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Ez Doze

Dr. Emil Nutrition
3.8
★ ★ ★ ★ ★
(493 ratings)
Theanine 175 mg
Lithium 3.8 mg
GABA 350 mg
Valerian 150 mg
Vitamin B12 156.8 mcg
5-HTP 30 mg
St. John's Wort 200 mg
Product Image
Score57
Useful theanine and GABA doses are outweighed by a complicated mood-active blend and an unusually high listed folate amount. Medication interactions and label verification make professional review important before use.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Stress Relief
Sleep Support

Score 57

Useful theanine and GABA doses are outweighed by a complicated mood-active blend and an unusually high listed folate amount. Medication interactions and label verification make professional review important before use.
How scoring works
$17.27($0.57 per serving)
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Analysis

L-theanine and GABA are the clearest strengths: both are openly dosed, with theanine in a well-aligned amount and GABA within a commonly used supplemental range. Methylcobalamin and magnesium bisglycinate are useful forms, although the magnesium amount is small.

Several other ingredients are less convincing. Valerian root powder is modestly dosed and has no extract ratio, St. John's wort lacks meaningful standardization details, and 5-HTP is below a typical starting amount; combining these with lithium orotate makes the formula harder to evaluate and use safely.

The supplied data list folate at 12,750 mcg DFE, which is an unusually high amount and should be checked against the original label before use. Even if that figure is a data error, the blend still requires careful medication screening because St. John's wort can affect many drugs and adds serotonergic concerns alongside 5-HTP and lithium.

Who is it for
  • Adults specifically seeking combined theanine and GABA who have reviewed the full formula with a qualified clinician
  • People not using serotonergic, sedating, hormonal, transplant, anticoagulant, or prescription lithium medicines
  • Shoppers willing to verify the folate and lithium label details before use
Best for
  • Combined theanine and GABA in one serving
  • Occasional evening use only after medication and interaction screening
  • People who want several calming herbs and amino acids in one capsule blend

Pros

  • Provides L-theanine at a clearly disclosed and well-aligned amount
  • GABA is transparently dosed within a commonly used supplemental range
  • Uses methylcobalamin for vitamin B12
  • Includes magnesium in a bisglycinate chelate form

Cons

  • St. John's wort lacks extract and standardization details
  • Valerian root powder and 5-HTP are modestly dosed
  • The lithium label does not clearly separate elemental lithium from the total orotate compound
  • Multiple mood-active and sedating ingredients make effects and tolerability harder to predict

Warnings

  • Do not combine St. John's wort, 5-HTP, and lithium orotate with SSRIs, SNRIs, MAO inhibitors, triptans, tramadol, or prescription lithium without direct medical supervision because serotonin-related and lithium-related adverse effects may increase.
  • St. John's wort can reduce the effectiveness of many medicines, including hormonal contraceptives, transplant drugs, anticoagulants, and some seizure or HIV medicines.
  • The supplied label data list 12,750 mcg DFE of folate, an unusually high amount; verify the original label and avoid use until the quantity is confirmed.
  • GABA, valerian, lemon balm, passion flower, and theanine may increase drowsiness when combined with alcohol, sleep medicines, benzodiazepines, or other sedatives.
  • St. John's wort can increase sensitivity to sunlight in some users, especially alongside other photosensitizing medicines.

Nutrient quality

43 Lower impact

GABA and L-theanine have useful amounts, while methylcobalamin and magnesium bisglycinate are favorable forms. The extreme folate amount, low-dose herbs, and overlapping mood-active ingredients create poor dose balance and substantial safety concerns.

.

Ingredient transparency

76 High impact

All active amounts are individually listed without a hidden blend. Botanical standardization, elemental lithium exposure, intake directions, and non-active ingredients remain unclear.

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Customer satisfaction

57 Moderate impact

The aggregate rating is mixed despite a substantial feedback count. No complaint-level evidence was supplied to identify recurring problems or confirm sleep and mood experiences.

.

Value for money

48 Lower impact

Useful theanine and GABA amounts provide some practical value per serving. Severe dose imbalance, medication interaction risk, and several weak additions make the complete formula a poor value for broad use.

