Product Image

Kyolic Omega-3

Kyolic
4.8
★ ★ ★ ★ ★
(1913 ratings)
EPA (Eicosapentaenoic Acid) 600 mg
Vitamin E 10 IU
Fish Oil 2000 mg
DHA 400 mg
Product Image
Score80
Best suited to anti-inflammatory support, with the clearest benefits coming from the disclosed active ingredients. The combined EPA and DHA amount is useful and clearly disclosed, but fish species, molecular form, purification, and independent testing are absent.
How scoring works
Quantity:180 Softgel(s) • (90 servings)
Goals:
Anti-Inflammatory Support
Heart Health
Cardiovascular Support
Mental Focus

Score 80

Best suited to anti-inflammatory support, with the clearest benefits coming from the disclosed active ingredients. The combined EPA and DHA amount is useful and clearly disclosed, but fish species, molecular form, purification, and independent testing are absent.
How scoring works

Also available as

1 option
90 servings E 10 IU, DHA 400 mg +2 more • 90 Softgel(s) • 45 servings $24.71 ($0.54 per serving)
$43.61($0.48 per serving)
iHerb
$ 43.61
Vitacost
$ 43.61
Report prices

Analysis

EPA and DHA combine with aged garlic for coherent cardiovascular and inflammatory support, while natural vitamin E helps protect the oil. The undisclosed oil form and purity evidence limit quality assurance, and the combination may increase bruising or bleeding tendency with anticoagulant or antiplatelet medicines.

EPA and DHA directly support production of inflammation-resolving lipid mediators, while aged garlic adds antioxidant and signaling support. Natural vitamin E helps protect the oil, creating a complementary three-part formula. The combined EPA and DHA amount is useful and clearly disclosed, but fish species, molecular form, purification, and independent testing are absent.

EPA and DHA may support mood and the brain environment, but they are not direct short-term focus enhancers. Aged garlic is more relevant to cardiovascular support than attention. The omega-3 amounts are substantial and clearly listed.

Who is it for
  • People seeking anti-inflammatory support support
  • People seeking heart health support
  • People seeking cardiovascular support support
Best for
  • Anti-Inflammatory Support
  • Heart Health
  • Cardiovascular Support

Pros

  • EPA and DHA combine with aged garlic for coherent cardiovascular and inflammatory support, while natural vitamin E helps protect the oil.
  • EPA and DHA directly support production of inflammation-resolving lipid mediators, while aged garlic adds antioxidant and signaling support.
  • Natural vitamin E helps protect the oil, creating a complementary three-part formula.
  • Aged garlic adds meaningful breadth, while the small vitamin E amount is better viewed as oil protection than a full antioxidant dose.
  • EPA and DHA provide strong direct support for lipid balance, while aged garlic adds a complementary vascular pathway.

Cons

  • The combined EPA and DHA amount is useful and clearly disclosed, but fish species, molecular form, purification, and independent testing are absent.
  • The disclosed fatty-acid amounts are meaningful, though the fish-oil molecular form and independent purity testing are not stated.
  • The focused combination gives useful depth without unnecessary ingredients.
  • Confidence is limited by missing details on molecular form, purification, fish source, and independent testing.
  • EPA and DHA may support mood and the brain environment, but they are not direct short-term focus enhancers.

Warnings

  • The undisclosed oil form and purity evidence limit quality assurance, and the combination may increase bruising or bleeding tendency with anticoagulant or antiplatelet medicines.
  • Fish oil and aged garlic may increase bleeding tendency when combined with anticoagulant or antiplatelet medicines.
  • Cost efficiency is fair, but the combination of fish oil and aged garlic may increase bleeding risk with anticoagulant or antiplatelet medicines.

Nutrient quality

82 Highest impact

EPA, DHA, and aged garlic are meaningfully dosed and align well with the intended use. Missing oil-form details and a medication-specific bleeding concern temper an otherwise coherent formula.

Ingredient transparency

78 High impact

Fish oil, EPA, DHA, aged garlic, and vitamin E have stated amounts. Daily directions and complete excipient details are not supplied.

Customer satisfaction

75 High impact

The supplied aggregate satisfaction metric is strong and supported by the available feedback volume. No feedback excerpts or complaint themes are supplied, so specific experience patterns cannot be verified.

Value for money

85 Highest impact

Meaningful active dosing supports favorable serving value. The focused ingredient profile avoids costly low-value extras.

