Product Image

Once Daily Adult 50+ Multivitamin

Solaray
4.8
★ ★ ★ ★ ★
(1504 ratings)
Iodine 150 mcg
Manganese 2 mg
Niacin 30 mg
Selenium 100 mcg
Chromium 200 mcg
Molybdenum 75 mcg
Biotin 300 mcg
Product Image
Score69
Best suited to immunity, with the clearest benefits coming from the disclosed active ingredients. Preformed vitamin A and several high amounts require attention to total intake, while hidden enzyme and food blends and many token additions reduce transparency and efficiency.
How scoring works
Quantity:90 VegCap(s) • (90 servings)
Goals:
Immunity
General Health
Energy
Metabolism Boost

Score 69

Best suited to immunity, with the clearest benefits coming from the disclosed active ingredients. Preformed vitamin A and several high amounts require attention to total intake, while hidden enzyme and food blends and many token additions reduce transparency and efficiency.
How scoring works
$21.29($0.23 per serving)
Vitacost
$ 27.69
iHerb
$ 27.69
Pure Formulas
$ 27.69
Walmart
$ 21.29
Vitacost
$ 27.69
Report prices

Analysis

Active B vitamins, vitamin D3, natural vitamin E, selenomethionine, carotenoids, and broad mineral coverage create a capable adult multivitamin. Preformed vitamin A and several high amounts require attention to total intake, while hidden enzyme and food blends and many token additions reduce transparency and efficiency.

Vitamin D3, vitamin C, zinc, selenium, vitamin A, and natural vitamin E create broad immune-nutrient coverage. Active B6 and B12 forms strengthen the wider multivitamin foundation. Several specialty antioxidants appear at small amounts, and two proprietary blends hide their individual contributions.

Iodine and selenium support normal thyroid hormone production and activation, while chromium may support glucose handling in some people. These roles can help correct nutrient gaps, but they do not make the multivitamin a direct appetite, thermogenic, or muscle-preservation aid. The key minerals use identified forms and are supplied in practical amounts, yet many small accessory ingredients add little weight-management value.

Who is it for
  • People seeking immunity support
  • People seeking general health support
  • People seeking energy support
Best for
  • Immunity
  • General Health
  • Energy

Pros

  • Active B vitamins, vitamin D3, natural vitamin E, selenomethionine, carotenoids, and broad mineral coverage create a capable adult multivitamin.
  • Vitamin D3, vitamin C, zinc, selenium, vitamin A, and natural vitamin E create broad immune-nutrient coverage.
  • Active B6 and B12 forms strengthen the wider multivitamin foundation.
  • Several specialty antioxidants appear at small amounts, and two proprietary blends hide their individual contributions.
  • The broad vitamin and mineral base aligns closely with filling common nutritional gaps and supporting daily physiology.

Cons

  • Preformed vitamin A and several high amounts require attention to total intake, while hidden enzyme and food blends and many token additions reduce transparency and efficiency.
  • The core immune nutrients remain useful, but the crowded label adds more breadth than proven depth.
  • Many vitamins are supplied at meaningful amounts, but several minerals and specialty ingredients appear too small for strong independent effects.
  • Active B6 and B12 forms strengthen the formula, although some source splits and proprietary blends remain unclear.
  • B vitamins and minerals provide baseline metabolic support, while small amounts of CoQ10 and alpha-lipoic acid add limited mitochondrial relevance.

Warnings

  • Iodine, selenium, chromium, and B vitamins support thyroid, glucose, and food-energy pathways.
  • Iodine and selenium support normal thyroid hormone production and activation, while chromium may support glucose handling in some people.
  • Vitamin K2 may interfere with warfarin dosing, and the iodine content deserves care in people with thyroid disease or those using thyroid medicine.
  • A single vegetable capsule makes dosing simple and avoids marine-source contamination concerns.

Nutrient quality

74 High impact

Pyridoxal phosphate, methylcobalamin, vitamin D3, natural vitamin E, K2, and selenomethionine are strong form choices. Core coverage is broad, but many minerals and accessory compounds are modest or use less established asporotate forms.

Ingredient transparency

54 Moderate impact

Many active amounts are disclosed, but two blends hide their individual components. Duplicate vitamin entries and absent excipient details further weaken label clarity.

Customer satisfaction

72 High impact

The supplied average rating is very strong and supported by a large review base. No review text is available to assess repeated complaints or experiences in older adults.

Value for money

80 High impact

Many good vitamin forms and a low serving cost support strong basic value. Hidden blends, modest minerals, and token-dose extras temper the apparent breadth.

Report analysis

Goals

Immunity
Immunity
Impact
Highest effect
A Goal FitA- Strength of SupportA- CoverageC Formula Quality
Magnesium · 10 mgVitamin C · 100 mgZinc · 15 mgVitamin A · 1500 mcg RAEVitamin D · 50 mcgSelenium · 100 mcg

Vitamin D3, vitamin C, zinc, selenium, vitamin A, and natural vitamin E create broad immune-nutrient coverage. Active B6 and B12 forms strengthen the wider multivitamin foundation.