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Report analysis

Goals

Stress Relief
Stress Relief
Impact
High effect
B+ Goal FitC+ Strength of SupportB CoverageD- Formula Quality
Magnesium · 20 mgFolate · 12750 mcg DFEVitamin B12 · 156.8 mcgGABA · 350 mgVitamin B6 · 6.23 mgTheanine · 175 mg

GABA and L-theanine are supplied at useful calming amounts, while magnesium bisglycinate and several herbs add complementary support. The formula reaches neurotransmitter, mineral, and botanical stress pathways.

Ashwagandha is absent, valerian and 5-HTP are low, and several mood-active ingredients create avoidable complexity. St John’s wort, 5-HTP, lithium orotate, and the extremely high folate amount raise serious interaction and safety concerns, especially with antidepressants or prescription lithium.

Study evidence
5-HTP Supportive 18 studies
Folate Supportive 19 studies
GABA Supportive 6 studies
Magnesium Supportive 13 studies
St. John's Wort Mixed 6 studies
Theanine Supportive 16 studies
Valerian Supportive 18 studies
Sleep Support
Sleep Support
Impact
High effect
B Goal FitC+ Strength of SupportB CoverageD- Formula Quality
Magnesium · 20 mgTheanine · 175 mg

Optimal theanine and substantial GABA give this blend meaningful calming potential. Valerian and 5-HTP add sleep-onset and serotonin-related context.

Valerian and 5-HTP are underdosed, while St. John’s wort, lithium, and multiple mood-active ingredients create substantial interaction and coherence concerns. The combination can interact seriously with antidepressants, serotonergic medicines, prescription lithium, and many other drugs, so it is a poor choice without professional review.

Study evidence
5-HTP Supportive 1 study
GABA Supportive 4 studies
Theanine Supportive 8 studies
Valerian Supportive 31 studies
Mood Support
Mood Support
Impact
Moderate effect
B Goal FitC- Strength of SupportB CoverageF Formula Quality
Folate · 12750 mcg DFEVitamin B6 · 6.23 mgVitamin B12 · 156.8 mcgMagnesium · 20 mg5-HTP · 30 mg

GABA, L-theanine, St John’s wort, lithium orotate, valerian, and 5-HTP touch several mood and calming pathways. Key actives are underdosed or poorly standardized, while folate is listed at an unusually excessive amount.

The combination creates serious interaction concerns because St John’s wort, 5-HTP, and lithium all affect mood-related signaling. Antidepressants, prescription lithium, hormonal contraceptives, anticoagulants, and many other medicines require professional review before use.

Study evidence
5-HTP Supportive 9 studies
Folate Supportive 84 studies
GABA Supportive 12 studies
Lithium Supportive 197 studies
Magnesium Supportive 60 studies
St. John's Wort Supportive 97 studies
Theanine Supportive 12 studies
Valerian Supportive 17 studies
Brain Health
Brain Health
Impact
Moderate effect
C- Goal FitC Strength of SupportB- CoverageD- Formula Quality
Folate · 12750 mcg DFEVitamin B12 · 156.8 mcgVitamin B6 · 6.23 mgMagnesium · 20 mg

Theanine, GABA, valerian, lemon balm, passionflower, and 5-HTP mainly target relaxation and sleep rather than direct cognitive performance. Methylcobalamin and a small amount of magnesium add limited foundational support.

The extremely high folate amount, folic acid form, St. John’s wort, 5-HTP, and lithium orotate create major safety and formulation concerns. St. John’s wort and 5-HTP can interact with antidepressants and many other medicines, while lithium exposure is unsuitable without clinician oversight.

Study evidence
Folate Supportive 90 studies
Magnesium Supportive 86 studies
Theanine Supportive 17 studies
Vitamin B12 Supportive 74 studies
Productivity Boost
Productivity Boost
Impact
Moderate effect
D Goal FitC+ Strength of SupportC- CoverageD- Formula Quality
Vitamin B12 · 156.8 mcgVitamin B12 · 156.8 mcgVitamin B6 · 6.23 mgMagnesium · 20 mgTheanine · 175 mg

Theanine may support calm attention, but the broader formula strongly favors relaxation and mood support. Valerian, GABA, 5-HTP, and St. John’s wort can work against daytime alertness.

