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Vitamin K2 Advantage 2200 mcg

4.8
★ ★ ★ ★ ★
(392 ratings)
Vitamin K 1820 mcg
Product Image
Score80
A potent, transparent three-form vitamin K formula with good value, but a very high total amount that demands careful medication screening.
How scoring works
Tablet
Quantity:120 Tablet(s) • (120 servings)
Goals:
Anti-Aging
General Health
Heart Health
Bone Health
Cardiovascular Support

Score 80

A potent, transparent three-form vitamin K formula with good value, but a very high total amount that demands careful medication screening.
How scoring works

Also available as

1 option
60 servings K 1820 mcg • 60 Tablet(s) • 60 servings $21.45 ($0.35 per serving)
$41.57($0.34 per serving)
iHerb
$ 41.57
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Analysis

MK-7 is supplied at a meaningful daily amount, while MK-4 and K1 broaden coverage across vitamin K-dependent proteins. Each form is separately listed, so the unusually high total intake is easy to identify.

The formula offers strong depth for calcium handling, bone support, and normal clotting. A dry tablet has no lipid carrier, and the small calcium addition does not turn it into a complete bone formula.

It fits adults who deliberately want multiple vitamin K forms and are not using conflicting anticoagulants. People needing only basic maintenance may find the total amount unnecessarily high.

Who is it for
  • Adults specifically seeking multiple vitamin K forms
  • Users wanting substantial MK-7
  • People with a clinician-approved high-vitamin-K plan
Best for
  • Calcium-placement support
  • Bone-protein activation
  • Broad vitamin K coverage

Pros

  • Meaningful MK-7 amount
  • MK-4 and K1 are separately disclosed
  • Strong value for a multi-form formula

Cons

  • Very high total vitamin K
  • Dry tablet has no lipid carrier
  • Little support beyond one nutrient family

Warnings

  • The high vitamin K amount can strongly oppose warfarin and related vitamin K antagonists
  • Do not start, stop, or change intake without the prescriber managing anticoagulation
  • Take the dry tablet with a meal containing fat unless the label directs otherwise

Nutrient quality

86 Highest impact

Menaquinone-4 and menaquinone-7 provide complementary vitamin K2 forms, and the combined vitamin K amount is substantial and covers multiple forms. The very large vitamin K1 amount is more aggressive than needed for routine general use, while calcium is the only secondary active and does not heavily pad the formula.

Ingredient transparency

84 Highest impact

Specific amounts are listed for every supplied active ingredient. No proprietary blend hides active doses, while capsule, softgel, or tablet excipients are not included in the supplied details.

Customer satisfaction

70 High impact

The supplied aggregate satisfaction metric is very strong, and the feedback volume is sufficient for a reasonably stable aggregate metric. No review excerpts were provided, so recurring complaints and purpose-specific experiences cannot be checked.

Value for money

76 High impact

Broad vitamin K coverage supports quality, though the high dose is unnecessary for many users. The serving provides substantial coverage at a moderate cost, while the formula avoids low-value specialty extras.

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Goals

Anti-Aging
Anti-Aging
Impact
Highest effect
B+ Goal FitA+ Strength of SupportB- CoverageA Formula Quality
Vitamin K · 180 mcg

The combination of vitamin K1 with MK-4 and MK-7 provides strong support for calcium handling in bone and soft tissue. Using both K2 forms gives the formula more depth than a basic vitamin K supplement.

All vitamin K forms and amounts are clearly disclosed, including a substantial MK-7 serving. Vitamin K can oppose warfarin and related vitamin K antagonists, so users of those medicines need clinician-guided consistency.

Study evidence
Vitamin K Supportive 27 studies
General Health
General Health
Impact
Highest effect
A- Goal FitA- Strength of SupportB- CoverageA Formula Quality
Vitamin K · 180 mcg

Multiple vitamin K forms provide focused support for normal blood clotting and calcium handling. The MK-7 amount is meaningful, while MK-4 and K1 broaden coverage within the same nutrient family.

A dry tablet may not optimize absorption of this fat-soluble vitamin, and the formula does not cover wider wellness pathways. People using warfarin or another vitamin K antagonist need consistent vitamin K intake because this high amount can alter anticoagulant control.

Study evidence
Vitamin K Supportive 34 studies
Heart Health
Heart Health
Impact
Highest effect
A- Goal FitA Strength of SupportB+ CoverageB+ Formula Quality
Vitamin K · 180 mcg

MK-7, MK-4, and vitamin K1 provide broad vitamin K coverage for calcium handling and normal clotting function. The MK-7 amount is well aligned with arterial-support use, although the dry tablet lacks a lipid carrier.