Several specialty antioxidants appear at small amounts, and two proprietary blends hide their individual contributions. The core immune nutrients remain useful, but the crowded label adds more breadth than proven depth.

Study evidence
Selenium Mixed 37 studies
Vitamin A Supportive 107 studies
Vitamin C Supportive 53 studies
Vitamin D Supportive 85 studies
Vitamin E Supportive 21 studies
Zinc Supportive 73 studies
General Health
General Health
Impact
Highest effect
A Goal FitB Strength of SupportB+ CoverageB- Formula Quality
Vitamin B12 · 100 mcgVitamin D · 50 mcgMagnesium · 10 mgVitamin K · 25 mcgSelenium · 100 mcgZinc · 15 mgVitamin C · 100 mg

The broad vitamin and mineral base aligns closely with filling common nutritional gaps and supporting daily physiology. The formula spans antioxidant, energy, immune, bone, eye, and mineral pathways.

Many vitamins are supplied at meaningful amounts, but several minerals and specialty ingredients appear too small for strong independent effects. Active B6 and B12 forms strengthen the formula, although some source splits and proprietary blends remain unclear.

Energy
Essential Energy Nutrients
Energy
Impact
High effect
B+ Goal FitC+ Strength of SupportB- CoverageC- Formula Quality
Iodine · 150 mcgVitamin D · 50 mcgVitamin B5 · 0.9 mgMagnesium · 10 mgRiboflavin · 5 mgThiamin · 5 mgVitamin B12 · 100 mcgPotassium · 5 mgCoenzyme Q-10 · 20 mg

B vitamins and minerals provide baseline metabolic support, while small amounts of CoQ10 and alpha-lipoic acid add limited mitochondrial relevance. The formula remains a broad senior multivitamin rather than a targeted energy product.

Methylcobalamin and several organic mineral forms are favorable, but their energy-related amounts are modest. A proprietary enzyme blend and broad food base add complexity without confirmed energy value.

Study evidence
Coenzyme Q-10 Supportive 32 studies
Magnesium Supportive 4 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
C+ Goal FitB- Strength of SupportC+ CoverageD+ Formula Quality
Biotin · 300 mcgNiacin · 30 mgVitamin B12 · 100 mcgRiboflavin · 5 mgThiamin · 5 mgVitamin B5 · 0.9 mgVitamin B6 · 5 mgVitamin D · 50 mcgZinc · 15 mgMagnesium · 10 mgCoenzyme Q-10 · 20 mg

Iodine, selenium, chromium, and B vitamins support thyroid, glucose, and food-energy pathways. Their role is mainly to prevent nutrient-related limitations rather than actively raise metabolic rate.

Chromium and iodine are meaningfully dosed, while CoQ10, alpha-lipoic acid, and several specialty ingredients appear in small amounts. Proprietary enzyme and food blends add unclear content and weaken focus.

Study evidence
Chromium Supportive 47 studies
Coenzyme Q-10 Disputed 11 studies
Iodine Mixed 17 studies
Selenium Mixed 28 studies
Detoxification
Detoxification
Impact
Moderate effect
C- Goal FitB- Strength of SupportC CoverageD+ Formula Quality
Vitamin B12 · 100 mcgVitamin B6 · 5 mgMolybdenum · 75 mcgSelenium · 100 mcgMagnesium · 10 mgVitamin E · 40 mgZinc · 15 mgVitamin C · 100 mgCholine · 7.8 mgRiboflavin · 5 mg

Selenium, molybdenum, active B vitamins, and antioxidants provide useful detoxification cofactors. Trace cofactors reach nutritional amounts, but hidden botanicals cannot be checked for effective dosing.

A proprietary blend and general-purpose nutrient design prevent the formula from functioning as a focused liver product. The micronutrients are broadly compatible, though the hidden blend makes the intended detox strategy unclear.

Study evidence
Molybdenum Adverse 1 study
Selenium Supportive 10 studies
Hair Health
Healthy Hair Growth Cycle
Hair Health
Impact
Moderate effect
C- Goal FitC Strength of SupportC- CoverageD- Formula Quality
Biotin · 300 mcgVitamin D · 50 mcgZinc · 15 mgVitamin C · 100 mg

Biotin, zinc, selenium, vitamin D3, vitamin C, and antioxidants support basic follicle nutrition. Biotin is modest, while hyaluronic acid, astaxanthin, and zeaxanthin appear only in token amounts.

Active B6, methylcobalamin, and selenomethionine improve form quality. Proprietary enzyme and food blends add broad label coverage without clear hair-specific depth.

Study evidence
Biotin Supportive 4 studies
Selenium Disputed 7 studies
Vitamin C Mixed 5 studies
Vitamin D Disputed 34 studies
Zinc Supportive 22 studies
Weight Loss
Weight Loss
Impact
Moderate effect
D- Goal FitB- Strength of SupportD+ CoverageD+ Formula Quality
Iodine · 150 mcgVitamin D · 50 mcgMagnesium · 10 mgSelenium · 100 mcgZinc · 15 mg

Iodine and selenium support normal thyroid hormone production and activation, while chromium may support glucose handling in some people. These roles can help correct nutrient gaps, but they do not make the multivitamin a direct appetite, thermogenic, or muscle-preservation aid.

The key minerals use identified forms and are supplied in practical amounts, yet many small accessory ingredients add little weight-management value. Vitamin K2 may interfere with warfarin dosing, and the iodine content deserves care in people with thyroid disease or those using thyroid medicine.

Study evidence
Chromium No effect 24 studies
Iodine Adverse 3 studies
Selenium Mixed 9 studies

Ingredients

IngredientAmount per serving
Vitamin A (Beta-Carotene, Retinyl Palmitate)
 1500 mcg RAE
Vitamin C (Acerola Cherry, Ascorbic Acid, Rosehips)
 100 mg
Vitamin D (Cholecalciferol, Vitamin D3)
 50 mcg
Vitamin E (D-Alpha-Tocopheryl Succinate)
 40 mg
Thiamine (Thiamine Mononitrate, Vitamin B1)
 5 mg
Riboflavin (Vitamin B2)
 5 mg
Niacin (Niacinamide, Vitamin B3)
 30 mg
Vitamin B6 (Pyridoxal 5-Phosphate)
 5 mg
Vitamin B12 (Methylcobalamin)
 100 mcg
Biotin
300 mcg
Pantothenic Acid (Calcium D-Pantothenate)
 0.9 mg
Choline (Choline Bitartrate)
 7.8 mg
Calcium (Calcium Asporotate)
 20 mg
Iodine (Potassium Iodide)
 150 mcg
Magnesium (Magnesium Asporotate)
 10 mg
Zinc (Zinc Asporotate)
 15 mg
Selenium (Selenomethionine)
 100 mcg
Manganese (Manganese Asporotate)
 2 mg
Chromium (Chromium Asporotate)
 200 mcg
Molybdenum (Molybdenum Asporotate)
 75 mcg
Potassium (Potassium Asporotate)
 5 mg
Inositol
20 mg
Alpha Lipoic Acid
20 mg
Coenzyme Q10
20 mg
Lutein (Marigold Flower Extract)
 6 mg
Hyaluronic Acid
5 mg
Zeaxanthin (Aztec Marigold flower extract)
 260 mcg
Astaxanthin (Haematococcus pluvialis extract)
 100 mcg
Vitamin K2 (Menaquinone-7)
 25 mcg
Proprietary Enzyme Blend
50 mg
Herb & Food Base
126 mg
Seniors 50+
Report overview
Iodine (Potassium Iodide) · 150 mcg OverallScore96
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

Potassium iodide supplies a clear daily amount in a stable, readily absorbed form. A single vegetable capsule makes dosing simple and avoids marine-source contamination concerns. Favorable serving cost plus meaningful selenium support a good balance for routine use.

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Manganese (Manganese Asporotate) · 2 mg OverallScore82
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyB+ Value

Manganese asporotate uses organic ligands associated with good mineral solubility, though it is less specifically characterized than a named premium chelate. The 2 mg elemental amount supports maintenance and is clearly disclosed. An economical serving cost fits the broad once-daily multivitamin format.

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Niacin (Niacinamide, Vitamin B3) · 30 mg OverallScore79
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyC Value

The 30 mg niacinamide amount is appropriate for a once-daily multivitamin. Clear form disclosure supports predictable low flush risk, while the capsule uses ordinary immediate release. The extensive age-focused nutrient profile makes the moderate serving cost reasonable.

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Loading alternative details
82 Performance

Multi for Men

MegaFood
Vitamin K2, vitamin D3, natural vitamin E, active folate, broad minerals, choline, and trace nutrients provide a strong foundational formula. It omits CoQ10, alpha-lipoic acid, and carotenoids, but has less reliance on hidden blends.
72 Performance

O.N.E. Multivitamin

Pure Encapsulations
Active folate and B-vitamin forms, vitamin D, selenium, chromium, molybdenum, CoQ10, alpha-lipoic acid, lutein, zeaxanthin, and lycopene closely match the original strengths. It lacks vitamin K and remains more expensive, but the specialty actives are individually named.
74 Performance

Ladies' One 40+

Bluebonnet
Vitamin D3, natural vitamin E, folate, broad minerals, choline, boron, and an older-adult focus provide strong general and bone-health coverage. The women-specific positioning may not fit every user and several blends remain grouped rather than individually dosed.
79 Budget

One Daily Men's 50+

21st Century
A lower serving cost preserves age-focused vitamins, minerals, vitamin K, selenium, chromium, molybdenum, and lycopene without hidden enzyme or food blends. It omits K2, CoQ10, alpha-lipoic acid, and several carotenoids, but the core label is easier to interpret.
77 Budget

