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Mega D-3 5000 IU & MK-7 180 mcg

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4.9
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(93076 ratings)
Vitamin K 180 mcg
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Score84
A potent, high-value D3 and MK-7 pairing is best reserved for users whose need for the high vitamin D amount is established.
How scoring works
Quantity:60 Capsule(s) • (60 servings)
Goals:
General Health
Bone Health
Heart Health
Anti-Aging
Cardiovascular Support

Score 84

A potent, high-value D3 and MK-7 pairing is best reserved for users whose need for the high vitamin D amount is established.
How scoring works
$10.40($0.17 per serving)
Vitacost
$ 17.27
Daily Vita
$ 10.40
Pure Formulas
$ 16.32
iHerb
$ 16.52
Vitacost
$ 17.27
iHerb
$ 16.52
Daily Vita
$ 15.60
iHerb
$ 16.52
Walmart
$ 19.36
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Analysis

Vitamin D3 at 125 mcg and MK-7 at 180 mcg provide substantial support for calcium absorption and placement. Both forms are appropriate and their amounts are fully disclosed.

The compact formula avoids padding and offers a large active dose at a low serving cost. Dry-capsule delivery provides no evident lipid carrier for the two fat-soluble vitamins.

It fits people with a documented reason for high-dose vitamin D more than casual maintenance users. Vitamin D status, total intake, and calcium balance matter when using this strength over time.

Who is it for
  • Adults with a monitored need for high-dose vitamin D
  • People seeking substantial MK-7 alongside D3
  • Users focused on bone and calcium handling
Best for
  • High-strength D3 and K2 supplementation
  • Clinician-guided vitamin D repletion plans
  • Potent two-nutrient support at low cost

Pros

  • Provides 180 mcg of MK-7
  • Uses 125 mcg of vitamin D3
  • Clearly discloses both forms and amounts
  • Excellent active-dose value

Cons

  • Vitamin D3 amount exceeds the usual adult daily upper intake level
  • Dry-capsule delivery gives no built-in fat source for this fat-soluble nutrient
  • Does not include calcium or magnesium
  • The supplied label does not identify a branded or verified all-trans MK-7 source

Warnings

  • Vitamin K can counteract warfarin and other vitamin K antagonist anticoagulants; use requires prescriber-guided consistency.
  • The 125 mcg vitamin D3 amount exceeds the usual adult daily upper intake level and warrants professional guidance for ongoing use.
  • High vitamin D exposure can raise calcium excessively in susceptible users, including those with hypercalcemia or some kidney conditions.
  • Total vitamin D from food, multivitamins, and other supplements should be counted before use.

Nutrient quality

84 Highest impact

Well-regarded forms and high-potency amounts create a focused combination. Aggressive vitamin D3 exposure makes the formula less suitable for routine unsupervised use.

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Ingredient transparency

83 Highest impact

The active forms and amounts are exceptionally clear without hidden blends. Missing directions and capsule excipients are the main disclosure gaps.

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Customer satisfaction

74 High impact

Aggregate satisfaction is very strong and supported by an extensive evidence base. No firsthand experience details are supplied, so recurring complaints and purpose alignment cannot be checked.

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Value for money

96 Highest impact

High-quality forms and a favorable serving position create strong value. The package compares very well with similar vitamin K products.

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Report analysis

Goals

General Health
Impact
Highest effect
A+ Goal FitA Strength of SupportB+ CoverageA+ Formula Quality
Vitamin D · 125 mcgVitamin K · 180 mcg

Vitamin D3 and vitamin K2 work together to support calcium handling, bone maintenance, and other foundational functions. Both ingredients use appropriate forms and are fully disclosed at substantial amounts.

The vitamin D amount is high for routine unsupervised use, so individual need is best guided by vitamin D status and total intake. Vitamin K2 can interfere with warfarin and other vitamin K antagonists, making this combination unsuitable without medication-specific guidance for those users.

Study evidence
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Bone Health
Impact
Highest effect
A+ Goal FitA Strength of SupportB CoverageA+ Formula Quality
Vitamin K · 180 mcgVitamin D · 125 mcg

Vitamin D3 and MK-7 provide complementary support for calcium absorption and calcium use in bone. Both actives have well-established skeletal roles.

The MK-7 amount is substantial, while the vitamin D3 amount is higher than many routine daily formulas and may be more than some users need. Calcium, magnesium, and protein-matrix nutrients are absent, so the product remains a focused cofactor pair rather than complete bone support.

Study evidence
Vitamin D Supportive 202 studies
Vitamin K Supportive 78 studies
Heart Health
Impact
Highest effect
B+ Goal FitA+ Strength of SupportB- CoverageA+ Formula Quality
Vitamin K · 180 mcgVitamin D · 125 mcg

Vitamin K2 as MK-7 provides direct calcium-management support that is relevant to arterial health. Vitamin D3 complements that pathway by supporting calcium absorption and regulation.