Each vitamin K form is separately disclosed, making the formula easy to assess. The high total vitamin K content can oppose warfarin and other vitamin K antagonists, so dose changes require supervision from the prescriber managing that medicine.

Study evidence
Vitamin K Mixed 62 studies
Bone Health
Bone Health
Impact
Highest effect
A Goal FitA Strength of SupportC+ CoverageB+ Formula Quality
Vitamin K · 180 mcgCalcium · 64 mg

Clearly identified MK-4 and MK-7 directly support proteins that guide calcium into bone. The MK-7 amount is within a well-supported daily range.

A small calcium amount adds context, but vitamin D and major structural minerals are largely absent. The very high total vitamin K content can disrupt warfarin dosing, so people using vitamin K antagonists need prescriber guidance.

Study evidence
Calcium Supportive 144 studies
Vitamin K Supportive 78 studies
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
B+ Goal FitA+ Strength of SupportC- CoverageB+ Formula Quality
Vitamin K · 180 mcg

MK-7 and MK-4 support vitamin K-dependent calcium management that is relevant to arterial health. The MK-7 amount is substantial, while the formula also includes a very high vitamin K1 amount.

Multiple K forms provide depth within one calcium-regulation pathway but do not address lipids, vascular tone, or cardiac energy. The high total vitamin K content can counteract warfarin and related vitamin K antagonists, making consistent clinician-guided intake essential.

Study evidence
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per serving
Calcium
64 mg
Vitamin K1
1820 mcg
Vitamin K2 (Menaquinone-4)
 200 mcg
Vitamin K2 (Menaquinone-7)
 180 mcg
Adults 18–50 Vegan Vegetarian
Report overview
Vitamin K · 1820 mcg OverallScore87
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Multiple vitamin K forms provide broad coverage, and the MK-7 amount falls in a well-supported daily range. The generic MK-7 source and dry tablet limit confidence in purity and absorption. The low cost per serving adds value, but the very high vitamin K content requires special care for people using vitamin K antagonist medicines.

View ingredientView products
Loading alternative details
86 Performance

Vitamin K2 MK-7 (Menaquinone-7) 90 mcg

Carlson
Compared with K1 together with MK-4 and MK-7 vitamin K2, the alternative provides 90 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger alignment with the Vitamin K collection. Its focused formula offers solid routine value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
87 Performance

Vitamin K2 as MK-7 100 mcg

Healthy Origins
Compared with K1 together with MK-4 and MK-7 vitamin K2, the alternative provides 100 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger alignment with the Vitamin K collection. Vitamin K2 can reduce the effect of warfarin-type anticoagulants.
87 Performance

Vitamin K2 100 mcg

SR Sports Research
Compared with K1 together with MK-4 and MK-7 vitamin K2, the alternative provides 100 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger alignment with the Vitamin K collection. Vitamin K2 can reduce the effect of warfarin-type anticoagulants, so intake changes require prescriber guidance.
88 Budget

Vitamin K2 MK-7 100 mcg

Nutricost
The supplied serving cost is lower, while the formula provides 100 mcg of MK-7 vitamin K2. Vitamin K2 can interfere with warfarin-type anticoagulants.
89 Budget

Mega D-3 5000 IU & MK-7 180 mcg

NOW
The supplied serving cost is lower, while the formula provides 125 mcg of vitamin D3 with 180 mcg of MK-7 vitamin K2. High vitamin D remains the main dosing limitation, while the dry capsule lacks stated fat-intake guidance.
85 Budget

Vitamin K2 MenaQ7 100 mcg

AN Amazing Nutrition Amazing Formulas
The supplied serving cost is lower, while the formula provides vitamin k2. Its vitamin K can counteract warfarin and related vitamin K antagonists, so people using those medicines need clinician-directed intake.
87 Value

MK-7 Vitamin K-2 100 mcg

NOW
100 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Its long supply supports strong value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
87 Value

Low Dose Vitamin K2 (MK-7) 45 mcg

Life Extension
45 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Its focused formula offers good routine value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
86 Value

Vitamin K2 MK-7 (Menaquinone-7) 90 mcg

Carlson
90 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Its focused formula offers solid routine value, though vitamin K can conflict with warfarin and similar vitamin K antagonists.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  2. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  3. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  4. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  5. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  6. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  7. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  8. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  9. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  10. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  11. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  12. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  13. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  14. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  15. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  16. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  17. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  18. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  19. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  20. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  21. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  22. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  23. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  24. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  25. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K