Report analysis

Goals

Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Highest effect
A+ Goal FitB+ Strength of SupportB+ CoverageA+ Formula Quality
Fish Oil · 2000 mgVitamin E · 10 IU

EPA and DHA directly support production of inflammation-resolving lipid mediators, while aged garlic adds antioxidant and signaling support. Natural vitamin E helps protect the oil, creating a complementary three-part formula.

The combined EPA and DHA amount is useful and clearly disclosed, but fish species, molecular form, purification, and independent testing are absent. Aged garlic adds meaningful breadth, while the small vitamin E amount is better viewed as oil protection than a full antioxidant dose.

Study evidence
Fish Oil Supportive 68 studies
Vitamin E Supportive 20 studies
Heart Health
Heart Health
Impact
Highest effect
A+ Goal FitB+ Strength of SupportB CoverageA+ Formula Quality
EPA (Eicosapentaenoic Acid) · 600 mg

EPA and DHA provide strong direct support for lipid balance, while aged garlic adds a complementary vascular pathway. The disclosed fatty-acid amounts are meaningful, though the fish-oil molecular form and independent purity testing are not stated.

The focused combination gives useful depth without unnecessary ingredients. Fish oil and aged garlic may increase bleeding tendency when combined with anticoagulant or antiplatelet medicines.

Study evidence
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
A Goal FitB+ Strength of SupportB+ CoverageA Formula Quality
Fish Oil · 2000 mgVitamin E · 10 IU

Fish oil supplies 1,000 mg of combined EPA and DHA, giving the formula strong support for lipid and inflammatory balance. Aged garlic adds a complementary vascular pathway.

Separate EPA and DHA amounts are clear, and natural vitamin E helps protect the oil from oxidation. Confidence is limited by missing details on molecular form, purification, fish source, and independent testing.

Study evidence
Fish Oil Supportive 185 studies
Vitamin E Mixed 79 studies
Mental Focus
Mental Focus
Impact
High effect
C Goal FitA- Strength of SupportC CoverageB- Formula Quality

EPA and DHA may support mood and the brain environment, but they are not direct short-term focus enhancers. Aged garlic is more relevant to cardiovascular support than attention.

The omega-3 amounts are substantial and clearly listed. Garlic broadens the formula without adding a dependable cognitive pathway.

Study evidence

Ingredients

IngredientAmount per serving
Vitamin E
10 IU
Omega-3 Fish Oil concentrate
2000 mg
Eicosapentaenoic Acid
600 mg
Docosahexaenoic Acid
400 mg
Aged Garlic extract powder
240 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
EPA (Eicosapentaenoic Acid) · 600 mg OverallScore64
D+ Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyB+ Value

The EPA dose and EPA-to-DHA balance are well aligned with an EPA-focused supplement. Molecular form and independent purity testing are not disclosed, while a single vitamin E antioxidant offers limited oxidation protection. Cost efficiency is fair, but the combination of fish oil and aged garlic may increase bleeding risk with anticoagulant or antiplatelet medicines.

View ingredientView products
Vitamin E · 10 IU OverallScore56
D Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyA+ Value

Natural d-alpha vitamin E offers better biological activity than a synthetic form, but the formula lacks broader vitamin E isomers. The amount is below the usual adult maintenance range. Cost efficiency is favorable for the natural form provided.

View ingredientView products
Fish Oil · 2000 mg OverallScore51
F Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyB+ Value

A 1,000 mg combined EPA and DHA dose provides a useful daily amount with clear active disclosure. Vitamin E supports oil stability, but molecular form, fish species, purification, and independent testing are not provided. Cost efficiency is favorable for the active dose.

View ingredientView products
Loading alternative details
78 Performance

Omega 3 Platinum+D

Zahler
<p>The ingredient profile is well aligned with the original’s omega-3 and vitamin focus, supplying 900 mg of EPA, 600 mg of DHA, 3000 mg of fish oil and 15 IU of vitamin E. Its combined EPA and DHA or total omega-3 amount matches or exceeds the original’s, giving it a strong core fatty-acid profile.</p>
75 Performance

Mega EPA/DHA

Life Extension
<p>The ingredient profile is well aligned with the original’s omega-3 and vitamin focus, supplying 720 mg of EPA, 480 mg of DHA, 2000 mg of fish oil and 2.7 mcg of vitamin E. Its combined EPA and DHA or total omega-3 amount matches or exceeds the original’s, giving it a strong core fatty-acid profile.</p>
73 Performance

Extreme Omega 2400 mg Lemon Natural Flavor

Natrol
<p>The ingredient profile is well aligned with the original’s omega-3 and vitamin focus, supplying 646 mg of EPA, 430 mg of DHA, 2400 mg of fish oil and 20.1 mg of vitamin E. Its combined EPA and DHA or total omega-3 amount matches or exceeds the original’s, giving it a strong core fatty-acid profile.</p>
76 Budget