Men's 50+ Complete Multivitamin

Bayer One A Day
A lower serving cost provides broad age-focused vitamins and minerals with vitamin K and lycopene in a straightforward formula. It lacks K2, CoQ10, alpha-lipoic acid, lutein, zeaxanthin, and astaxanthin, but avoids proprietary blends.
78 Budget

Multi For Him

Nature Made
A lower serving cost supplies broad vitamins, minerals, vitamin K, selenium, chromium, and molybdenum with clear core coverage. It is not specifically labeled for older adults and omits the original accessory antioxidants, but avoids hidden blends.
77 Value

Pro Edge

Bayer One A Day Men's
A serving cost close to the original provides broad vitamins, minerals, vitamin K, selenium, chromium, and strong general-health coverage. It omits older-adult specialty ingredients such as K2, CoQ10, lutein, and zeaxanthin, but the core formula is clear.
70 Value

Daily Vits

NOW
A lower serving cost supplies broad vitamins, minerals, vitamin K, chromium, molybdenum, lutein, and lycopene. A fruit-and-vegetable blend is not detailed and the formula lacks K2 and CoQ10, but foundational coverage is economical.
85 Value

Essential Blend Multi Mineral

Jigsaw Health
Chelated iodine, zinc, selenium, copper, manganese, chromium, and molybdenum provide a high-quality trace-mineral core at a moderate serving cost. It is not a complete multivitamin and cannot replace vitamins, choline, carotenoids, K2, or CoQ10.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults.
    Ivory K; Prieto E; Spinks C; Armah CN; Goldson AJ; Dainty JR; Nicoletti C · Clinical nutrition (Edinburgh, Scotland) · 2018
    Randomized trial117 participantsImmunity forSelenium
  2. A pilot study of chromium picolinate for weight loss.
    Yazaki Y; Faridi Z; Ma Y; Ali A; Northrup V; Njike VY; Liberti L; Katz DL · Journal of alternative and complementary medicine (New York, N.Y.) · 2010
    Randomized trial80 participantsWeight Loss forChromium
  3. Effect of L-arginine and selenium added to a hypocaloric diet enriched with legumes on cardiovascular disease risk factors in women with central obesity: a randomized, double-blind, placebo-controlled trial.
    Alizadeh M; Safaeiyan A; Ostadrahimi A; Estakhri R; Daneghian S; Ghaffari A; Gargari BP · Annals of nutrition & metabolism · 2012
    Randomized trial84 participantsWeight Loss forSelenium
  4. Energy level and fatigue after surgery for thyroid cancer: A population-based study of patient-reported outcomes.
    Hughes DT; Reyes-Gastelum D; Kovatch KJ; Hamilton AS; Ward KC; Haymart MR · Surgery · 2020
    Cohort study2,584 participantsEnergy forIodine
  5. Iodine Intake Estimated by 24 h Urine Collection in the Italian Adult Population: 2008-2012 Survey.
    Iacone R; Iaccarino Idelson P; Formisano P; Russo O; Lo Noce C; Donfrancesco C; Macchia PE; Palmieri L; Galeone D; di Lenarda A; Giampaoli S; Strazzullo P · Nutrients · 2021
    Cross-sectional study2,378 participantsWeight Loss forIodine
  6. Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency.
    Mao J; Pop VJ; Bath SC; Vader HL; Redman CW; Rayman MP · European journal of nutrition · 2016
    Randomized trial230 participantsImmunity forSelenium
  7. The Effects of Zinc and Selenium Supplementation on Body Composition and Thyroid Function in Individuals with Overweight or Obesity: A Systematic Review.
    Zavros A; Giannaki CD; Aphamis G; Roupa Z; Andreou E · Journal of dietary supplements · 2023
    Systematic review13 studies pooledWeight Loss forSelenium
  8. Chromium picolinate balances the metabolic and clinical markers in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial.
    Kooshki F; Moradi F; Karimi A; Niazkar HR; Khoshbaten M; Maleki V; Pourghassem Gargari B · European journal of gastroenterology & hepatology · 2021
    Randomized trial46 participantsWeight Loss forChromium
  9. Association of radioactive iodine treatment with survivorship symptoms and primary care utilisation in women of reproductive age with thyroid cancer: a retrospective cohort study.
    Devanarayan P; Hartman M; Partin M · Family medicine and community health · 2026
    Cohort study10,882 participantsEnergy forIodine
  10. Iodine intake in adults: Sociodemographic and dietary determinants from a National Health survey.
    Durán-Agüero S; Daga R · Clinical nutrition ESPEN · 2026
    Cross-sectional study1,230 participantsWeight Loss forIodine
  11. Association Between Essential and Non-essential Metals, Body Composition, and Metabolic Syndrome in Adults.
    Ngu YJ; Skalny AV; Tinkov AA; Tsai CS; Chang CC; Chuang YK; Nikolenko VN; Zotkin DA; Chiu CF; Chang JS · Biological trace element research · 2022
    Cross-sectional study150 participantsWeight Loss forChromium
  12. Selenium supplementation for critically ill adults.
    Allingstrup M; Afshari A · The Cochrane database of systematic reviews · 2016
    Meta-analysis2,084 participants16 studies pooledImmunity forSelenium
  13. Effects of selenium supplementation on Polycystic Ovarian Syndrome: a systematic review and meta-analysis on randomized clinical trials.