The folate amount is extremely high and the serotonergic combination raises safety concerns. St. John’s wort and 5-HTP can interact with SSRIs, SNRIs, MAO inhibitors, and other serotonergic medicines.

Study evidence
Magnesium Supportive 10 studies
Theanine Supportive 5 studies
Cognitive Support
Cognitive Support
Impact
Moderate effect
F Goal FitB- Strength of SupportF CoverageD+ Formula Quality
Vitamin B6 · 6.23 mgFolate · 12750 mcg DFEVitamin B12 · 156.8 mcgMagnesium · 20 mgTheanine · 175 mg

L-theanine, GABA, inositol, valerian, lemon balm, and 5-HTP are aimed at relaxation and sleep rather than active cognitive support. Theanine is usefully dosed, but the rest of the stack may impair alertness during daytime use.

The label discloses individual amounts, yet the extremely high folate amount is difficult to justify in a sleep formula. Valerian and other calming agents may cause next-day drowsiness, while 5-HTP can interact with serotonergic medicines.

Study evidence
Folate Supportive 68 studies
Theanine Supportive 25 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxine Hydrochloride)
 6.23 mg
Folate (Folic Acid)
 12750 mcg DFE
Vitamin B12 (Methylcobalamin)
 156.8 mcg
Magnesium (Magnesium Bisglycinate Chelate)
 20 mg
GABA
350 mg
St. John's Wort (Hypericin)
 200 mg
Inositol
175 mg
L-Theanine
175 mg
Valerian root powder
150 mg
Lemon Balm
75 mg
Passion Flower extract
55 mg
5-Hydroxytryptophan
30 mg
Lithium Orotate
3.8 mg
Adults 18–50 Women
Report overview
Theanine · 175 mg OverallScore88
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

The active L-isomer is clearly identified at an optimal dose. Generic sourcing provides no branded purity assurance, although the exact amount is transparent. Cost per standard theanine amount is competitive, while the small 5-HTP amount does not justify an adjustment.

View ingredientView products
Lithium · 3.8 mg OverallScore82
A+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyC Value

Lithium orotate is the preferred compound for this collection, and the listed amount falls within the intended nutritional range. The label presentation does not clearly separate elemental lithium from the total orotate compound, which makes the true lithium exposure harder to verify. Methylcobalamin adds some value, but the relatively high serving cost and a complex blend with St. John's wort, 5-HTP, and sedating herbs reduce its appeal as a focused lithium supplement.

View ingredientView products
GABA · 350 mg OverallScore75
B- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyD- Value

The 350 mg GABA dose is transparent and falls within the preferred standalone range, though it uses an unbranded standard form. Conventional capsule delivery and a high serving cost limit its GABA-specific value. The unusually high folate amount and added St. John's wort create important safety concerns, including masking vitamin B12 deficiency and interactions with serotonergic medicines and many other drugs.

View ingredientView products
Loading alternative details
76 Performance

Best-Rest Formula

Pure Encapsulations
Valerian, GABA, L-theanine, lemon balm, hops, passionflower, chamomile, and melatonin create a focused sleep blend without St. John's wort, lithium, or 5-HTP. That removes several of the original's most concerning interaction pathways while retaining multiple calming ingredients.
68 Performance

Revitalizing Sleep Formula

Nature's Way
Substantial listed amounts of valerian, passionflower, L-theanine, 5-HTP, hops, and lemon balm give the formula a clearer sleep focus. It avoids St. John's wort and lithium, though 5-HTP can still interact with serotonergic medicines.
72 Performance

Insomnitol

Designs for Health
Standardized valerian plus passionflower, lemon balm, chamomile, GABA, L-theanine, 5-HTP, and melatonin provide a more deliberate sleep formulation. It removes St. John's wort and lithium, but 5-HTP and melatonin still require care around medicines and sedation.
76 Budget