The 180 mcg MK-7 amount is clearly disclosed, and the MK-7 form has a long duration of action. The pairing is compact and logically constructed. Vitamin K can counteract warfarin and other vitamin K antagonist medicines, so users of those drugs need clinician-guided intake. The high vitamin D3 amount also warrants care in people prone to high calcium levels.

Study evidence
Vitamin K Mixed 62 studies
Anti-Aging
Impact
Highest effect
B Goal FitA Strength of SupportB- CoverageA+ Formula Quality
Vitamin K · 180 mcgVitamin D · 125 mcg

Vitamin D3 and MK-7 support bone integrity, calcium handling, and physical function during aging. Both are supplied at substantial amounts, though these foundational nutrients do not address mitochondrial decline or structural proteins broadly.

The 5,000 IU D3 serving is high for unsupervised long-term maintenance and can raise calcium excessively when unnecessary. MK-7 can oppose warfarin, so users of vitamin-K-antagonist anticoagulants need stable intake and prescriber guidance.

Study evidence
Vitamin D Supportive 50 studies
Vitamin K Supportive 27 studies
Cardiovascular Support
Impact
Highest effect
B Goal FitA- Strength of SupportC+ CoverageA Formula Quality
Vitamin K · 180 mcgVitamin D · 125 mcg

High-dose vitamin D3 and MK-7 provide a strong calcium-handling combination with vascular relevance. Evidence supports nutrient status and calcification-related markers, while direct cardiovascular outcome evidence remains incomplete.

The 180 mcg MK-7 amount is strong, while 125 mcg D3 exceeds common daily maintenance intake. The pairing is coherent, but MK-7 can oppose warfarin and the 125 mcg D3 amount may raise excess-intake risk without monitoring.

Study evidence
Vitamin D Mixed 170 studies
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per serving
Vitamin D-3 (Lanolin)
125 mcg
Vitamin K-2 (Menaquinone-7)
180 mcg
Gluten Free Adults 18–50 Kosher Dairy Free
Report overview
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

A 180 mcg MK-7 dose sits within the preferred range and is paired with Vitamin D3. The generic source and dry capsule leave room for improvement in sourcing and absorption. The 125 mcg Vitamin D3 amount exceeds the usual adult daily upper limit, so long-term use deserves care.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  2. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  3. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  4. Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging.
    Pan Z; Zeng J; Chen Z; Chen S; Yang J; Li H; Wang S; Wang J; Li N; Gong Y; Liu M; Li C · The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Cohort study389,217 participantsAnti-Aging forVitamin D
  5. Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong Associations With Age and All-Cause Mortality Independent From Telomere Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels.
    Schöttker B; Hagen L; Zhang Y; Gào X; Holleczek B; Gao X; Brenner H · The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Cohort study9,940 participantsAnti-Aging forVitamin D
  6. Sex-specific associations of serum 25-hydroxyvitamin D concentrations with incident sarcopenia in older adults: A 2-year follow-up study.
    Song S; Lim JY; Kim M; Won CW; Park HY · The journal of nutrition, health & aging · 2025
    Cohort study1,292 participantsAnti-Aging forVitamin D
  7. Vitamin D deficit is associated with accelerated brain aging in the general population.
    Terock J; Bonk S; Frenzel S; Wittfeld K; Garvert L; Hosten N; Nauck M; Völzke H; Van der Auwera S; Grabe HJ · Psychiatry research. Neuroimaging · 2022
    Cross-sectional study1,865 participantsAnti-Aging forVitamin D
  8. Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP).
    Zhao C; Tsapanou A; Manly J; Schupf N; Brickman AM; Gu Y · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Cohort study1,759 participantsAnti-Aging forVitamin D
  9. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  10. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  11. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  12. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  13. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  14. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  15. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  16. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  17. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  18. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  19. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  20. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  21. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  22. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support forVitamin D
  23. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
    Kumar V; Yadav AK; Lal A; Kumar V; Singhal M; Billot L; Gupta KL; Banerjee D; Jha V · Journal of the American Society of Nephrology : JASN · 2017
    Randomized trial120 participantsCardiovascular Support forVitamin D
  24. Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
    Porto C; Petribu K; Barbosa N; Magalhães R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; Magalhães J; Sougey E; Silva T; Junio A; Bandeira F; Leão R · American heart journal plus : cardiology research and practice · 2025
    Randomized trial224 participantsCardiovascular Support forVitamin D
  25. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
    Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y · PloS one · 2017
    Randomized trial70 participantsCardiovascular Support forVitamin D
  26. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsCardiovascular Support forVitamin D
  27. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  28. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  29. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  30. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  31. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  32. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  33. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  34. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  35. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  36. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  37. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  38. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  39. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  40. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  41. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K