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Kyolic Omega-3

Kyolic
4.8
★ ★ ★ ★ ★
(1914 ratings)
EPA (Eicosapentaenoic Acid) 600 mg
Fish Oil 2000 mg
DHA 400 mg
Vitamin E 10 IU
Product Image
Score79
Best suited to cardiovascular support, with the clearest benefits coming from the disclosed active ingredients. The key fatty acids and garlic amount are individually disclosed, though fish-oil purification certification is not stated.
How scoring works
Quantity:90 Softgel(s) • (45 servings)
Goals:
Cardiovascular Support
Heart Health
Anti-Inflammatory Support
Mental Focus

Score 79

Best suited to cardiovascular support, with the clearest benefits coming from the disclosed active ingredients. The key fatty acids and garlic amount are individually disclosed, though fish-oil purification certification is not stated.
How scoring works
$24.71($0.54 per serving)
Pure Formulas
$ 41.54
iHerb
$ 24.71
Vitacost
$ 24.71
Report prices

Analysis

EPA and DHA combine with aged garlic for coherent cardiovascular and inflammatory support, while natural vitamin E helps protect the oil. The undisclosed oil form and purity evidence limit quality assurance, and the combination may increase bruising or bleeding tendency with anticoagulant or antiplatelet medicines.

A full gram of EPA and DHA combines strong lipid support with aged garlic for vascular and blood-pressure pathways. Vitamin E adds oxidation protection to a well-focused cardiovascular formula. The key fatty acids and garlic amount are individually disclosed, though fish-oil purification certification is not stated.

EPA and DHA provide long-term brain-membrane and inflammatory support rather than immediate focus. Evidence for sharper attention is indirect, and the aged garlic is more relevant to cardiovascular support than cognition. The fatty-acid amounts are useful, while vitamin E offers some oxidation protection.

Who is it for
  • People seeking cardiovascular support support
  • People seeking heart health support
  • People seeking anti-inflammatory support support
Best for
  • Cardiovascular Support
  • Heart Health
  • Anti-Inflammatory Support

Pros

  • EPA and DHA combine with aged garlic for coherent cardiovascular and inflammatory support, while natural vitamin E helps protect the oil.
  • A full gram of EPA and DHA combines strong lipid support with aged garlic for vascular and blood-pressure pathways.
  • Vitamin E adds oxidation protection to a well-focused cardiovascular formula.
  • Fish oil and aged garlic may increase bruising or bleeding tendency when combined with antiplatelet or anticoagulant medicines.
  • The disclosed 600 mg EPA and 400 mg DHA provide a meaningful omega-3 amount for general cardiovascular support.

Cons

  • The key fatty acids and garlic amount are individually disclosed, though fish-oil purification certification is not stated.
  • EPA and DHA are fully disclosed, though fish-oil molecular form and third-party testing are not stated.
  • EPA reaches a useful serving amount and an EPA-centric ratio, but no purity testing is disclosed.
  • The molecular form, purification method, and independent testing are not stated.
  • Disclosed actives provide good cost efficiency, though the missing quality details remain important.

Warnings

  • The undisclosed oil form and purity evidence limit quality assurance, and the combination may increase bruising or bleeding tendency with anticoagulant or antiplatelet medicines.
  • Fish oil and aged garlic may increase bruising or bleeding tendency when combined with antiplatelet or anticoagulant medicines.
  • Combining fish oil and aged garlic may increase bruising or bleeding risk with anticoagulant or antiplatelet medicines.
  • The omega-3 molecular form is not disclosed, and garlic may add bleeding risk when combined with anticoagulant or antiplatelet medicines.

Nutrient quality

82 Highest impact

EPA, DHA, and aged garlic are meaningfully dosed and align well with the intended use. Missing oil-form details and a medication-specific bleeding concern temper an otherwise coherent formula.

Ingredient transparency

78 High impact

Fish oil, EPA, DHA, aged garlic, and vitamin E have stated amounts. Daily directions and complete excipient details are not supplied.

Customer satisfaction

75 High impact

The supplied aggregate satisfaction metric is strong and supported by the available feedback volume. No feedback excerpts or complaint themes are supplied, so specific experience patterns cannot be verified.