Omega-3 Fish Oil 1000 mg Lemon

Natrol
<p>A lower cost per serving makes this a practical budget alternative, while it supplies 180 mg of EPA, 120 mg of DHA and 1000 mg of fish oil. Its combined EPA and DHA or total omega-3 amount is lower than the original’s, so the trade-off is a lighter omega-3 serving. Unlike the original, it does not disclose vitamin e.</p>
79 Budget

Omega-3 Fish Oil with Vitamin D 1000 mg Lemon Flavored

Swanson
<p>A lower cost per serving makes this a practical budget alternative, while it supplies 180 mg of EPA, 120 mg of DHA and 1000 mg of fish oil. Its combined EPA and DHA or total omega-3 amount is lower than the original’s, so the trade-off is a lighter omega-3 serving. Unlike the original, it does not disclose vitamin e.</p>
78 Budget

CoQ10 60 mg With Omega-3 Fish Oil

NOW
<p>A lower cost per serving makes this a practical budget alternative, while it supplies 40 mg of EPA, 25 mg of DHA, 250 mg of fish oil and 10 IU of vitamin E. Its combined EPA and DHA or total omega-3 amount is lower than the original’s, so the trade-off is a lighter omega-3 serving.</p>
80 Value

Alaska Wild Fish Oil Mega Omega-3

21st Century
<p>Strong serving value is paired with 965 mg of EPA, 385 mg of DHA and 1950 mg of fish oil. It matches or exceeds the original’s disclosed omega-3 amount and keeps both EPA and DHA clearly quantified, balancing cost-effectiveness with a useful ingredient profile. Unlike the original, it does not disclose vitamin e.</p>
81 Value

Omega-3

Solgar
<p>Strong serving value is paired with 1008 mg of EPA, 756 mg of DHA and 2800 mg of fish oil. It matches or exceeds the original’s disclosed omega-3 amount and keeps both EPA and DHA clearly quantified, balancing cost-effectiveness with a useful ingredient profile. Unlike the original, it does not disclose vitamin e.</p>
78 Value