    Zhao J; Dong L; Lin Z; Sui X; Wang Y; Li L; Liu T; Liu J · BMC endocrine disorders · 2023
    Meta-analysis389 participantsWeight Loss forSelenium
  14. Iodine deficiency among Belgian pregnant women not fully corrected by iodine-containing multivitamins: a national cross-sectional survey.
    Vandevijvere S; Amsalkhir S; Mourri AB; Van Oyen H; Moreno-Reyes R · The British journal of nutrition · 2013
    Cross-sectional study1,311 participantsWeight Loss forIodine
  15. Health-Related Quality of Life in Differentiated Thyroid Cancer Survivors: A Cross-Sectional Study From Turkey.
    Gültekin A; Kahraman MY; Şengöz T; Şimşek FS · Head & neck · 2026
    Cross-sectional study202 participantsEnergy forIodine
  16. Selenium and immune function: a systematic review and meta-analysis of experimental human studies.
    Filippini T; Fairweather-Tait S; Vinceti M · The American journal of clinical nutrition · 2023
    Meta-analysis9 studies pooledImmunity forSelenium
  17. The Influences of Chromium Supplementation on Metabolic Status in Patients with Type 2 Diabetes Mellitus and Coronary Heart Disease.
    Farrokhian A; Mahmoodian M; Bahmani F; Amirani E; Shafabakhsh R; Asemi Z · Biological trace element research · 2021
    Randomized trial64 participantsWeight Loss forChromium
  18. Dietary selenium intake modulates thyroid hormone and energy metabolism in men.
    Hawkes WC; Keim NL · The Journal of nutrition · 2004
    Non-randomized trial11 participantsWeight Loss forSelenium
  19. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  20. Chromium picolinate supplementation in women: effects on body weight, composition, and iron status.
    Lukaski HC; Siders WA; Penland JG · Nutrition (Burbank, Los Angeles County, Calif.) · 2007
    Randomized trial83 participantsWeight Loss forChromium
  21. Gender Differences with Dose⁻Response Relationship between Serum Selenium Levels and Metabolic Syndrome-A Case-Control Study.
    Lu CW; Chang HH; Yang KC; Chiang CH; Yao CA; Huang KC · Nutrients · 2019
    Case-control study1,165 participantsWeight Loss forSelenium
  22. Humoral immune response to COVID-19 mRNA vaccination in relation to selenium status.
    Demircan K; Chillon TS; Sun Q; Heller RA; Klingenberg GJ; Hirschbil-Bremer IM; Seemann P; Diegmann J; Bachmann M; Moghaddam A; Schomburg L · Redox biology · 2022
    Cohort study126 participantsImmunity forSelenium
  23. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes.
    Martin J; Wang ZQ; Zhang XH; Wachtel D; Volaufova J; Matthews DE; Cefalu WT · Diabetes care · 2006
    Randomized trial37 participantsWeight Loss forChromium
  24. Zinc and selenium supplementation on treated HIV-infected individuals induces changes in body composition and on the expression of genes responsible of naïve CD8+ T cells function.
    Osuna-Padilla IA; Rodríguez-Moguel NC; Aguilar-Vargas A; Tolentino-Dolores M; Perichart-Perera O; Ahumada-Topete V; Ávila-Ríos S; Soto-Nava M; Diaz-Rivera D; De León-Lara E; Wilson-Verdugo M; Briceño O · Frontiers in nutrition · 2024
    Randomized trial60 participantsWeight Loss forSelenium
  25. Selenium and immune functions in humans.
    Arvilommi H; Poikonen K; Jokinen I; Muukkonen O; Räsänen L; Foreman J; Huttunen JK · Infection and immunity · 1983
    Randomized trial40 participantsImmunity forSelenium
  26. Chromium picolinate reduces insulin resistance in polycystic ovary syndrome: Randomized controlled trial.
    Ashoush S; Abou-Gamrah A; Bayoumy H; Othman N · The journal of obstetrics and gynaecology research · 2017
    Randomized trial100 participantsWeight Loss forChromium
  27. The effect of hypocaloric diet enriched in legumes with or without L-arginine and selenium on anthropometric measures in central obese women.
    Alizadeh M; Daneghian S; Ghaffari A; Ostadrahimi A; Safaeiyan A; Estakhri R; Gargari BP · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2011
    Randomized trial84 participantsWeight Loss forSelenium
  28. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  29. Chromium picolinate does not improve key features of metabolic syndrome in obese nondiabetic adults.
    Iqbal N; Cardillo S; Volger S; Bloedon LT; Anderson RA; Boston R; Szapary PO · Metabolic syndrome and related disorders · 2009
    Randomized trial63 participantsWeight Loss forChromium
  30. Significant reverse association between dietary selenium intake and visceral adiposity in the CODING study.
    Yu S; Zhang H; Du J; Sun G · Scientific reports · 2025
    Cross-sectional study3,244 participantsWeight Loss forSelenium
  31. The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities.
    Huang Z; Rose AH; Hoffmann PR · Antioxidants & redox signaling · 2012
    Narrative reviewImmunity forSelenium
  32. Effect of chromium supplementation on the glucose homeostasis and anthropometry of type 2 diabetic patients: Double blind, randomized clinical trial: Chromium, glucose homeostasis and anthropometry.
    Guimarães MM; Carvalho AC; Silva MS · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2017