Mood Support

NOW
GABA, St. John's wort, valerian, 5-HTP, and L-theanine preserve much of the original mood-and-relaxation profile at lower serving cost. It still combines serotonergic ingredients and St. John's wort, so the same medication-interaction concerns remain important.
69 Budget

Sleep Support

Bluebonnet Targeted Choice
Valerian, L-theanine, passionflower, 5-HTP, and chamomile provide a simpler sleep-focused blend at lower serving cost. Removing St. John's wort and lithium reduces two major interaction concerns, although 5-HTP can still conflict with serotonergic medicines.
79 Budget

Superior Sleep

Doctor's Best
L-theanine, 5-HTP, GABA, ashwagandha, and melatonin provide a focused sleep-and-stress blend at slightly lower serving cost. It avoids St. John's wort and lithium, but 5-HTP and melatonin still warrant medication and tolerance checks.
77 Value

Sleep Support

The Vitamin Shoppe
Valerian, L-theanine, GABA, 5-HTP, and melatonin closely match the original's sleep ingredients in a simpler and more economical formula. It avoids St. John's wort and lithium, though the high listed 5-HTP amount still calls for caution with serotonergic medicines.
77 Value

Lights Out Sleep

ALLMAX
Standardized valerian, GABA, chamomile, passionflower, 5-HTP, L-theanine, lavender, and melatonin provide broad sleep support with favorable value. The formula removes St. John's wort and lithium, while 5-HTP and melatonin remain meaningful safety considerations.
72 Value