Super Omega-3

Life Extension
<p>Strong serving value is paired with 700 mg of EPA and 500 mg of DHA. It matches or exceeds the original’s disclosed omega-3 amount and keeps both EPA and DHA clearly quantified, balancing cost-effectiveness with a useful ingredient profile. Unlike the original, it does not disclose vitamin e.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. EPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHD.
    Gustafsson PA; Birberg-Thornberg U; Duchén K; Landgren M; Malmberg K; Pelling H; Strandvik B; Karlsson T · Acta paediatrica (Oslo, Norway : 1992) · 2011
    Randomized trial92 participantsMental Focus forEPA (Eicosapentaenoic Acid)
  2. The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose-response meta-analysis.
    Suh SW; Lim E; Burm SY; Lee H; Bae JB; Han JW; Kim KW · BMC medicine · 2024
    Meta-analysis9,660 participants24 studies pooledMental Focus forEPA (Eicosapentaenoic Acid)
  3. Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial.
    Song J; Hu M; Li C; Yang B; Ding Q; Wang C; Mao L · Food & function · 2018
    Randomized trial201 participantsAnti-Inflammatory Support forFish Oil
  4. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients.
    Lin YL; Wang CL; Chiang TI · Frontiers in nephrology · 2024
    Randomized trial60 participantsAnti-Inflammatory Support forFish Oil
  5. Lowering effects of fish oil supplementation on proinflammatory markers in hypertension: results from a randomized controlled trial.
    Yang B; Ren XL; Li ZH; Shi MQ; Ding F; Su KP; Guo XJ; Li D · Food & function · 2020
    Randomized trial77 participantsAnti-Inflammatory Support forFish Oil
  6. The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning.
    Meng Z; Dong Y; Gao H; Yao D; Gong Y; Meng Q; Zheng T; Cui X; Su X; Tian Y · The Journal of international medical research · 2019
    Randomized trial174 participantsAnti-Inflammatory Support forFish Oil
  7. Effects of Omega-3 Fatty Acid Intake in Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Liu R; Jiang J; Fu Z; Liu C; Yao L; Quan H · Journal of the American Nutrition Association · 2022
    Meta-analysis49 studies pooledAnti-Inflammatory Support forFish Oil
  8. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
    Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  9. Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
    Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
    Meta-analysis495 participants12 studies pooledAnti-Inflammatory Support forVitamin E
  10. Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
    Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
    Meta-analysis46 studies pooledAnti-Inflammatory Support forVitamin E
  11. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
    Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
    Meta-analysis8 studies pooledAnti-Inflammatory Support forVitamin E
  12. Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
    Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
    Randomized trial71 participantsAnti-Inflammatory Support forVitamin E
  13. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
    Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
    Meta-analysis127,477 participants13 studies pooledCardiovascular Support forFish Oil
  14. Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
    Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
    Randomized trial309 participantsCardiovascular Support forFish Oil
  15. A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
    Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
    Meta-analysis1,524 participants17 studies pooledCardiovascular Support forFish Oil
  16. Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
    Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial422 participantsCardiovascular Support forFish Oil
  17. Effect of High-Dose Marine Omega-3 Fatty Acids on Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
    Sekikawa A; Cui C; Sugiyama D; Fabio A; Harris WS; Zhang X · Nutrients · 2020
    Meta-analysis6 studies pooledCardiovascular Support forFish Oil
  18. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis.
    Loffredo L; Perri L; Di Castelnuovo A; Iacoviello L; De Gaetano G; Violi F · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016
    Meta-analysis16 studies pooledCardiovascular Support forVitamin E
  19. Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
    Chen B; Li Y; Li Z; Hu X; Zhen H; Chen H; Nie C; Hou Y; Zhu S; Xiao L; Li T · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025
    Randomized trial90 participantsCardiovascular Support forVitamin E
  20. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
    Lonn E; Bosch J; Yusuf S; Sheridan P; Pogue J; Arnold JM; Ross C; Arnold A; Sleight P; Probstfield J; Dagenais GR; HOPE and HOPE-TOO Trial Investigators · JAMA · 2005
    Randomized trial9,541 participantsCardiovascular Support forVitamin E
  21. Independent and combined associations of dietary antioxidant exposure with all-cause and cause-specific mortality in the general population.
    Liu Z; He Z; Xing Y · Journal of nutritional science · 2026
    Cohort study34,955 participantsCardiovascular Support forVitamin E
  22. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
    Chin SF; Ibahim J; Makpol S; Abdul Hamid NA; Abdul Latiff A; Zakaria Z; Mazlan M; Mohd Yusof YA; Abdul Karim A; Wan Ngah WZ · Nutrition & metabolism · 2011
    Randomized trial62 participantsCardiovascular Support forVitamin E
  23. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.
    Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Saito Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Japan EPA lipid intervention study (JELIS) Investigators · Lancet (London, England) · 2007
    Randomized trial18,645 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  24. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS).
    Saito Y; Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; JELIS Investigators, Japan · Atherosclerosis · 2008
    Randomized trial14,981 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  25. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis.
    Dinu M; Sofi F; Lotti S; Colombini B; Mattioli AV; Catapano AL; Casula M; Baragetti A; Wong ND; Steg PG; Ambrosio G · European journal of preventive cardiology · 2024
    Meta-analysis134,144 participants18 studies pooledHeart Health forEPA (Eicosapentaenoic Acid)
  26. Incremental effects of eicosapentaenoic acid on cardiovascular events in statin-treated patients with coronary artery disease.
    Matsuzaki M; Yokoyama M; Saito Y; Origasa H; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Matsuzawa Y; JELIS Investigators · Circulation journal : official journal of the Japanese Circulation Society · 2009
    Randomized trialHeart Health forEPA (Eicosapentaenoic Acid)
  27. Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association.
    Skulas-Ray AC; Wilson PWF; Harris WS; Brinton EA; Kris-Etherton PM; Richter CK; Jacobson TA; Engler MB; Miller M; Robinson JG; Blum CB; Rodriguez-Leyva D; de Ferranti SD; Welty FK; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology · Circulation · 2020
    OtherHeart Health forEPA (Eicosapentaenoic Acid)
  28. Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA)-Should They Be Mandatory Supplements in Pregnancy?
    Amza M; Haj Hamoud B; Sima RM; Dinu MD; Gorecki GP; Popescu M; Gică N; Poenaru MO; Pleș L · Biomedicines · 2024
    Narrative reviewMental Focus forEPA (Eicosapentaenoic Acid)
  29. Supplementation with oil rich in eicosapentaenoic acid, but not in docosahexaenoic acid, improves global cognitive function in healthy, young adults: results from randomized controlled trials.
    Patan MJ; Kennedy DO; Husberg C; Hustvedt SO; Calder PC; Khan J; Forster J; Jackson PA · The American journal of clinical nutrition · 2021
    Randomized trial310 participantsMental Focus forEPA (Eicosapentaenoic Acid)