    Randomized trial56 participantsWeight Loss forChromium
  33. Significant Beneficial Association of High Dietary Selenium Intake with Reduced Body Fat in the CODING Study.
    Wang Y; Gao X; Pedram P; Shahidi M; Du J; Yi Y; Gulliver W; Zhang H; Sun G · Nutrients · 2016
    Cross-sectional study3,214 participantsWeight Loss forSelenium
  34. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  35. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial.
    Kleefstra N; Houweling ST; Jansman FG; Groenier KH; Gans RO; Meyboom-de Jong B; Bakker SJ; Bilo HJ · Diabetes care · 2006
    Randomized trial46 participantsWeight Loss forChromium
  36. Human molybdenum exposure risk in industrial regions of China: New critical effect indicators and reference dose.
    Kuang HX; Li MY; Zeng XW; Chen D; Zhou Y; Zheng T; Xiang MD; Wu QZ; Chen XC; Dong GH; Yu YJ · Ecotoxicology and environmental safety · 2024
    Cross-sectional study2,267 participantsDetoxification forMolybdenum
  37. Supplementation with selenium can influence nausea, fatigue, physical, renal, and liver function of children and adolescents with cancer.
    Vieira ML; Fonseca FL; Costa LG; Beltrame RL; Chaves CM; Cartum J; Alves SI; Azzalis LA; Junqueira VB; Pereria EC; Rocha KC · Journal of medicinal food · 2015
    Randomized trialDetoxification forSelenium
  38. [Selenium and oxidative stress in cancer patients].
    Gorozhanskaia ÉG; Sviridova SP; Dobrovol'skaia MM; Zybrikhina GN; Kashnia ShR · Biomeditsinskaia khimiia · 2014
    Single-arm trial40 participantsDetoxification forSelenium
  39. Comprehensive Insights into the Health Effects of Selenium Exposure and Supplementation Among the Chinese Community Middle-Aged and Elderly: a Combined Retrospective Cohort Study and Intervention Study.
    Li C; Peng X; Zheng J; Shi K; Qin L; Yang Q; Wang Z; Liu Y; Huang L · Biological trace element research · 2024
    Other40 participantsDetoxification forSelenium
  40. Heavy metals and metalloids exposure and liver function in Chinese adults - A nationally representative cross-sectional study.
    Wang S; Lyu Y; Ji S; Liu N; Wu B; Zhao F; Li Z; Qu Y; Zhu Y; Xie L; Li Y; Zhang Z; Song H; Hu X; Qiu Y; Zheng X; Zhang W; Yang Y; Li F; Cai J; Zhu Y; Cao Z; Tan F; Shi X · Environmental research · 2024
    Cross-sectional study9,445 participantsDetoxification forSelenium
  41. Selenium-Biofortified Strawberries Improve Glucose Homeostasis and Hepatic Function: A 30-Day Randomized Controlled Trial in Healthy Adults.
    Vasto S; Di Rosa L; Ferrantelli V; Fiore AS; Giordano CP; Cannizzaro A; Sabatino L; Macaluso A; Caldarella R; Caldara GF; Baldassano S · Nutrients · 2026
    Randomized trial35 participantsDetoxification forSelenium
  42. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
    Qu H; Guo M; Chai H; Wang WT; Gao ZY; Shi DZ · Journal of the American Heart Association · 2019
    Meta-analysis575 participants12 studies pooledEnergy forCoenzyme Q-10
  43. Coenzyme Q10 Supplementation in Athletes: A Systematic Review.
    Fernandes MSS; Fidelis DEDS; Aidar FJ; Badicu G; Greco G; Cataldi S; Santos GCJ; de Souza RF; Ardigò LP · Nutrients · 2026
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  44. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Tsai IC; Hsu CW; Chang CH; Tseng PT; Chang KV · Frontiers in pharmacology · 2024
    Meta-analysis1,126 participants13 studies pooledEnergy forCoenzyme Q-10
  45. Antifatigue effects of coenzyme Q10 during physical fatigue.
    Mizuno K; Tanaka M; Nozaki S; Mizuma H; Ataka S; Tahara T; Sugino T; Shirai T; Kajimoto Y; Kuratsune H; Kajimoto O; Watanabe Y · Nutrition (Burbank, Los Angeles County, Calif.) · 2008
    Randomized trial17 participantsEnergy forCoenzyme Q-10
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    Mehrabani S; Askari G; Miraghajani M; Tavakoly R; Arab A · Complementary therapies in medicine · 2019
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  47. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
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    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  49. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  50. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  51. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
  52. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  53. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  54. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  55. Beyond Efficacy: 0.6% Selenium Disulfide Shampoo Matches 2% Ketoconazole for Seborrheic Dermatitis with Superior Cosmesis.
    Farris PK; Barbosa V; Houshman EB; Kovylkina N · Journal of drugs in dermatology : JDD · 2026
    Randomized trial87 participantsHair Health forSelenium
  56. Selenium Disulfide-based shampoo applied for 4 weeks significantly improves dandruff and seborrheic dermatitis.
    Turcu G; Artenie C; Nowicka D; Arenbergerová M; Lazaridou E; Khobzei K; Ataseven A; Part M; Leclerc-Mercier S · European journal of dermatology : EJD · 2023