Value for money

83 Highest impact

Meaningful active dosing supports favorable serving value. The focused ingredient profile avoids costly low-value extras.

Report analysis

Goals

Cardiovascular Support
Impact
Highest effect
A Goal FitA Strength of SupportA- CoverageA Formula Quality
Fish Oil · 2000 mgVitamin E · 10 IU

A full gram of EPA and DHA combines strong lipid support with aged garlic for vascular and blood-pressure pathways. Vitamin E adds oxidation protection to a well-focused cardiovascular formula.

The key fatty acids and garlic amount are individually disclosed, though fish-oil purification certification is not stated. Fish oil and aged garlic may increase bruising or bleeding tendency when combined with antiplatelet or anticoagulant medicines.

Study evidence
Fish Oil Supportive 185 studies
Vitamin E Mixed 79 studies
Heart Health
Impact
Highest effect
A+ Goal FitA- Strength of SupportB+ CoverageA+ Formula Quality
EPA (Eicosapentaenoic Acid) · 600 mg

The disclosed 600 mg EPA and 400 mg DHA provide a meaningful omega-3 amount for general cardiovascular support. Human evidence is strong for triglyceride management at higher therapeutic intakes and useful for broader heart-related markers.

Aged garlic adds a complementary vascular pathway, and vitamin E offers some oxidation protection. Combining fish oil and aged garlic may increase bruising or bleeding risk with anticoagulant or antiplatelet medicines.

Study evidence
Anti-Inflammatory Support
Impact
Highest effect
A Goal FitB+ Strength of SupportB CoverageA Formula Quality
Fish Oil · 2000 mgVitamin E · 10 IU

EPA, DHA, and aged garlic provide direct inflammation-resolving and antioxidant support. Omega-3s have strong human evidence, while aged garlic adds credible complementary support.

The combined 1,000 mg of EPA and DHA is meaningful, while garlic and vitamin E serve supportive roles. EPA and DHA are fully disclosed, though fish-oil molecular form and third-party testing are not stated.

Study evidence
Fish Oil Supportive 68 studies
Vitamin E Supportive 20 studies
Mental Focus
Impact
Moderate effect
D+ Goal FitB- Strength of SupportD+ CoverageC+ Formula Quality

EPA and DHA provide long-term brain-membrane and inflammatory support rather than immediate focus. Evidence for sharper attention is indirect, and the aged garlic is more relevant to cardiovascular support than cognition.

The fatty-acid amounts are useful, while vitamin E offers some oxidation protection. The omega-3 molecular form is not disclosed, and garlic may add bleeding risk when combined with anticoagulant or antiplatelet medicines.

Study evidence

Ingredients

IngredientAmount per serving
Vitamin E
10 IU
Omega-3 Fish Oil concentrate
2000 mg
Eicosapentaenoic Acid
600 mg
Docosahexaenoic Acid
400 mg
Aged Garlic extract powder
240 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
D+ Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyB+ Value

The molecular form is unspecified and EPA concentration is moderate, while vitamin E provides some oxidation protection. EPA reaches a useful serving amount and an EPA-centric ratio, but no purity testing is disclosed. Cost per EPA amount is competitive and supports the formula’s practical value.

Fish Oil · 2000 mg OverallScore51
F Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyB+ Value

The combined 1,000 mg EPA and DHA amount provides a standard effective dose at about 50% of the fish oil, indicating standard concentration. The molecular form, purification method, and independent testing are not stated. Disclosed actives provide good cost efficiency, though the missing quality details remain important.

DHA · 400 mg OverallScore48
D+ Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyC Value

The serving provides 400 mg of DHA and 600 mg of EPA with vitamin E protection against oxidation. DHA form and fish species are not disclosed, and EPA plus DHA make up half of the oil. The cost per gram of DHA is moderate, while the lack of contaminant-testing evidence remains a limitation.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.
    Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Saito Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Japan EPA lipid intervention study (JELIS) Investigators · Lancet (London, England) · 2007
    Randomized trial18,645 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  2. Effect of omega-3 long-chain polyunsaturated fatty acid supplementation on heart rate: a meta-analysis of randomized controlled trials.
    Hidayat K; Yang J; Zhang Z; Chen GC; Qin LQ; Eggersdorfer M; Zhang W · European journal of clinical nutrition · 2019
    Meta-analysis3,000 participants51 studies pooledHeart Health forEPA (Eicosapentaenoic Acid)
  3. Long-Chain Polyunsaturated Fatty Acids Are Associated with Blood Pressure and Hypertension over 10-Years in Black South African Adults Undergoing Nutritional Transition.
    Zec MM; Schutte AE; Ricci C; Baumgartner J; Kruger IM; Smuts CM · Foods (Basel, Switzerland) · 2020
    Cohort study300 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  4. The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose-response meta-analysis.
    Suh SW; Lim E; Burm SY; Lee H; Bae JB; Han JW; Kim KW · BMC medicine · 2024
    Meta-analysis9,660 participants24 studies pooledMental Focus forEPA (Eicosapentaenoic Acid)
  5. EPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHD.
    Gustafsson PA; Birberg-Thornberg U; Duchén K; Landgren M; Malmberg K; Pelling H; Strandvik B; Karlsson T · Acta paediatrica (Oslo, Norway : 1992) · 2011
    Randomized trial92 participantsMental Focus forEPA (Eicosapentaenoic Acid)
  6. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
    Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
    Meta-analysis127,477 participants13 studies pooledCardiovascular Support forFish Oil
  7. A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
    Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
    Meta-analysis1,524 participants17 studies pooledCardiovascular Support forFish Oil
  8. Marine n-3 fatty acid treatment for carotid plaques in patients with type 2 diabetes.
    Zhuang P; Liu X; Jia W; Zheng W; Wan X; Chen W; Gu J; Li Y; Lan X; Li H; Tong W; Wu Y; Wu X; Ao Y; Ye H; Wu F; Zhu L; Zhang L; Li Y; Meng D; Tian Y; Wang A; Wu S; Zhu F; Zhang Y; Shi H; Yu X; Zhang F; Zhang Y; Jiao J · Cardiovascular diabetology · 2026
    Randomized trial415 participantsCardiovascular Support forFish Oil
  9. Fish oil, enriched with polyunsaturated fatty acids of the omega-3-type accelerates the nucleation time in healthy subjects.
    Janowitz P; Swobodnik W; Wechsler JG; Janowitz A; Saal D; Ditschuneit H · Klinische Wochenschrift · 1991
    Non-randomized trial24 participantsCardiovascular Support forFish Oil
  10. Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial.
    Song J; Hu M; Li C; Yang B; Ding Q; Wang C; Mao L · Food & function · 2018
    Randomized trial201 participantsAnti-Inflammatory Support forFish Oil
  11. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients.
    Lin YL; Wang CL; Chiang TI · Frontiers in nephrology · 2024
    Randomized trial60 participantsAnti-Inflammatory Support forFish Oil
  12. Lowering effects of fish oil supplementation on proinflammatory markers in hypertension: results from a randomized controlled trial.
    Yang B; Ren XL; Li ZH; Shi MQ; Ding F; Su KP; Guo XJ; Li D · Food & function · 2020
    Randomized trial77 participantsAnti-Inflammatory Support forFish Oil
  13. The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning.
    Meng Z; Dong Y; Gao H; Yao D; Gong Y; Meng Q; Zheng T; Cui X; Su X; Tian Y · The Journal of international medical research · 2019
    Randomized trial174 participantsAnti-Inflammatory Support forFish Oil
  14. Effects of Omega-3 Fatty Acid Intake in Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Liu R; Jiang J; Fu Z; Liu C; Yao L; Quan H · Journal of the American Nutrition Association · 2022
    Meta-analysis49 studies pooledAnti-Inflammatory Support forFish Oil
  15. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
    Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  16. Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
    Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
    Meta-analysis495 participants12 studies pooledAnti-Inflammatory Support forVitamin E
  17. Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
    Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
    Meta-analysis46 studies pooledAnti-Inflammatory Support forVitamin E
  18. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
    Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
    Meta-analysis8 studies pooledAnti-Inflammatory Support forVitamin E
  19. Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
    Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
    Randomized trial71 participantsAnti-Inflammatory Support forVitamin E
  20. Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
    Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
    Randomized trial309 participantsCardiovascular Support forFish Oil
  21. Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
    Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial422 participantsCardiovascular Support forFish Oil
  22. Effect of High-Dose Marine Omega-3 Fatty Acids on Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
    Sekikawa A; Cui C; Sugiyama D; Fabio A; Harris WS; Zhang X · Nutrients · 2020
    Meta-analysis6 studies pooledCardiovascular Support forFish Oil
  23. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis.
    Loffredo L; Perri L; Di Castelnuovo A; Iacoviello L; De Gaetano G; Violi F · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016
    Meta-analysis16 studies pooledCardiovascular Support forVitamin E
  24. Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
    Chen B; Li Y; Li Z; Hu X; Zhen H; Chen H; Nie C; Hou Y; Zhu S; Xiao L; Li T · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025
    Randomized trial90 participantsCardiovascular Support forVitamin E
  25. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
    Lonn E; Bosch J; Yusuf S; Sheridan P; Pogue J; Arnold JM; Ross C; Arnold A; Sleight P; Probstfield J; Dagenais GR; HOPE and HOPE-TOO Trial Investigators · JAMA · 2005
    Randomized trial9,541 participantsCardiovascular Support forVitamin E
  26. Independent and combined associations of dietary antioxidant exposure with all-cause and cause-specific mortality in the general population.
    Liu Z; He Z; Xing Y · Journal of nutritional science · 2026
    Cohort study34,955 participantsCardiovascular Support forVitamin E
  27. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
    Chin SF; Ibahim J; Makpol S; Abdul Hamid NA; Abdul Latiff A; Zakaria Z; Mazlan M; Mohd Yusof YA; Abdul Karim A; Wan Ngah WZ · Nutrition & metabolism · 2011
    Randomized trial62 participantsCardiovascular Support forVitamin E
  28. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS).
    Saito Y; Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; JELIS Investigators, Japan · Atherosclerosis · 2008
    Randomized trial14,981 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  29. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis.
    Dinu M; Sofi F; Lotti S; Colombini B; Mattioli AV; Catapano AL; Casula M; Baragetti A; Wong ND; Steg PG; Ambrosio G · European journal of preventive cardiology · 2024
    Meta-analysis134,144 participants18 studies pooledHeart Health forEPA (Eicosapentaenoic Acid)
  30. Incremental effects of eicosapentaenoic acid on cardiovascular events in statin-treated patients with coronary artery disease.
    Matsuzaki M; Yokoyama M; Saito Y; Origasa H; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Matsuzawa Y; JELIS Investigators · Circulation journal : official journal of the Japanese Circulation Society · 2009
    Randomized trialHeart Health forEPA (Eicosapentaenoic Acid)
  31. Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association.
    Skulas-Ray AC; Wilson PWF; Harris WS; Brinton EA; Kris-Etherton PM; Richter CK; Jacobson TA; Engler MB; Miller M; Robinson JG; Blum CB; Rodriguez-Leyva D; de Ferranti SD; Welty FK; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology · Circulation · 2020
    OtherHeart Health forEPA (Eicosapentaenoic Acid)
  32. Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA)-Should They Be Mandatory Supplements in Pregnancy?
    Amza M; Haj Hamoud B; Sima RM; Dinu MD; Gorecki GP; Popescu M; Gică N; Poenaru MO; Pleș L · Biomedicines · 2024
    Narrative reviewMental Focus forEPA (Eicosapentaenoic Acid)
  33. Supplementation with oil rich in eicosapentaenoic acid, but not in docosahexaenoic acid, improves global cognitive function in healthy, young adults: results from randomized controlled trials.
    Patan MJ; Kennedy DO; Husberg C; Hustvedt SO; Calder PC; Khan J; Forster J; Jackson PA · The American journal of clinical nutrition · 2021
    Randomized trial310 participantsMental Focus forEPA (Eicosapentaenoic Acid)