Power to Sleep PM

Irwin Naturals
Valerian, ashwagandha, hops, lemon balm, passionflower, GABA, L-theanine, and melatonin form a coherent sleep blend with reasonable serving value. Avoiding St. John's wort, lithium, and 5-HTP reduces several interaction concerns compared with the original.
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
    Ziegler G; Ploch M; Miettinen-Baumann A; Collet W · European journal of medical research · 2003
    Randomized trial202 participantsSleep Support forValerian
  2. A systematic review of insomnia and complementary medicine.
    Sarris J; Byrne GJ · Sleep medicine reviews · 2011
    Systematic review20 studies pooledSleep Support forValerian
  3. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  4. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  5. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsSleep Support Brain Health Cognitive Support forTheanine
  6. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsSleep Support forTheanine
  7. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder.
    Yatham LN; Kennedy SH; Parikh SV; Schaffer A; Bond DJ; Frey BN; Sharma V; Goldstein BI; Rej S; Beaulieu S; Alda M; MacQueen G; Milev RV; Ravindran A; O'Donovan C; McIntosh D; Lam RW; Vazquez G; Kapczinski F; McIntyre RS; Kozicky J; Kanba S; Lafer B; Suppes T; Calabrese JR; Vieta E; Malhi G; Post RM; Berk M · Bipolar disorders · 2019
    Guideline / consensusMood Support forLithium
  8. Reappraising lithium, triiodothyronine and second-generation antipsychotic augmentation treatment for major depression: a systematic review and meta-analysis with bias-adjustment analyses.
    Hsu TW; Hsu CW; Thompson T; Carvalho AF; Stubbs B; Tseng PT; Yang FC; Yu CL; Tu YK; Liang CS · BMJ mental health · 2026
    Meta-analysis13,616 participants56 studies pooledMood Support forLithium
  9. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  10. The impact of missing data on clinical trials: a re-analysis of a placebo controlled trial of Hypericum perforatum (St Johns wort) and sertraline in major depressive disorder.
    Grobler AC; Matthews G; Molenberghs G · Psychopharmacology · 2014
    Randomized trial340 participantsMood Support forSt. John's Wort
  11. Documentary Analysis of Hypericum perforatum (St. John's Wort) and Its Effect on Depressive Disorders.
    Otero MC; Ceric F; Miranda-Rojas S; Carreño C; Escares R; Escobar MJ; Saracini C; Atala C; Ramírez-Barrantes R; Gordillo-Fuenzalida F · Pharmaceuticals (Basel, Switzerland) · 2025
    Narrative reviewMood Support forSt. John's Wort
  12. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  13. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  14. B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis.
    Wang Z; Zhu W; Xing Y; Jia J; Tang Y · Nutrition reviews · 2022
    Meta-analysis46,175 participants95 studies pooledBrain Health Cognitive Support forFolate
  15. Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial.
    Catena A; Muñoz-Machicao JA; Torres-Espínola FJ; Martínez-Zaldívar C; Diaz-Piedra C; Gil A; Haile G; Györei E; Molloy AM; Decsi T; Koletzko B; Campoy C · The American journal of clinical nutrition · 2016
    Randomized trial136 participantsBrain Health forFolate
  16. Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.
    Liu Y; Yu Z; Cai Z; Zhao L; Wang Y; Guo Y; Su X; Miao Y; Yi B; Wang Y; Zhang X · The journal of prevention of Alzheimer's disease · 2025
    Randomized trial220 participantsBrain Health forFolate
  17. Circulating folate concentrations and the risk of mild cognitive impairment: A prospective study on the older Chinese population without folic acid fortification.
    Fu J; Liu Q; Zhu Y; Sun C; Duan H; Huang L; Zhou D; Wang Z; Zhao J; Li Z; Ma F; Li W; Liu H; Zhang X; Chen Y; Wang G; Du Y; Huang G · European journal of neurology · 2022
    Cohort study3,974 participantsBrain Health forFolate
  18. Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment.
    Jang S; Han JW; Shin J; Kim TH; Kwak KP; Kim K; Kim BJ; Kim SG; Kim JL; Kim TH; Moon SW; Park JY; Park JH; Byun S; Suh SW; Seo J; So Y; Ryu SH; Youn JC; Lee KH; Lee DY; Lee DW; Lee SB; Lee JJ; Lee JR; Jeong H; Jeong HG; Jhoo JH; Han K; Hong JW; Kim KW · Psychiatry investigation · 2020
    Cohort study3,910 participantsBrain Health forFolate
  19. Antenatal magnesium sulfate and neuroprotection.
    Doyle LW · Current opinion in pediatrics · 2012
    Meta-analysis6,145 participants5 studies pooledBrain Health forMagnesium
  20. No. 376-Magnesium Sulphate for Fetal Neuroprotection.
    Magee LA; De Silva DA; Sawchuck D; Synnes A; von Dadelszen P · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2020
    Guideline / consensus4,446 participantsBrain Health forMagnesium
  21. Magnesium Sulfate Before Preterm Birth for Neuroprotection: An Updated Cochrane Systematic Review.
    Shepherd ES; Goldsmith S; Doyle LW; Middleton P; Marret S; Rouse DJ; Pryde P; Wolf HT; Crowther CA · Obstetrics and gynecology · 2024
    Systematic review5,917 participants6 studies pooledBrain Health forMagnesium
  22. Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta-analysis and trial sequential analysis.
    Wolf HT; Huusom LD; Henriksen TB; Hegaard HK; Brok J; Pinborg A · BJOG : an international journal of obstetrics and gynaecology · 2020
    Meta-analysis5,917 participants6 studies pooledBrain Health forMagnesium
  23. Magnesium sulfate and fetal neuroprotection: overview of clinical evidence.
    Chollat C; Marret S · Neural regeneration research · 2020
    Narrative reviewBrain Health forMagnesium
  24. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  25. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support forTheanine
  26. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  27. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Productivity Boost forTheanine
  28. Relationship between vitamin B12 levels and motor development: A systematic review.
    Dos Santos MERA; da Silva KG; da Silva Souza AP; da Silva ABJ; da Silva RF; da Silva EHA; de Souza SL; Barros WMA · Clinical nutrition ESPEN · 2024
    Systematic review1,559 participants8 studies pooledBrain Health forVitamin B12
  29. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsBrain Health forVitamin B12
  30. Structural and Functional Brain Changes Associated with Vitamin B12 Deficiency using Magnetic Resonance Imaging: A Systematic Review and Meta-analysis.
    Alghamdi A · Current medical imaging · 2023
    Meta-analysis12 studies pooledBrain Health forVitamin B12
  31. Maternal vitamin B12, vitamin D, and folic acid status during pregnancy and child neurodevelopment: a systematic review.
    Franco L; de Andrade CVF; Margini LV; Sousa N · Frontiers in neuroscience · 2026
    Systematic review22 studies pooledBrain Health forVitamin B12
  32. Higher vitamin B12 from mid- to late life is related to slower rates of cognitive decline.
    Marino FR; Rogers G; Miller JW; Selhub J; Mez J; Crane PK; Mukherjee S; Saykin AJ; Hohman TJ; Trittschuh EH; Au R; Jacques PF; Hwang PH · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Cohort study1,994 participantsBrain Health forVitamin B12
  33. Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China.
    Ma F; Wu T; Zhao J; Han F; Marseglia A; Liu H; Huang G · The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Randomized trial180 participantsCognitive Support forFolate
  34. Serum folate and B12 levels in association with cognitive impairment among seniors: results from the VELESTINO study in Greece and meta-analysis.
    Michelakos T; Kousoulis AA; Katsiardanis K; Dessypris N; Anastasiou A; Katsiardani KP; Kanavidis P; Stefanadis C; Papadopoulos FC; Petridou ET · Journal of aging and health · 2013
    Meta-analysis8,122 participants9 studies pooledCognitive Support forFolate
  35. Homocysteine and folate as risk factors for dementia and Alzheimer disease.
    Ravaglia G; Forti P; Maioli F; Martelli M; Servadei L; Brunetti N; Porcellini E; Licastro F · The American journal of clinical nutrition · 2005
    Cohort study816 participantsCognitive Support forFolate
  36. Folate mediates cognitive impairment of aged people with periodontitis.
    Liu F; Liu Y; Feng Y; Zhao J; Wang M; Ye M; Zhang Y; Gan X; Pan Q; Shen J · Nutritional neuroscience · 2025
    Cross-sectional study1,966 participantsCognitive Support forFolate
  37. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  38. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support forTheanine
  39. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  40. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  41. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  42. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  43. The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials.
    Firth J; Teasdale SB; Allott K; Siskind D; Marx W; Cotter J; Veronese N; Schuch F; Smith L; Solmi M; Carvalho AF; Vancampfort D; Berk M; Stubbs B; Sarris J · World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025
    Systematic review10,951 participants33 studies pooledMood Support forFolate
  44. Continuous supplementation of folic acid in pregnancy and the risk of perinatal depression-A meta-analysis.
    Jin X; Cheng Z; Yu X; Tao Q; Huang R; Wang S · Journal of affective disorders · 2022
    Meta-analysis26,275 participants15 studies pooledMood Support forFolate
  45. Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials.
    Borges-Vieira JG; Cardoso CKS · Nutritional neuroscience · 2023
    Systematic review2,256 participants20 studies pooledMood Support forFolate
  46. Folate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses.
    Gao S; Khalid A; Amini-Salehi E; Radkhah N; Jamilian P; Badpeyma M; Zarezadeh M · Food science & nutrition · 2024
    Meta-analysis11 studies pooledMood Support forFolate
  47. Oral 5'-methyltetrahydrofolic acid in senile organic mental disorders with depression: results of a double-blind multicenter study.
    Passeri M; Cucinotta D; Abate G; Senin U; Ventura A; Stramba Badiale M; Diana R; La Greca P; Le Grazie C · Aging (Milan, Italy) · 1993
    Randomized trial96 participantsMood Support forFolate
  48. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsMood Support Stress Relief forGABA
  49. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  50. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  51. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  52. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  53. GERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder.
    Young RC; Mulsant BH; Sajatovic M; Gildengers AG; Gyulai L; Al Jurdi RK; Beyer J; Evans J; Banerjee S; Greenberg R; Marino P; Kunik ME; Chen P; Barrett M; Schulberg HC; Bruce ML; Reynolds CF; Alexopoulos GS; GERI-BD Study Group · The American journal of psychiatry · 2017
    Randomized trial224 participantsMood Support forLithium
  54. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder.
    Bowden CL; Calabrese JR; Sachs G; Yatham LN; Asghar SA; Hompland M; Montgomery P; Earl N; Smoot TM; DeVeaugh-Geiss J; Lamictal 606 Study Group · Archives of general psychiatry · 2003
    Randomized trial175 participantsMood Support forLithium
  55. Mood stabilizers and/or antipsychotics for bipolar disorder in the maintenance phase: a systematic review and network meta-analysis of randomized controlled trials.
    Kishi T; Ikuta T; Matsuda Y; Sakuma K; Okuya M; Mishima K; Iwata N · Molecular psychiatry · 2022
    Meta-analysis9,821 participants41 studies pooledMood Support forLithium
  56. A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder.
    Goodwin GM; Bowden CL; Calabrese JR; Grunze H; Kasper S; White R; Greene P; Leadbetter R · The Journal of clinical psychiatry · 2004
    Meta-analysis638 participants2 studies pooledMood Support forLithium
  57. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  58. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support Stress Relief forMagnesium
  59. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  60. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  61. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  62. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  63. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  64. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort
  65. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort
  66. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  67. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsMood Support Stress Relief forTheanine
  68. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  69. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsMood Support Stress Relief forTheanine Stress Relief forGABA
  70. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  71. Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
    Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
    Randomized trial80 participantsMood Support Sleep Support Stress Relief forValerian
  72. Chemotypic diversity and neuroactive potential of Valeriana jatamansi Jones: a systematic review on phytochemistry, pharmacology and standardisation challenges.
    Nisar S; Jan N; Hassan I; Andleeb L; Shabir PA · Natural product research · 2026
    Meta-analysis12 studies pooledMood Support forValerian
  73. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
    Shinjyo N; Waddell G; Green J · Journal of evidence-based integrative medicine · 2021
    Meta-analysis6,894 participants60 studies pooledMood Support forValerian
  74. Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study.
    Farah GJ; Ferreira GZ; Danieletto-Zanna CF; Luppi CR; Jacomacci WP · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2020
    Randomized trial20 participantsMood Support forValerian
  75. Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.
    Araújo JO; Bergamaschi CC; Lopes LC; Guimarães CC; de Andrade NK; Ramacciato JC; Motta RHL · BMJ open · 2021
    Systematic review327 participants12 studies pooledMood Support Stress Relief forValerian
  76. Cross-sectional and longitudinal associations of magnesium intake and cognition in the Healthy Aging Longitudinal Study in Taiwan.
    Tao MH; Chuang SC; Wu IC; Chan HT; Cheng CW; Chen HL; Lee MM; Chang HY; Hsiung CA; Hsu CC · European journal of nutrition · 2024
    Cohort study5,663 participantsProductivity Boost forMagnesium
  77. Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients.
    Tu X; Qiu H; Lin S; He W; Huang G; Zhang X; Wu Y; He J · Neuropsychiatric disease and treatment · 2022
    Cohort study327 participantsProductivity Boost forMagnesium
  78. The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
    Lopresti AL; Smith SJ · Frontiers in nutrition · 2026
    Randomized trial100 participantsProductivity Boost forMagnesium
  79. Hypomagnesemia and Acute Cognitive Decline in Older Adults: An Evaluation of Clinical Practice and Cognitive Outcomes at a National Health Service (NHS) Trust in England.
    Lai XN; Sadhwani V; Ng WM; Gani A · Cureus · 2025
    Cohort study667 participantsProductivity Boost forMagnesium
  80. Magnesium Depletion Score as a Novel Predictor of Cognitive Impairment: A Population-Based Cross-Sectional Study From NHANES.
    Chen M; Xue R; Zhang M; Zhang J; Zheng J; Ye D; Sun J · Journal of the American Medical Directors Association · 2025
    Cross-sectional study2,768 participantsProductivity Boost forMagnesium
  81. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledProductivity Boost forTheanine
  82. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsProductivity Boost Stress Relief forTheanine
  83. Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
  84. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsProductivity Boost forTheanine
  85. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  86. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  87. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsSleep Support Stress Relief forGABA
  88. Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
  89. The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  90. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine
  91. Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.
    Hajizadeh I; Jamshidi M; Kazemi M; Kargar H; Sadeghi T · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2023
    Randomized trial40 participantsSleep Support forValerian
  92. Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.
    Schicktanz N; Gerhards C; Schlitt T; Aerni A; Müggler E; de Quervain D; Papassotiropoulos A; Boonen G; Drewe J; Butterweck V · Brain and behavior · 2025
    Randomized trial40 participantsSleep Support forValerian
  93. Valerian for sleep: a systematic review and meta-analysis.
    Bent S; Padula A; Moore D; Patterson M; Mehling W · The American journal of medicine · 2006
    Meta-analysis1,093 participants16 studies pooledSleep Support forValerian
  94. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  95. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  96. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  97. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  98. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  99. Influence of folic acid on postprandial endothelial dysfunction.
    Wilmink HW; Stroes ES; Erkelens WD; Gerritsen WB; Wever R; Banga JD; Rabelink TJ · Arteriosclerosis, thrombosis, and vascular biology · 2000
    Randomized trial20 participantsStress Relief forFolate
  100. The effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled clinical trial.
    Bahmani F; Karamali M; Shakeri H; Asemi Z · Clinical endocrinology · 2015
    Randomized trial69 participantsStress Relief forFolate
  101. Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials.
    Taylor MJ; Carney SM; Goodwin GM; Geddes JR · Journal of psychopharmacology (Oxford, England) · 2004
    Meta-analysis247 participants3 studies pooledStress Relief forFolate
  102. Depressive symptoms and associated factors among women preparing for pregnancy: a population-based study from the Seoul metropolitan preconception health management program.
    Lee HJ; Shin W; Han JY; Choi HZ; Kang J; Woo SY · BMC women's health · 2026
    Cross-sectional study14,004 participantsStress Relief forFolate
  103. Folate administration decreases oxidative status and blood pressure in postmenopausal women.
    Cagnacci A; Cannoletta M; Xholli A; Piacenti I; Palma F; Palmieri B · European journal of nutrition · 2016
    Randomized trial30 participantsStress Relief forFolate
  104. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  105. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  106. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  107. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  108. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  109. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  110. Comparison of St John's wort and imipramine for treating depression: randomised controlled trial.
    Woelk H · BMJ (Clinical research ed.) · 2000
    Randomized trial324 participantsStress Relief forSt. John's Wort
  111. Differential therapy of mild to moderate depressive episodes (ICD-10 F 32.0; F 32.1) with St. John's wort.
    Friede M; Henneicke von Zepelin HH; Freudenstein J · Pharmacopsychiatry · 2002
    Randomized trial240 participantsStress Relief forSt. John's Wort
  112. Kava and St. John's Wort: current evidence for use in mood and anxiety disorders.
    Sarris J; Kavanagh DJ · Journal of alternative and complementary medicine (New York, N.Y.) · 2009
    Systematic reviewStress Relief forSt. John's Wort
  113. Do early changes in the HAM-D-17 anxiety/somatization factor items affect the treatment outcome among depressed outpatients? Comparison of two controlled trials of St John's wort (Hypericum perforatum) versus a SSRI.
    Bitran S; Farabaugh AH; Ameral VE; LaRocca RA; Clain AJ; Fava M; Mischoulon D · International clinical psychopharmacology · 2012
    Other475 participantsStress Relief forSt. John's Wort
  114. Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.
    Lakhan SE; Vieira KF · Nutrition journal · 2011
    Systematic review2,619 participants24 studies pooledStress Relief forSt. John's Wort
  115. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  116. Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.
    Velasquez ACA; Tsuji M; Dos Santos Cordeiro L; Petinati MFP; Rebellato NLB; Sebastiani AM; da Costa DJ; Scariot R · Oral and maxillofacial surgery · 2024
    Randomized trial54 participantsStress Relief forValerian
  117. Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions.
    Cropley M; Cave Z; Ellis J; Middleton RW · Phytotherapy research : PTR · 2002
    Non-randomized trial54 participantsStress Relief forValerian
  118. Stress-induced insomnia treated with kava and valerian: singly and in combination.
    Wheatley D · Human psychopharmacology · 2019
    Single-arm trial24 participantsStress Relief forValerian