    Observational study1,407 participantsHair Health forSelenium
  57. A Comparative Randomized Clinical Study Assessing the Efficacy of a 1% Selenium Disulfide-Based Shampoo versus 2% Ketoconazole Shampoo in Subjects with Moderate to Severe Scalp Seborrheic Dermatitis.
    Barbosa V; Melo DF; Vañó-Galván S; Lutchmanen-Kolanthan V; Sant'Anna B; Leclerc-Mercier S; Reygagne P · Skin appendage disorders · 2025
    Randomized trial64 participantsHair Health forSelenium
  58. Changes of serum trace elements level in patients with alopecia areata: A meta-analysis.
    Jin W; Zheng H; Shan B; Wu Y · The Journal of dermatology · 2018
    Meta-analysis764 participantsHair Health forSelenium
  59. Scientific opinion on the tolerable upper intake level for selenium.
    EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA); Turck D; Bohn T; Castenmiller J; de Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Peláez C; Pentieva K; Siani A; Thies F; Tsabouri S; Vinceti M; Aggett P; Crous Bou M; Cubadda F; Ciccolallo L; de Sesmaisons Lecarré A; Fabiani L; Titz A; Naska A · EFSA journal. European Food Safety Authority · 2023
    Systematic reviewHair Health forSelenium
  60. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  61. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  62. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  63. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  64. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
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  65. Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis.
    Lee S; Kim BJ; Lee CH; Lee WS · Journal of the European Academy of Dermatology and Venereology : JEADV · 2018
    Meta-analysis2,039 participants14 studies pooledHair Health forVitamin D
  66. Intralesional vitamin D3 in treatment of alopecia areata: A randomized controlled clinical trial.
    Rashad AF; Elgamal E; Fouda I · Journal of cosmetic dermatology · 2022
    Randomized trial60 participantsHair Health forVitamin D
  67. Vitamin D and its Analogs in Treatment of Mild to Moderate Alopecia Areata: Systematic Review and Meta-Analysis.
    Alsaati AA; Kaliyadan F; Alsaadoun D; Alzakry LM; Alzabadin RA; Hakami TH; Rubaian NFB · Indian dermatology online journal · 2025
    Meta-analysisHair Health forVitamin D
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    El Taieb MA; Hegazy EM; Ibrahim HM; Osman AB; Abualhamd M · Archives of dermatological research · 2020
    Randomized trial60 participantsHair Health forVitamin D
  69. Serum 25 hydroxyvitamin D in non-scarring alopecia: A systematic review and meta-analysis.
    Chen Y; Dong X; Wang Y; Li Y; Xiong L; Li L · Journal of cosmetic dermatology · 2024
    Meta-analysis10,670 participants23 studies pooledHair Health forVitamin D
  70. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  71. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
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    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
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    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
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    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
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    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
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    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
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    Semba RD; Muhilal; Scott AL; Natadisastra G; Wirasasmita S; Mele L; Ridwan E; West KP; Sommer A · The Journal of nutrition · 1992
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    Roy SK; Islam A; Molla A; Akramuzzaman SM; Jahan F; Fuchs G · European journal of clinical nutrition · 1997
    Randomized trial50 participantsImmunity forVitamin A
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    Coutsoudis A; Broughton M; Coovadia HM · The American journal of clinical nutrition · 1991
    Randomized trial60 participantsImmunity forVitamin A
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    Coutsoudis A; Kiepiela P; Coovadia HM; Broughton M · The Pediatric infectious disease journal · 1992
    Randomized trial60 participantsImmunity forVitamin A
  81. Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children.
    Long KZ; Santos JI; Estrada Garcia T; Haas M; Firestone M; Bhagwat J; Dupont HL; Hertzmark E; Rosado JL; Nanthakumar NN · The Journal of nutrition · 2006
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  82. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
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    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
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    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
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    Ernst MK; Evans ST; Techner JM; Rothbaum RM; Christensen LF; Onay UV; Biyashev D; Demczuk MM; Nguyen CV; Honda KS; McCormick TS; Tsoi LC; Gudjonsson JE; Cooper KD; Lu KQ · JCI insight · 2023
