  53. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  54. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  55. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  56. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP