Co-Enzyme B-Complex

Co-Enzyme B-Complex

NOW4.8 (4,638 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 30 servings
Goals

Product analysis

61 out of 100

Co-Enzyme B-Complex may help fill B-vitamin gaps that affect normal energy use, mood and attention. Several combined forms have undisclosed proportions, making the formula harder to compare precisely.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality51

The named B6 and B5 forms are strengths, while several other ingredients are less clearly described. Combining different forms does not establish greater benefit, especially when their proportions are undisclosed.

Ingredient Transparency70

Amounts are stated for the active ingredients, but some forms are omitted. The proportions within the combined forms are also undisclosed, making exact comparisons harder.

Value For Money47

Value varies across the ingredients, with B6 and betaine looking more economical than niacin, B5 and choline. Value for several other components remains uncertain, so the combination has no clear price advantage as a whole.

Customer Satisfaction91

Customer ratings are very positive across thousands of buyers. The broad feedback supports a clear satisfaction pattern without proving any health benefit.

Product Focus55

The clearest purpose is filling nutritional gaps that can affect energy, mood and attention. The broad mix does not establish extra benefits when intake is already adequate, or show that the coenzyme forms work better.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.54
Customer rating
4.8 · 4,638 ratings
Report analysis

Goals

Impact
Highest effect
B+ Ingredient FitB+ PathwaysB+ EvidenceA+ Formulation Logic
Folate · 667 mcg DFEVitamin B12 · 250 mcgVitamin C · 60 mg

B vitamins contribute to normal nutrient metabolism, while folate supports the nutritional needs associated with blood formation. These nutrients can help fill dietary gaps, without establishing additional health benefits when intake is already adequate. The small vitamin C and CoQ10 declarations were not counted in the saved amount comparison.

How this product is rated for Everyday Health

Ingredient fit80

B vitamins provide the recognized nutritional fit in a broader formula. Most counted B-vitamin amounts meet the comparison; vitamin C and CoQ10 fall below the counting threshold.
Goal fit
B vitamins provide the recognized nutritional fit in a broader formula.
Dose adequacy
Most counted B-vitamin amounts meet the comparison; vitamin C and CoQ10 fall below the counting threshold.

Pathways80

Energy metabolism and blood formation are covered.
Depth
Energy metabolism and blood formation are covered.
Breadth
Two nutrient-related pathways reach the breadth threshold.

Evidence82

Folate drives the strongest recognized contribution. The supported contribution is nutrient availability, rather than established extra energy or routine CoQ10 benefit.
Evidence strength
Folate drives the strongest recognized contribution. The supported contribution is nutrient availability
Studied preparation
The counted nutrient declarations match the saved preparation criteria; no chemical form or delivery superiority is established.

Formulation logic100

No configured formulation conflict was matched. All ingredients included in this amount check meet the saved minimum threshold; that does not establish a clinically effective dose.
Partner coverage
Recognized ingredients can stand alone or have their required partners; this does not establish an added combination benefit.
Conflicts
No configured formulation conflict was matched.
Effective doses
All ingredients included in this amount check meet the saved minimum threshold; that does not establish a clinically effective dose.
Study evidence
Folate Supportive 80 studies
Vitamin C Supportive 56 studies
Impact
Moderate effect
B- Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Vitamin B5 · 50 mgRiboflavin · 50 mgThiamin · 50 mgVitamin B12 · 250 mcgCoenzyme Q-10 · 10 mg

B vitamins and vitamin C can help fill nutritional gaps related to tiredness and fatigue. CoQ10 participates in mitochondrial energy processes, but its 10 mg amount makes a limited contribution under the saved assessment.

How this product is rated for Energy

Ingredient fit75

The saved findings consider 8 relevant ingredients alongside 5 other actives.
Goal fit
8 ingredients contribute to the saved finding, while 5 other actives and links to other goals broaden its focus.
Dose adequacy
The saved amount finding considers 8 ingredients against their individual references.

Pathways0

The saved assessment records nutritional contributions without assigning a contribution to its specific energy mechanisms.
Depth
No assessed energy mechanism receives a saved contribution.
Breadth
No assessed area reaches the saved coverage threshold.

Evidence81

Vitamin B12 leads the saved evidence finding. The supplied references distinguish nutritional adequacy or limited fatigue findings from a general energy boost.
Evidence strength
Vitamin B12 has the strongest saved evidence finding among ingredients meeting the amount reference.
Studied preparation
The saved assessment marks the preparations of all 8 counted ingredients as matching its evidence requirements.

Formulation logic100

The saved checks account for required partners and record no matched conflict.
Partner coverage
Each counted ingredient can contribute independently under the saved assessment or has its required partner.
Conflicts
No configured ingredient conflict is recorded.
Effective doses
All 8 counted ingredients meet the saved minimum amount threshold.
Study evidence
Thiamin Disputed 12 studies
Impact
Moderate effect
C+ Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Biotin · 1000 mcgVitamin C · 60 mg

Low biotin can cause diffuse shedding; correcting that shortage may help. That makes biotin most relevant when a nutrient shortage is behind the hair loss. Taking extra when you already get enough has no clear regrowth benefit, and the amount in a serving cannot tell you what is causing the shedding.

How this product is rated for Hair Health

Ingredient fit67

Low biotin can cause diffuse shedding; correcting that shortage may help.
Goal fit
Low biotin can cause diffuse shedding; correcting that shortage may help.
Dose adequacy
The relevant ingredients have differing serving amounts; these do not establish daily intake or predict hair regrowth.

Pathways0

Low biotin can cause diffuse shedding; correcting that shortage may help.
Depth
Low biotin can cause diffuse shedding; correcting that shortage may help.
Breadth
Low biotin can cause diffuse shedding; correcting that shortage may help.

Evidence80

The ingredient identities match the relevant preparation comparisons, but this does not guarantee hair growth.
Evidence strength
Low biotin can cause diffuse shedding; correcting that shortage may help.
Studied preparation
The ingredient identities match the relevant preparation comparisons, but this does not guarantee hair growth.

Formulation logic100

No particular ingredient conflict is identified, and the relevant ingredients do not need an additional partner for their described roles.
Partner coverage
The relevant ingredients do not require another ingredient partner for their described roles.
Conflicts
No particular ingredient conflict is identified in this combination.
Effective doses
The relevant amounts are declared; they do not by themselves predict a hair benefit.
Study evidence
Biotin Supportive 4 studies
Folate Mixed 15 studies
Niacin Disputed 2 studies
Impact
High effect
B Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 1000 mcgNiacin · 100 mgVitamin B12 · 250 mcgRiboflavin · 50 mgThiamin · 50 mgVitamin B5 · 50 mgVitamin B6 · 50 mgCoenzyme Q-10 · 10 mg

B vitamins help the body carry out normal energy-yielding metabolism: thiamin supports carbohydrate processing, riboflavin and niacin provide coenzymes, and B6 participates in protein and glycogen metabolism. These essential functions do not show that extra vitamins raise resting or daily calorie expenditure when intake is adequate. The declared amounts therefore do not establish a faster metabolic rate or sustained weight loss.

How this product is rated for Metabolism Support

Ingredient fit75

B vitamins provide the main connection. The included amounts provide only a partial match to reference exposures; this does not establish effective doses for raising calorie expenditure.
Goal fit
B vitamins provide the main metabolic connection, within a formula also associated with other health goals.
Dose adequacy
The included amounts provide only a partial match to reference exposures; this does not establish effective doses for raising calorie expenditure.

Pathways0

No direct thermogenic pathway was identified beyond the ordinary nutrient roles. No pathway reached the coverage threshold, so direct support for a metabolism boost remains limited.
Depth
No direct thermogenic pathway was identified beyond the ordinary nutrient roles.
Breadth
No pathway reached the coverage threshold, so direct support for a metabolism boost remains limited.

Evidence100

Thiamin leads the saved comparison, but normal carbohydrate metabolism does not establish increased calorie expenditure from extra thiamin.
Evidence strength
Thiamin leads the saved comparison, but normal carbohydrate metabolism does not establish increased calorie expenditure from extra thiamin.
Studied preparation
The included preparations match the saved comparison, which does not establish a measured increase in energy expenditure.

Formulation logic100

No missing required partner or configured conflict was identified. The included amounts meet the minimum exposure comparison without demonstrating an extra benefit from combining them.
Partner coverage
No missing required partner was identified; the combination does not establish an additional metabolic-rate effect.
Conflicts
No configured ingredient conflict was identified in the supplied facts.
Effective doses
The included ingredients meet the minimum exposure comparison, which does not establish an effective thermogenic or weight-loss dose.
Study evidence
Biotin Supportive 5 studies
Niacin Supportive 17 studies
Thiamin Supportive 11 studies
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per servingScore
Vitamin C (Magnesium Ascorbate)
60 mg
Thiamin (Cocarboxylase, Thiamine Hydrochloride)
50 mg 76
Riboflavin (Riboflavin-5-Phosphate Sodium)
50 mg 78
Niacin (Inositol Hexanicotinate, NAD Trihydrate)
100 mg 40
Vitamin B-6 (P-5-P Monohydrate, Pyridoxine Hydrochloride)
50 mg 73
Folate (Glucosamine Salt, Quatrefolic (6S)-5-MTHF)
667 mcg DFE
Vitamin B12 (Dibencozide, Methylcobalamin)
250 mcg 61
Biotin
1000 mcg 69
Pantothenic Acid (Calcium Pantothenate, Pantethine, Vitamin B5)
50 mg 70
Choline (Choline Bitartrate)
25 mg 50
Betaine Anhydrous
50 mg 100
Alpha Lipoic Acid
50 mg
PABA
25 mg 78
Inositol (Inositol Hexanicotinate, Inositol Hexaphosphate)
30 mg
CoQ10
10 mg 40
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Vegetarian
Report overview
A+ Ingredient Form & Label QualityF Dose, Safety & Label TransparencyA- Value
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
The label lists 50 mg of betaine anhydrous per serving, so its amount is clear. A whole-product serving costs about $0.54, placing it in the lower price tier.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The ingredient is identified as betaine anhydrous.
Betaine Form (Anhydrous/TMG vs. HCl)
The label specifies the anhydrous form of betaine.

Dose, Safety & Label Transparency100

The disclosed amount is 50 mg of betaine anhydrous per serving.
Label Transparency & Blend Disclosure
The betaine anhydrous amount is listed as 50 mg per serving.

Value100

A whole-product serving costs about $0.54, placing it in the lower price tier.
Price per Active Dose Efficiency
The whole-product serving price is about $0.54, in the lower price tier.
PABA · 25 mg OverallScore78
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value
Each serving lists 25 mg of PABA. The whole-product price works out to about $2.16 per 100 mg of PABA.
How this ingredient is rated

Active Ingredient Quality & Bioavailability80

PABA is named; a specific purity grade is not recorded in the saved facts.
PABA Source & Grade
PABA is named; a specific purity grade is not recorded in the saved facts.

Dose, Safety & Label Transparency95

The PABA amount is individually stated as 25 mg per serving. None of the three checked additive categories are recorded in the saved ingredient information: artificial dyes, titanium dioxide, or hydrogenated oils.
PABA Dosage Alignment
25 mg per serving falls in the evaluation's B-complex amount category.
Label Disclosure Clarity
The PABA amount is individually stated as 25 mg per serving.
Additive and Excipient Quality
None of the three checked additive categories are recorded in the saved ingredient information: artificial dyes, titanium dioxide, or hydrogenated oils.

Value40

The whole-product price works out to about $2.16 per 100 mg of PABA.
Price per 100mg PABA
The whole-product price works out to about $2.16 per 100 mg of PABA.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
    Qu H; Guo M; Chai H; Wang WT; Gao ZY; Shi DZ · Journal of the American Heart Association · 2019
    Meta-analysis575 participants12 studies pooledEnergy forCoenzyme Q-10
  2. Coenzyme Q10 Supplementation in Athletes: A Systematic Review.
    Fernandes MSS; Fidelis DEDS; Aidar FJ; Badicu G; Greco G; Cataldi S; Santos GCJ; de Souza RF; Ardigò LP · Nutrients · 2026
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  3. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Tsai IC; Hsu CW; Chang CH; Tseng PT; Chang KV · Frontiers in pharmacology · 2024
    Meta-analysis1,126 participants13 studies pooledEnergy forCoenzyme Q-10
  4. Antifatigue effects of coenzyme Q10 during physical fatigue.
    Mizuno K; Tanaka M; Nozaki S; Mizuma H; Ataka S; Tahara T; Sugino T; Shirai T; Kajimoto Y; Kuratsune H; Kajimoto O; Watanabe Y · Nutrition (Burbank, Los Angeles County, Calif.) · 2008
    Randomized trial17 participantsEnergy forCoenzyme Q-10
  5. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies.
    Mehrabani S; Askari G; Miraghajani M; Tavakoly R; Arab A · Complementary therapies in medicine · 2019
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  6. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  7. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  8. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  9. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  10. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Support forRiboflavin
  11. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  12. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  13. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  14. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  15. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  16. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  17. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  18. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  19. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  20. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12