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    Bychinin MV; Klypa TV; Mandel IA; Yusubalieva GM; Baklaushev VP; Kolyshkina NA; Troitsky AV · Scientific reports · 2022
    Randomized trial110 participantsImmunity forVitamin D
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    Anitua E; Tierno R; Alkhraisat MH · Clinical nutrition (Edinburgh, Scotland) · 2022
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    Chen S; Ahmad B; Palanisamy UD; Hafid SRA; Selvaduray KR; Radhakrishnan AK · Nutrition research (New York, N.Y.) · 2026
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    Mahalingam D; Radhakrishnan AK; Amom Z; Ibrahim N; Nesaretnam K · European journal of clinical nutrition · 2011
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    Hemilä H; Virtamo J; Albanes D; Kaprio J · Chest · 2004
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    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
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    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
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    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
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    Jamilian M; Asemi Z · Annals of nutrition & metabolism · 2016
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    Kooshki F; Tutunchi H; Vajdi M; Karimi A; Niazkar HR; Shoorei H; Pourghassem Gargari B · Clinical and experimental pharmacology & physiology · 2024
    Systematic review33 studies pooledMetabolism Boost forChromium
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    Hu X; Wang W; Su X; Peng H; Tan Z; Li Y; Huang Y · PeerJ · 2023
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    San Mauro-Martin I; Ruiz-León AM; Camina-Martín MA; Garicano-Vilar E; Collado-Yurrita L; Mateo-Silleras Bd; Redondo Del Río Mde P · Nutricion hospitalaria · 2017
    Meta-analysis13 studies pooledMetabolism Boost forChromium
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    Zhang P; Chen K; He T; Guo H; Chen X · Nutrition & metabolism · 2022
    Randomized trial101 participantsMetabolism Boost forCoenzyme Q-10
  108. Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise.
    Diaz-Castro J; Mira-Rufino PJ; Moreno-Fernandez J; Chirosa I; Chirosa JL; Guisado R; Ochoa JJ · Food & function · 2021
    Randomized trial100 participantsMetabolism Boost forCoenzyme Q-10
  109. Effects of Coenzyme Q10 on Lipid, Glycemic, and Inflammatory Markers in Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Zhang Z; Liu Z; Geng Y; Huang Y; Hu R; Li F; Song Y; Zhang M · Journal of diabetes research · 2026
    Meta-analysis3,422 participants64 studies pooledMetabolism Boost forCoenzyme Q-10
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    Ahmadi Asouri S; Asemi R; Aghadavod E; Jamilian M · Annals of medicine and surgery (2012) · 2024
    Randomized trial40 participantsMetabolism Boost forCoenzyme Q-10
  111. Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial.
    Herter-Aeberli I; Cherkaoui M; El Ansari N; Rohner R; Stinca S; Chabaa L; von Eckardstein A; Aboussad A; Zimmermann MB · The Journal of nutrition · 2015
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    Zimmermann MB; Adou P; Torresani T; Zeder C; Hurrell RF · European journal of clinical nutrition · 2000
    Single-arm trial51 participantsMetabolism Boost forIodine
  113. Serum Iodine Concentration as a Biomarker for Individual Iodine Nutrition and Thyroid Function in Pregnant Women: A Cross-Sectional Study in Hubei Province.
    Xu M; Dai X; Wang Z; Guo C; Zhang B; Guo H · Public health nutrition · 2026
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    Zimmermann MB · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2002
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    Zimmermann M; Adou P; Torresani T; Zeder C; Hurrell R · The American journal of clinical nutrition · 2000
    Non-randomized trial109 participantsMetabolism Boost forIodine
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    Asemi Z; Jamilian M; Mesdaghinia E; Esmaillzadeh A · Nutrition (Burbank, Los Angeles County, Calif.) · 2016
    Randomized trial70 participantsMetabolism Boost forSelenium
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    Randomized trial70 participantsMetabolism Boost forSelenium
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    Karamali M; Dastyar F; Badakhsh MH; Aghadavood E; Amirani E; Asemi Z · Biological trace element research · 2021
    Randomized trial36 participantsMetabolism Boost forSelenium
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    Niu X; Zhang Y; Liu Y; Zhu Y; Fang B; Hu C; Xu X; Wang R; Sang Y; Zhang Q; Guo J · Frontiers in nutrition · 2026
    Randomized trial58 participantsMetabolism Boost forSelenium
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    Fazelian S; Rouhani MH; Bank SS; Amani R · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2018
    Meta-analysis351 participants7 studies pooledWeight Loss forChromium